ライフサイエンスコーパス: macula

1 c leakage, and 6 eyes had leakage within the macula.

2 n within the disc region associated with the macula.

3 R retinal disease and inability to image the macula.

4 ve microvasculature in 3 plexuses around the macula.

5 decline commences in the late 30s across the macula.

6 retinal disruption than those located in the macula.

7 ith AMD are not exclusive to the area of the macula.

8 al pigment epithelium (CHRRPE) involving the macula.

9 scotomas were more prevalent in the central macula.

10 TA) scans centered on the fovea and temporal macula.

11 iagnosed with arRP and pseudocoloboma of the macula.

12 with IRX1 preferentially expressed in fetal macula.

13 ging of the superior, inferior, and/or nasal macula.

14 red to patients with disease confined to the macula.

15 eral multiple early-onset yellow dots at the macula.

16 mporal margin of the coloboma closest to the macula.

17 ue architecture of the fovea and surrounding macula.

18 ateral symmetric multiple yellow dots at the macula.

19 to quantitate individual networks within the macula.

20 continuously across the central 3 mm of the macula.

21 nd retinal pigment epithelium atrophy in the macula.

22 d by advanced AMD and drusen temporal to the macula.

23 tered subretinal hemorrhages external to the macula.

24 ts of 52 highly myopic eyes with dome-shaped macula.

25 red with conventional structural loss in the macula.

26 us cavity, no longer casting a shadow on the macula.

27 eral retina in a single shot centered on the macula.

28 ss associated with geographic atrophy of the macula.

29 on and outer retinal streaks in the superior macula.

30 sess the impact of a vitreous opacity on the macula.

31 domain optical coherence tomography (OCT) of macula.

32 ed at the optic nerve and separated from the macula.

33 iber and ganglion cell layers at the central macula.

34 gs was not visible at any other level of the macula.

35 ents showed evenly distributed damage at the macula.

36 n and Muller glial distribution in the human macula.

37 CMD being a developmental abnormality of the macula.

38 was found in the central 1-mm region of the macula.

39 ns on OCT examination in clinically "normal" maculas.

40 uals/decade) at 15 eccentricities across the macula (0, 230 um, 460 um, 690 um, 1,150 um, 1,380 um an

41 temporal (14%), inferior (11%), and superior macula (5%) (P = .001).

42 er cracks were more prevalent in the central macula (51%) than in the nasal (19%), temporal (14%), in

43 vs. 33.8%, P < 0.001), tumor location in the macula (57.4% vs. 67.5%, P = 0.01), subretinal fluid on

44 iphery alone (10.1%), and both periphery and macula (57.4%).

45 circumpapillary RNFL (83/190; 43.68%) or the macula (57/190; 30.0%).

46 ferent types of retinal fluid in the central macula affect the reproducibility of choroidal thickness

47 examined, 81.1% had AMD-like changes in the macula alone (13.6%), periphery alone (10.1%), and both

48 sthesis was implanted successfully under the macula, although in 2 patients, it was implanted in unin

49 3 OCT angiography instruments in the central macula, an area where the superficial and deep vascular

50 2x9-mm structural OCT volume centered on the macula and a 6x6-mm OCTA scan centered on the optic nerv

51 it is only able to capture a limited view of macula and does not show leakage.

52 rformed on a 3 x 3-mm region centered on the macula and en face angiograms of the superficial and dee

53 By SD-OCT and OCT-A, thinning of the macula and flow voids in both the superficial and deep r

54 The macula and fovea located at the optical centre of the re

55 ral and functional traits typical of primate macula and fovea.

56 By comparison, average sensitivity in the macula and mid periphery declined by 0.38 and 0.61 dB/ye

57 and pigmentary abnormalities in the central macula and no evidence of macular fluid on routine OCT i

58 s primarily based on animal models having no macula and no fovea.

59 also for optimization of gene editing in the macula and of cone cell replacement in general.

60 , and 4) all thickness measurements from the macula and ONH (thickness GBC).

61 s (ONH GBC), 3) all VD measurements from the macula and ONH (vessel density GBC), and 4) all thicknes

62 GBCs that combine OCTA and OCT macula and ONH measurements can improve diagnostic accur

63 OCTA of the macula and ONH was obtained for a subset of patients enr

64 degree digital fundus images centered on the macula and optic disc of 213 patients were graded.

65 ong vitreous traction and adhesion above the macula and optic disc.

66 and optical coherence tomography imaging of macula and optic disc.

67 matous eyes with OCTA and OCT imaging of the macula and optic nerve head (ONH) were studied.

68 optical coherence tomography (SD OCT) of the macula and optic nerve head (ONH), infrared reflectance,

69 ively the possible structural changes of the macula and optic nerve head in the free eyes of unilater

70 etry and optical coherence tomography of the macula and optic nerve head.

71 We found primary cultured Muller cells from macula and peripheral retina display significant morphol

72 th AMD, RPE mtDNA damage was measured in the macula and peripheral sections from individual donors.

73 ne-expression differences between developing macula and periphery and between distinct populations of

74 y allows mapping of light sensitivity of the macula and provides topographic information on visual fu

75 When the effect on the macula and RNFL near the optic nerve disk is investigate

76 have bilateral outer retinal streaks in the macula and the superior peripheral retina on both ophtha

77 ed with extensive drusen accumulation in the macula and throughout the fundus, as well as with a high

78 hemorrhagic and exudative changes within the macula and/or peripapillary region leading to vision los

79 FHs involved the periphery, 83% involved the macula, and 71% involved multiple layers of the retina.

80 ant isoform in Bruch's membrane (BrM) of the macula, and factor H (FH).

81 the TECS protocol workup and OCT nerve, OCT macula, and FTF examination on the same day.

82 regions of the human visual system (retina, macula, and retinal pigment epithelium/choroid) reveals

83 ntrast sensitivity, light sensitivity in the macula, and rod-mediated dark adaptation.

84 the position of the lacquer crack within the macula, and the relationships between perforating sclera

85 Structural changes in the macula are associated with many ocular diseases, includi

86 e at one visit, despite achievement of a dry macula, are associated with retreatment at the next visi

87 changes, particularly outside of the central macula, are not well characterized in X-linked retinosch

88 s of adults older than 60 years with healthy maculas as determined by color fundus photography (CFP)

89 sel density were measured across the central macula at 1 and 3 hours after a 100 mg oral dose of sild

90 rior to diagnosis and chorioretinitis in the macula at presentation were associated with >/= 2 Snelle

91 ented areas suggestive of atrophy within the macula at some time during follow-up.

92 ased with age across the central 5 mm of the macula, but the greatest increase was found in the centr

93 more likely to demonstrate RRD involving the macula, but there was no difference between age groups i

94 greatest increases were found in the central macula C(1) regions and the smallest increases in the pe

95 angle alpha is the angular width between the macula center and the proximity of RNFL defect, and angl

96 ement, lesion growth, and involvement of the macula center.

97 ular edema (DME) involving the center of the macula (center-involved DME [CI-DME]) with visual acuity

98 n which dilated fundus photographs (disc and macula centered) were obtained and graded for the presen

99 Macula-centered 3D OCT images were segmented with a full

100 The macula-centered 45-degree photographs were graded twice

101 The concentric rings method consists of 6 macula-centered concentric rings divided into 12 segment

102 "macula-centered image(s) only" if only the macula-centered image of one or both eyes was gradable,

103 was gradable, and "unsuccessful" if neither macula-centered image was gradable.

104 53 (72%; 95% CI, 65-78) patients, success of macula-centered image(s) only in 47 (22%; 95% CI, 17-28)

105 ry (P = .093), and the frequency of gradable macula-centered image(s) only increased with increasing

106 ial" if both images of 1 eye were gradable, "macula-centered image(s) only" if only the macula-center

107 Macula-centered images were more often gradable in both

108 RNFL regions of the disc associated with the macula (central +/-8 degrees were delin eated.

109 group (II); a significant thinning of total macula, central fovea, ganglion cell layer (GCL), gangli

110 -related increases in FDs within the central macula confound the correlations between the ERs of GA a

111 o detection of structural progression in the macula consist of the magnitude of and the variable amou

112 st that abnormal CC perfusion throughout the macula contributes to disease progression in eyes with G

113 l participants underwent OCTA imaging of the macula covering a 3 x 3-mm area using OCTA software (Cir

114 and volume changes between visits with a dry macula ("D") and immediate preceding visits ("D-1") were

115 Optical coherence tomography of the macula demonstrated complete preservation of the inner s

116 ain optical coherence tomography through the macula demonstrated perifoveal outer retinal layers loss

117 r upregulation of NOS1beta expression in the macula densa affects sodium excretion and salt-sensitive

118 1 (NOS1)-dependent nitric oxide (NO) in the macula densa and blunting the tubuloglomerular feedback

119 a is a primary NOS1 isoform expressed in the macula densa and regulates the tubuloglomerular feedback

120 erences in glomerular tuft contractility and macula densa cell calcium handling were observed.

121 tion, sodium-glucose cotransport by SGLT1 on macula densa cells triggers the production of nitric oxi

122 We recently found that macula densa expresses alpha-, beta-, and gamma-splice v

123 ase 1 (NOS1), and NOS1beta expression in the macula densa increases on a high-salt diet.

124 merular cell granules and exhibit an altered macula densa morphology.

125 Furthermore, macula densa NO production was similar in the isolated p

126 It also suggests that the altered macula densa phenotype is related to the activity of the

127 tubuloglomerular feedback through increased macula densa sodium and chloride delivery, leading to af

128 was unable to rescue the abnormality seen in macula densa structure.

129 e induces tubuloglomerular feedback from the macula densa to increase GFR.

130 wherein increases in luminal glucose at the macula densa upregulate the expression and activity of N

131 ) senses increases in luminal glucose at the macula densa, enhancing generation of neuronal nitric ox

132 s of tubular glucose on NO generation at the macula densa, TGF, and GFR in wild-type and macula densa

133 Compared with control mice, mice with macula densa-specific knockout of all nitric oxide synth

134 In macula densa-specific NOS1 knockout mice, glucose had no

135 macula densa, TGF, and GFR in wild-type and macula densa-specific NOS1 knockout mice.

136 in vitro and stimulates NO generation at the macula densa.

137 e also showed that SGLT1 is expressed at the macula densa; in the presence of tubular glucose, SGLT1

138 flow metrics of all capillary layers in the macula following PRP, unrelated to macular edema or thic

139 uded the deep vascular plexus in the central macula for all 3 instruments.

140 ve fiber layer (RNFL), optic nerve head, and macula for assessing glaucoma progression.

141 nt between FA and OCTA scans centered on the macula for capillary nonperfusion (intraclass correlatio

142 ents were classified as either predominantly macula ganglion cell-inner plexiform layer (mGCIPL), pre

143 1) all macula VD and thickness measurements (Macula GBC), 2) all ONH VD and thickness measurements (O

144 A significantly thickened total macula, GCL, GCC, and pRNFL in study group (I) compared

145 One patient with end-stage disease in the macula had normal periphery results on the color images.

146 ably, cones from retinal organoids and human macula had similar single-cell transcriptomes, and so di

147 tal of 9.21% patients with clinically normal maculas had subtle pathology detected on OCT, but this s

148 Loss of cone photoreceptors in the human macula has the greatest impact on sight as these cells p

149 dent, canine, and feline models with no true macula have substantive limitations.

150 Description of HMM module-obtained macula images.

151 retinal detachment in 2 (12%), a dome-shaped macula in 1 (6%), a choroidal neovascularization-related

152 een patients underwent SD-OCT imaging of the macula in 2017.

153 ular pigment abnormalities were noted in the macula in 5 patients.

154 d deep capillary plexus (DCP) in the central macula in all 6 patients were compared with 5 normal sub

155 bnormalities in the perifoveal region of the macula in all eyes, whereas FA appeared normal in 9 of 1

156 planting a retinal prosthesis in the central macula in AMD patients [3, 4] leads to an intriguing sit

157 These should look beyond the central macula in Asian patients.

158 nd healthy controls underwent imaging of the macula in both eyes with a swept-source optical coherenc

159 l aging effects of the inner 6 layers of the macula in contrast to the minimum neuroretinal rim width

160 enrolled in the Ranibizumab for Edema of the Macula in Diabetes: Protocol 3 with High Dose (READ-3) s

161 served regions of cpRNFL associated with the macula in eyes with advanced glaucoma if there is a pres

162 ions could affect clinical evaluation of the macula in healthy patients and disease states.

163 nerve fiber layer around the optic disc and macula in patients with cerebral vein thrombosis (CVT) w

164 and analyze retinal light sensitivity of the macula in STGD1 using fundus-controlled perimetry (micro

165 possessing a visual streak similar to human macula-in the study of diabetic retinopathy and diabetic

166 e was significant thinning identified in the macula inferior inner, temporal inner, superior inner an

167 ons typically appear first in the perifoveal macula, initially sparing the foveal center, and over ti

168 NEER undergoing surgical repair with primary macula-involving retinal detachments.

169 f the raw B-scan images of both the RNFL and macula is critical to identify artifacts and true glauco

170 tenance of otolith tethering to the saccular macula is dependent on tectorin alpha (tecta) function,

171 The human macula is more susceptible than the peripheral retina to

172 To directly test a long-held belief that the macula is selectively damaged with AMD, RPE mtDNA damage

173 AMD patients the disease is localized to the macula, leaving the peripheral vision intact.

174 At the macula level, we achieved an area under the ROC of 93.83

175 The macula, located near the center of the retina in the hum

176 es were overlaid digitally based on disc and macula location onto stereographically projected UWF ima

177 ntral retinal degeneration of the vulnerable macula, marked by the development of pseudocysts.

178 evaluating involvement of the center of the macula may differ, probably because of macular pigmentat

179 entially affects perfusion in the SVC in the macula more than the deeper plexuses.

180 By contrast, the cone-rich macula of a nonhuman primate (NHP) closely mirrors that

181 entative histologic section from the central macula of a normal eye was used as an exemplar.

182 o evaluate segmentation accuracy of a normal macula of a white man in his 60s as an emblematic exampl

183 al and deep retinal capillary density in the macula of patients with amblyopia.

184 ndomized clinical trial (Lutein Influence on Macula of Persons Issued From AMD Parents [LIMPIA]) with

185 ents that are centered on the foveola in the macula of the human eye.

186 Fundoscopy revealed an inferior macula off rhegmatogenous retinal detachment.

187 h SF6 tamponade with macula-on (34 eyes) and macula-off (28 eyes) RRD preoperatively.

188 ely in 54% of the patients in the group with macula-off and in 32% of the patients with macula-on RRD

189 ort significant improved visual outcomes for macula-off ARD.

190 Macula-off detachment (-0.44 logMAR, P < .001) and clock

191 r macula-on detachments versus 6.8 lines for macula-off detachments (P = 0.027) at final follow-up (a

192 (HFE) of five patients (mean age 59.8 years, macula-off duration 0.5 days to 5.5 days) OBSERVATION PR

193 es (HFE) of 5 patients (mean age 59.8 years, macula-off duration 0.5 days to 5.5 days).

194 echnique, we present a 13-year-old girl with macula-off exudative retinal detachment secondary to Vog

195 onths of the follow-up both in macula-on and macula-off group.

196 ) between follow-up examinations only in the macula-off group.

197 acular region in OCT both with macula-on and macula-off group.

198 Macula-on and macula-off patients were assigned to intervention group

199 ion: Five eyes after vitrectomy with gas for macula-off retinal detachment (retinal detachment eyes,

200 ION: Five eyes after vitrectomy with gas for macula-off retinal detachment (retinal detachment eyes,

201 significantly increased risk of developing a macula-off retinal detachment in patients who did not un

202 tional changes of cones after vitrectomy for macula-off retinal detachment.

203 tional changes of cones after vitrectomy for macula-off retinal detachment.

204 Macula-off retinal detachments showed significantly impr

205 ide (SF6) gas tamponade due to macula-on and macula-off rhegmatogenous retinal detachment (RRD) durin

206 ents who underwent pars plana vitrectomy for macula-off rhegmatogenous retinal detachment were includ

207 Fourteen eyes with macula-off RRD (with fovea on and off) that achieved ret

208 (PSF group) were compared with 62 eyes with macula-off RRD (with fovea on and off) that did not demo

209 VA outcomes were limited by the high rate of macula-off RRD and the underlying macular disease.

210 %) after surgery (equally with macula-on and macula-off RRD) showed morphological changes in OCT in t

211 In eyes with macula-off RRD, SSAS was 81% in eyes treated with PPV an

212 ination, and mild disturbance of the central macula on detailed retinal imaging.

213 rwent successful PPV with SF6 tamponade with macula-on (34 eyes) and macula-off (28 eyes) RRD preoper

214 during the 6 months of the follow-up both in macula-on and macula-off group.

215 anges in the macular region in OCT both with macula-on and macula-off group.

216 Macula-on and macula-off patients were assigned to inter

217 lfur hexafluoride (SF6) gas tamponade due to macula-on and macula-off rhegmatogenous retinal detachme

218 of 62 eyes (47%) after surgery (equally with macula-on and macula-off RRD) showed morphological chang

219 sit before diagnosis of RRD was 1.0 line for macula-on detachments versus 6.8 lines for macula-off de

220 0 COVID-19 pandemic were less likely to have macula-on disease and more likely to delay seeking treat

221 For macula-on or split cases, SB had significantly better vi

222 Ninety-eight patients with macula-on RD were included.

223 nts divided among 3 cohorts of patients with macula-on RD were included.

224 resses during interruptions in patients with macula-on RD.

225 d positioning is prescribed to patients with macula-on retinal detachment (RD) to prevent RD progress

226 of conjunctival erosion and 1 inferotemporal macula-on retinal detachment, which were successfully re

227 outcome was the proportion of patients with macula-on RRD at presentation.

228 Significantly fewer patients demonstrated macula-on RRD in the 2020 cohort (20/82 patients [24.4%]

229 In eyes with macula-on RRD, SSAS was 88% in eyes treated with PPV and

230 h macula-off and in 32% of the patients with macula-on RRD.

231 us (P = 0.02) were independent predictors of macula-on status in the 2020 cohort.

232 claim that the disease is panretinal and not macula only.

233 OCT of the macula, optic nerve head, and peripapillary retina.

234 ome was influenced by tumor growth under the macula or macular ischemia.

235 Macula pigment 3D topography was evaluated using specula

236 xanthophyll substrates, including the unique macula pigment meso-zeaxanthin.

237 ide the 6-mm diameter circle centered at the macula), presence of peripapillary RPD, pattern of RPD,

238 R for CM (with 100% of the dose given to the macula) present major changes at both plexuses but also

239 robustly characterizing the structure of the macula, probing retina signaling pathways, and conductin

240 ny/increased intraocular pressure (IOP); (7) macula pucker/epiretinal membrane; (8) cataract; and (9)

241 In unaffected regions of the macula, qAF was calculated within predetermined circular

242 and the smallest increases in the peripheral macula R(2.5) regions.

243 tatistics from retinal thickness maps of the macula region.

244 ography (SDOCT) images of the optic disc and macula regions at baseline and at 3 and 6 months.

245 cs for several structures (i.e., optic disc, macula, retina, globe, lens, ciliary body) correlated wi

246 OCT macula scans were obtained by Heidelberg Spectralis, and

247 However, the pigeon retina and the human macula share a number of structural and functional prope

248 SDOCT imaging of the macula showed decreased choroidal thickness in all eyes.

249 The macula showed RNFL thinning of -6.18 mum (-8.07 to -4.28

250 The near-maximum dose to the macula showed the strongest correlation with VA deterior

251 In the macula, significantly thinner RNFL (nasally), ganglion c

252 mates are the only mammals to possess a true macula similar to humans, and spontaneously develop drus

253 The preceding RRD was macula-sparing for 6 of 9 patients; all of them involved

254 of race/ethnicity, age, gender, lens status, macula status, and lattice degeneration status did not v

255 Angiographic findings in dome-shaped macula suggest the choroid as a target for possible trea

256 eye disease characterized by lesions in the macula that can resemble the wings of a butterfly.

257 itially obtained VA gain and thinning of the macula that were maintained for two years, but were lost

258 ion and metabolism of these nutrients in the macula, the best way to measure MPOD, and the clinical b

259 decrease with age in Bruch's membrane of the macula, the decreased heparin recognition of SCR7(H402)

260 As only primates have a macula, the nonhuman primate (NHP) models have a crucial

261 ect of oral contraceptive pills (OCP) on the macula, the retinal nerve fiber layer (RNFL), the gangli

262 Tomography (SD-OCT) was used to evaluate the macula, the RNFL, the GCL, and the CT.

263 the human vestibular endorgan, the utricular macula, using postmortem specimens from individuals with

264 constituting the BLB in the human vestibular macula utricle from normal and Meniere's disease.

265 our GBCs were evaluated that combined 1) all macula VD and thickness measurements (Macula GBC), 2) al

266 domain optical coherence tomography (SD-OCT) macula volume scans centered at the fovea and fundus aut

267 Predictive model of preserved macula vs. GA/fibrotic scar showed sensibility of 77.78%

268 by pro re nata injections until a fluid-free macula was achieved on optical coherence tomography.

269 anti-VEGF injections were given until a dry macula was achieved, and treatment deferred.

270 e co-prevalence of artifacts in the RNFL and macula was assessed, as well as the association of clini

271 The macula was attached in 45% eyes, and grade C proliferati

272 At the time of RRD diagnosis, the macula was attached in 9 patients (37.5%).

273 hy (OCT) imaging of the optic nerve head and macula was conducted in patients and healthy control sub

274 larization-dependent properties of the human macula was extended by incorporating neuronal adaptation

275 The macula was found to be detached in 118 cases (80.3%) and

276 The central macula was imaged with the Optovue RTVue XR Avanti using

277 The center of the macula was involved in 51% of color photographs and 56%

278 Serous RD in dome-shaped macula was likely caused by choroidal vascular changes,

279 e for vitreous traction on the optic disc or macula was seen in any eye.

280 The macula was thicker (514+/-85 mum vs. 257+/-59 mum; P < 0

281 ll-depth retinal projections centered at the macula were analyzed for multiple metrics including fove

282 elay of diagnosis and chorioretinitis in the macula were associated with visual loss in these patient

283 ssociated with less probability of preserved macula were diagnosis in 2009, older age, worse vision,

284 Patients with unilateral BRVO involving the macula were enrolled.

285 ary network and the vascular plexuses in the macula were evaluated with OCT angiography.

286 Cystoid fluid collections in the macula were found in 50% of RP patients.

287 0/32 to 20/320 and DME involving the central macula were randomly assigned to intravitreous ranibizum

288 nd retinal ganglion cell layer (RGCL) in the macula were segmented using an ETDRS grid.

289 ty-five eyes with massive SRHs involving the macula were studied with initial VAs from light percepti

290 ds that are highly concentrated in the human macula, where they protect the eye from oxidative damage

291 al retina, whereas cones are enriched in the macula, which is responsible for central vision and visu

292 the relative anatomical preservation of the macula, which suggested the presence of a therapeutic wi

293 ease, one developed tractional detachment at macula while the other, an epiretinal membrane.

294 In macula-wide analyses, spectral-domain (SD) optical coher

295 etinal layers reflect the development of the macula with age.

296 s and a large yellowish lesion involving the macula with an overlying sub-retinal detachment, extendi

297 ular pseudodrusen were found commonly in the macula with relative sparing of the fovea and also were

298 e retinal arteries around the optic nerve or macula with severe vision loss.

299 choroidal effusion and retinal striae at the macula with the increase in macular thickness was observ

300 weeks in eyes with DME involving the central macula with vision impairment.