ライフサイエンスコーパス: main target

1 respiratory illness with pneumocytes as its main target.

2 acetylcholinesterase (AChE), which is their main target.

3 ic effects in the nervous system, one of its main targets.

4 ident macrophage population being one of the main targets.

5 vasodilatory EP2 and EP4 receptors as their main targets.

6 LDL cholesterol remained the main target and a variety of drugs to lower LDL choleste

7 use it displayed balanced affinities for the main targets and clear selectivity over the two off-targ

8 ural features conducive to activities at the main targets and investigated activities at two off-targ

9 with a reduction of P2RY12 mRNA, one of its main targets, and platelet P2Y(12) expression and functi

10 PLA(2)R1 is the main target antigen in 70%-80% of cases, but the pathoge

11 Megalin (gp330) is the main target antigen involved in the induction of Heymann

12 Proteinase 3 (PR3) is the main target antigen of antineutrophil cytoplasmic antibo

13 The main target audience of this tutorial is synthetic chemi

14 classes that differed with respect to their main target binding areas.

15 lassic IPC in which cardiac myocytes are the main target, cardiac mast cells are the critical site at

16 ng human primary lung endothelial cells, the main target cell infected in HPS patients.

17 hoid tissues (LTs), due to the fact that the main target cell of human immunodeficiency virus (HIV) i

18 These studies establish the main target cell type and region of the gut for producti

19 reperfusion injury, suggesting Tregs as the main target cell type for Sema4A in the development of t

20 indicates that neutrophils appear to be the main target cells for ACT, but not for PT.

21 The main target cells for Epstein-Barr virus (EBV) infection

22 The main target cells for IAV replication are epithelial cel

23 intermediate progenitor cells (IPCs) are the main target cells for ZIKV.

24 Our studies identify IPCs as the main target cells for ZIKV.

25 epithelium abundantly express TMPRSS2, these main target cells in the olfactory epithelium may become

26 Dendritic cells (DCs) are the main target cells of DENV, and we investigated their rol

27 Foxp3(+) regulatory T cells (Tregs) are the main target cells of IL-27, mediating its immunoregulato

28 The main target cells were macrophages, including Kupffer ce

29 tection of neuropsychiatric disorders as the main target condition.

30 gen, suggesting that the latter would be its main target during coagulation.

31 n yield and selecting large seeds has been a main target during plant domestication.

32 ptor-dependent treatments, PCSK9 remains the main target for adjunctive therapy to statins and ezetim

33 point to striatal dopamine D2 receptors, the main target for all current antipsychotic medications, a

34 (HPA)-1a, located on integrin beta3, is the main target for alloantibodies responsible for fetal and

35 scular endothelial growth factor (VEGF), the main target for anti-angiogenic-based therapies, and int

36 The ribosome is the main target for antibiotics that inhibit protein biosynt

37 e IKKbeta, demonstrating that Cys-179 is the main target for attack by SNO.

38 e predominant betaAR in the heart and is the main target for beta-adrenergic antagonists, widely used

39 a duplex oligonucleotide substrate with one main target for bleomycin-induced damage.

40 n PDA cell lines and human PDA samples, as a main target for both compounds.

41 beta1 integrin is the main target for Cdc42-mediating interaction of cancer ce

42 the S2 subdomain of the S protein being the main target for cross-reactivity.

43 -1 virus, which explains why it has been the main target for design of drugs against acquired immunod

44 dentification of Galalpha1,3Gal (Gal) as the main target for human xenoreactive (anti-pig) antibodies

45 repeats, suggesting these repeats to be the main target for hypomethylation in MPNSTs.

46 Therefore, the main target for improving the outcome of pregnancy in wo

47 indicating that T cell proliferation is the main target for intervention.

48 fficking, with fully mature enzyme being the main target for lysosomal degradation.

49 The subthalamic nucleus (STN) is the main target for neurosurgical treatment of motor signs o

50 y syndrome coronavirus 2 (SARS-CoV-2) is the main target for neutralizing antibodies (NAbs).

51 The D1 reaction center protein is the main target for photodamage(2), with repair involving th

52 the dogma that the DNA of the nucleus is the main target for radiation-induced genotoxicity and, as f

53 gen-associated molecular patterns and is the main target for recognition by host innate immune cells.

54 st visual center in most vertebrates and the main target for retinal ganglion cells (RGCs) conveying

55 g of the mammalian cortical amygdala, is the main target for this olfactory information and has been

56 by neutralizing antibodies (NAbs) and is the main target for vaccine design.

57 Serotonin transporter (SERT) is the main target for widely used antidepressant agents.

58 The main targets for ADC development are antigens commonly e

59 ole in synaptic plasticity and is one of the main targets for alcohol (ethanol) in the brain.

60 and long propriospinal interneurons are the main targets for brainstem inputs adjusting gait (Danner

61 lso performed tests that represent the three main targets for C difficile detection: bacterium (gluta

62 The NMDA receptor channel is one of the main targets for ethanol in the brain.

63 on in primary CD4+ T cells that serve as the main targets for HIV-1 replication in vivo.

64 chronic infections in the liver, one of the main targets for in vivo gene therapy, raise important c

65 nd drug resistance of cancer; thus, they are main targets for many anticancer drugs.

66 GF19/FGFR4 autocrine signaling is one of the main targets for multi-kinase inhibitors (MKIs).

67 's carboxyl-terminal serine residues are the main targets for phosphorylation by rhodopsin kinase.

68 One of the main targets for PKA modulation is the cardiac L-type Ca

69 we investigated whether neutrophils are the main targets for PT and/or ACT activity in promoting bac

70 uggest that these interneurons represent the main targets for supraspinal and sensory afferent signal

71 the importance of promoter sequences as the main targets for the activation mechanism of the human a

72 teins, including major antigens S and N: the main targets for vaccine and antibody testing efforts.

73 /proliferating CD4(+) T cells, which are the main targets for viral replication.

74 This Perspective provides an overview of the main targets from a structural point of view, together w

75 tl1-deficient mice indicate that Rtl1 is the main target gene of miR-127 in placental development.

76 IL-27 as well as its main target genes are up-regulated in colonic tissue and

77 Two main target genes of Haa1 are the multidrug resistance g

78 , and of heme oxygenase-1 (HO-1), one of its main target genes, in OA cartilage from T2DM and non-T2D

79 nsity-lipoprotein cholesterol (LDL-C) is the main target in atherosclerotic cardiovascular disease (A

80 mitogen-activated protein (MAP) kinase is a main target in drug research concerning inflammatory dis

81 Human porphobilinogen synthase (PBGS) is a main target in lead poisoning.

82 Pattern-recognition receptors are the main target in the study of innate immunity in the intes

83 sm allowed us to identify that clofazimine's main target in this pathogen is the respiratory complex

84 One of the main targets in current clinical oncology is the develop

85 fic innervation, i.e., interneurons were the main targets in the alveus, both interneurons and pyrami

86 to screen for autoantibodies, identify their main targets, investigate the mechanism behind their ind

87 s (MTDLs) has been based on the selection of main targets involved in the "cholinergic" and the "B-am

88 s (MTDLs) has been based on the selection of main targets involved in the "cholinergic" and the "beta

89 ure of the native form of this enzyme, whose main target is ADP-ribose 1",2"-cyclic phosphate, a prod

90 ty of human CHK2 to phosphorylate one of its main targets, Kap1, in Chek2 knockout mES cells, 31 miss

91 The main targeted metabolites were flavonoids and cuticular

92 Accordingly, Rac1 is the main target of 6-TP in activated T-cells.

93 Synaptic function is a main target of A-to-I editing, which can selectively rec

94 12S rRNA carrying the A1555G mutation is the main target of aminoglycosides.

95 roteins promote entry into cells and are the main target of antibodies.

96 Thrombin is the main target of anticoagulant therapy, and major efforts

97 function and is currently recognized as the main target of antiphospholipid Abs responsible for comp

98 It is also the main target of antiphospholipid antibodies (aPL) in the

99 ypothesis that the dopamine transporter is a main target of antipsychotic drugs and predicting that d

100 terial function of white blood cells, is the main target of arsenic-induced ROS production.

101 The main target of cAMP is PKA, the main regulatory subunit

102 thermosensory input to the lateral horn, the main target of central thermosensory pathways and a regi

103 Neocortical layer 1 (L1) is the main target of cortical and subcortical inputs that prov

104 CE STATEMENT Neocortical layer 1 (L1) is the main target of corticocortical and subcortical projectio

105 stidine residues of the bis-His site are the main target of Cu-catalyzed oxidation, with predominant

106 ulosis (TB), and CD4+ T cell immunity is the main target of current TB vaccine candidates.

107 lls and the co-inhibitory receptor PD-1, the main target of currently approved immunotherapies.

108 xO transcription factor DAF-16, which is the main target of DAF-2 ILS.

109 ) neurons is crucial since it represents the main target of deep brain stimulation for the treatment

110 The CB1 cannabinoid receptor, the main target of Delta(9)-tetrahydrocannabinol (THC), the

111 Cannabinoid 1 receptors, the main target of Delta9-tetrahydrocannabinol (THC), the pr

112 ple other processes, but angiogenesis is the main target of drugs such as the tyrosine kinase inhibit

113 The cerebral cortical area that is the main target of each output channel is a major source of

114 oliferator-activated receptor y (PPARy) is a main target of EDCs, for which most experimental data ha

115 Furthermore, cysteine was the main target of effective reactive species in the CAPs me

116 he G protein-coupled receptor family and the main target of endogenous opioid neuropeptides and morph

117 If deacidification is the main target of fermentation, strains that produce less a

118 lacements involving Lys14 of histone H3 (the main target of Gcn5), but not other H3 or H4 lysine resi

119 the inner core oligosaccharide as a possible main target of GP12.

120 The main target of HIV-1 infection is the CD4(+) helper T ly

121 The viral spike glycoprotein is the main target of host neutralizing antibodies that help to

122 unterintuitive result that knocking down the main target of ICI (ERalpha) increased the effectiveness

123 ts and show CD14(+)CD16(+) monocytes are the main target of infection, with ZIKV replication detected

124 s or 'podocytes', the cell type which is the main target of injury in MCN.

125 ced the splicing of mRNA encoding XBP1s, the main target of IRE1 activity.

126 As the main target of LA and with its strong projection to CeM,

127 me that regulates the inositol cycle and the main target of lithium in neurons.

128 CD4(+) T cell responses to spike, the main target of most vaccine efforts, were robust and cor

129 ivers of multiple sclerosis (MS) and are the main target of MS disease-modifying therapies (DMT).

130 an striatal medium spiny neurons (MSNs), the main target of neurodegeneration in ChAc.

131 Prefusion SARS-CoV-2 S is the main target of neutralizing antibodies and the focus of

132 The SARS-CoV-2 spike (S) glycoprotein is the main target of neutralizing antibodies elicited during v

133 F glycoprotein and its identification as the main target of neutralizing antibodies have provided new

134 ly conserved surface glycoprotein and is the main target of neutralizing antibodies induced by natura

135 f variants harboring mutations in spike, the main target of neutralizing antibodies.

136 in promotes entry into host cells and is the main target of neutralizing antibodies.

137 nd E2 mediate viral entry, with E2 being the main target of neutralizing antibody responses.

138 In other words, the main target of our critique is the model of change that

139 Lsdp1 is the main target of PKA, suggesting that this protein is a ma

140 e spike's receptor-binding domain (RBD), the main target of plasma neutralizing activity.

141 s virus hemagglutinin (MeV-H) protein is the main target of protective neutralizing antibodies.

142 We identified subtypes of the main target of R7, the Dm8 neurons, each specific to the

143 y and motor areas and mostly in layer 4, the main target of relay thalamic inputs, and layer 3.

144 though human airway epithelial cells are the main target of respiratory syncytial virus (RSV), it als

145 defense in the respiratory tract and are the main target of respiratory viruses.

146 holipid cardiolipin molecules are likely the main target of ROS because they are particularly rich in

147 pre- and postfusion conformation and is the main target of RSV-neutralizing antibodies.

148 SIRT1 has been described as the main target of RSV.

149 t this antibody was mischaracterized and the main target of SC35 mAb is SRRM2, a spliceosome-associat

150 sual regions which apparently constitute the main target of stabilizing extra-retinal oculomotor infl

151 he substantia nigra pars reticulata (SNr), a main target of striatal efferents and the primary output

152 hese results support the hypothesis that the main target of the antibiotics is the mitochondrial 12S

153 The main target of the antilipolytic action of insulin is be

154 hepatic mitochondria were identified as the main target of the beneficial effect of both butyrate-ba

155 the surface of the cells and constitute the main target of the current drugs on the market.

156 DAF-16 is thought to be the main target of the DAF-2 pathway.

157 We show here that the main target of the elevated p27/Kip1 in this system is c

158 proximal tubule region of the nephron is the main target of the Hg-induced oxidative stress.

159 ctivity of Yes-associated protein (YAP), the main target of the Hippo pathway, which results in decre

160 he CCHFV membrane fusion glycoprotein Gc the main target of the host neutralizing antibody response a

161 he CCHFV membrane fusion glycoprotein Gc-the main target of the host neutralizing antibody response-a

162 k, and selected the community containing the main target of the inhibitor used to treat cells.

163 ifelong cumulative intake of saturated fats, main target of the intervention, was also associated wit

164 ts sexually active before the trial were the main target of the intervention.

165 ranscription and pioneer factor c-Jun is the main target of the JNK cell stress pathway that is known

166 Transcriptionally active genes, the main target of the NER pathways in mice, contain HMGN1 p

167 ecially in the piriform cortex, which is the main target of the olfactory bulb.

168 riments using GR chimeras indicated that the main target of the p38-mediated (but not JNK-mediated) i

169 After this, the main target of the Plains Paleoindian hunters consisted

170 The main target of the study was to evaluate the diagnostic

171 A main target of this field is to distinguish the endocran

172 ainst T. cruzi, C2C12 cells and cruzain, the main target of this parasite.

173 The main target of this review is to give fundamental insigh

174 A main target of this sensory information is the superior

175 step in cap-dependent translation and is the main target of translational control mechanisms.

176 TTR protein secretor organ, it has been the main target of treatments developed these last years, in

177 cardiomyopathies and confirms the heart as a main target of TSFM dysfunction.

178 The main target of tumor-specific T cells are neoantigens ar

179 The main targets of 5-HT+ terminals were spines and distal d

180 These data suggest that mitochondria are the main targets of alpha-synuclein and their defective auto

181 suggests that genes distal to Erbb2 are the main targets of amplification.

182 The main targets of anterograde transport were the deep laye

183 and pilosebaceous-unit inflammation, are the main targets of antibiotic-based therapy against acne vu

184 reported to inhibit the ribosome, one of the main targets of antibiotics in the bacterial cell(6,7).

185 and fusion (F) glycoproteins, which are the main targets of antibody responses.

186 b cell viability, therefore PG is one of the main targets of antimicrobial drugs.

187 d neurofascin-186 and neurofascin-140 as the main targets of autoantibodies in five patients presenti

188 a and androgen receptor, which are two known main targets of bisphenols.

189 nd glutamate-gated channels might not be the main targets of compound 1.

190 proteins of hepatitis C virus (HCV) are the main targets of compounds that directly inhibit HCV infe

191 amily of transcription factors is one of the main targets of cytokines and other agents that induce H

192 ion and serological conversion have been the main targets of diagnostic assessment for many years, ho

193 These dual-phenotype neurons are the main targets of E2 in the region and are more than twice

194 and EIL1, we show that EIN3 and EIL1 are the main targets of EBF1/2.

195 analysis confirmed that WUS and CLV3 are the main targets of ERf signaling and uncovered new ones.

196 One of the main targets of estrogens in the immune system is the th

197 inor histocompatibility (H) antigens are the main targets of graft-versus-host and graft-versus-leuke

198 The main targets of hepatitis C virus (HCV) are hepatocytes,

199 HDAC3 is one of the main targets of histone deacetylase (HDAC) inhibitors in

200 CD4 T cells are also the main targets of HIV infection, and their activation stat

201 ydryl groups of protein-cysteines constitute main targets of HNE.

202 se mechanisms to protect their proteins, the main targets of HOCl, from HOCl-mediated damage.

203 mononuclear phagocytes, and hepatocytes are main targets of infection, and IHC showed an association

204 The main targets of M1R+ terminals forming asymmetrical syna

205 The main targets of M1R+ terminals forming symmetrical synap

206 The main targets of M2R(+) terminals forming asymmetrical (p

207 The main targets of M2R(+) terminals forming symmetrical (pu

208 duced IFN-beta in the brains and livers, two main targets of MHV replication, of infected wild-type m

209 on in the central nervous system and are the main targets of neurodegenerative disease.

210 These immunodominant antigenic sites are the main targets of neutralizing antibodies and are subject

211 ) and fusion (F) glycoproteins which are the main targets of neutralizing antibodies.

212 One of the main targets of orexinergic neurons is the arcuate nucle

213 As proteins are one of the main targets of oxidative damage, understanding how the

214 reactive oxygen species, but also one of the main targets of oxidative damage.

215 ing and cellular excitability, which are the main targets of pharmaceutical treatments for uterine co

216 ur amino acids in them, were found to be the main targets of positive selection.

217 sed on graft skin and urethral lining as the main targets of rejection.

218 bulbocavernosus and levator ani muscles, the main targets of SNB motoneurons, was not affected in eit

219 ing that conventional CD4(+) T cells are the main targets of TGF-beta to suppress T1D.

220 This CPS is known to be one of the main targets of the adaptive immune response in humans a

221 chment (G) and fusion (F) glycoproteins, the main targets of the humoral immune response.

222 protein (GPC) and nucleoprotein (NP) are the main targets of the Lassa virus-specific T cell response

223 The BLC is also one of the main targets of the mesolimbic dopamine (DA) system.

224 lamina monopolar cells, L1 and L2, were the main targets of the R cell pathway, L1 and L2 each fed a

225 ind that locally translated proteins are the main targets of the ubiquitin-proteasome system in growt

226 fic subsets of CD4(+) T cells, which are the main targets of virus infection and differ substantially

227 ction and suggest that NK cell is one of the main targets of VPA, but further work is needed to ascer

228 t macrophages accumulated in the kidney, the main target organ of infection, and formed direct contac

229 The gill was the main target organ where immature and mature poxvirus par

230 renal phenotypes, support the kidney as the main target organ.

231 d on clinical symptoms in one or more of the main target organs (skin, liver, gastrointestinal tract)

232 ssues implicated the kidney and liver as the main target organs and prioritized potentially causal ge

233 sis, transcript levels were evaluated in two main target organs of JH, fat body and ovary.

234 The cAMP-dependent phosphorylation of PKA's main target, originally described as p29 in Paramecium,

235 ough secondary effects downstream from their main target pathways.

236 Because pregnant women are the main target population for ZIKV treatment, therapeutic c

237 nal cortex but not in the dentate gyrus, its main target region, while 24 h later it was also impaire

238 ermeable to calcium, has been considered the main target responsible for calcium overload in ischemic

239 Knowledge of the main target sequences for Sau1 will facilitate the synth

240 MEF8-E549A failed to restore editing at the main target sites but was able to restore editing at the

241 ubthalamic nucleus and internal pallidum are main target sites for deep brain stimulation in Parkinso

242 The PVN or CeA are probably not the main target sites of immediate BT action.

243 A common denominator of the main target sites of the Foxb1-positive axons of the par

244 monstrated that otoferlin interacts with two main target-SNARE proteins of the hair-cell synaptic com

245 e central role of Atlantic cod, which is the main target species but cannot be persistently overfishe

246 One of the main target structures of 5-HT(4) receptors on 'cognitiv

247 admission and significant improvement in the main target symptoms.

248 aptic connections between DAN-i1 and its two main targets, the Kenyon cells and the mushroom body out

249 ation of APL has an inhibiting effect on its main targets, the mushroom body Kenyon cells.

250 concomitant increased activity in one of its main targets, the posterior nucleus of the thalamus (PO)

251 ation between the granule cell layer and its main targets, the Purkinje cells, Golgi cells and molecu

252 as been linked to elevated expression of the main target, thymidylate synthase (TYMS), which catalyse

253 domains in immune cells and/or eQTLs in the main target tissue, salivary glands.

254 hon running performance, and hip muscles the main target when we simulated strength training for spri