ライフサイエンスコーパス: major

1 ived C-terminal peptides (TCPs), including a major 11-kDa fragment (TCP96), are produced through clea

2 irome that is dominated by RNA viruses, with major additional contributions from reverse-transcribing

3 -Cas genome editing tools continues to drive major advances in the life sciences.

4 Detailed data analyses show that the major advantage of MAGELLAN is attributed to the power o

5 At 5 years, the incidence of major adverse cardiovascular and cerebrovascular events

6 l artery disease (PAD) have a higher risk of major adverse cardiovascular events (MACE) compared with

7 13 to 2016 were 0.73 (95% CI, 0.62-0.84) for major adverse cardiovascular events, 0.92 (95% CI, 0.85-

8 Major arterial or venous thromboembolism, major adverse cardiovascular events, and symptomatic ven

9 median follow-up of 6.6 years, there were 8 major adverse events: 6 relapses, 1 treatment-related de

10 ascular events, 0.92 (95% CI, 0.85-1.00) for major adverse limb events, 0.60 (95% CI, 0.48-0.74) for

11 ve rapid point-of-care genotyping of CYP2C19 major alleles (*2, *3, *17) via salivary swab (genotyped

12 hat this was not attributable to established major allergenic components of the extracts (0%-36%); in

13 ; 95% confidence interval: 1.28 to 1.40) and major amputation or peripheral revascularization (hazard

14 In contrast, the adjusted hazard ratio for major amputations was 1.00 (95% CI, 0.90-1.11) when comp

15 Lactoperoxidase (LPO) is one of the major antibacterial ingredients in milk and an extensive

16 A major application of these EFs is as an emerging cancer

17 Major arterial or venous thromboembolism, major adverse

18 centromeres of chromosomes and provides the major attachment point for spindle microtubules during m

19 ribe the immune environments associated with major B-cell lymphomas with an emphasis on the immune es

20 re the important contribution of PE in these major biological processes.IMPORTANCE Phosphatidylserine

21 levant bleeding (4.8% vs. 2.9%, p = 0.34) or major bleeding (3.6% vs. 1.6%, p = 0.18).

22 lowed by P2Y12 inhibitor monotherapy reduces major bleeding after percutaneous coronary intervention

23 ay mortality, irrespective of periprocedural major bleeding and vascular complications.

24 therapy was associated with reduced risk for major bleeding compared with triple therapy (risk differ

25 he risk of the composite of recurrent VTE or major bleeding was nonsignificantly lower with DOACs tha

26 device related death or adverse events, and major bleeding within 72 hours after BEC directed therap

27 schemic stroke, 0.92 (95% CI, 0.75-1.12) for major bleeding, 0.54 (95% CI, 0.39-0.76) for cardiovascu

28 and targeting of modifiable risk factors for major bleeding, as well as the application of decision r

29 ces were identified for the risk of MI, CVD, major bleeding, or all-cause hospitalization when compar

30 as stroke and the primary safety outcome was major bleeding.

31 ping objects that may be tightly packed is a major bottleneck in standard deep learning-based models.

32 ed with volumes of serotonergic axons in all major brain regions can be generalized to map and quanti

33 derivatives, the aortic arch artery and its major branches; however, their specific functions are no

34 The first major build-up of Antarctic glaciation occurred in two c

35 End-stage liver disease (ESLD) is a major burden on public health, particularly in sub-Sahar

36 n the synthesis of the N-glycan of the viral major capsid protein in PBCV-1 and establishes that a si

37 The incidence of major cardiovascular disease was associated with increas

38 tween procedural success and outcomes of all major cardiovascular procedures.

39 Respiratory syncytial virus (RSV) is a major cause of acute lower respiratory infection (ALRI)

40 Human advance on natural habitats is a major cause of biodiversity loss.

41 Streptococcus pneumoniae is a major cause of community-acquired pneumonia leading to h

42 A major cause of damage is local inflammatory responses, w

43 The major cause of death in prostate cancer patients can be

44 a severe gastrointestinal disease that is a major cause of diarrhea-associated mortality in humans.

45 via mitophagy and mutations in Parkin are a major cause of early-onset Parkinson's disease (PD).

46 is.IMPORTANCE Enteric viral infections are a major cause of gastroenteritis worldwide and have the po

47 It is considered a major cause of health loss, but data for the global burd

48 Chronic HBV infection is a major cause of liver disease and cancer worldwide.

49 Coronary artery disease (CAD) is a major cause of morbidity and mortality worldwide.

50 d 35-70 years, cardiovascular disease is the major cause of mortality globally.

51 f 287 269 single cardiac nuclei, revealing 9 major cell types and 20 subclusters of cell types within

52 Hippo pathway is activated in major cellular components of the blood-brain barrier, in

53 Hepatic stellate cells (HSC) are the major cellular contributors to excess extracellular matr

54 ssociated with immunoregulation and were the major cellular source of IL-22 binding protein (IL-22BP)

55 its viability by imaging the distribution of major cellulases and xylanases in Trichoderma reesei usi

56 pests and their associated diseases, with a major challenge being the establishment of artificial Wo

57 However, eradication of HIV is a major challenge due to cellular and anatomical viral res

58 However, the vast diversity of HIV-1 is a major challenge for both active and passive immunization

59 o their exceptional adaptability and poses a major challenge for developing effective strategies to r

60 However, a major challenge for LC-MS-based methods is that there ca

61 A major challenge in cell and developmental biology is the

62 n fully describe TB resistance patterns is a major challenge in ensuring that all persons diagnosed w

63 c variation to phenotypical traits remains a major challenge in evolutionary genetics.

64 A major challenge in neurobiology in the 21st century is t

65 ired resistance to hormone therapy remains a major challenge in treating advanced prostate cancer.

66 o androgen deprivation therapy represent the major challenge in treating prostate cancer.

67 A major challenge of intracellular parasite research is co

68 easing prevalence of type 2 diabetes poses a major challenge to societies worldwide.

69 reproducibility of biomedical research is a major challenge.

70 s within these association regions remains a major challenge.

71 lt from processing of used nuclear fuel is a major challenge.

72 Analysis of major challenges in the field along with exciting opport

73 ial immune-related adverse events remain two major challenges.

74 raction and reduced protein synthesis but no major changes in m(2) (6,6)A levels in 18S rRNA.

75 ws, alpine lakes and streams will experience major changes in temperature regimes, absolute and relat

76 Erythroblastopenia is the major characteristic of the disease, which is a model fo

77 Activation of Tnfa and its receptors or major chemokine receptor-ligand subsets persisted in the

78 Gal d 7 represents a novel major chicken meat allergen.

79 ypic evolution are detected at the origin of major clades and body plans, but not concurrent with pre

80 ed structures, these provide coverage of the major class B GPCR subfamilies.

81 ed electrocyclization of dithienylethenes, a major class of molecular switches.

82 Here, we review each major class of ncRNA that is currently annotated in the

83 The RBGs are grouped into three major classes based on molecular and morphological chara

84 Here, we show that the three major classes of LCCBs activate STIM/ORAI-mediated Ca(2+

85 However, several major classes of therapeutically relevant proteins have

86 variation remained after adjustment for the major clinical conditions.

87 Six major clusters of genes exhibiting distinctive features

88 auditory, and cutaneous abnormalities, with major complications of infection and skin cancer.

89 The cell adhesion molecule E-cadherin is a major component of adherens junctions and marks Langerha

90 Thus, PKD2 channels are a major component of functional flow sensing in the vascul

91 Thus, TLV was the major component of TLG, whereas SUL(average) was a minor

92 ts to a more compact conformation and is the major component.

93 ggregated alpha-synuclein (alpha-Syn) as the major component.

94 The major compounds identified in the fruit flesh included s

95 the form of the statistical analysis produce major conceptual and operational challenges for empirici

96 g prediction methods lack an analysis of the major conformational states and might underestimate the

97 This strategy removes ventilation as the major constraint to exercise capacity in COPD, allowing

98 the leading cause of global mortality and a major contributor to disability.

99 being a key aspect of the nursing role and a major contributor to positive outcomes for service users

100 ysomelidae), is a serious insect pest in the major corn growing areas of North America and in parts o

101 To clarify this, two major crops, corn and soybean differing in iron uptake s

102 duce the primary cardiovascular end point of major CVD events (composite of myocardial infarction, st

103 Two major cytoskeletal components, microtubules and actin fi

104 The major dechlorinating species in the seed culture, Dehalo

105 o variations in their median LOS as follows: major decrease, moderate decrease, and no decrease.

106 fracture repair, patients in hospitals with major decreases in LOS had a higher risk of severe adver

107 owth and that the double knockout cells have major defects in proliferation.

108 The causes of this major deficiency and consequences thereof are so far not

109 mes were the proportion of participants with major depression and function scores at 6 months post-tr

110 luence psychiatric symptomatology, including major depression and schizophrenia.

111 We compare participants diagnosed with Major Depressive Disorder (MDD) (n = 64) to healthy cont

112 Major depressive disorder (MDD) and Alzheimer's disease

113 Major depressive disorder (MDD) is a leading cause of di

114 Major depressive disorder (MDD) is a serious, heterogene

115 om meta-GWASs of self-reported and recurrent major depressive disorder (MDD), bipolar disorder and sc

116 rcRNAs in psychiatric diseases, particularly major depressive disorder (MDD), remains largely unknown

117 t response has been a clinical challenge for major depressive disorder (MDD).

118 tom alleviation and quality of life (QoL) in major depressive disorder (MDD).

119 by minimal phenotyping and strictly defined major depressive disorder (MDD): the former has a lower

120 luded 67,807 individuals with a diagnosis of major depressive disorder or depressive disorder not oth

121 were also observed in human fibroblasts from major depressive disorder patients.

122 d genetic risk for behavioral disinhibition, major depressive disorder, depressive symptoms, autism s

123 Lithium has been used to treat major depressive disorder, yet the neural circuit mechan

124 ynapses is a primary objective when treating major depressive disorder-a disease that afflicts ~20% o

125 s strongly with recurrent and single-episode major depressive disorder.

126 hods using real RNA-seq data from a study of major depressive disorder.The cnCV method has similar tr

127 thetic activation, and in heart failure is a major determinant of cardiac physiology and pathophysiol

128 Myocardial fibrosis is a major determinant of clinical outcomes in heart failure

129 with multiple immune-mediated diseases are a major determinant of interindividual variability in patt

130 re-domain potassium channels (K(2P)) are the major determinants of the background potassium conductan

131 tations in the primary toxicity target and a major detoxification enzyme.

132 across adolescence and early adulthood for 2 major dietary patterns and their associations with child

133 Although no major difference was observed after other types of liver

134 tic domain, we found that ULK1 and ULK2 have major differences in their autophagy-related interactors

135 pathways that were opened in neuroscience by major discoveries and set the stage for the next 50 year

136 oietic system has a remarkable tolerance for major disruptions in chromatin structure and reveal a ro

137 pentameric cytoskeletal SCAR/WAVE complex, a major downstream target of RAC1, in a mouse model of mel

138 However, a major drawback is the need for invasive implantation of

139 Gene duplication and divergence is a major driver in the emergence of evolutionary novelties.

140 Land-use change is a major driver of biodiversity loss worldwide.

141 le postoperative myocardial injury remains a major driver of morbidity and mortality, the ability to

142 gradation and loss of natural habitat is the major driver of the current global biodiversity crisis.

143 These results suggest that nitrogen is a major driver of the physiological ecology of E. huxleyi

144 evalence and compares the relative effect of major drivers of stunting decline between countries.

145 However, the major driving force for clearance remains largely unknow

146 Since cures are currently unavailable, major efforts in improving brain health need to focus on

147 18)O(sw) displayed positive excursion during major El Nino events of 1983, 1997/98 and 2015/16, indic

148 erobic respiratory chains, whereas UQ is the major electron carrier in the reduction of dioxygen.

149 For metabolism, diet and nutrition are the major environmental aspects and have emerged as key comp

150 ollution <2.5 mum in diameter (PM(2.5)) is a major environmental threat to global public health.

151 we demonstrate that the RarA protein makes a major enzymatic contribution to RecA-independent recombi

152 he process of poly(ADP-ribosyl)ation and the major enzyme that catalyses this reaction, poly(ADP-ribo

153 During major epidemic outbreaks, demand for healthcare workers

154 No additional major errors (MEs) or VMEs were found.

155 Replication protein A (RPA), a major eukaryotic ssDNA-binding protein, is essential for

156 ) and gamma-aminobutyric acid (GABA) are the major excitatory (E) and inhibitory (I) neurotransmitter

157 alpha-Actinins are major F-actin bundlers that are inhibited by Ca(2+) in n

158 oducibility provided by the array may have a major facilitating impact on the field of electromicrobi

159 data suggest that cellular environment is a major factor dictating stability.

160 te that the base rate of true effects is the major factor that determines the replication rate of sci

161 IRF7 are closely related IRF members and the major factors for the induction of interferons, a key co

162 The 2 major factors lowering BP in tilt-induced vasovagal sync

163 ific delta(13)C and Delta(13)C values of the major fatty acids, provides chemical evidence for milk,

164 rfluorooctanesulfonate (PFOS) and PFOA in P. major feathers and plasma were significantly and positiv

165 -specific inter-hemispheric asymmetry is one major feature of meditation, and that mental processes s

166 rhythms in V4 that became apparent when the major feedforward input to V4 was removed by lesioning V

167 cal data continue to be rapidly generated, a major focus of bioinformatics research has been aimed to

168 se and targeting this class of proteins is a major focus of interest.

169 ity of early-life gluten exposure has been a major focus of prevention efforts.

170 input after such an injury, and is clearly a major focus of reorganization.

171 ese results suggest that neurexins perform a major function at the calyx synapse in coupling presynap

172 rsely affect the thyroid hormone system, and major gaps have been identified in the tools available f

173 Somatic mutations are major genetic contributors to cancers and many other age

174 Staphylococcus aureus ST45 is a major global MRSA lineage with huge strain diversity and

175 One of the major goals for astronomy in the next decades is the rem

176 ing community assembly processes across four major habitat types (free-living, particle-associated, b

177 phoidal Salmonellosis in particular remain a major health and economic burden worldwide.

178 A total of 151 patients who underwent a major hepatic resection were randomized (mean age = 62.8

179 unbiased approach identified autophagy as a major HIF-1-targeted pathway in IEC.

180 e protein-derived antigens in the context of major histocompatibility complex (MHC) class Ia and clas

181 -7 (HHV-7) U21 glycoprotein binds to class I major histocompatibility complex (MHC) molecules in the

182 Adaptive immunity vitally depends on major histocompatibility complex class I (MHC I) molecul

183 ific CD8(+) T cells, applying peptide-loaded major histocompatibility complex class I (pMHCI) tetrame

184 These results indicate that major histocompatibility complex II-associated susceptib

185 However, the mechanisms by which major histocompatibility complex-associated genetic susc

186 Major host insults are reactive oxygen and reactive nitr

187 gnized as highly immunosuppressive, posing a major hurdle for inducing immune-mediated destruction of

188 ently infected HPCs is reexpression of viral major immediate early (MIE) genes.

189 li and links its associated metabolites to a major immunological marker of IBD.

190 Food has a major impact on all aspects of health.

191 -terminal acetylation, a modification with a major impact on cytoskeletal dynamics.

192 st non-salmonid disease that has resulted in major impacts globally.

193 wastewater microbial communities, which is a major impediment for the design of sustainable peptide-b

194 heterogeneity of intralesional drug PK, have major implications for antimicrobial drug development.

195 es from a civilian or military source, is of major importance for society and future improvements in

196 Field-scaling brings about two major improvements.

197 /132), which was minor in 26/132 (19.7%) and major in 83/132 (62.9%).

198 evidence of graft-versus-host disease, with major infection at 1 year in one and new-onset seizures

199 dimerizes in silico and in vitro through two major interfaces: (i) beta-interface, mapped to Switch I

200 ins on human and zebrafish PR and highlights major interspecies differences in their activity, which

201 Missing values are a major issue in quantitative data-dependent mass spectrom

202 The major issue is modeling the complex crosstalk among tran

203 ovel approach has promise for overcoming two major issues in human islet transplantation: (a) poor yi

204 of this landslide complex at the head of the major knickzone defining the fluvial edge of the Tibetan

205 and mechanisms, and we identify the current major knowledge gaps for future research.

206 Strontium-90 ((90)Sr) is the major long-lived radionuclide derived from the Chernobyl

207 tion of METTL3 (the catalytic subunit of the major m(6)A methyltransferase complex), m(6)A demethylas

208 Two major mechanism hypotheses, both involving ESAA relief,

209 ue to alternative splicing, while the second major mechanism-RNA editing due to post-transcriptional

210 is to acute gamma-radiation exposure and the major mechanisms it uses to recover from this stress.

211 tools facilitate analyses of one of the two major mechanisms of transcriptome diversity, namely, dif

212 remains a risk factor for CVD independent of major metabolic factors.

213 Obesity is a major modifiable risk factor for pancreatic ductal adeno

214 ight ventricular failure (RVF) is a cause of major morbidity and mortality after left ventricular ass

215 xperiments show that the variant exists in a major native state, two minor native-like states, and tw

216 hat advances in prevention and management of major neurological disorders are not sufficiently effect

217 A major objective of the present study was to identify the

218 e-scale ivermectin treatment and overcomes a major obstacle to the elimination of onchocerciasis in a

219 tumor growth and progression, and also pose major obstacles for cancer therapy.

220 Osiurak and Reynaud highlight a major omission of models of cumulative technological cul

221 the ability of a C. trachomatis recombinant major outer membrane protein (rMOMP) vaccine to elicit c

222 We investigated whether duodenal major papilla morphology could be a risk factor for fail

223 binant libraries consisting of as few as one major pathogen antigen.

224 perative FOLFOX chemotherapy did not improve major pathological response rate (TRG1 = 8%) but was ass

225 Though neglected, these parasites can cause major pathology and mortality to livestock leading to si

226 ction requires the primary cilium (PC) where major pathway components are dynamically enriched.

227 in particular, the association with P-gp, a major pathway for clarithromycin metabolism.

228 e objective of this work was to classify the major phenolic compounds, compare the effectiveness of t

229 am target miRNAs, miR-30c-2*, and miR-497 as major players that can suppress progression and metastas

230 S20G fibrils, by contrast, contain two major polymorphs.

231 We report that a major portion of this interkinase (571 residues out of 6

232 Proteolysis is a major posttranslational regulator of biology inside and

233 k demonstrates that drug-target binding is a major predictor of bacterial responses to antibiotics.

234 ("bleaching") under heat stress has become a major problem for reef-building corals worldwide.

235 A major problem with such mouse models is that bnAb expres

236 erm graft dysfunction constitute some of the major problems.

237 Plasmacytoid DCs (pDCs), the major producers of type I interferon, are principally re

238 c analysis was conducted that identified the major proteins present in the culture supernatant.

239 Due to PTMs' extremely important roles, many major PTMs have been studied, while the functional and m

240 unctional and mechanical characterization of major PTMs is well documented in several databases.

241 Heart failure is a major public health problem affecting over 23 million pe

242 macrophages.IMPORTANCE HIV continues to be a major public health problem worldwide, with over 36 mill

243 terium tuberculosis (Mtb) infection and is a major public health problem.

244 Based on the 5.2 M SNP dataset, major QTLs were located on chromosomes 3 and 7 for Mn co

245 t in mice, where loss of VISTA disrupted the major quiescent naive T cell subset and enhanced self-re

246 First, the major redox couples in the mitochondrial matrix (NAD, NA

247 ted with effective post-operative analgesia, major reductions in in-hospital consumption of opioids,

248 Thus, [Ca(2+)](ER) is a major regulator of InsP(3)R channel activity and InsP(3)

249 convolutional neural network to segment six major renal structures: glomerular tuft, glomerulus incl

250 Median TTR for major respiratory pathogens by organism ranged from 29.2

251 ian follow-up was 59 months, and overall and major response rates were 90.5% and 79.4%, respectively.

252 tunately do not offer an opportunity to make major revisions in the way that journals do.

253 homeostasis, with insulin resistance being a major risk factor for metabolic diseases such as type 2

254 Epstein-Barr virus (EBV) DNAemia is a major risk factor for posttransplant lymphoproliferative

255 A major roadblock for predicting how tropical deforestatio

256 microtubule-associated protein that plays a major role in Alzheimer's disease (AD) and other tauopat

257 hange between homologous chromosomes plays a major role in evolution by breaking linkage between adva

258 and archaea), 2 microbial groups that play a major role in the global carbon cycle.

259 h virus (NiV) matrix protein (NiV M) plays a major role in virus assembly.

260 We attribute a major role to post-melting temperature-dependent diffusi

261 Living in various habitats, tardigrades play major roles as consumers and decomposers in the trophic

262 Store-operated Ca2+ entry (SOCE) is the major route of Ca2+ influx in platelets.

263 Short photoperiod and low temperature, the major seasonal cues heralding winter, suppress branching

264 The major sensory nerve pathway between the colon and centra

265 The receptor adopts two major signaling conformations, one of which couples almo

266 rmation about the evolutionary roots of this major signaling pathway, will shed light on the origins

267 DNA methylation is a major silencing mechanism of transposable elements (TEs)

268 oping microbiome of the small intestine, the major site for nutrient metabolism and absorption.

269 The pig's rostrum has three major skin-folds.

270 advancements in groundbreaking science with major societal implications, communicating about science

271 results suggest that recent vomiting is the major source of airborne norovirus and imply a connectio

272 the retinal pigment epithelium (RPE) is the major source of fundus autofluorescence (FAF).

273 In precision oncology, two major strategies are being pursued for predicting clinic

274 ecreased oxygen concentration (hypoxia) is a major stressor that generally subverts life of aerobic s

275 Histological examinations did not reveal major structural changes at proximal sciatic nerve branc

276 -beta-(1->6)-N-acetylglucosamine (PNAG) is a major structural determinant of bacterial biofilms respo

277 At 3 and 5 days, 2 major subsets of Siglecf(hi) (enriched for eg, Icam1 and

278 the MERS coronavirus Spike (S) protein, the major surface antigen of coronaviruses, which is current

279 ognitive decline is an adverse outcome after major surgery associated with increased risk for mortali

280 statistically significant increased risk of major surgical complications.

281 Erythropoietin (EPO) provides the major survival signal to maturing erythroid precursors (

282 Thus, ATR is a major target for cancer therapies in homologous recombin

283 henomenon, as its fruit are astomatous and a major target for desiccation resistance to enhance shelf

284 in penicillin-binding protein 2X (PBP2X), a major target of beta-lactam antibiotics in pathogenic ba

285 NA regulation and their co-regulation in two major TGCT subtypes.

286 HIV drug resistance is a major threat to achieving long-term viral suppression in

287 ity caused by habitat conversion, which is a major threat to biodiversity(5).

288 carcinoma (HCC) development, representing a major threat to human health.

289 velopment of multicellularity was one of the major transitions in evolution and occurred independentl

290 As a major transnational enterprise, illegal wildlife trade i

291 y been deemed to reveal a previously unknown major tropical eruption in 1108 CE.

292 ork shows that severe disturbances caused by major tropical hurricanes facilitate gene-flow and incre

293 In contrast, guaiacyl (G) lignin, the other major type of lignin monomer, is derived from polymeriza

294 The two major types of reactions that are catalyzed by AOXs are

295 We meta-analysed the risk ratio (RR) for major vascular events (a composite of cardiovascular dea

296 y, P(interaction)=0.02; 2.7% versus 1.7% for major vascular events, P(interaction)<0.0001).

297 n of blood flow in the human fetal heart and major vessels.

298 Major virulence genes carried by each of the top 7 STEC

299 ent nucleotide modification has emerged as a major way of controlling the processing, localization, s

300 ght into the binding interaction between the major whey protein, beta-Lactoglobulin (betaLG) and vita