1 .5 (10-23) days, respiratory failure was the
major cause.
2 eases that involve reduced inhibition as the
major cause.
3 pesticide exposure has been proposed as the
major causes.
4 of overall mortality and mortality from all
major causes.
5 Leishmania
major causes cutaneous leishmaniasis.
6 ion is a frequent cardiovascular event and a
major cause for cardiomyocyte loss.
7 Graft-versus-host disease (GvHD) presents a
major cause for morbidity and mortality after allogeneic
8 AL is a
major cause for morbidity and mortality after colorectal
9 Heart failure is a
major cause for premature death.
10 of uncorrected refractive error remained the
major cause for presenting visual impairment.
11 Metastasis to distant organs is a
major cause for solid cancer mortality, and the acquisit
12 This redox zonation may be the
major cause for the Earth's upper mantle being more oxid
13 Drug resistance is a
major cause for the failure of cancer chemotherapy or ta
14 Of these, 91.1% had traumatic deaths, with
major causes including nonhead blunt injuries (43.2%) an
15 causes lifelong chronic infections and is a
major cause of abortions in humans and livestock.
16 Neurocysticercosis (NCC) is a
major cause of acquired epilepsy in most of the world.
17 Hepatitis B virus (HBV) infection is a
major cause of acute and chronic liver disease and assoc
18 Despite its rarity, it represents the
major cause of acute liver failure (ALF) requiring liver
19 Respiratory syncytial virus (RSV) is a
major cause of acute lower respiratory infection (ALRI)
20 It is a
major cause of acute lower respiratory tract infection a
21 throughput screen for inhibitors of HPIV3 (a
major cause of acute respiratory infection), we identifi
22 Norovirus infections are a
major cause of acute viral gastroenteritis and a signifi
23 Plasmodium falciparum in pregnancy is a
major cause of adverse pregnancy outcomes.
24 s for diverse diseases, but also represent a
major cause of adverse reactions.
25 Alzheimer disease (AD) is a
major cause of age-related dementia.
26 llen in Northern and Central Europe and is a
major cause of allergic rhinitis and, possibly, asthma s
27 unistic pathogen Pseudomonas aeruginosa is a
major cause of antibiotic-tolerant infections in humans.
28 A high level of serum cholesterol is a
major cause of atherosclerosis.
29 he synaptic scaffolding protein SHANK3 are a
major cause of autism and are associated with prominent
30 misfolding caused by the P23H mutation is a
major cause of autosomal dominant retinitis pigmentosa (
31 Biallelic variants in the EYS gene are a
major cause of autosomal recessive inherited retinal dis
32 Human advance on natural habitats is a
major cause of biodiversity loss.
33 Irreversible photoreceptor cell death is a
major cause of blindness in many retinal dystrophies.
34 of age-related macular degeneration (AMD), a
major cause of blindness in the elderly.
35 Diabetic retinopathy (DR) is a
major cause of blindness, and there is a lack of effecti
36 Diabetes is a
major cause of blindness, kidney failure, heart attacks,
37 age-related macular degeneration (AMD), is a
major cause of blindness.
38 Prostate cancer (PCa) is a
major cause of cancer death among men.
39 atocellular carcinoma (HCC) has emerged as a
major cause of cancer deaths globally.
40 n aggressive epithelial tumor that remains a
major cause of cancer morbidity and mortality in women.
41 Prostate cancer is a
major cause of cancer morbidity and mortality.
42 Colorectal cancer (CRC) is a
major cause of cancer mortality worldwide, however, the
43 Brain metastasis is a
major cause of cancer mortality, but its molecular mecha
44 Metastasis is a
major cause of cancer mortality.
45 a primary challenge in treating cancer and a
major cause of cancer mortality.
46 ) is one of the most prevalent cancers and a
major cause of cancer related mortality worldwide.
47 Colorectal cancer is a
major cause of cancer-related death in Western countries
48 Cancer metastasis accounts for the
major cause of cancer-related deaths.
49 Fusion genes are a
major cause of cancer.
50 Atherosclerosis is the
major cause of cardiovascular disease (CVD).
51 ibition, rather than error induction, is the
major cause of cell growth inhibition by viomycin.
52 Malaria, a
major cause of child mortality in Africa, is engendered
53 enital cytomegalovirus (cCMV) infection is a
major cause of childhood hearing loss and neurodevelopme
54 Respiratory syncytial virus (RSV) is a
major cause of childhood medically attended respiratory
55 Diphtheria, once a
major cause of childhood morbidity and mortality, all bu
56 Acute bacterial meningitis remains a
major cause of childhood mortality in sub-Saharan Africa
57 ive impairment is an increasingly recognized
major cause of chronic disability and is commonly found
58 Lead (Pb) is extremely toxic and a
major cause of chronic diseases worldwide.
59 licobacter pylori (H. pylori) infection is a
major cause of chronic gastritis, peptic ulcer diseases
60 A
major cause of chronic kidney disease (CKD) is glomerula
61 Hepatitis C virus (HCV) infection is a
major cause of chronic liver disease and associated morb
62 d intervertebral disc degeneration (IVDD) as
major cause of chronic low back pain represent the most
63 vaccines against hepatitis C virus (HCV), a
major cause of cirrhosis and cancer, has been stymied by
64 Glomerular injury is a
major cause of CKD, which is epidemic and without therap
65 cy in the intended disease indication is the
major cause of clinical phase drug development failure.
66 Human Rhinovirus (HRV) is a
major cause of common cold, bronchiolitis, and exacerbat
67 Streptococcus pneumoniae is a
major cause of community-acquired pneumonia leading to h
68 Mycoplasma pneumoniae is a
major cause of community-acquired pneumonia.
69 Sinkholes are the
major cause of concern in Florida for their direct role
70 aemophilus ducreyi causes chancroid and is a
major cause of cutaneous ulcers in children.
71 A
major cause of damage is local inflammatory responses, w
72 Relapse of the original disease is a
major cause of death after allogeneic hematopoietic cell
73 rculosis, which is often undiagnosed, is the
major cause of death among HIV-positive people.
74 Tuberculosis is a
major cause of death and disability among children globa
75 Stroke is a
major cause of death and disability globally.
76 Cardiac involvement is the
major cause of death and manifests as dilated cardiomyop
77 Metastatic cancer is a
major cause of death and remains largely incurable.
78 Severe anemia is a
major cause of death by malaria.
79 ost common subtype of ovarian cancer, is the
major cause of death due to gynecologic malignancy in th
80 Cerebral malaria (CM) is a
major cause of death due to Plasmodium infection.
81 Consequently, disease relapse has become the
major cause of death following allo-HSCT.
82 caused mortality to show that lightning is a
major cause of death for the largest trees in an old-gro
83 Skin squamous cell carcinomas (SCCs) are a
major cause of death in patients who have undergone or w
84 Metastasis is the
major cause of death in patients with cancer; with no th
85 The
major cause of death in prostate cancer patients can be
86 last 2 decades, but sepsis continues to be a
major cause of death in this population Immunocompromise
87 Although these bites are the
major cause of death of lorises in captivity, the functi
88 ervention of cardiac diseases, SCD remains a
major cause of death.
89 a severe gastrointestinal disease that is a
major cause of diarrhea-associated mortality in humans.
90 Cryptosporidiosis is a
major cause of diarrheal disease.
91 Human noroviruses are a
major cause of diarrheal illness, but pathogenesis is po
92 Enteroaggregative E. coli (EAEC) are a
major cause of diarrhoea worldwide.
93 Lactose malabsorption (LM) is a
major cause of digestive discomfort from dairy products.
94 stems, and nervous system disease (NSD) is a
major cause of disability and mortality.
95 TANCE Seasonal influenza infection remains a
major cause of disease and death, underscoring the need
96 ammatory response induced by SARS-CoV-2 is a
major cause of disease severity and death in infected pa
97 ory syndrome coronavirus 2 (SARS-CoV-2) is a
major cause of disease severity and death.
98 occus (GAS) is a human-specific pathogen and
major cause of disease worldwide.
99 upport altered RNA regulation by TDP-43 as a
major cause of disease, specific changes within MNs that
100 Temporal lobe epilepsy represents a
major cause of drug-resistant epilepsy.
101 e of an abnormal number of chromosomes, is a
major cause of early pregnancy loss in humans.
102 via mitophagy and mutations in Parkin are a
major cause of early-onset Parkinson's disease (PD).
103 Departure delays are a
major cause of economic loss and inefficiency in the gro
104 A nonreceptive uterus is a
major cause of embryo implantation failure.
105 cantonensis (Ac), or the rat lungworm, is a
major cause of eosinophilic meningitis.
106 A
major cause of failed drug discovery programs is subopti
107 lular bacterium Orientia tsutsugamushi, is a
major cause of fever across the Asia Pacific region with
108 Salmonella Typhi is a
major cause of fever in children in low- and middle-inco
109 tial incapacitating bioterrorism agent and a
major cause of food poisoning, we developed a "class T"
110 Salmonella enterica serovar Enteritidis is a
major cause of foodborne disease in Uruguay since 1995.
111 ms, such as amotivation and anhedonia, are a
major cause of functional impairment in schizophrenia.
112 ontyphoidal Salmonella (NTS) organisms are a
major cause of gastroenteritis and bacteremia, but littl
113 Rotavirus is a
major cause of gastroenteritis in children <5 years of a
114 is.IMPORTANCE Enteric viral infections are a
major cause of gastroenteritis worldwide and have the po
115 e translocations or deletions, making them a
major cause of genomic instability, a driving force of m
116 ave been linked to cardiovascular disease, a
major cause of global mortality and morbidity.
117 D) are increasing and may jointly become the
major cause of HCC globally.
118 ac myosin heavy chain gene (beta-MyHC) are a
major cause of HCM, but the specific mechanistic changes
119 ed incidence and mortality, sepsis remains a
major cause of health loss worldwide and has an especial
120 It is considered a
major cause of health loss, but data for the global burd
121 inetobacter baumannii infection has become a
major cause of healthcare-associated infection and a cri
122 eatosis to fibrotic steatohepatitis and is a
major cause of hepatic morbidity.
123 These results uncover a
major cause of hepatic vascular cavernomas and provide a
124 HBV chronic infection remains the
major cause of hepatocellular carcinoma worldwide, with
125 (+) T cell depletion has been considered the
major cause of HIV-induced reactivation of LTBI, recent
126 ratory tract illness in young children and a
major cause of hospital admissions globally.
127 ndeed, multidrug-resistant A. baumannii is a
major cause of hospital-acquired infections and has been
128 Vancomycin-resistant enterococci (VRE) are a
major cause of hospital-acquired infections.
129 Respiratory syncytial virus (RSV) is a
major cause of hospitalization in infants.
130 Our data reveal that blood clotting is the
major cause of host death following inflammasome activat
131 A
major cause of human blindness is the death of rod photo
132 n clock and external environmental cues is a
major cause of human cognitive dysfunction.
133 Colorectal cancer (CRC) is a
major cause of human death.
134 sure of lung tissues to cigarette smoke is a
major cause of human disease and death worldwide.
135 Seasonal influenza viruses are a
major cause of human disease worldwide.
136 Enteroviruses are a
major cause of human disease.
137 Influenza A virus (IAV), a
major cause of human morbidity and mortality, continuous
138 POLE mutations are a
major cause of hypermutant cancers, yet questions remain
139 easonal outbreaks of influenza A virus are a
major cause of illness and death around the world each y
140 A
major cause of inadequate quantification is the separati
141 rearrangements (MLL-r) such as MLL-AF4 are a
major cause of incurable acute lymphoblastic leukemias (
142 spiratory syncytial virus (RSV) disease is a
major cause of infant morbidity and mortality.
143 Neural tube closure defects are a
major cause of infant mortality, with exencephaly accoun
144 Escherichia coli ST131 is a
major cause of infection with extensive antimicrobial re
145 Cytomegalovirus (CMV) is a
major cause of infection-related morbidity and mortality
146 on harbors herpes simplex virus 1 (HSV-1), a
major cause of infectious corneal blindness.
147 Enterotoxigenic Escherichia coli (ETEC) is a
major cause of infectious diarrhea in children, traveler
148 Fungi represent a
major cause of infectious morbidity and mortality in imm
149 Adenoviruses are a
major cause of infectious mortality in children followin
150 Primary Ovarian Insufficiency (POI) is a
major cause of infertility, but its etiology remains poo
151 proteins.IMPORTANCE Influenza A virus is the
major cause of influenza, a respiratory disease in human
152 ollowing conventional cold storage (CS) is a
major cause of injury leading to graft loss after LT.
153 Although incidence decreased, NTS remained a
major cause of invasive bacterial infection and mortalit
154 Optic neuropathy is a
major cause of irreversible blindness worldwide, and no
155 particularly its inflammatory reactions, the
major cause of irreversible neuropathy in leprosy.
156 Atherosclerosis is the
major cause of ischemic coronary heart diseases and char
157 Enterohemorrhagic E. coli (EHEC) is a
major cause of large outbreaks worldwide associated with
158 Transplant glomerulopathy (TG) is a
major cause of late allograft loss.
159 Peri-implantitis is widely recognized as a
major cause of late implant failure, both in pristine an
160 vestibular areflexia syndrome (CANVAS) and a
major cause of late onset ataxia.
161 detection of the hepatitis B virus (HBV)-the
major cause of liver cirrhosis and hepatocellular carcin
162 Chronic HBV infection is a
major cause of liver disease and cancer worldwide.
163 oholic steatohepatitis (NASH), have become a
major cause of liver transplant and liver-associated dea
164 Alcoholic liver disease (ALD) is a
major cause of liver-related mortality.
165 Fibrosis is a
major cause of loss of renal function in autosomal domin
166 This leakage is probably a
major cause of low product coupling ratios in all FDHs.
167 It is a
major cause of maternal and fetal morbidity and mortalit
168 Preeclampsia is a
major cause of maternal and fetal morbidity.
169 d, and, to our knowledge, it remains the one
major cause of maternal mortality without a systematic r
170 d vaccines, Neisseria meningitidis remains a
major cause of meningitis and sepsis in humans.
171 rment, which often progresses to dementia, a
major cause of morbidity and disability.
172 hropod vectors, such as mosquitoes, remain a
major cause of morbidity and mortality [1].
173 Cytomegalovirus (CMV)-infection remains a
major cause of morbidity and mortality after lung transp
174 Human cytomegalovirus (HCMV) is a
major cause of morbidity and mortality among immunocompr
175 Infections have become the
major cause of morbidity and mortality among patients wi
176 Atrial fibrillation (AF) is a
major cause of morbidity and mortality globally, and muc
177 strointestinal (GI) tract involvement is the
major cause of morbidity and mortality in acute graft-ve
178 Anthracycline-induced cardiotoxicity is a
major cause of morbidity and mortality in childhood canc
179 Typhoid fever is a
major cause of morbidity and mortality in developing cou
180 Graft-versus-host disease (GVHD) is a
major cause of morbidity and mortality in hematopoietic
181 Cytomegalovirus (CMV) infection is a
major cause of morbidity and mortality in kidney transpl
182 Thrombotic complications are a
major cause of morbidity and mortality in patients with
183 ctions including cytomegalovirus (CMV) are a
major cause of morbidity and mortality in solid organ tr
184 Bacterial meningitis is a
major cause of morbidity and mortality in sub-Saharan Af
185 rom obstructive coronary artery disease is a
major cause of morbidity and mortality in the developed
186 Rationale: In cystic fibrosis the
major cause of morbidity and mortality is lung disease c
187 ase (GVHD), while relatively rare, remains a
major cause of morbidity and mortality posttransplant.
188 Diarrheal illness is a
major cause of morbidity and mortality throughout the wo
189 HF remains a
major cause of morbidity and mortality worldwide, and wi
190 e therapeutic advances, heart failure is the
major cause of morbidity and mortality worldwide, but wh
191 Infectious diseases are a
major cause of morbidity and mortality worldwide, exacer
192 Valvular heart disease is a
major cause of morbidity and mortality worldwide.
193 Coronary artery disease (CAD) is a
major cause of morbidity and mortality worldwide.
194 ith preserved ejection fraction (HFpEF) is a
major cause of morbidity and mortality, accounting for t
195 Fibrotic diseases remain a
major cause of morbidity and mortality, yet there are fe
196 Hospital-acquired pneumonia is a
major cause of morbidity and mortality.
197 evelopment of type 2 diabetes mellitus and a
major cause of morbidity and mortality.
198 Venous thromboembolism is a
major cause of morbidity and mortality.
199 Enteric fever remains a
major cause of morbidity in developing countries with po
200 lmonella Paratyphi), this disorder remains a
major cause of morbidity worldwide with an estimated 17
201 Infection remains a
major cause of morbidity, mortality and technique failur
202 Congestive heart failure is a
major cause of morbidity, mortality, and cost.
203 Cardiovascular disease (CVD) is the
major cause of morbidity, mortality, and health care cos
204 rvivors of traumatic brain injury (TBI) is a
major cause of morbidity, with no effective therapies to
205 efficacy against pulmonary tuberculosis, the
major cause of mortality and disease transmission(1,2).
206 ptococcus pneumoniae (the pneumococcus) is a
major cause of mortality and morbidity globally, and the
207 Dilated cardiomyopathy (DCM) is a
major cause of mortality and morbidity in laminopathies.
208 us prevalence is increasing rapidly and is a
major cause of mortality and morbidity worldwide.
209 Metastasis is the
major cause of mortality for patients with cancer, and d
210 d 35-70 years, cardiovascular disease is the
major cause of mortality globally.
211 Cryptococcal meningoencephalitis (CM) is a
major cause of mortality in immunosuppressed patients an
212 Although aortic rupture is the
major cause of mortality in MFS, patients also experienc
213 Background Cardiovascular disease is a
major cause of mortality in patients with nonalcoholic f
214 eous arterial dissection and/or rupture, the
major cause of mortality.
215 hemotherapy-resistant cancer recurrence is a
major cause of mortality.
216 Infection-induced preterm birth is a
major cause of neonatal mortality and morbidity and lead
217 Preterm birth (PTB) is a
major cause of neonatal mortality and morbidity, often t
218 of perinatal acquisition of S. agalactiae, a
major cause of neonatal sepsis.
219 ith altered disease risks, whereas ADH1 is a
major cause of non-surgical hypoparathyroidism.
220 as revealed that Clostridioides difficile, a
major cause of nosocomial diarrheal disease, exhibits ph
221 in-resistant Enterococcus faecium (VRE) is a
major cause of nosocomial infections.
222 Loss of estrogens at menopause is a
major cause of osteoporosis and increased fracture risk.
223 to group A Streptococcus (GAS) represents a
major cause of outpatient visits and antibiotic use in t
224 , its role in gastric cancer metastasis, the
major cause of patient death, remains unknown.
225 Cancer cachexia is a
major cause of patient morbidity and mortality, with no
226 Vertical transmission is the
major cause of pediatric hepatitis C virus (HCV) infecti
227 Respiratory syncytial virus (RSV) is a
major cause of pediatric respiratory disease.
228 em cavitation resulting in air embolism is a
major cause of plant death during drought, yet the sprea
229 Streptococcus pneumoniae is a
major cause of pneumonia, wherein infection of respirato
230 Metastasis-associated recurrence is the
major cause of poor prognosis in hepatocellular carcinom
231 ned placenta following vaginal delivery is a
major cause of postpartum haemorrhage.
232 ird of the world's adult population and is a
major cause of premature death despite considerable adva
233 Delay in such treatment is a
major cause of premature graft loss in these patients.
234 Posttraumatic HS is a
major cause of preventable death.
235 Elevated blood pressure (BP) is a
major cause of preventable disease in the United States
236 ir genes that drive tumorigenesis could be a
major cause of prostate cancer (PCa) heritability.
237 rotein complex stoichiometry imbalances as a
major cause of protein aggregation in aneuploid cells.
238 Diabetic kidney disease is a
major cause of renal failure that urgently necessitates
239 Acute respiratory viral infections are a
major cause of respiratory morbidity and mortality, espe
240 hication and thermal stress continue to be a
major cause of seagrass decline worldwide, but the assoc
241 s also a "high priority" pathogen which is a
major cause of serious nosocomial infections such as bac
242 Copy number variants (CNVs) are a
major cause of several genetic disorders, making their d
243 Respiratory syncytial virus (RSV) is a
major cause of severe acute lower respiratory tract infe
244 ression vectors.IMPORTANCE Rotaviruses are a
major cause of severe gastroenteritis in infants and you
245 infection with hepatitis C virus (HCV) is a
major cause of severe liver diseases responsible for nea
246 m falciparum infection during pregnancy is a
major cause of severe maternal illness and neonatal mort
247 Cerebral small vessel disease is a
major cause of stroke and dementia, but its genetic basi
248 common sustained cardiac arrhythmia and is a
major cause of stroke and morbidity.
249 common heart rhythm disorder in adults and a
major cause of stroke.
250 Reentrant ventricular arrhythmias are a
major cause of sudden death in patients with structural
251 Anthropogenic disturbance is a
major cause of the biodiversity crisis.
252 tissue by a tumour mass is believed to be a
major cause of the clinical symptoms seen in patients wi
253 The tumour microenvironment (TME) is a
major cause of the failure of both nanomedicines and imm
254 tumor growth into adjacent soft tissues is a
major cause of the frequent recurrence and tumor-related
255 ter nor the upwelling of deep fluids was the
major cause of the observed water level rise.
256 Periodontitis is a
major cause of tooth loss globally.
257 modulating a target gene's expression as the
major cause of trait variation.
258 ietic stem cell transplantation (HSCT) and a
major cause of transplant-related mortality.
259 ial stage of cancer metastasis, which is the
major cause of tumor recurrence and mortality.
260 mycin (mTOR) pathway genes are emerging as a
major cause of type II focal cortical dysplasia (FCD), h
261 t uropathogenic Escherichia coli (UPEC), the
major cause of urinary tract infections.
262 PDA is a
major cause of US cancer-related deaths.
263 Noroviruses are the
major cause of viral gastroenteritis.
264 served therapy confirmed nonadherence as the
major cause of virologic failure for 9 (45%) of 20 highl
265 Age-related macular degeneration is a
major cause of vision impairment in the Western world am
266 nvolved diabetic macular edema (ci-DME) is a
major cause of vision loss.
267 ge-related macular degeneration (exAMD) is a
major cause of visual deterioration.
268 Choroidal neovascularization (CNV) is a
major cause of visual impairment in patients suffering f
269 Cancer of mucosal tissues is a
major cause of worldwide mortality for which only pallia
270 a Enteritidis and Salmonella Typhimurium are
major causes of bloodstream infection and diarrheal dise
271 Lung cancer is one of the
major causes of cancer death and clarification of its mo
272 ial tumor progression and dissemination, the
major causes of cancer mortality.
273 Lung cancer is one of the
major causes of cancer-related deaths worldwide.
274 to develop therapeutics against some of the
major causes of death and disease in the modern world.
275 uences of sex and gender as modifiers of the
major causes of death and morbidity.
276 Suicide is one of the
major causes of death in young people, in whom suicide c
277 Mortality from these
major causes of death is also known to be elevated after
278 yocardial infarction (MI) remains one of the
major causes of death worldwide, and its treatment is a
279 ortality risk tended to be increased for all
major causes of death.
280 y myocardial infarction (MI)) and cancer are
major causes of death.
281 The
major causes of deaths were AIDS- or tuberculosis-relate
282 Here, we review the
major causes of diagnostic heterogeneity in depression,
283 Vaccines against
major causes of diarrhea may be feasible but likely need
284 transplantation, infection and rejection are
major causes of graft loss.
285 ids in protein-coding regions are one of the
major causes of human phenotypic variation and diseases.
286 eases caused by photoreceptor cell death are
major causes of irreversible vision loss.
287 Lymphatic valve defects are one of the
major causes of lymph transport dysfunction.
288 Lymphatic valve defects are one of the
major causes of lymph transport dysfunction; however, th
289 water and household air pollution (HAP) are
major causes of morbidity and mortality among children u
290 d populations, and harvesting was one of the
major causes of mortality for bears throughout their ran
291 e ATP-binding cassette family, is one of the
major causes of multidrug resistance in tumors.
292 dable interventions to prevent and treat the
major causes of preterm death.
293 We aimed to establish the
major causes of preterm mortality in preterm infants in
294 immunothrombotic responses are thought to be
major causes of respiratory failure and death, how they
295 The
major causes of SMOs were postpartum haemorrhage and sev
296 ningococcus), and Haemophilus influenzae are
major causes of this invasive disease.
297 ocardial ischaemia and reperfusion (I-R) are
major causes of ventricular arrhythmias in patients with
298 Retinopathies remain
major causes of visual impairment in diabetic patients a
299 Uncorrected refractive error remains the
major causes of visual impairment.
300 ocation has been well-known to be one of the
major causes responsible for the unfavorable carrier dyn