ライフサイエンスコーパス: maladaptive

1 with the hybrid nuclear genome and therefore maladaptive.

2 lse, because many social norms are obviously maladaptive.

3 nclear whether these changes are adaptive or maladaptive.

4 physiological or pathological, adaptive, or maladaptive.

5 ibution is often not necessary and sometimes maladaptive.

6 atory type 2 macrophage state, inhibition of maladaptive adverse left ventricular remodeling, reversa

7 n each behavior or phenotype is individually maladaptive, alternating between these losing strategies

8 eveal that context-impoverished memories are maladaptive and can be improved or distorted after recal

9 ar responses toward nonthreatening cues is a maladaptive and debilitating dimension of trauma- and an

10 ormation and conscious intention, leading to maladaptive and disabling gait abnormalities.

11 pically, this phenomenon has been considered maladaptive and may preclude vision restoration in the b

12 s which upon repetition may become habitual, maladaptive and resistant to extinction as observed in o

13 dings, we suggest that tics are exaggerated, maladaptive, and persistent motor habits reinforced by a

14 Excess activation of this pathway can be maladaptive as in adulthood acute strong activation of M

15 This response appeared maladaptive, as mice with beta cell-specific-deficient N

16 Here intense maladaptive attractions are created in laboratory rats b

17 CeA-induced maladaptive attractions, even to the painful shock-rod,

18 How do brain mechanisms create maladaptive attractions?

19 Evidence indicates that maladaptive autoimmune responses in the arterial wall pl

20 eneficial foods, such as insect protein; and maladaptive avoidance behavior in neuropsychiatric condi

21 nsight into mechanisms underlying normal and maladaptive avoidance behaviors and response inhibition.

22 c stress disorder (PTSD) is characterized by maladaptive avoidance responses to stimuli or behaviors

23 ates." Though not often framed this way, the maladaptive behavior observed in individuals with SUDs m

24 he DMS may be an important substrate for the maladaptive behavior observed in SUDs.

25 he intimal layer, implicating T cells in the maladaptive behavior of vessel wall endogenous cells.

26 elicit complex emotional states, and thereby maladaptive behavior, as a function of their ascribed va

27 k cost effect, an interesting and well-known maladaptive behavior, is pervasive in real life, and thu

28 ce use disorders (SUDs) are characterized by maladaptive behavior.

29 ay prove useful for uncovering mechanisms of maladaptive behavior.

30 association between exposure to violence and maladaptive behavior.

31 with altered glutamatergic transmission and maladaptive behavior.

32 cial learning can also lead to mismatched or maladaptive behavior.

33 atial memory engram can alleviate associated maladaptive behavior.

34 specific cell types and circuits in driving maladaptive behavior.

35 interactions can lead to either adaptive or maladaptive behavioral outcomes.

36 viduals with anorexia nervosa (AN) engage in maladaptive behaviors (restrictive food choices and over

37 nmental approaches to prevent stress-induced maladaptive behaviors and synaptic malfunctions converge

38 iven the central role of ovBNST in mediating maladaptive behaviors associated with stress exposure, o

39 nd circuit activity and leading over time to maladaptive behaviors in vulnerable individuals.

40 inflexible thought patterns; inflexible and maladaptive behaviors).

41 tary behavior in humans and is used to study maladaptive behaviors, such as overeating, drug taking,

42 sensory hypersensitivity, which can lead to maladaptive behaviors, such as tactile defensiveness.

43 ie the link between exposure to violence and maladaptive behaviors.

44 ders in which excessive avoidance results in maladaptive behaviors.

45 of negative memories, as well as extinguish maladaptive behaviors.

46 -20; higher scores indicate higher levels of maladaptive behaviors; minimal clinically important diff

47 ystems, and when executive control over this maladaptive behaviour is diminished.

48 y, hyperactivity, stereotyped and sometimes, maladaptive behaviours.

49 e estimation of independent contributions of maladaptive bias (mean departure from optimum) and impre

50 tive effort early in life is predicted to be maladaptive by accelerating ageing disproportionally, de

51 hales over millions of years, but may become maladaptive by playing a role in mass strandings induced

52 er-lasting SERCA stimulation and may sustain maladaptive Ca(2+) handling.

53 that SAC/VAL acts directly on CF to prevent maladaptive cardiac fibrosis and dysfunction during pres

54 ) channel mediates pressure overload-induced maladaptive cardiac fibrosis by forming stably functiona

55 (mammalian target of rapamycin) activity and maladaptive cardiac remodeling with increased apoptosis,

56 on reduces hypertension, ultimately limiting maladaptive cardiac remodeling.

57 ispensable for the progression of VO-induced maladaptive cardiac remodeling.

58 er transplantation may contribute to ongoing maladaptive cardiovascular remodeling.

59 h proteotoxic gain-of-function activation of maladaptive cell signaling pathways including cell death

60 initiated by molecular defects that pattern maladaptive cellular mechanisms of pathological cardiac

61 adverse left ventricular (LV) remodeling, a maladaptive change associated with progressive heart fai

62 pt, and BNST PACAP signaling may mediate the maladaptive changes associated with chronic stress.

63 chronic dysregulation of CRF systems induces maladaptive changes in amygdalar eCB signaling.

64 data support the hypothesis that age-related maladaptive changes involving nAChRs within thalamocorti

65 setting of AF and appears to counteract the maladaptive changes that lead to intracellular Ca(2+) si

66 ivation in vivo prevented the stress-induced maladaptive changes to amydalo-cortical physiology and m

67 ivation in vivo prevented the stress-induced maladaptive changes to amydalo-cortical physiology and m

68 ting that reward-concurrent cues precipitate maladaptive choice via a unique mechanism unrelated to s

69 These maladaptive choices were further shown to be unaffected

70 Maladaptive circuit changes in emotional valence process

71 thway, benign sensations from the gut induce maladaptive cognitive or affective processes that amplif

72 ncreased the proportion of rats exhibiting a maladaptive cognitive response to cocaine self-administr

73 ls, acute illness can also produce profound, maladaptive, cognitive dysfunction including delirium, b

74 g the relationships between the adaptive and maladaptive consequences of the epigenetic modifications

75 In other patients, maladaptive consequences such as phantom limb pain can o

76 e to stressful stimuli can result in several maladaptive consequences, including increased anxiety-li

77 however, these responses may induce apparent maladaptive consequences.

78 rence with memory reconsolidation can weaken maladaptive context-drug memories and reduce the propens

79 lly susceptible to problem drinking via this maladaptive coping mechanism.

80 P) trait are particularly vulnerable to this maladaptive coping mechanism.

81 sight into how pain becomes chronic with the maladaptive coping of the PAG to pain sensation.

82 ls and other social support; 4) adaptive and maladaptive coping strategies; and 5) impact of RP on wo

83 eover, they suggest that TMSR may counteract maladaptive cortical plasticity typically found after li

84 e are a potential therapeutic target for the maladaptive cue-motivated behavior that marks many psych

85 te the neurobiological mechanisms underlying maladaptive decision making in addiction, thereby improv

86 Yet, the circuit-level mechanisms underlying maladaptive decision making in psychopathy remain unclea

87 s linking valuation, affective deficits, and maladaptive decision making in psychopathy remain unclea

88 ortico-striatal circuit dysregulation drives maladaptive decision making in psychopathy, supporting t

89 Maladaptive decision making is associated with several n

90 models to provide insight into drug-induced maladaptive decision making that may ultimately identify

91 chanism by which salient cues can invigorate maladaptive decision making, an important and understudi

92 use is a multifaceted disorder that involves maladaptive decision making.

93 gic- and stress-dependent sex differences to maladaptive decision making.

94 n dopamine network dynamics that may promote maladaptive decision-making after chronic adolescent alc

95 Although maladaptive decision-making is a defining feature of dru

96 rug-induced alterations, cocaine taking, and maladaptive decision-making processes, however, are diff

97 show that adolescent alcohol use may produce maladaptive decision-making through a disruption in dopa

98 n ways that are relevant to both healthy and maladaptive decision-making.

99 nd cognitive limitations which may result in maladaptive decisions.

100 on activation can be either host adaptive or maladaptive, depending on the pathogen and organ system.

101 acutely stressful events have been linked to maladaptive development and compromised health and behav

102 ure, leads to the overexpression of GRKs and maladaptive downregulation of GPCRs on the cell surface.

103 orm reward-based positive reinforcement into maladaptive drug seeking.

104 iction is a chronic illness characterized by maladaptive drug-induced neuroplastic changes that confe

105 havior in adaptive (e.g., locating food) and maladaptive (e.g., binge eating) ways.

106 um of adult mice was sufficient to phenocopy maladaptive eating behaviors of VAChTcKO mice.

107 hereby promoting habits and vulnerability to maladaptive eating in mice.

108 VAChTcKO mice were more prone to habits and maladaptive eating.

109 gic interneurons play in habit formation and maladaptive eating.

110 Because of this, it is theorized that maladaptive eCB signaling may contribute to the developm

111 Here we show that this maladaptive effect of antipsychotic treatment is mediate

112 ultrasociality in humans may be mediated by maladaptive effects of modern civilization on family gro

113 ual speech does not exert previously assumed maladaptive effects on CI success, but instead provides

114 n whether this process induces beneficial or maladaptive effects, but morphological and behavioral st

115 sympathetic nervous system, among many other maladaptive effects.

116 MPH serves to reduce maladaptive electrophysiological precursors of lapsing a

117 vidence for a disynaptic pathway controlling maladaptive emotional behavior.

118 These maladaptive emotional states can lead to involuntary opi

119 oteome-wide connectivity defects mediated by maladaptive epichaperomes.

120 functions to blunt excessive CHOP to prevent maladaptive ER stress-induced cell death and adverse car

121 is system could contribute to disorders with maladaptive fear circuitry.

122 , as manifested in acute stress symptoms and maladaptive fears.

123 these changes may be reversed or persist as maladaptive features, leading to axon degeneration.

124 merging hypothesis is that the transition to maladaptive feeding behavior seen in eating disorders or

125 ortical changes in a way that may facilitate maladaptive food-seeking behaviors.

126 t has been suggested that visual language is maladaptive for hearing restoration with a cochlear impl

127 to signal threats to survival, it should be maladaptive for highly-erroneous expectations to yield u

128 hardwired behavioral responses (including a maladaptive form of "identity management") can offer dra

129 l and mouse models of FTLD showed this to be maladaptive, fueling a positive feedback cycle of enhanc

130 ann cell c-Jun is implicated in adaptive and maladaptive functions in peripheral nerves.

131 r, concerns about outbreeding depression and maladaptive gene flow limit the use of human-mediated ge

132 Contrary to the classic view of maladaptive gene flow, our study reveals conditions unde

133 It has been challenging to target maladaptive generalized memories without affecting adapt

134 licated Grief-Revised for Children to assess maladaptive grief symptoms in the past 4 weeks.

135 thm differentiated functionally adaptive and maladaptive groups.

136 evel, groups were separated by problem type (maladaptive groups; internalizing vs. externalizing prob

137 Gut dysbiosis, defined as a maladaptive gut microbial imbalance, has been demonstrat

138 Environmental degradation can cause maladaptive habitat selection, inducing ecological traps

139 ndings identify brain-behaviour pathways for maladaptive habitual learning and motivation in chronic

140 exhibit collective 'wisdom' and other times maladaptive 'herding' is an enduring conundrum.

141 interacting with SARS-CoV-2 or mediating the maladaptive host response to COVID-19 can help to identi

142 tive selection could arise from avoidance of maladaptive hybridization.

143 During compensatory and maladaptive hypertrophy, mitochondria become more active

144 olesteryl-esters in macrophages can elicit a maladaptive immune response leading to the development a

145 complement and neutrophils contribute to the maladaptive immune response that fuels hyperinflammation

146 In concert with hyperlipidemia, maladaptive immune system activities can contribute to d

147 Maladaptive immunity and inflammation provoke changes in

148 not appropriately regulated they can also be maladaptive in a context-dependent manner.

149 elp cope with chronic stress but have become maladaptive in modern societies, worsening health.

150 ntages for infectious diseases, but that are maladaptive in modern-day environments.

151 tive behavioral state transitions can become maladaptive in psychiatric disorders such as depression.

152 owever, these plastic responses could become maladaptive in temperate regions, where a warmer climate

153 t the current level of thermal plasticity is maladaptive in the context of anthropogenic climate chan

154 l and reactivity which could be related to a maladaptive increase in the automated sensory change det

155 eased top-down inhibition of behavior and/or maladaptive, inflexible decision-making and planning.

156 on after myocardial infarction are offset by maladaptive innate immune cell function, and therapeutic

157 (HF) is a complex syndrome associated with a maladaptive innate immune system response that leads to

158 Thus, Pf triggers maladaptive innate viral pattern-recognition responses,

159 ontoinsular dynamics confer vulnerability to maladaptive introspection, which in turn contributes to

160 In conclusion, obesity promotes a maladaptive ISR during asparaginase exposure.

161 ol in the pathogenesis of AKI, incomplete or maladaptive kidney repair and chronic kidney disease.

162 and profibrotic signaling in the setting of maladaptive kidney repair.

163 abnormal loading conditions, they can become maladaptive, leading to impaired function and cardiac pa

164 on can be conceptualized at a basic level as maladaptive learning and memory.

165 way to modify neurobiological mechanisms of maladaptive learning in anxiety and depressive disorders

166 he mechanisms underlying adaptive as well as maladaptive learning, and has the potential to inform th

167 Drug addiction results in part from maladaptive learning, including the formation of strong

168 iences when animals are awakened may produce maladaptive long-term memory, or may interrupt consolida

169 to manifestations of personality pathology, maladaptive LPF is conditional to the diagnosis of perso

170 c and nongenetic determinants that lead to a maladaptive macrophage state.

171 extinction are two approaches for weakening maladaptive memories in disorders such as addiction and

172 hem, has important implications for treating maladaptive memories that contribute to some psychiatric

173 apeutic strategies for selectively reversing maladaptive memories.

174 rence may provide a means to rapidly rewrite maladaptive memory and should be further pursued in alco

175 Increased exposure to predators via maladaptive migratory behaviour reduces hybrid survival

176 anding how opioid drugs initiate adaptive or maladaptive modifications in neural function or regulati

177 cord injury (SCI) involves poorly understood maladaptive modulation of neuronal excitability.

178 of D1-mGlu5 functional heteromers mediating maladaptive molecular and motor responses in the dopamin

179 ng acute sickness but might also account for maladaptive, motivational changes that underpin the asso

180 s the suppression or inhibition of errant or maladaptive motor responses, often called cognitive cont

181 y to cue onset, and provide insight into the maladaptive nature of memory.

182 ed organ perfusion and congestion as well as maladaptive neurohormonal activation, oxidative stress,

183 n fraction with the use of agents that block maladaptive neurohormonal pathways.

184 logic and electrophysiological signatures of maladaptive neuronal plasticity; a phenomenon associated

185 which, at high doses, is theorized to induce maladaptive neuroplastic changes that attenuate self-reg

186 motor control and paresthesia, and generates maladaptive neuroplasticity as central networks attempt

187 ocampal insult resulted in both adaptive and maladaptive neuroplasticity: i.e., sparing contextual me

188 ations during nicotine abstinence may foster maladaptive nicotine taking in addicts.

189 ists produce hyperalgesic priming, a form of maladaptive nociceptor neuroplasticity, resulting in pai

190 Youths with irritability also show maladaptive orienting to, interpreting, and labeling of

191 lation impulsively and an increased risk for maladaptive outcomes, including substance abuse.

192 terior cingulate cortex (ACC) might underlie maladaptive pain phenotypes.

193 Addiction is a maladaptive pattern of behavior following repeated use o

194 Food intake is essential for survival, but maladaptive patterns of intake, possibly encoded by a pr

195 ontextual factors in shaping adaptive versus maladaptive patterns of thought and behavior.SIGNIFICANC

196 itions require flexibility, helps to explain maladaptive performance that is not readily explained by

197 elevance, the neural circuitry governing the maladaptive persistence of anxiety remains unclear.

198 rizes a cohort with inducible ischemia and a maladaptive physiological response to exercise.

199 plasticity might allow further insights into maladaptive plasticities that underlie anxiety and post-

200 porting DA release in striatum, and reveal a maladaptive plasticity in early parkinsonism that impair

201 s within these neurons, which could regulate maladaptive plasticity observed in chronic pain.

202 Maladaptive plasticity of neurons in lamina I of the spi

203 implications for understanding adaptive vs. maladaptive plasticity that drives food- and drug-seekin

204 4.2 channels as a molecular mechanism of MSN maladaptive plasticity underlying depression-like behavi

205 applications of microstimulation to correct maladaptive plasticity underlying dysfunctional decision

206 genetics have aided our understanding of the maladaptive plasticity underlying NeuP.

207 after complete SCI) sufficiently diminishes maladaptive plasticity within the spinal sympathetic ref

208 brain function and prevent trauma-associated maladaptive plasticity.

209 an if plasticity was absent, consistent with maladaptive plasticity.

210 uption of the pericardial cavity accelerated maladaptive post-MI cardiac remodeling.

211 Specifically, we explore the maladaptive potential of ISF in the San Francisco, Calif

212 appear irrationally impulsive (namely, show maladaptive preference for immediacy).

213 k but also diminished the frequency of these maladaptive pretarget increases through a reduction of a

214 d ventricular dysfunction suggesting chronic maladaptive processes affecting allograft health.

215 ocusing on how miRNAs can play a role in the maladaptive processes associated with ELS both at adoles

216 hown to play a critical role in adaptive and maladaptive processes by regulating gene expression with

217 ptors on which opioids act to initiate these maladaptive processes remain disputed, which has prevent

218 ity, inappropriate gene activation and other maladaptive processes.

219 Maladaptive processing of the DNA damage by DNA repair e

220 defiant disorder) have an elevated risk for maladaptive reactive aggression.

221 , as occurs in heart failure, contributes to maladaptive remodeling and progressive functional declin

222 ng the processes that initiate transition to maladaptive remodeling are of major clinical interest.

223 The ability to reverse this maladaptive remodeling by ligation of this AVF is unknow

224 Maladaptive remodeling of ECM networks has been reported

225 hypertrophic response to TAC with decreased maladaptive remodeling, including markedly decreased fib

226 ical attempt to repair tissue damaged during maladaptive remodeling.

227 controversial theory is that it results from maladaptive reorganization of the sensorimotor cortex, s

228 Maladaptive repair after AKI may lead to progressive fib

229 ponse can restore homeostasis, a consecutive maladaptive repair and persistent inflammation represent

230 romised cells persist, then they may lead to maladaptive repair and proinflammatory changes, thereby

231 Maladaptive repair mechanisms that persist following the

232 jury is mitigated by a poorly characterized, maladaptive repair response.

233 bition suppressed renal oxidative stress and maladaptive repair, identifying Rac as a novel therapeut

234 and homeostasis but also senescence-induced maladaptive repair, renal fibrosis, and transplant failu

235 gnatures of both successful and unsuccessful maladaptive repair.

236 vancing age in AKI onset was associated with maladaptive response and kidney fibrosis.

237 associated with T cell aging culminates in a maladaptive response that directly contributes to chroni

238 shape for optimal function, and as part of a maladaptive response that increases diastolic stiffness,

239 by which these changes are integrated into a maladaptive response that leads to alcohol dependence ar

240 nd consequent loss of neuronal glycogen is a maladaptive response that limits neuronal stress resista

241 current understanding of the EC adaptive or maladaptive response to acute inflammation or bacterial

242 infiltrates, and the artery responds with a maladaptive response to injury, leading to intramural ne

243 1 upregulation in the failing heart may be a maladaptive response.

244 cessary to consolidate this rapidly acquired maladaptive response.

245 onged exposure to ghrelin has been linked to maladaptive responses and behaviors in the realm of psyc

246 The relationship between these maladaptive responses and physical activity often forms

247 ge to maintain contractile function from the maladaptive responses associated with disease.

248 neural pathway may underlie a broad array of maladaptive responses in stress-related psychiatric diso

249 pathways are also apparently involved in the maladaptive responses observed after repeated injury.

250 gy is available that specifically attenuates maladaptive responses of cardiac fibroblasts, the effect

251 es associated with striatal paths, including maladaptive responses such as drug seeking, social withd

252 dysfunction of these circuits can result in maladaptive responses that are associated with psychopat

253 (2) transport cascade and attenuation of the maladaptive responses to chronic hypoxia that can impair

254 hysiologic settings and at the same time for maladaptive responses to disease.

255 Maladaptive responses to stress are a hallmark of alcoho

256 Maladaptive responses to stress might play a role in the

257 us is particularly well known as a target of maladaptive responses to stress.

258 d to set goals, plan for the future, inhibit maladaptive responses, and change behavior flexibly.

259 ct on CeA stress- and nociception-associated maladaptive responses, which can be ameliorated upon rec

260 depends on a complex network of adaptive and maladaptive responses.

261 Maladaptive reward memories (MRMs) are involved in the d

262 Angiotensin II has been implicated in maladaptive right ventricular (RV) hypertrophy and fibro

263 e speculate that these mechanisms may play a maladaptive role in human pathological conditions such a

264 sponses, and thereby exert both adaptive and maladaptive roles in disease pathogenesis.

265 pand our understanding of the beneficial and maladaptive roles of opioids and opioid receptor signali

266 en species, non-ideal selection for four and maladaptive selection for one.

267 rsonality types or traits, and it represents maladaptive self (identity and self-direction) and inter

268 This is indicative of maladaptive sex behavior following Meth and sex experien

269 ata suggest that loss of dopamine triggers a maladaptive shift in the balance of synaptic excitation

270 4E signaling completely blocked and reversed maladaptive shortening in the length of axon initial seg

271 SGLT2 inhibitors reverse this maladaptive signaling by triggering a state of fasting a

272 ggers cardiac injury, and this initiation of maladaptive signaling can be blocked by pharmacological

273 in as a molecular checkpoint of adaptive and maladaptive signaling in the diabetic heart.

274 ilated cardiomyopathy by not only preventing maladaptive signaling, but also improving cardiac functi

275 Maladaptive social behaviour accordingly was a major for

276 llnesses and may be caused and reinforced by maladaptive social cognition.

277 mutant eIF2B complex in vivo, abrogating the maladaptive stress response.

278 cterized by persistence of fear memories and maladaptive stress responses.

279 er weaker selective pressure accumulate more maladaptive substitutions and are more prone to splicing

280 ontext of social hierarchies) and can become maladaptive (such as in clinical settings involving anor

281 They can become maladaptive, such as when learned food cues drive feedin

282 Yet, sleep-based processing might become maladaptive, such as when worries are excessively revisi

283 shed corticomotor excitability, suggesting a maladaptive supraspinal pain modulatory state.

284 gments cardiac efficiency via attenuation of maladaptive sympathetic signaling in the setting of obes

285 These findings identify a maladaptive sympathetic-neuroendocrine adrenal reflex me

286 till responsive state of the early withdrawn maladaptive synapses may help in the treatment of alcoho

287 It would be maladaptive to learn about catastrophes by trial and err

288 this context, CRISPR-Cas immune systems are maladaptive to the host, owing to the severe immunopatho

289 If so defined, LPF distinguishes itself from maladaptive traits (Criterion B of the AMPD) and capture

290 While Criterion B maladaptive traits provide important descriptive nuance

291 oured in an ancient environment might become maladaptive upon environmental changes.

292 cts of the entire secretory pathway, whereas maladaptive UPR outputs trigger apoptosis.

293 contribution of the NOX4-mediated pathway in maladaptive upregulation of ENaC-mediated sodium reabsor

294 f different memory systems for understanding maladaptive use, clinical research parsing what AUD pati

295 berrantly high, contribute to lung fibrosis, maladaptive vascular remodeling, and allergic asthma.

296 t only in cardiac morphology but also in the maladaptive ventricular responses and extracellular chan

297 nes and potential mechanisms contributing to maladaptive versus beneficial host responses-information

298 keeps away harmful events and can be highly maladaptive when individuals elude harmless situations i

299 s, with long-term cortisol exposure becoming maladaptive, which can lead to a broad range of problems

300 Maladaptive wound healing responses to chronic tissue in