ライフサイエンスコーパス: main chain

1 of bonds orthogonal to an elongated polymer main chain.

2 onfiguration between the side chains and the main chain.

3 arity primarily due to the trajectory of the main chain.

4 carbene (NHC) orthogonally connected to its main chain.

5 ffects of a bulkier chiral side group on its main chain.

6 15), while the remaining contacts are to the main chain.

7 dergoing a change in the overall fold of the main chain.

8 nor-acceptor building block into the polymer main chain.

9 Tra1 enabled tracing of the majority of its main chain.

10 the redox state of ferrocene in the polymer main chain.

11 group attached to the CoNP colloidal polymer main chain.

12 nhancing electronic delocalization along the main-chain.

13 Phe(B25), which mimics the Phe(B24) side and main chains.

14 nyl-alpha-aminoamide-substituted polypeptide main chains.

15 table to the formation of polarons along the main chains.

16 he hydrogen-bonding interactions between the main chains.

17 IR probes, such as main chain (13)C=(18)O, have been widely employed to obt

18 by insertion of a single amino acid into the main chain, adjacent to cysteine 147.

19 a canonical conformation in which the ligand main chain adopts an extended beta-strand conformation b

20 sp174 form ion-pairing interactions with the main chain alpha-carboxyl and alpha-amino-groups, respec

21 minus to investigate whether the polypeptide main chain amide bonds in the N-terminus of SDF-1alpha p

22 ng and internalization is dependent upon the main chain amide bonds in the N-terminus of SDF-1alpha.

23 Thr(352), and stabilize an oxyanion hole via main chain amide hydrogen bonds.

24 firms that the oxyanion is stabilized by the main chain amide of Ser-201 and by the side chains of Hi

25 unlikely source of this proton is the Cys302 main chain amide.

26 ative oxyanion hole that is constituted of a main-chain amide (Ser-201) and two conserved side chains

27 ists between adjacent carbonyl groups of the main-chain amide bonds.

28 Unexpectedly, the main-chain amide group of Gln 230 in the universally con

29 tive-state hydrogen-exchange NMR analysis of main-chain amide hydrogens.

30 As seen for the RF1 complex, the main-chain amide nitrogen of glutamine in the GGQ motif

31 Main-chain amide relaxation of CTD-SP-NC was measured in

32 h known Raman tensors for modes of the pVIII main chain (amide I) and Trp and Tyr side chains to reve

33 's side chain carboxylates and the protein's main chain amides.

34 ive site, was bound by hydrogen bonds to two main-chain amides and to two basic residues, H129 and R1

35 NaAD are recognized by interaction with the main-chain amides of Thr85 and Tyr117, a positive helix

36 he motif, involving H-bond interactions with main-chain amides within the turn.

37 most of the SLC5 family, interacts with the main chain amino group of G444, capping the alpha-helix

38 base Glu(212) side chain interacts with the main chain amino group of P1 and P1'.

39 e apolar domain consists of a perfluorohexyl main chain and a butyl hydrogenated branch as a side cha

40 accommodated by local shifts of the protein main chain and by adoption of alternative side chain rot

41 binding to the MHC, repositions the peptide main chain and generates subtly enhanced interactions be

42 wo-dimensional (2D) pi-conjugation along the main chain and in the lateral direction, leading to high

43 attention to the general orientation of the main chain and mutual spatial arrangement of secondary s

44 For CaM-L7 bound to C28W, main chain and side chain chemical shift perturbations i

45 This is most likely due to the fact that the main chain and side chain of Asp46 form a characteristic

46 ons for protein binding; they also use their main chain and side chains to form polar contacts and hy

47 a water molecule hydrogen bonded between its main chain and side-chain oxygen atoms.

48 affold with repeating S = 1/2 centers in the main chain and suggest antiferromagnetic interactions be

49 onformations differ via a translation of the main chain and the corresponding side chains in the 5- t

50 ortant interactions between the PTS1 peptide main chain and up to five invariant Asn side chains of P

51 drical copolypeptide brushes, where both the main chains and side chains can be prepared with control

52 eals sinefungin-specific polar contacts with main-chain and side-chain atoms that can explain the 3-f

53 Both binding events lead to perturbation of main-chain and side-chain dynamics at sites distal to th

54 e modulated by molecular manipulation of the main-chain and side-chain isomeric structures.

55 t rely on arrays of basic residues; instead, main-chain and side-chain nitrogen atoms and two calcium

56 rities and differences in bonding modes, for main-chain and side-chain structure, and for the importa

57 These temporal (main chain) and triggered (side chain) degradation proce

58 alpha analogues with a modified N-methylated main chain at position 2, 3, or 5 retain significant CXC

59 side chains interact mostly with the epitope main chain atoms and side-chain carbons.

60 serine residues form hydrogen bonds with the main chain atoms of gp120.

61 (MHC-II) products, which make contacts with main chain atoms of their peptide cargo.

62 nformation regarding the displacement of the main chain atoms that form the oxyanion hole and movemen

63 bond cysteines coordinating the AMP with its main chain atoms, a nucleotide-binding motif that appear

64 edicted and measured structures is 3.9 A for main chain atoms.

65 alogs show very similar interactions for the main-chain atoms and the conserved P1 Asp and P4 Asp, wh

66 actions while water molecules cross-link the main-chain atoms of alpha-synuclein to atoms of NbSyn2,

67 4017 forms hydrogen bonds with the conserved main-chain atoms of Asp29 and Asp30 of the protease.

68 rahydrofuranyl urethane moiety of TMC114 and main-chain atoms of D29 and D30.

69 A) showed differences in the position of the main-chain atoms of residue 82 compared to PR structure

70 ecognition is substantially mediated through main-chain atoms of the amino acid.

71 through formation of a beta-zipper involving main-chain atoms, burying an important hydrophobic surfa

72 As OPUS-PSP excludes interactions among main-chain atoms, its success highlights the crucial imp

73 ween the di-mannose ligand and predominantly main-chain atoms.

74 or complexes of PR1 with an RMSD of 1.1 A on main-chain atoms.

75 an-square (CRMS) in the transmembrane region main-chain atoms.

76 rotates approximately 180 degrees about the main chain axis, requiring surrounding side chains to re

77 In addition, the removal of side-chain/main-chain backbonding distorts the helix, which alters

78 estigated the impact of threonine side-chain/main-chain backbonding on the backbone dynamics of the a

79 erchain interaction only through the protein main chain, beta-carbon, or associated hydrogen atoms.

80 is and characterization of a novel series of main-chain boron-containing conjugated polymers (CPs), b

81 BPAs), which represent the first examples of main-chain boron-containing CPs without aromatic moietie

82 es (AXOS) having 2-10 xylose residues in the main chain but no unsubstituted xylooligosaccharides (XO

83 Here, several polymer films with similar main chains but different functional groups on the side

84 Thus, preorganization of a main chain by subtle changes to side chains can confer e

85 nd density of these functional groups on the main chain can determine both the polarity and density o

86 a methyl group at the beta carbon along the main chain can drastically affect selectivity, but its i

87 The presence of thioether groups on the main chain can further induce metal-ligand coordination

88 ents on each of its four -CH(2)-CH=CH-CH(2)- main-chain carbon atoms.

89 The main chain carbonyl group of His-161, Arg-300, and Lys-3

90 teractions of Arg130, Glu86, Arg135, and the main chain carbonyl groups of Cys132 and Leu55 appears t

91 otassium ion is directly coordinated by five main chain carbonyl groups, and we show this site is ess

92 This position was suggestive because its main chain carbonyl is within hydrogen-bonding distance

93 de chains of Asp123, Glu136, His146, and the main chain carbonyl of Ile137.

94 en the phenolic hydroxide of the SHA and the main chain carbonyl of Pro132, between the carbonyl oxyg

95 it is coordinated at the dimer interface by main chain carbonyl oxygen atoms from the midmembrane br

96 Both structures show a main chain carbonyl oxygen closer to the active site ser

97 e hPNMT active site has been identified, the main chain carbonyl oxygen of Asn39.

98 e SAM headgroup (H(3)C- and/or HO-) near the main chain carbonyl oxygen of Cys153 and that Phe88 (ana

99 ne (TM) alpha-helix 2, hydrogen bonds to the main chain carbonyl oxygen of Ile-259 on TM alpha-helix

100 We have surveyed the bridging of pairs of main chain carbonyl oxygens by cations or by delta(+) hy

101 hored by halogen bonding of an iodine with a main-chain carbonyl and (ii) an acetylene linker, enabli

102 When the activated asparagine attacks its main-chain carbonyl carbon, the resulting oxyanion is st

103 sidechains, a water molecule, a serine and a main-chain carbonyl in the unwound stretch of trans-memb

104 no moiety participates in three H-bonds: two main-chain carbonyl oxygen atoms (from R194 itself and f

105 t to the intracellular side, is made of four main-chain carbonyl oxygen atoms and four threonine side

106 extracellular side, are made of exclusively main-chain carbonyl oxygen atoms.

107 g of both inhibitors that interacts with the main-chain carbonyl oxygen of Tyr188.

108 participates in Ca(2+) coordination with its main-chain carbonyl oxygen, and this function is not exp

109 These macromolecules can be transformed into main-chain cationic polymers upon quaternization of the

110 s--Textal, Resolve and ARP/WARP--in terms of main chain completeness, sidechain identification and cr

111 which share common features: (i) a galactan main chain composed of two 1-->3 beta-linked trigalactos

112 ree of branching, and monosaccharide residue main chain composition.

113 e biosynthesis is initiated by a spontaneous main-chain condensation reaction.

114 set of PDZ domains bind peptides with a bent main-chain conformation and the specificities of these n

115 dicted side-chain packing interactions and a main-chain conformation indistinguishable from the wild-

116 The rigid-rod main-chain conformation of these polymers drastically lo

117 domains, but the C(alpha) domain exhibits a main-chain conformation remarkably different from those

118 These involve discrete changes in main-chain conformation, expanding the site; few continu

119 AP-1 appears to be facilitated by a strained main-chain conformation, which suggests a potential role

120 facilitate domoate binding by affecting the main-chain conformation.

121 y toward Ins(1,2,4,5,6)P5 These features are main-chain conformational differences in loops adjacent

122 sequence diversity, length variability, and main-chain conformational plasticity.

123 Main-chain conformational restraint was applied to facil

124 ed in the structure, and there are alternate main chain conformations for the magnesium positioning l

125 Since the structures, especially main chain conformations, of two EF-lobes in holo-form a

126 2.0-A-resolution structure reveals canonical main-chain conformations for the V(alpha), V(beta), and

127 Two of the four helices have alternate main-chain conformations that differ by a 1.3-1.7A shift

128 ems, the effects of fluorine substitution on main-chain conformations, packing, and electronic coupli

129 The linear main chain connectivity and molecular topology were conf

130 of inorganic polymeric materials featuring a main chain consisting of P(V)-O bonds and aryl side grou

131 in a pocket on the proteasome surface using main chain contacts of its C-terminal residues and uses

132 protein (GFP) is triggered by a spontaneous main chain cyclization reaction of residues 65-67.

133 reactive sites, low toxicity, and controlled main-chain degradability has not been realized, yet this

134 t intermolecular interactions induced by the main-chain deuteration are shown to change the film crys

135 ity and fit of predicted and observed [/psi] main chain dihedral angle propensities.

136 ty and fit of predicted and observed phi/psi main chain dihedral angle propensities.

137 tereoelectronic effects that preorganize the main-chain dihedral angles in the conformation found in

138 structure are particularly sensitive to the main-chain disrupting effects of Pro replacements.

139 o the suggestion that amyloid is a primitive main chain-dominated structure.

140 The main chain dynamics of calmodulin are found to be largel

141 drogen bond, apparently caused by changes in main chain dynamics, provide a mechanism for the long di

142 ns from molecular dynamics indicate that the main-chain dynamics of the protein show little variation

143 toconvertible class of FPs, a light-mediated main chain elimination reaction partakes in the formatio

144 olysaccharides and not the more recalcitrant main chains, especially cellulose.

145 e helix with insignificant deviations to its main chain, even though 2/3 of the residues are nonnatur

146 o Pro in order to test the impact of reduced main chain flexibility at the putative hinge position.

147 computing the Shannon entropy of the protein main-chain fluctuations.

148 tiation and control of the polymerization of main chain fluorinated monomers as exemplified by vinyli

149 The main chain fold of G311 can be superimposed on the wild-

150 The main-chain fold of the enzyme belongs to the (beta/alpha

151 25; alpha7, M131-E141) that adopt an overall main-chain fold similar to that of PBPs found in Anthera

152 ts indicate that the mutant has very similar main chain folding compared to wild-type.

153 sights into the relationship between shapes, main-chain folds, and complex formation.

154 philic polymer with cleavable side chain and main chain functional groups has been designed and synth

155 N-alkyl alpha-bisimines were employed as main-chain functional groups in acyclic diene metathesis

156 nd relatively tolerant of alterations to the main-chain functional groups in order to achieve this sp

157 ituted proline amino acids, with the peptide main chain functioning to "protect" the proline amino an

158 the active site hydrogen-bonding network and main-chain geometry at Asp120, a key component of the bi

159 Thus, the force does not directly break the main chain H-bonds: it destabilizes them in such a way t

160 Recent studies suggest the dominant role of main-chain H-bond formation in specifying beta-sheet top

161 f the design and supported the importance of main-chain H-bonds in determining beta-sheet topology.

162 of a small chiral bias to fully control the main chain helicity of polymers and assemblies.

163 y linking the side-chain protons to proximal main-chain HNs via bipartite graph matching.

164 due to effects of local sequence sterics and main-chain hydration on the persistence length of the ch

165 re extended than previously suspected due to main-chain hydration or local sterics.

166 the hydration interaction of the hydrophobic main-chain hydrocarbons.

167 ine residue in the hinge removes a conserved main chain hydrogen bond donor.

168 a strands that is centered near a bifurcated main chain hydrogen bond interaction between these two s

169 ha-helix in which the N-terminal i and i + 4 main chain hydrogen bond is replaced with a carbon-carbo

170 to predict inter-atomic distance bounds, the main chain hydrogen bond network, and torsion angles, wh

171 ses have a cross beta-sheet structure, where main chain hydrogen bonding occurs between beta-strands

172 rils have a cross-beta-sheet structure where main chain hydrogen bonding occurs between beta-strands

173 The main chain hydrogen bonding pattern in parallel beta-she

174 All NESs also participate in main chain hydrogen bonding with human CRM1 Lys568 side

175 air, only one of the residues is involved in main chain hydrogen bonding with the strand containing t

176 accommodate a wide range of residues, while main chain hydrogen bonds may help dictate substrate-bin

177 I, and the G440A mutation, which abolishes a main-chain hydrogen bond associated with the interaction

178 ificial alpha-helices in which an N-terminal main-chain hydrogen bond is replaced by a carbon-carbon

179 e in allosteric pathways in these proteases, main-chain hydrogen bond networks are analyzed by calcul

180 ge in place of the characteristic N-terminal main-chain hydrogen bond of canonical helices.

181 polyglutamine beta-strands are stabilized by main-chain hydrogen bonding.

182 enthalpic barriers by eliminating inhibitory main-chain hydrogen bonds in the precursor state.

183 hydrophobic interactions while cross-strand main-chain hydrogen bonds manifested the ordered oligome

184 d an NMR-based site-specific analysis of the main-chain hydrogen bonds that stabilize its native conf

185 Up to four main-chain hydrogen bonds to the inhibitor also appear s

186 An antiparallel beta-sheet with six main-chain hydrogen bonds was dominant in the implicit s

187 er with a two-residue register shift and six main-chain hydrogen bonds.

188 formed by the beta-sheet extension along the main-chain hydrogen-bond direction, whereas the other ha

189 s for the generation of all the chirality of main chain hydroxyaldehyde, while the appended side-chai

190 ed by replacing an N-terminal intramolecular main chain i and i + 5 hydrogen bond with a carbon-carbo

191 lated rhamnose as the capping residue of the main chain, (ii) a hyperbranched fucose unit, and (iii)

192 s mainly from the exceptional ability of the main chain in a structurally relaxed beta-conformation t

193 e, hydroxyl, and aldehyde to the polysulfone main chain in excellent conversion.

194 egy, we show that complete assignment of the main chain (including prolyl residues) can be achieved w

195 Deletion mapping indicates that main chain interaction(s) of residues 182-186 of SNAP25

196 glutamate, confirming the importance of this main-chain interaction in GluR6.

197 ADP is tightly bound through side-chain and main-chain interactions, whereas at the other two sites

198 t these contacts involve both side-chain and main-chain interactions.

199 and S3) the ADP molecules are only bound by main-chain interactions.

200 mers that do not contain single bonds in the main chain is reported.

201 Degradation of the main chain is shown to cause morphology of the supramole

202 The Frq1 main chain is similar to that in free Frq1 and related p

203 that side chain (13)C=(18)O will complement main chain isotope labeling in future IR studies of amyl

204 ight that was otherwise inaccessible through main chain labeling.

205 A photocurable, thus DLP-printable main-chain liquid crystal elastomer (LCE) resin is repor

206 particles, of controlled diameter, made from main-chain liquid crystalline polymers using a mini-emul

207 mposed of d(5)-vanadium metal centers in the main chain, making it a rare example of a spin-carrying

208 n its native state, the coupling between the main-chain (MC) motions [represented by coarse-grained d

209 cting the controlled synthesis of high order main-chain mechanically interlocked polymers.

210 The prevalence of non-specific main chain-mediated interactions demonstrates that poten

211 migration insertion polymerization (MIP) for main chain metal-containing polymer (MCP) synthesis.

212 ar dynamics simulations focused on measuring main-chain movement.

213 ow that when the H-bonding capability of the main-chain N-H of the conserved glutamine is eliminated

214 rovided the highest affinity at pY+1 and its main chain NH is involved with a hydrogen bond with Stat

215 catalysis, such as a hydrogen bond between a main chain nitrogen atom and the flavin redox center (N5

216 te to form hydrogen bond interactions to the main chain nitrogen atoms of Cys356 and Leu314, and hydr

217 between a porphyrin and amino acid through a main chain nitrogen has been optimized and applied in th

218 ol oxidase has revealed an unusual elongated main chain nitrogen to hydrogen bond distance positionin

219 the side-chain oxygen atom of Asp169 and the main-chain nitrogen of Arg112 binds together the incomin

220 Here we present main-chain nitrogen-15 relaxation measurements for the u

221 ized through measurement of enzyme kinetics, main chain NMR relaxation, X-ray crystallographic studie

222 e bound DRV lacks one hydrogen bond with the main chain of Asp30 in PR(L76V) relative to PR, possibly

223 lose, especially xylan that is composed of a main chain of beta-1,4-linked xylopyranoside residues de

224 hich are repeated every fifth residue in the main chain of ELPs.

225 pe II (FAS-II) multienzyme system builds the main chain of mycolic acids (MAs), important lipid patho

226 The insertion of trisubstituted ureas in the main chain of N,N'-linked oligourea foldamers locally im

227 med intrinsic localized modes (ILMs), of the main chain of proteins based on all-atom molecular dynam

228 the E-dimer interface, including the exposed main chain of the E fusion loop and the two conserved gl

229 al change requires modest adjustments to the main chain of the heme crevice loop and is facilitated b

230 The main chain of the lipid is installed via a highly stereo

231 the hydrogen-bonding network provided by the main chain of the protein scaffold.

232 the ligand proximal carboxylic group and the main chain of two conserved loops in the protein structu

233 ackbone by side chains of D109 and Y113; and main chains of P81 and W112.

234 een JMJD2A and peptides largely involves the main chains of the enzyme and the peptide.

235 ionalities are orthogonally connected to the main chains of the respective polymers have been synthes

236 The main-chain of the peptide is well defined and makes a se

237 esent a simple strategy for the synthesis of main chain oligonucleotide rotaxanes with precise contro

238 and whether these contacts emanate from the main chain or side chain.

239 ell-established, readily accessible class of main chain organosilicon metallopolymer consisting of al

240 Our main-chain orthogonal assembly approach allows the engin

241 The main-chain oxygen atoms, which were exposed to the pore

242 anscription factor is due in large part to a main-chain perturbation rather than to specific features

243 Here, we compare the distributions of main chain (Phi,Psi) angles (i.e., Ramachandran maps) of

244 e directly preorganizes the collagen peptide main-chain (phi, psi) dihedrals for triple helical assem

245 Blending of monomers with bioinspired main-chain polybenzoxazine derivatives provided formulat

246 ily of bioinspired small-molecule resins and main-chain polybenzoxazines derived from biologically av

247 oactuation within the local structure of the main chain polymer results in a mechanically controlled

248 tives with a poly(vinyl alcohol)MW27kD (PVA) main-chain polymer bearing poly(ethylene glycol)MW2000 (

249 o afford a linear, mechanically interlocked, main-chain polymer.

250 A novel strategy for the synthesis of main-chain polymers through radical ring-closing/ring-op

251 Here we report the synthesis of metalated main-chain polypseudorotaxanes via ring-opening olefin m

252 contrast, foldamers with aryl rings in their main chains possess distinct conformations that may give

253 3S-Flp), like 4S-Flp, should preorganize the main chain properly for triple-helix formation but witho

254 ater flexibility that glycine confers on the main-chain provides no advantage in terms of the persist

255 gesting that both side-chain disordering and main-chain rearrangement play important roles in alterin

256 d and ADP-bound forms, involving significant main-chain rearrangement.

257 Arg141, but also requires substantial local main chain rearrangements relative to the structurally h

258 dy of this article is focused on a series of main chain redox and beta-elimination reactions mediated

259 -vis spectra demonstrate that the conjugated main chains remain essentially planar through the alpha

260 h ionic substituents directly bound to their main chain repeat units is a strategy for generating str

261 ng the primary monomer sequence of a polymer main chain represents a considerable challenge in polyme

262 brillar LCs involves an inducible N-terminal main chain reversal that results in the formation of a p

263 ucture comprises two beta-grasp folds having main chain root mean square deviation (r.m.s.d.) values

264 due loops in the PLOP benchmark, the average main-chain root mean square deviation of the best scored

265 al residues in Elk have significantly higher main-chain root-mean-square deviations than their counte

266 activated mechanophore that does not lead to main chain scission and an elastomeric polyurethane enab

267 ater ability to depth profile due to ease of main chain scission.

268 onversions of polymers comprising pendant or main-chain secondary amines were observed for an array o

269 hs provide an unbiased method for evaluating main-chain segmental motions; they resolve an apparent d

270 cyclic ether groups with a stiff polycyclic main chain, serves as a grafted polymer skin on the Li m

271 late induced 1-1 diad repeats in the polymer main chain shedding unique light on the relative contrib

272 te a highly strained disulfide and localized main chain structural changes that presumably account fo

273 The main chain structure of the central domain in solution a

274 The overall main chain structure resembles an immunoglobulin variabl

275 The PASs have a previously unreported main chain structure that is composed of pyranose rings

276 The overall main-chain structure of recoverin in the complex is simi

277 synthesis of polymers incorporating complex main-chain structures and degradable functionalities.

278 The main-chain structures are first constructed from initial

279 This contribution introduces main-chain supramolecular ABC and ABB'A block copolymers

280 een side-chain fluorinated benzyl esters and main-chain terminal arenes, in turn controlling the conf

281 In contrast to the main chain, the motions of the methyl-bearing side chain

282 chains and connected with the donors on the main chain through an efficient pi-bridge.

283 ent: (1) as suggested by informatic studies, main-chain to base hydrogen bonding makes up an importan

284 moiety and the carbonyl of hyp distorts the main-chain torsion angles that typically accompany a C(g

285 oelectronic and steric effects that restrict main-chain torsion angles.

286 n rotation is accompanied by a change in the main chain torsional angles of Asp402, a conserved resid

287 c, much larger than is typically seen in the main chain transition at these anesthetic concentrations

288 It produces, for the system above the main chain transition of the saturated lipid, phase diag

289 of disulfide bonds' rich proteins with intra main-chain triazole links.

290 and a Gal 6-linked to Gal-1 and Gal-2 of the main-chain trigalactosyl repeats; (iii) a common side ch

291 er with NHCs orthogonally positioned along a main chain upon generation in situ.

292 (i.e., molecular muscles) can be linked into main-chain Upy-based supramolecular polymers.

293 units randomly distributed in the polymers' main chain were synthesized via the terpolymerization of

294 zes the proper docking of the Ile(181) (P1') main chain, whereas the hydrophobic pockets stabilize th

295 ty destroys or recovers the curvature of the main chain, which demonstrates external control over the

296 train of the substituted ketal groups in the main chain, while for polymers with linear (acyclic) ket

297 n structure calculations revealed a galactan main chain with a reverse turn involving the beta-1-->6

298 nsisting of a 1,4-linked beta-mannopyranosyl main chain with branch decorations.

299 ins for solubility, that alternate along the main chain with electron-rich aromatic segments comprisi

300 n to sugar precursors requires the action of main chain xylanases as well as alpha-glucuronidases tha