ライフサイエンスコーパス: major pathway

1 dependent proteasomal degradation (UPD) as a major pathway.

2 ese motifs involve cross-talk among multiple major pathways.

3 roduced in the biosphere is derived from two major pathways.

4 ng Pb toxicity by these two fungi have three major pathways.

5 asts identified Rho signal transduction as a major pathway activated by TL1A and inhibition of this p

6 Among the major pathways activated by HER2/HER3 signaling, the PI3

7 phage polarization and osteogenesis were the major pathways affected by Notch1 haploinsufficiency.

8 Major pathways affected included those involved in metab

9 ating that alpha-secretase processing is the major pathway and that BACE1 processing is the minor pat

10 Here, we review the major pathways and dominant genetic modifiers known to b

11 the cell biology of autophagy, detailing the major pathways and proteins involved, as well as the rol

12 grees C, HCONH(2) decomposes by dehydration (major pathway) and decarbonylation (minor pathway) to li

13 ut the key features in mutational landscape, major pathways, and tumor evolution and heterogeneity in

14 which particles can nucleate ice; two of the major pathways are deposition and immersion freezing.

15 For the benzylic radical ions, two major pathways are in competition, namely, depolymerizat

16 The major pathways are recursive: the dorsolateral pallium (

17 Two major pathways are reported to account for photochemical

18 fied previously unrecognized AR functions in major pathways associated with clinical PCa progression.

19 tiation and endochondral ossification as the major pathways associated with disease which correlated

20 with the promoters of genes involved in the major pathways associated with observed and well-studied

21 lated from measured concentrations for three major pathways: atmospheric processes, tributary runoff,

22 Whether there exist any major pathways beyond this canonical auditory neuraxis r

23 at EVI1 induces MDS in the mouse through two major pathways, both of which require the interaction of

24 ective transition-state stabilization of the major pathway by the thiourea catalyst in the rate- and

25 clinical and basic research suggests that a major pathway by which APOE4 increases the risk of AD is

26 istant to restimulation-induced apoptosis, a major pathway by which autoimmune and chronically restim

27 nonhomologous DNA end-joining (NHEJ) is the major pathway by which DNA double-strand breaks are repa

28 e of T-cell extravasation into tissue is the major pathway by which efalizumab leads to improvement i

29 Soil respiration (Rs) is a major pathway by which fixed carbon in the biosphere is

30 A major pathway by which hcrt/orx neurons are thought to p

31 al membrane proteins known as porins are the major pathway by which hydrophilic antibiotics cross the

32 These findings identify Trem2 signaling as a major pathway by which macrophages respond to loss of ti

33 The major pathway by which the brain obtains essential omega

34 The MCU complex is the major pathway by which these signals are integrated in m

35 This reinforces the view that HR is the major pathway by which transforming DNA is integrated in

36 odynamic model that quantifies and links the major pathways by which mutations inactivate p53.

37 liary excretion of cholesterol represent two major pathways by which the body regulates cholesterol h

38 gdA mutant in X47, a strain deficient in the major pathway (cag pathogenicity island [PAI] encoded) f

39 se studies define the mechanism by which two major pathways can be simultaneously activated in metast

40 biosynthesis in plants proceeds through two major pathways compartmentalized in the chloroplast and

41 ction requires the primary cilium (PC) where major pathway components are dynamically enriched.

42 The model's three major pathways compute expected values of cues, timed pr

43 Two major pathways contribute to Ras-proximate-1-mediated in

44 This implicates reduced trophic support as a major pathway contributing to striatal degeneration in H

45 dentified 50 susceptibility regions, finding major pathways contributing to risk, with some loci shar

46 ation, and cell-cycle regulatory pathways as major pathways controlled by PEAK1.

47 sarum cells and that the che1 cluster is the major pathway controlling swimming bias and chemotaxis.

48 brane was generally thought to occur via two major pathways: cotranslational targeting by signal reco

49 ularly through the Notch effector HES5, is a major pathway critical for the onset and maintenance of

50 Therefore, the two major pathways delivering information to CA1 pyramidal n

51 Our findings identify EGFR signaling as a major pathway determining SG activity and suggest a func

52 Base excision repair (BER) is the major pathway employed to excise oxidized DNA lesions.

53 complement-and-coagulation cascades were the major pathways enhanced in DBD donors.

54 The major pathway for activation of copper/zinc SOD (CSD) in

55 ce and priming, and reveal that priming is a major pathway for adaptation during initial infection.

56 show that activation of the Pho regulon, the major pathway for adaptation to phosphate limitation, re

57 Thalamocortical (TC) projections provide the major pathway for ascending sensory information to the m

58 oltage-dependent anion channel (VDAC) is the major pathway for ATP, ADP, and other respiratory substr

59 A major pathway for B cell acquisition of lymph-borne part

60 suggesting endogenous photoinactivation is a major pathway for bacterial decay.

61 ctivated Ca(2+) (CRAC) channels constitute a major pathway for Ca(2+) influx and mediate many essenti

62 to MPO in vitro, suggesting that MPO is the major pathway for chlorination and nitration of HDL in h

63 y cytochrome P450 7A1 (CYP7A1) initiates the major pathway for cholesterol elimination in mammals.

64 cytochrome P450 46A1 (CYP46A1) initiates the major pathway for cholesterol removal from the brain.

65 Cotransporter Isoform-1 (NKCC1) provides the major pathway for Cl(-) accumulation in glioma cells.

66 in particular, the association with P-gp, a major pathway for clarithromycin metabolism.

67 ght be mediated via P-glycoprotein (P-gp), a major pathway for clarithromycin metabolism.

68 Clathrin-mediated endocytosis (CME) is the major pathway for concentrative uptake of receptors and

69 Kinetically, Cr(III)-muscovite provides a major pathway for Cr(VI) formation and Cr(VI) production

70 Autophagy, a major pathway for degradation of macromolecules in the v

71 te-independent, 'direct entry' cleavage is a major pathway for degrading and processing RNA.

72 th a defect in non-homologous end joining, a major pathway for DNA double-strand break (DSB) repair,

73 homologous end-joining pathway, which is the major pathway for DNA double-strand break repair.

74 er, it is uncertain whether VRAC serves as a major pathway for EAA release from swollen cells.

75 Clathrin-mediated transport is a major pathway for endocytosis.

76 vers from PEPCK KO mice, indicating that the major pathway for entry of hyperpolarized [1-(13)C]pyruv

77 on and transform faults act as an additional major pathway for fluid circulation.

78 and how metabolite signals feed through to a major pathway for gut homeostasis.

79 A major pathway for HIV-1 resistance to nucleoside reverse

80 Food is a major pathway for human exposure to hazardous chemicals.

81 tofore unappreciated role for caspase-8 as a major pathway for IL-1beta processing and release in mur

82 get cell at the immunological synapse is the major pathway for inducing apoptosis of virus-infected c

83 and FcgammaRIV receptors on neutrophils is a major pathway for induction of anaphylaxis.

84 ults indicate that acyl editing of PC is the major pathway for initial incorporation of fatty acids i

85 crohomology-mediated end joining (MMEJ) is a major pathway for Ku-independent alternative nonhomologo

86 Clathrin-mediated endocytosis, the major pathway for ligand internalization into eukaryotic

87 One major pathway for Listeria entry involves binding of the

88 der neutral conditions, protonolysis was the major pathway for metal-carbon cleavage, while under bas

89 In yeast, the major pathway for mRNA decay is initiated by deadenylati

90 One major pathway for mRNA turnover occurs by deadenylation,

91 exchanger isoform 1) in dendrites presents a major pathway for Na(+) overload.

92 The major pathway for NTC recruitment occurs after U4 releas

93 The major pathway for O2 binding to mammalian myoglobins (Mb

94 Macroautophagy, a major pathway for organelle and protein turnover, has be

95 River discharge appeared to be the major pathway for PCBs into the Arctic Ocean with 115 +/

96 Base excision repair (BER) is the major pathway for processing of simple lesions in DNA, i

97 The ubiquitin-proteasome system is the major pathway for protein degradation in eukaryotic cell

98 The Sec machinery constitutes the major pathway for protein translocation in bacteria.

99 Clathrin-mediated endocytosis is the major pathway for recycling of granule membrane componen

100 er SGLT2 in the early proximal tubule is the major pathway for renal glucose reabsorption.

101 A major pathway for repair of DNA double-strand breaks is

102 Homologous recombination is a major pathway for repair of DNA double-strand breaks.

103 initiated base excision repair (BER) is the major pathway for repair of oxidative DNA base damage 8-

104 The NEIL3 pathway is the major pathway for repairing psoralen-ICL, and the FA/BRC

105 show that polyamine oxidation is not only a major pathway for ROS production in prostate, but inhibi

106 e-sensitive Na-Cl cotransporter (NCC) is the major pathway for salt reabsorption in the mammalian dis

107 The ubiquitin-proteasome system is the major pathway for selective degradation of cellular prot

108 The ubiquitin-proteasome system is the major pathway for selective protein degradation in eukar

109 gs suggest that dormant origins constitute a major pathway for stalled fork recovery, contributing to

110 riven tension or actin dynamics regulate the major pathway for synaptic vesicle retrieval.

111 d by the Orai family of proteins represent a major pathway for the agonist-induced entry of calcium a

112 Autophagy is a major pathway for the clearance of harmful material from

113 drial fatty acid beta-oxidation (FAO) is the major pathway for the degradation of fatty acids and is

114 pendent anion channel (VDAC) constitutes the major pathway for the entry and exit of metabolites acro

115 Base excision repair is a major pathway for the removal of simple lesions in DNA i

116 n occur throughout the cell cycle and is the major pathway for the repair of double-strand breaks in

117 Homologous recombination (HR) is a major pathway for the repair of double-strand DNA breaks

118 NHEJ is the major pathway for the repair of double-strand DNA breaks

119 rly identical sequence composition, and is a major pathway for the repair of double-stranded DNA brea

120 Base excision repair (BER) is the major pathway for the repair of simple, non-bulky lesion

121 CT) catalyzes the rate-controlling step in a major pathway for the synthesis of phosphatidylethanolam

122 d store-operated calcium entry (SOCE) as the major pathway for this Ca(2+) influx.

123 cerol 3-phosphate dehydrogenase (mGPDH) is a major pathway for transfer of cytosolic reducing equival

124 Radical addition-elimination reactions are a major pathway for transformation of unsaturated hydrocar

125 othalamic (ST) system has been viewed as the major pathway for transmitting nociceptive and thermocep

126 Clathrin-mediated endocytosis is a major pathway for uptake of lipid and protein cargo at t

127 n-mediated endocytosis (CME) constitutes the major pathway for uptake of signaling receptors into euk

128 The major pathway for visual information reaching cerebral c

129 oascorbate degradation into erythrulose as a major pathway for vitamin C degradation in vivo.

130 Several major pathways for Abeta clearance include receptor-medi

131 Two major pathways for apoptosis have been identified, invol

132 trumental in disclosing the contributions of major pathways for central carbon and amino acid metabol

133 usal link between the UPS and autophagy, the major pathways for degradation of intracellular substrat

134 Cells use two major pathways for DSB repair: nonhomologous end joining

135 ubsequent degradation of Abeta is one of the major pathways for its clearance in the brain.

136 microvesicle shedding models constitute the major pathways for nonclassical IL-1 beta secretion from

137 ific recombination and transposition are the major pathways for rearranging genomes on both long- and

138 vents in eukaryotic cells, and there are two major pathways for repairing them: homologous recombinat

139 ommon in all living cells, and there are two major pathways for their repair.

140 h factor 1 receptor signaling cascade as two major pathways for therapeutic development.

141 Arabidopsis by regulating the expression of major pathway genes in response to developmental and env

142 calcineurin signaling cascade is one of the major pathways governed by intracellular calcium.

143 g strong evidence that the E7 channel is the major pathway (>/=90%) for ligand entry in human hemoglo

144 is at the transcriptional level, and several major pathways have been elucidated in recent years.

145 Two major pathways have been identified, One direct, in whic

146 DSBs are repaired by two major pathways, homologous recombination (HR) and classi

147 uble-strand breaks (DSB) is performed by two major pathways, homology-dependent repair and classical

148 trand breaks (DSBs) are repaired through two major pathways, homology-directed recombination (HDR) an

149 ology (GO) and pathway analyses revealed the major pathways impacted in endophthalmitis includes: met

150 phate dehydrogenase (GAPDH), which activates major pathways implicated in diabetic complications, inc

151 In this review, we explore some of the major pathways implicated in HCC.

152 A major pathway in Arabidopsis thaliana generates IAA in t

153 Base excision repair is the major pathway in mammalian cells responsible for correct

154 factor 2alpha (EIF2AK2/eIF2alpha) axis as a major pathway in mediating septic AKI.

155 f P. gingivalis on beta-catenin signaling, a major pathway in the control of cell proliferation and t

156 The kynurenine pathway is the major pathway in the metabolism of tryptophan.

157 Our results indicate that a major pathway in the target association process for the

158 thways revealed that ERK1/2 functions as the major pathway in TIMP-3 expression, whereas Akt plays a

159 These findings delineate major pathways in a large segment of the flavone metabol

160 The major pathways in melanoma signaling mediated through BR

161 There are two major pathways in oncogenic Ras-driven proliferation: MA

162 Major pathways in primary metabolism were identified, in

163 line is critical for normative function of 3 major pathways in the brain, including acetylcholine bio

164 The human genetic studies implicate some major pathways in the pathogenesis of IBD, including epi

165 Although the major pathways in turnover have been identified, account

166 The data suggests that several major pathways including (1) energy metabolism, (2) prot

167 Transcription-coupled repair (TCR) is the major pathway involved in the removal of UV-induced phot

168 endent endocytosis and macropinocytosis were major pathways involved in lipo-Tat uptake, and actin-fi

169 Additionally, apoptosis was one of the major pathways involved in splenic cell death, which coi

170 roxide production causes the activation of 5 major pathways involved in the pathogenesis of complicat

171 In animals this major pathway is located within the cytoplasm of cells,

172 3))(OAc)(2)(OH(2)) has been studied, and the major pathway is proposed to involve pre-equilibrium ace

173 The major pathway is the canonical ethylene signal transduct

174 programmed death ligand-1 (PD-L1) pathway, a major pathway known to control diabetes occurrence, coul

175 urs is, however, not understood, because the major pathway known to upregulate FT, the photoperiod pa

176 1 does not appear to act in any of the three major pathways known to mend DNA DSBs, namely homologous

177 Both of the major pathways lead directly to the formation of the met

178 t 5-endo-dig cyclization was found to be the major pathway leading to good yields of dehydropyrrolidi

179 identified the canonical inflammasome as the major pathway leading to interleukin-18 (IL-18) release

180 llagen-induced GPVI-mediated pathway, is the major pathway leading to platelet activation after laser

181 s and gain in fat mass, in older adults is a major pathway leading to the onset of functional decline

182 We also found four major pathways leading to these docking poses after the

183 he canonical arm of the NF-kappaB pathway, a major pathway linked to the NSCLC tumorigenesis.

184 Novel major pathways linked to XRN2 include cell cycle control

185 oltage-dependent anion channel (VDAC) is the major pathway mediating the transfer of metabolites and

186 Consistent with the literature, one of the major pathways mediating the antidepressant action of ke

187 elite athletes, finding that every gene in a major pathway metabolizing lactate to propionate is at h

188 module was observed, integrating all of the major pathways needed for lipid storage.

189 classical pathway had been assumed to be the major pathway of activation leading to injury, the manno

190 Inhibition of CD73 eliminates a major pathway of ADO production in the TME and can rever

191 glycosylation, but not glycoxidation, as the major pathway of AGE formation.

192 e cellular response to replication stress, a major pathway of apoptosis induction by many chemotherap

193 The major pathway of biosynthesis is from ornithine through

194 i are the most abundant plant symbiont and a major pathway of carbon sequestration in soils.

195 tes, suggesting that plastic debris can be a major pathway of chemical pollutants into seabirds.

196 Cytochrome P450 46A1 (CYP46A1) initiates the major pathway of cholesterol elimination from the brain

197 tion rather than oxidative metabolism as the major pathway of citrate formation.

198 tions with birnessite has been shown to be a major pathway of Cr(VI) production in serpentine soils.

199 cyclization of the heptadienone moiety as a major pathway of degradation.

200 enzyme, a protein machine essential for the major pathway of DNA break-repair and recombination.

201 Nonhomologous DNA end-joining (NHEJ) is a major pathway of DNA double-strand break (DSB) repair in

202 Nonhomologous end joining (NHEJ), a major pathway of DNA double-strand break (DSB) repair, i

203 A study has found that the major pathway of DNA repair is altered with age in the t

204 tions in Escherichia coli and constitute the major pathway of error-free DSB repair.

205 cated that bioconcentration of PFASs was the major pathway of exposure in the aquatic food web and bi

206 monium oxidation with nitrite (anammox) is a major pathway of fixed nitrogen removal in the anoxic zo

207 The major pathway of genetic recombination and DNA break rep

208 Gene gain by horizontal gene transfer is a major pathway of genome innovation in bacteria.

209 ated calcium (CRAC) channels constitutes the major pathway of intracellular Ca(2+) increase.

210 Autophagy is a major pathway of intracellular degradation mediated by f

211 elective lipid uptake (SLU) is known to be a major pathway of lipoprotein cholesterol metabolism in e

212 ein kinase B/Akt (PKB/Akt), a component of a major pathway of mammalian antiapoptotic signaling syste

213 x), an inner membrane Ca(2+) transporter and major pathway of mitochondrial Ca(2+) entry.

214 In yeast, a major pathway of mRNA decay begins with deadenylation fo

215 Denitrification represents the major pathway of N(2) O production in river systems, whe

216 phosphorylation of p150(Glued) might be one major pathway of NEBD regulation.

217 activation by IL-8 has been identified as a major pathway of NET formation in patients.Conclusions:

218 The ubiquitin-proteasome system is the major pathway of non-lysosomal intracellular protein deg

219 Atmospheric deposition is a major pathway of PCDD/Fs to the Baltic Sea.

220 ns-cinnamic acid, the committed step for the major pathway of Phe metabolism.

221 One major pathway of platelet activation is triggered by 2 r

222 ential protein SecA1, a key component of the major pathway of protein secretion across the cytoplasmi

223 '-to-3' translocase) that is involved in the major pathway of recombinational repair.

224 e ubiquitin-proteasome system represents the major pathway of selective intracellular protein degrada

225 2)(+)](SR) ( >600 mum) where sparks become a major pathway of SR Ca(2)(+) leak.

226 TNF blockade with infliximab can suppress a major pathway of the adaptive immune response and this o

227 One major pathway of this anthropogenic N input into ecosyst

228 In summary, we show that a major pathway of vLEEs involves DEA-mediated cleavage of

229 he cholesterol 24-hydroxylase initiating the major pathways of cholesterol removal from the brain, an

230 on of pathogens and altered self through two major pathways of complement activation.

231 ent developments in the understanding of the major pathways of extracellular vesicle biogenesis and h

232 We recently reported that one of the major pathways of neuronal apoptosis in PPT1-knockout (P

233 Both major pathways of protein degradation, the proteasome an

234 t shock factor 1 (HSF1) regulates one of the major pathways of protein quality control and is essenti

235 Three major pathways of proteolysis have been identified as be

236 operative involvement of each of these three major pathways of proteolysis within the cardiac sarcome

237 erstand the caveats of regeneration, so that major pathways of repair and regrowth can be exploited i

238 erial gene transfer agent and illustrate the major pathways of stress response that can be used to pr

239 nzannulation, and oxy-Cope rearrangement are major pathways of transforming the putative sigma-alkylp

240 amplicons, as well as their cooperation with major pathways of tumorigenesis.

241 retina is processed in parallel through two major pathways, one reaching the primary visual cortex t

242 The cross-talk between the two major pathways-one mediated by cAMP and the other by EFA

243 hing pathways, either precedes P(i) release (major pathway) or occurs simultaneously with it (minor p

244 2,3-dihalopropanoates, debromination is the major pathway providing 3-phenylacrylate derivatives in

245 In the major pathway, Rec10 is loaded, together with Rec25 and

246 Folate transport is mediated by 3 major pathways, reduced folate carrier (RFC), proton-cou

247 Wnt signaling is a major pathway regulating cell fate determination, cell p

248 of TGF-beta and that ShcA/ERK signaling is a major pathway regulating the tumor-promoting activity of

249 , we investigated the role of one of the two major pathways regulating innate immunity in invertebrat

250 dy shows that simultaneous inhibition of two major pathways regulating redox homeostasis using l-buth

251 at remineralization of organic matter is the major pathway releasing DFe throughout the water column

252 Isc pathway, but not the Suf pathway, is the major pathway required for conversion of O(2)-inactivate

253 al oxidative phosphorylation (OXPHOS) as the major pathway required for optimal proliferation in low

254 ATR-dependent cell cycle checkpoint are the major pathways responsible for repair of UV-induced DNA

255 BMP signaling is one of the major pathways responsible for the patterning of the Dro

256 There are the two major pathways responsible for the repair of DNA double-

257 ative 5' splice site selection is one of the major pathways resulting in mRNA diversification.

258 K activation has been shown to be one of the major pathways resulting in the activation of Nrf2 and i

259 Thus, while apoptosis is a major pathway that causes muscle weakness in OPMD, other

260 Thus, the need for a major pathway that controls integrin adhesion turnover d

261 BER is a major pathway that copes with DNA damage induced by seve

262 The cGAS-STING pathway has emerged as a major pathway that detects intracellular DNA.

263 RNA-directed DNA methylation (RdDM) is the major pathway that initiates de novo DNA methylation in

264 A major pathway that mediates brain Abeta clearance is the

265 Calmodulin (CaM) is the major pathway that transduces intracellular Ca2+ increas

266 A major pathway that was compromised, when TCR signaling w

267 l biological function and a critical role in major pathways that are closely linked to cancer.

268 In summary, we have identified two major pathways that control perineural and cortex glioge

269 We summarize the major pathways that govern the first cell fate decisions

270 3 posttranscriptionally regulates one of the major pathways that promotes chondrogenesis, the transfo

271 ulated kinases 1/2 (ERK1/2) pathways are two major pathways that regulate autophagy induced by nutrie

272 PK via two distinct mechanisms as follows: a major pathway (the APPL1/LKB1-dependent pathway) that pr

273 Cells undergo apoptosis through two major pathways, the extrinsic pathway (death receptor pa

274 s and the IkappaB kinase complex through two major pathways: the canonical and non-canonical NF-kappa

275 tabolite induces apoptosis by converging two major pathways: the death receptor-mediated extrinsic an

276 Although NPC1/NPC2 constitutes the major pathway, therapies that amplify minor egress route

277 es available or under development target the major pathways thought essential in the pathogenesis of

278 o mediate cellular Abeta uptake and define a major pathway through which Abeta gains entry to neurona

279 rendered dysfunctional, and that A-NHEJ is a major pathway to process dysfunctional telomeres.

280 Non-homologous end joining (NHEJ) is a major pathway to repair DNA double-strand breaks (DSBs),

281 Taken together, the NEIL3 pathway is the major pathway to repair psoralen-ICL through a unique DS

282 Recent studies suggest that one of the major pathways to the pathogenesis of autism is reduced

283 However, the impact of the other major pathway triggered by intracellular DNA, the absent

284 Lytic granule exocytosis is the major pathway used by CD8+ CTL to kill virally infected

285 tein kinase C, though activated, was not the major pathway used for bacterium-induced viral reactivat

286 Autophagy is a major pathway used to degrade long-lived proteins and or

287 The frequency of mutations within the 4 major pathways varied markedly across genetic subtypes.

288 Three major pathways were identified among these proteins: the

289 Changes in three major pathways were involved in this transition to a mul

290 ongitudinal and medio-lateral axes, in which major pathways were local condensations.

291 atom abstraction from dG is unlikely to be a major pathway when HO(.) reacts with dG.

292 ary production by phytoplankton represents a major pathway whereby atmospheric CO(2) is sequestered i

293 ironmental or oncogenic stress constitutes a major pathway whereby p53 exerts its tumor suppressor fu

294 The first and major pathway, which involves 4-hydroxy-4-phosphoacyl-Co

295 at the top of a hierarchy that directs three major pathways, which are specified by CENP-C, -I, and A

296 We find three major pathways, which provide new insights into (un)bind

297 atively described by a mechanism involving a major pathway with a series of intermediate states and a

298 with hydrogen abstraction from C13 being the major pathway with unlabeled AA but abstraction from C10

299 ation of adult stem cells homeostasis by two major pathways with opposing functions to coordinate bet

300 sion and hyperinsulinism in INS, identifying major pathways worthy of future research in this current