ライフサイエンスコーパス: macular hole

1 12 months in patients affected by idiopathic macular hole.

2 adhesion can lead to pathologic traction and macular hole.

3 matic vitreomacular adhesion with or without macular hole.

4 the pathogenesis and treatment of idiopathic macular hole.

5 , macular folds, angle-closure glaucoma, and macular hole.

6 spots, area where endolaser was applied, and macular hole.

7 togenous retinal detachment and a coexisting macular hole.

8 raphy was used to observe the closure of the macular hole.

9 al characterization of different subtypes of macular hole.

10 r-acting gases in the surgical management of macular hole.

11 %) operated eyes had complete closure of the macular hole.

12 ration was seen in 73% of eyes with lamellar macular hole.

13 e eyes additionally showed an outer lamellar macular hole.

14 a control group with epiretinal membrane or macular hole.

15 vitreomacular traction and a full-thickness macular hole.

16 n the fellow eye and 50% developed bilateral macular holes.

17 maps were identified before the formation of macular holes.

18 anes (ERMs) were present in 71% of eyes with macular holes.

19 r holes, reopened macular holes, and chronic macular holes.

20 e obtained in patients with acute idiopathic macular holes.

21 itreous detachment in the natural history of macular holes.

22 l approach, and surgical outcomes of stage 2 macular holes.

23 ILM) peeling for the treatment of idiopathic macular holes.

24 ver, this approach lacks efficacy for larger macular holes.

25 M with prominent inner retinal thickening or macular holes.

26 ctomy and ILM peeling for primary idiopathic macular holes.

27 enty-two patients with persistent or chronic macular holes.

28 during the study, of which 12 were secondary macular holes.

29 ar scar 0.37%, retinal vein occlusion 0.50%, macular hole 0.20%, retinitis pigmentosa 0.12%. and reti

30 age-related macular degeneration (AMD) (12), macular hole (10), presumed ocular histoplasmosis syndro

31 ed from 25 eyes of 25 patients with lamellar macular holes (11 eyes) and macular pseudoholes (14 eyes

32 ular schitic cavity (79.63%), Outer Lamellar Macular hole (31.48%), Pachychoroid vessels (35.19%), Ou

33 Measurable F1 scores were obtained for macular hole (36.4%; 95% CI, 0-71.4), pigment epithelial

34 ic VMA/VMT, including when associated with a macular hole 400 mum or smaller, were studied.

35 beneficial in challenging surgeries such as macular holes accompanied with a detached retina.

36 The study was prompted by the observation of macular hole after an inadvertent BB shot in a previousl

37 st description of spontaneous closure of the macular hole after vitrectomy for vitreomacular traction

38 and may help the spontaneous closure of the macular hole after vitrectomy for vitreomacular traction

39 nd 1(2.6%) patient each had a full-thickness macular hole, an intraretinal cyst, and photoreceptor la

40 Of the remainder, 12% developed a macular hole and 8% elected to proceed with surgery for

41 19.4 months between the first and fellow eye macular holes and a male-to-female ratio of 1:2.42.

42 onates within the orbit and can explain both macular holes and optic nerve damage after ocular PBI.

43 ecimens were removed from 10 eyes with small macular holes and vitreomacular traction during vitrecto

44 th both tractional and degenerative lamellar macular holes and were classified as mixed lesions.

45 al thickening), 9 into ERM group 3 (ERM with macular hole), and 10 into ERM group 4 (full thickness m

46 d vitrectomy, inverted ILM inserted into the macular hole, and air-fluid exchange.

47 plications (branch retinal artery occlusion, macular hole, and corneal decompensation).

48 us from eyes obtained after death, eyes with macular hole, and eyes with proliferative diabetic retin

49 of traction), progression to full-thickness macular hole, and surgical intervention were analyzed.

50 proliferative retinopathy, retinal lesions, macular holes, and cataract surgery were confirmed.

51 re useful for failed macular holes, reopened macular holes, and chronic macular holes.

52 cystoid macular edema, epiretinal membrane, macular holes, and external limiting membrane, ellipsoid

53 Idiopathic full-thickness macular holes are visually disabling with a prevalence o

54 wly developed area-based indices such as the macular hole area index (MAI), macular hole tissue area

55 for PDR and of 52 non-diabetic patients with macular holes as controls were studied.

56 We characterized macular hole-associated epiretinal proliferation (MHEP)

57 eous detachment and nonsurgical closure of a macular hole at 28 days, avoidance of vitrectomy, and ch

58 ty-eight consecutive patients with traumatic macular holes at a single tertiary referral center were

59 hole after fluid-gas exchange had a stage IV macular hole before the primary vitrectomy and a hole si

60 that classically is associated with lamellar macular holes, but its prevalence and association with f

61 rgone successful vitrectomies for idiopathic macular holes by a single surgeon with postoperative fol

62 Full-thickness macular hole can cause central vision loss, and outcomes

63 re invited to submit clinical details of all macular hole cases receiving surgery.

64 ng membrane flap techniques and achieved 90% macular hole closure and 90% retinal reattachment rates.

65 The main outcomes were primary macular hole closure and postoperative visual acuity at

66 (ILM) peeling, and gas tamponade to promote macular hole closure and restore retinal integrity.

67 Idiopathic macular hole closure could be delayed to beyond 1 year f

68 ole index (DHI), hole form factor (HFF), and macular hole closure index (MHCI), as well as newly deve

69 86%-97%), while the long-term full thickness macular hole closure rate was 72% (95% CI: 55%-85%).

70 The primary retinal reattachment rate and macular hole closure rate were 100% (11/11) after initia

71 urements were the retinal reattachment rate, macular hole closure rate, and final postoperative best-

72 axial length, retinal reattachment rate, and macular hole closure rate.

73 Macular hole closure rates were highest in the combined

74 Retinal reattachment rates, macular hole closure rates, functional outcomes, and com

75 Further studies are required to evaluate macular hole closure rates, visual outcomes, and retinal

76 gh retinal reattachment rates, and favorable macular hole closure rates.

77 hieves favorable anatomical reattachment and macular hole closure rates.

78 The rate of macular hole closure was 95.0% (2214/2330).

79 Primary macular hole closure was achieved in 143 of 145 (99%) ca

80 Macular hole closure was achieved in all patients in bot

81 Macular hole closure was achieved with a single surgical

82 Macular hole closure with one surgery was achieved in 10

83 graphy examination was performed to document macular hole closure.

84 clusively, and not to epiretinal membrane or macular hole codes.

85 The treatment of macular hole continues to evolve as modifications to the

86 , macular hole tissue area index (MTAI), and macular hole cystoid space area index (MCSAI), were reco

87 In one patient, an asymptomatic macular hole developed, and although the occurrence was

88 Three-weeks later, a full thickness macular hole developed, and repeat surgery was performed

89 ventful phaco-vitrectomy to treat a complete macular hole, developing macular phototoxicity in the po

90 Of the 436 eyes, macular hole development occurred in 42 eyes (9.6%).

91 This report reviews current concepts of macular hole development, focusing on the pathoanatomy,

92 patients: healthy individuals and those with macular hole, diabetic macular edema, central serous cho

93 ed macular degeneration, retinal detachment, macular hole, diabetic retinopathy, uveitis, and cystoid

94 on without release of traction or closure of macular holes during follow-up.

95 Inverted ILM insertion into a macular hole effectively helps close the macular hole in

96 iabetic retinopathy, retinal vein occlusion, macular hole, epiretinal membrane, macular degeneration,

97 These conditions include macular holes, epiretinal membranes, retinal detachments

98 s support recommending FDP for patients with macular holes exceeding 400 mum pending further investig

99 that the effect may be more substantial for macular holes exceeding 400 mum.

100 We present a case of a macular hole formation and its spontaneous closure after

101 The incidence of postoperative macular hole formation was significantly lower (OR = 0.1

102 s the primary pathogenic event in idiopathic macular hole formation.

103 avoidance of excessive foveal stretching and macular hole formation.

104 on syndrome (VMT) (n = 3) and full thickness macular hole (FTMH) (n = 3), were also collected.

105 of late closure of idiopathic full-thickness macular hole (FTMH) after vitrectomy with the inverted i

106 al VMA at day 28, nonsurgical full-thickness macular hole (FTMH) closure at month 6, and categoric im

107 lopathies encountered were: a full-thickness macular hole (FTMH) in 4 eyes, a premacular subhyaloid h

108 ear-old woman who sustained a full-thickness macular hole (FTMH) in the right eye following accidenta

109 Full-thickness macular hole (FTMH) is a rare complication in retinitis

110 Full-thickness macular hole (FTMH) is defined as a foveal lesion with i

111 MH closure, and postoperative full-thickness macular hole (FTMH) rates between ST and FE; no comparat

112 and functional success after full-thickness macular hole (FTMH) surgery is explored in this meta-ana

113 es and the occurrence rate of full-thickness macular hole (FTMH) were studied in both groups.

114 presence and minimum width of full thickness macular hole (FTMH), and presence of epiretinal membrane

115 f symptomatic VMA, closure of full-thickness macular hole (FTMH), mean change from baseline in best-c

116 3 were identified as having a full-thickness macular hole (FTMH).

117 eomacular traction, including full-thickness macular hole (FTMH).

118 Eyes with full-thickness macular hole (FTMH, 12/72 eyes, 16.7%) displayed a "sunf

119 evalence and association with full-thickness macular holes (FTMH) have not been well described.

120 ts over 50 years with primary full-thickness macular holes (FTMH).

121 gas tamponade for idiopathic full-thickness macular holes (FTMHs) and to explore differential treatm

122 l detachment, and lamellar or full-thickness macular holes (FTMHs).

123 oup 3, n = 10) and an epiretinal membrane or macular hole group (group 4, n = 10).

124 y higher compared to baseline, except in the macular hole group (p = 0.103).

125 Eyes that developed a macular hole had a smaller baseline adhesion diameter th

126 r three weeks showed that the full-thickness macular hole had spontaneously closed.

127 itrectomy and ILM peeling for full-thickness macular hole has several major limitations.

128 the pathogenesis and evolution of idiopathic macular holes has developed.

129 rgoing surgery for idiopathic full-thickness macular holes (iFTMHs) by means of an individual partici

130 ard ILM peeling in idiopathic full-thickness macular holes (iFTMHs) remains unclear.

131 Full-thickness idiopathic macular hole (IMH) usually causes serious visual deformi

132 embrane flap (i-ILMF) surgery for idiopathic macular hole (IMH).

133 rom control subjects (n = 4) with idiopathic macular holes (IMH) and eyes from test subjects (n = 12)

134 changed perifoveal function in 1 patient and macular hole in 1 patient suggest foveal vulnerability t

135 V included ERM in 57 (46.3%), full thickness macular hole in 57 (46.3%) and lamellar macular hole in

136 ness macular hole in 57 (46.3%) and lamellar macular hole in 9 (7.3%) patients.

137 laucoma (IOP = 25 mmHg) and a full thickness macular hole in his right eye, underwent ab-interno Xen

138 o a macular hole effectively helps close the macular hole in MH-associated RD in high myopia.

139 he fellow eye at the time of presentation of macular hole in the first eye.

140 n resolved vitreomacular traction and closed macular holes in significantly more patients than did in

141 clinical course, specific dimensions of the macular hole, including diameters, height, configuration

142 al MHs with smaller minimal diameter, higher macular hole index (MHI) and higher tractional hole inde

143 Preoperative OCT measurements of macular hole index (MHI), traction hole index (THI), hol

144 ements and calculated indices, including the macular hole index (MHI), tractional hole index (THI), d

145 In sealed macular holes, intact ELMs predicted good postoperative

146 Full-thickness macular hole is primary if caused by vitreous traction o

147 Full-thickness macular hole is subclassified by size of the hole as det

148 revision of the current concept of lamellar macular holes is needed.

149 taneous closure of full-thickness idiopathic macular holes is still not completely understood.

150 -sparing (FS) peeling techniques in lamellar macular hole (LMH) surgery.

151 evolutional processes of idiopathic lamellar macular hole (LMH) were studied with spectrum domain opt

152 eristics and response to surgery of lamellar macular holes (LMHs) with and without lamellar hole-asso

153 ing a variety of retinal diseases, including macular holes, macular edema, and central serous chorior

154 ociated epiretinal proliferation of lamellar macular holes mainly consisted of fibroblasts and hyaloc

155 urs in the macular area and a full-thickness macular hole may develop.

156 Degenerative and tractional lamellar macular holes may be 2 distinct clinical entities.

157 Patients with bilateral macular holes may consider undergoing bilateral macular

158 radial scanning in the setting of suspected macular holes may lead to a delay in surgical treatment,

159 LM removal in the treatment of large stage 4 macular hole (MH) > 400 mum and to evaluate reconstructi

160 plana vitrectomy and phacoemulsification for macular hole (MH) and epiretinal membrane (ERM).

161 -RPE granular deposits was correlated to the macular hole (MH) characteristics and SD-OCT markers of

162 outer retinal attenuation and full-thickness macular hole (MH) closure.

163 and reproductive risk factors for idiopathic macular hole (MH) development using data provided by the

164 G dye to repair an idiopathic full-thickness macular hole (MH) in his right eye.

165 To investigate the risk of primary macular hole (MH) in the fellow eye, and to evaluate bas

166 ical technique for successful full-thickness macular hole (MH) repair.

167 termining which factors influence idiopathic macular hole (MH) size is important because it is a majo

168 OVD to stabilize inverted ILM flap onto the macular hole (MH) were reviewed.

169 e (ILM) flap technique and ILM insertion for macular hole (MH) without retinal detachment in eyes wit

170 ere graded for vitreomacular traction (VMT), macular hole (MH), and epiretinal membrane (ERM) accordi

171 Macular hole (MH)-related RD accounted for 57% of cases

172 Crude incidence of macular hole (MH).

173 endolaser, for retinal detachment (RD), and macular hole (MH).

174 eatment of the epiretinal membrane (ERM) and macular hole (MH).

175 inal VA, visual gain, and time to closure of macular hole (MH).

176 nitive workload and the surgical outcomes of macular hole(MH) surgery performed on a 3D versus a Conv

177 Idiopathic macular holes (MHs) are a cause of decreased vision amon

178 Macular holes (MHs) are a leading cause of visual impair

179 lability on the management of full-thickness macular holes (MHs) is important for vitreoretinal surge

180 ap techniques are used for the management of macular holes (MHs).

181 noperated eyes, only 1 eye with the smallest macular hole (minimum diameter: 168 mum) closed spontane

182 retinal detachment (n = 14), full-thickness macular hole (n = 11), rhegmatogenous retinal detachment

183 vitreous hemorrhage (n = 40), full-thickness macular hole (n = 33), recurrent proliferative vitreoret

184 e or giant retinal tears (n = 1167), and (5) macular holes (n = 153).

185 (RR, 0.43; 95% CI, 0.25-0.73; P = 0.002) and macular hole nonclosure or reopening (RR, 0.18; 95% CI,

186 Symptomatic Vitreomacular Adhesion Including Macular Hole (OASIS) trial was designed to evaluate the

187 stoid macular edema (CME), macular scarring, macular hole, optic neuropathy, or macular ischemia.

188 o a disorder of the vitreomacular interface (macular hole or epimacular membrane).

189 eneration (OR, 0.75; 95% CI, 0.68-0.82), and macular hole or epiretinal membrane (OR, 0.55; 95% CI, 0

190 Patients due to undergo PPV for either macular hole or epiretinal membrane were recruited.

191 or vitreomacular interface disorders (either macular hole or epiretinal membrane), 1 patient had vitr

192 d unless patients developed a full-thickness macular hole or required surgical intervention for sympt

193 thogenesis and natural history of idiopathic macular holes over the last 10 years has led to a more o

194 ter PPV for epiretinal membrane (p = 0.555), macular hole (p = 0.695), and vitreous hemorrhage (p = 0

195 l procedures for an epiretinal membrane or a macular hole performed in France from January 1, 2006 to

196 es in pathogenesis in a subgroup of lamellar macular holes presenting lamellar hole-associated epiret

197 agnosis, follow-up, and better management of macular hole-prone patients.

198 ng may not be necessary for acute idiopathic macular holes, provided a complete posterior vitreous de

199 tissues, such as the optic disc, fovea, and macular hole reached mean AUPR values of 0.928 +/- 0.013

200 were not found to be associated with risk of macular hole recurrence.

201 Macular hole-related RD carried a slightly worse prognos

202 Macular hole-related RD comprised 33% of RD cases.

203 Macular hole-related RD comprises one third of RD cases

204 peeling and endolaser are useful for failed macular holes, reopened macular holes, and chronic macul

205 Macular hole reopening occurred in 7 eyes (8.0%).

206 presumed (the eye laterality was not coded) macular hole reoperations within 2, 3, and 12 months wer

207 -term effects of retinal phototoxicity after macular hole repair surgery using xenon endolight illumi

208 ted techniques for retinitis pigmentosa with macular hole result in excellent visual and anatomic out

209 ing membrane (ILM) flap for the treatment of macular hole retinal detachment (MHRD).

210 here is no consensus regarding management of macular hole retinal detachment (MHRD).

211 ese include vitreomacular traction syndrome, macular hole, retinoschisis, macular edema, central sero

212 ular edema (ROR = 3.87, 95% CI = 1.89-7.92), macular hole (ROR = 20.90, 95% CI = 2.65-165.01), and pa

213 (RR 13.1), retinal vein occlusion (RR 12.9), macular hole (RR 7.7), and epiretinal membrane (RR 5.7).

214 m eyes of 10 deceased donors and 9 eyes with macular holes served as control specimens.

215 Every patient with a macular hole should be given the opportunity to improve

216 Outer Lamellar Macular holes showed excellent regression after surgery

217 pe and MH size specifically in the RCTS with macular hole size > 400 mum (MD = -0.13, 95% CI = -0.17

218 to explore differential treatment effects by macular hole size and FDP duration.

219 The main outcome measures were macular hole size, FAF patterns, retina outer segment fr

220 oninferiority was demonstrated regardless of macular hole size.

221 tom duration of less than 1 year and earlier macular hole stage yielded the best visual acuity after

222 en men (P = 0.001), and showed more advanced macular hole stages than those without MHEP (P = 0.010).

223 aphy has clarified the pathoanatomy of early macular hole stages, beginning with a foveal pseudocyst

224 Records of 23465 macular hole surgeries among 20 764 patients were analyz

225 enous retinal detachment was associated with macular hole surgery (incidence rate ratio [IRR], 1.76;

226 Surgical closure rate was 89% with the first macular hole surgery and 98.8% with the second surgery.

227 All patients underwent bilateral macular hole surgery at a single-site, multisurgeon cent

228 stic factors for postoperative outcome after macular hole surgery in a retinal referral clinic in Nor

229 Lamellar macular hole surgery involves pars plana vitrectomy with

230 improves the anatomic and visual outcomes of macular hole surgery modestly and indicates that the eff

231 Standard macular hole surgery seems to be effective in gaining an

232 between 2006 and 2016, and it was higher for macular hole surgery than for epiretinal membrane surger

233 ular holes may consider undergoing bilateral macular hole surgery to improve visual acuity.

234 Macular hole surgery was performed alone or in combinati

235 Macular hole surgery was performed by 3 vitreoretinal su

236 Patients with macular hole surgery were identified.

237 the anatomical and visual outcomes following macular hole surgery with 2 cc pure (100 %) sulfur hexaf

238 Macular hole surgery with 2 cc pure SF6 gas tamponade ac

239 Macular hole surgery with 3-day postoperative positionin

240 orkload is markedly reduced while performing macular hole surgery with a 3D viewing system.

241 Macular hole surgery with broad ILM peeling, 20% SF6 gas

242 ents were identified who underwent bilateral macular hole surgery with ILM peeling without other visi

243 iting membrane (ILM) flaps versus peeling in macular hole surgery, considering hole size, symptom dur

244 Prior to macular hole surgery, his visual acuity in the right eye

245 pportunity to improve his or her vision with macular hole surgery.

246 r epiretinal membrane surgery, and 3.43% for macular hole surgery.

247 s are typically used as tamponading agent in macular hole surgery.

248 ed for 7 clinically important outcomes after macular hole surgery: closure rate, visual acuity (VA) i

249 ing stage at baseline and longer duration of macular hole symptoms (P = 0.032) and worse visual acuit

250 ent that was diagnosed with a full-thickness macular hole that spontaneously closed after the resolut

251 Not all macular holes that fail to close in the early postoperat

252 retrospective study of eyes with idiopathic macular holes that underwent 23-gauge pars plana vitrect

253 cation of Diseases, 10th Revision, code for "macular hole" that underwent PPV, and demonstrated all O

254 ped acute foveal thinning, and 1 developed a macular hole); the rest showed no gross changes in fovea

255 In lamellar macular hole, the morphologic features of the foveal pho

256 Despite successful anatomical closure of the macular hole, the patient's visual prognosis remained gu

257 structure connecting the inner walls of the macular hole, thus connecting the remnants of the Muller

258 s such as the macular hole area index (MAI), macular hole tissue area index (MTAI), and macular hole

259 he optimal management of pediatric traumatic macular holes (TMH) is unclear from lack of prospective

260 e increased the closure rates for idiopathic macular holes to more than 90%.

261 y, and the other 13 for epiretinal membrane, macular hole, vitreous opacities, or dislocated intraocu

262 Nine-months after the second surgery the macular hole was closed with near complete resorption of

263 In OCT imaging, the presence of lamellar macular hole was defined according to the following find

264 verted ILM flap technique, especially if the macular hole was not covered with the ILM flap.

265 A macular hole was noted only in one eye (0.6%).

266 Nonsurgical closure of macular holes was achieved in 40.6% of ocriplasmin-injec

267 Fifty-four patients with lamellar macular hole were enrolled in the study.

268 Two different subtypes of lamellar macular hole were identified: tractional and degenerativ

269 Thirty eyes of 30 patients with idiopathic macular hole were included in the study.

270 In this sample, reoperations for macular hole were performed at low rates.

271 If a neovascularization or macular hole were present, bilateral occurrence was freq

272 consecutive patients diagnosed with lamellar macular hole were reviewed.

273 gical procedures for epiretinal membranes or macular holes were recorded in France.

274 eling revealed glial cells and hyalocytes in macular holes, whereas myofibroblasts were predominant i

275 l neurosensory detachment and outer lamellar macular hole, which were associated with significant mid

276 ogenous retinal detachment with a coexisting macular hole who underwent vitrectomy with internal limi

277 Macular hole with retinal detachment (MHRD) often presen

278 surgical manipulation was used to cover the macular hole with the ILM flap.

279 Vitrectomy may be successful in closing the macular hole with visual acuity improvement in most of t

280 ravitreous ocriplasmin injection for a small macular hole with vitreomacular adhesion.

281 Successful closure rates of bilateral macular holes with ILM peeling in this series are better

282 For macular holes with retinal detachment, SPOT successfully

283 le), and 10 into ERM group 4 (full thickness macular hole without ERM and vitreomacular traction with