ライフサイエンスコーパス: maleimide

1 zed on the AFM substrate functionalized with maleimide.

2 on of a Diels-Alder adduct of anthracene and maleimide.

3 t was inaccessible to tetramethylrhodamine-6-maleimide.

4 ble thiol reagent methoxypolyethylene glycol maleimide.

5 l crotonate, dimethyl fumarate, styrene, and maleimide.

6 with a lipophilic substrate mimic, Bodipy FL maleimide.

7 ero-bifunctional cross-linker benzophenone-4-maleimide.

8 nadine E was described from tryptamine-based maleimide.

9 ith a 9-ethynylanthracene optical tag, and a maleimide.

10 eic anhydride and a C18-alkyl chain-modified maleimide.

11 e-reactive, membrane-impermeable reagent PEG-maleimide.

12 eled the resulting proteins with fluorophore-maleimides.

13 tituted cyclohexenones to N-(2-t-butylphenyl)maleimides.

14 eneration of singlet oxygen from the excited maleimides.

15 oaddition of benzodiazafulvenium methides to maleimides.

16 omputationally with a range of N-substituted maleimides.

17 1,3-dicarbonyls, aldehydes, isocyanides, and maleimides.

18 classical photochemistry has been found for maleimides.

19 ol-yne ''click'' reactions involving N-allyl maleimide (1) and N-propargyl maleimide (2).

20 group N-[2-(4-(18)F-fluorobenzamido) ethyl] maleimide ((18)F-FBEM) was conjugated to Ac-Cys-Z(EGFR:1

21 fts with N-[2-(4-(18)F-fluorobenzamido)ethyl]maleimide ((18)F-FBEM)-HER(2:342) Affibody.

22 FDG- or (18)F-4-fluorobenzamido-N-ethylamino-maleimide ((18)F-FBEM)-labeled leukocytes was performed

23 -specific N-2-(4-(18)F-fluorobenzamido)ethyl]maleimide ((18)F-FBEM)-Z(HER2:342) Affibody molecule and

24 obenzoate (1) and TIPS-protected N-propargyl maleimide (2).

25 olving N-allyl maleimide (1) and N-propargyl maleimide (2).

26 eutral pHs, especially the surface using the maleimide acceptor.

27 ne, thiol, thioester, ketone, hydroxylamine, maleimide, acrylate, azide, alkene, alkyne, aryl halide,

28 eater efficacy than thioether conjugation to maleimide activated KLH (mKLH).

29 The system was primarily tested on maleimide activated microtitre plates as a proof-of-conc

30 Conjugation of the PI3P hapten to maleimide-activated keyhole limpet hemocyanin (KLH) prov

31 d probes were anchored with good efficacy on maleimide-activated microplates (MAM) and gold electrode

32 prepare METH-conjugated vaccines (MCV) from maleimide-activated proteins.

33 lerated retro-Diels-Alder reactions of furan/maleimide adducts.

34 ive intermediates reacted with N-substituted maleimides affording new 1H-indazoles characterized by a

35 vely and quantitatively to the electron poor maleimide alkene of 1 and 2 under base (Et3N) initiated

36 including nitrobenzofurazan-based scaffolds, maleimides, alkylating agents, and electrophilic aldehyd

37 h toxin binding to the channel pore precedes maleimide alkylation of a nucleophilic amino acid.

38 dified at the chain ends with either biotin, maleimide, aminooxy, or nitrilotriacetic acid.

39 segment ligation on a polymer support via a maleimide anchor.

40 Topology analysis of TM1 with biotin maleimide and 2-((5(6)-tetramethylrhodamine)carboxylamin

41 y distinct inhibitors of MGL [N-arachidonoyl maleimide and 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-y

42 ell labeling with a membrane-permeant biotin maleimide and a membrane-impermeant 2-((5(6)-tetramethyl

43 oscopy, as well as labeling of the liberated maleimide and furan moieties with appropriate chromophor

44 rived microvesicles were labeled with BODIPY-maleimide and incubated with THP-1-derived macrophages.

45 nd also the reaction of cyclopentadiene with maleimide and N-phenylmaleimide.

46 pecifically labeled by tetramethyl-rhodamine-maleimide and showed significant changes in the emission

47 edia with Met(858) accessible to both biotin maleimide and TAMRA and Thr(926)-Ala(929) only to TAMRA

48 ing of cysteine residues by a lipophilic dye-maleimide and the blocking of Nile red efflux by covalen

49 and delivery of the model probe fluorescein-maleimide and the medicinal agent paclitaxel (PTX) into

50 Orthogonal maleimide and thiol deprotections were combined with thi

51 The activity is insensitive to both N-ethyl-maleimide and ubiquitin aldehyde, indicating that it lac

52 cts of blocking the thiol group with N-ethyl-maleimide and using carboxypeptidase-A to stabilize the

53 y anoxia/euxinia because euxinic biomarkers (maleimides and aryl isoprenoids) are present in very low

54 d unsymmetrical azobenzene derivatives, with maleimides and maleate esters.

55 The reaction between maleimides and resin-linked diene-polyamides allows the

56 lement a system with this topology using two maleimides and two nitrones of different sizes-either sh

57 plicable for N-alkyl- and N-aryl-substituted maleimides and unsubstituted maleimides, and it also tol

58 nes were labeled with tetramethylrhodamine-6-maleimide, and voltage-dependent conformational changes

59 ryl-substituted maleimides and unsubstituted maleimides, and it also tolerates the variety of functio

60 (methyl acrylate) (PMA) chains anchored by a maleimide-anthracene cycloadduct were synthesized to dem

61 Each individual maleimide-anthracene mechanophore exhibits binary behavi

62 Maleimide-anthracene mechanophores located at the interf

63 These data demonstrate that N-aryl maleimides are a convenient and flexible platform to imp

64 A variety of valuable polysubstituted maleimides are assembled in good yields.

65 Maleimides are often used to covalently attach drugs to

66 In case protected maleimides are used, maleimide deprotection and Diels-Al

67 using the thiol-ene addition of cysteine and maleimide as a stoppering protocol.

68 when alkenes are used is avoided by choosing maleimide as an alkene, which cannot undergo beta-hydrid

69 elimination to give diarylmethyl-substituted maleimides as coupling products.

70 characterized the reactivity of an arsenical-maleimide (As-Mal) that can be efficiently conjugated to

71 a second-generation photoswitch for LiGluR, maleimide-azobenzene-glutamate 0 with peak efficiency at

72 R6 using a family of photoiosomerizable MAG (maleimide-azobenzene-glutamate) PTLs that covalently att

73 technique uses a combination of genetics and maleimide-based click chemistry in which a cysteine subs

74 treatment of mood disorders, SAR studies on maleimide-based compounds were undertaken.

75 development of second-generation cobalt- and maleimide-based liposomes that have improved in vitro st

76 veloped an analogue of compound 1 that lacks maleimide-based reactivity but retains RAD51 inhibitory

77 A 4-methylbenzothiazole linked maleimide-based single molecular bifunctional probe 1 ha

78 Maleimide-based, alkylating, and aldehydic thiol labelin

79 e dose of trastuzumab-Lx-AF outperformed its maleimide benchmark trastuzumab-Mal-AF and FDA-approved

80 s in DAT as probed by a membrane-impermeable maleimide-biotin conjugate.

81 labeled with both membrane permeant (biotin maleimide (BM)) and impermeant (2-((5(6)-tetramethylrhod

82 permeable, cysteine-specific chemical biotin maleimide (BM).

83 und to the MspA mutant MspAA96C via cysteine-maleimide bonds.

84 In all instances, the introduction of a maleimide bridge across positions 9 and 10 of the anthra

85 can insert into a disulfide bond, forming a maleimide bridge, and this is illustrated on the peptide

86 llows for subsequent substitution of the two maleimide bromides by the generated thiols.

87 ives that differ by the substituent on their maleimide C horizontal lineC bond.

88 ags or reporter enzymes as well as efficient maleimide chemistry for fluorophore coupling.

89 he most commonly used method still relies on maleimide chemistry involving cysteine residues in the p

90 Thiol-maleimide chemistry was utilised to covalently ligate th

91 ached covalently to phospholipid anchors via maleimide chemistry, and served as receptors for the rec

92 cessible N-terminal Cys residue to 20kDa PEG-maleimide (Co-hArgI-C(PEG-20K)); (ii) engineering of the

93 th clinically validated and widely available maleimide compounds, while also enabling proximity-based

94 fication of cysteines by polyethylene glycol maleimide confirms the cytoplasmic location of the conse

95 were derivatized under a more stable N-ethyl maleimide conjugate.

96 Large maleimide-conjugated molecules can also be used to physi

97 an plasma and in mice than the corresponding maleimide conjugates.

98 igh molecular weight multifunctionalized PEG-maleimide conjugation intermediate.

99 s with high efficiency and was available for maleimide conjugation or self-reaction depending on posi

100 odified phosphorothioate DNA and biotin- and maleimide-containing bifunctional linkers.

101 nstable in vivo because they are formed from maleimide-containing components conjugated to reactive t

102 thiol of cysteine is often used for coupling maleimide-containing linker-payloads to antibodies resul

103 rge and DNA loading capacity with increasing maleimide content.

104 Thiol-maleimide coupling and ADC stabilization via thiosuccini

105 ldehyde-containing cross-linkers using thiol-maleimide coupling at cysteine residues introduced into

106 Labeling was accomplished by maleimide coupling of NOTA to a unique cysteine residue

107 -coordinating directing groups are used with maleimide coupling partners.

108 thiol deprotections were combined with thiol-maleimide coupling to synthesize discrete oligomers/macr

109 upling, copper-free click coupling and thiol-maleimide coupling were quantitatively controlled during

110 Derivatization of Cys78 with maleimide creates a solution mimic of the Lys-ligated cy

111 Fifteen substituted maleimide cycloadducts of anthracene derivatives were sy

112 In the case of maleimide-cysteine-based dimerization of proteins, we sh

113 In case protected maleimides are used, maleimide deprotection and Diels-Alder cycloaddition can

114 from the cyclohexadiene intermediate to the maleimide derivative (therefore producing succinimides).

115 The same applies to a maleimide derivative carrying a BODIPY dye which was cho

116 -VS-NT were compared with the thiol-specific maleimide derivative N-[2-(4-(18)F-fluorobenzamido)ethyl

117 We prepared a series of fluorogenic coumarin maleimide derivatives that differ by the substituent on

118 ycloaddition reaction between anthracene and maleimide derivatives with high turnover.

119 t nucleophilicity of sulfur to react it with maleimide derivatives, achieving covalent functionalizat

120 of biologically relevant cyclic amides with maleimide derivatives.

121 es are commercially available in the form of maleimide-derivatives of fluorescent dyes and bioaffinit

122 bsRICs were constructed by reacting the maleimide-derivatized trastuzumab Fab fragments that bin

123 he cDbs were site-specifically conjugated to maleimide-desferrioxamine for (89)Zr radiolabeling and s

124 t Ruthenium(II) aminophenanthroline-viologen maleimide Diads (Ru-Diads) have been successfully bound

125 Mechanochemical activation of a furan-maleimide Diels-Alder adduct reveals a latent furfuryl c

126 further level of orthogonality, namely furan/maleimide Diels-Alder chemistry.

127 largely dependent on the substituent on the maleimide double bond but minimally affected by the subs

128 CpHK at position K274 reacted with the maleimide drug-linker AZ1508 at a rate of ~79 m(-1) s(-1

129 sines, whereas JVZ-007-cys was conjugated to maleimide-DTPA via the C-terminal cysteine.

130 We labeled filaments first with a green maleimide dye and then, following an additional period o

131 g an additional period of growth, with a red maleimide dye.

132 for subsequent labeling with thiol-reactive maleimide dyes.

133 zed, the drug-linker is no longer subject to maleimide elimination reactions, preventing nonspecific

134 a self-assembled monolayer (SAM) containing maleimide end groups and oligo(ethylene glycol) spacer s

135 ed thiol-reactive linkers in plasma owing to maleimide exchange with reactive thiols in albumin, free

136 uccinimide ring hydrolysis and negatively by maleimide exchange with thiol-reactive constituents in p

137 Cysteine-linked ADCs prepared with N-aryl maleimides exhibited less than 20% deconjugation in both

138 the P2X7R using as readouts (i) the covalent maleimide fluorescence accessibility of the surface-boun

139 d fluorescence changes from the Alexa 546 C5 maleimide fluorophore attached to residues in the extrac

140 al iron transporters and modifying them with maleimide fluorophores, we generated living cells or pur

141 Using DyLight-maleimide fluors and a modified biotin switch method, we

142 tion of surface loop residues by fluorescein maleimide (FM) was strongly temperature-dependent in viv

143 cation of the obtained cysteine mutants with maleimides, followed by computational elucidation of the

144 vable trigger in the linker and consist of a maleimide for cysteine antibody conjugation, a hydrophil

145 a fluorescent probe, tetramethylrhodamine-5-maleimide, for biophysical studies.

146 Here, we report that N-aryl maleimides form stable antibody conjugates under very mi

147 for tethering to peptides and proteins via a maleimide function have been prepared.

148 ntermediate enone required protection of the maleimide function through their Diels-Alder adducts wit

149 ee cysteine residues relative to established maleimide functional reagents.

150 work, the CNT-mer entails a N-hydroxyphenyl maleimide functionality to be utilized in the chain prop

151 rough either MaHA concentration (1-5wt.%) or maleimide functionalization (10-40%f).

152 de and a tetrazole, as ligation partners for maleimide functionalized polymers, was investigated when

153 uorous-phase immobilization and capture by a maleimide-functionalized affinity tag to selectively enr

154 d at 50- to 100-fold excess of the uncharged maleimide-functionalized BODIPY dyes over Cys.

155 cis-(PEt(3))(2)Pt(II)(OTf)(2), and amine- or maleimide-functionalized isophthalate forms discrete hex

156 Here, using maleimide-functionalized lipid vesicles, we successfully

157 d alkyl substituents ("legs") was coupled to maleimide-functionalized molecular switches or motors un

158 bstrate and subsequently derivatized using a maleimide-functionalized oligomer of ethylene glycol.

159 pt for the quantification of PEG ligands for maleimide-functionalized PEG molecules and the determina

160 molecular weight (M(n)) or liberation of the maleimide, furan, or anthracene moieties was observed (i

161 eoselective Diels-Alder reaction with N-aryl maleimides furnishing isoquinuclidines in overall five s

162 equimolar amounts of thiol and N-substituted maleimides give complex mixtures of products.

163 The maleimide group is a widely used reagent for bioconjugat

164 ar cycloaddition reactions with a stoppering maleimide group, forming rotaxane and thread, respective

165 orms of this toxin bearing cysteine-reactive maleimide groups are available through total synthesis a

166 Maleimide groups are used extensively in bioconjugation

167 es covalently immobilized to pendant surface maleimide groups are used to bind and successfully discr

168 The amino or maleimide groups decorating the isophthalate pillars of

169 n photochemistry that dictates reactivity of maleimide groups in two-photon mode.

170 5 kDa), thiolated and covalently attached to maleimide groups on lipid-coated microbubbles.

171 inase and a synthetic reagent containing two maleimide groups, for selective attachment to cysteines

172 m salts bearing terminal carboxylic acid and maleimide groups.

173 Maleimide has been used as a selective coupling partner

174 irected 1,4-addition of an ortho C-H bond to maleimides has been developed using Co(III) catalyst.

175 selective synthesis of both mono- and diaryl maleimides have been innovated.

176 owever, ADCs formed with traditional N-alkyl maleimides have variable stability in the bloodstream le

177 1,2-a]indol-3-yl]-3-(1-methyl-1H-indo l-3-yl)maleimide, HCl, bisindolylmaleimide X, HCl), GRK2 [C-ter

178 DOTA or (125)I-iodo-((4-hydroxyphenyl)ethyl) maleimide (HPEM).

179 Maleimide Id-KLH elicited tumor-specific IgG Abs and T c

180 9-hydroxymethylanthracene with N-substituted maleimide in the aqueous medium.

181 The reaction of N-aryl acrylamides with maleimides in the presence of a ruthenium/rhodium cataly

182 H activation of aliphatic amide, followed by maleimide insertion, triggers a relayed, second C(sp(3))

183 1,2-Addition of Grignard reagent to maleimide, internal activation of formed lactamol for in

184 eaction of polycyclic 1,2-dithiolethiones to maleimides is described.

185 H bond alkylation of 8-methyl quinoline with maleimides is reported.

186 (4,4-difluoro-4-bora-3a,4a-diaza-s-indacene)-maleimide-labeled platelet microparticles.

187 teine-scanning mutagenesis and fluorescein-5-maleimide labeling we found that positions throughout th

188 Using western blots and fluorescein-5-maleimide labeling, we conclude that EtOH exposure modif

189 SA) was synthesized by reaction of a pendant maleimide ligand with human serum albumin.

190 the C-terminal sequence of minigastrin, the maleimide-linked compound DOTA-GSC(succinimidopropionyl-

191 In addition, Au102 was functionalized with a maleimide linker (Au102_C6MI) for maleimide-thiol conjug

192 ctive thiol in cysteine is used for coupling maleimide linkers in the generation of antibody conjugat

193 n this study to understand the impact of the maleimide linkers on ADC stability.

194 obenzoic acid)44 clusters, functionalized by maleimide linkers to target cysteines of viral capsid pr

195 of the Affibody molecule for the coupling of maleimide linkers, and 3 radiolabeling strategies were a

196 In particular, the maleimide liposomes captured HIV-1 Env trimers via a mor

197 Exposure of this DCL to two maleimides, M(p) and M(m), each equipped with a carboxyl

198 te addition reactions used both acrylate and maleimide Michael acceptors.

199 The divergent growth via thiol-maleimide Michael coupling allows precise arrangements o

200 polymerization of styrene with N-substituted maleimides (MIs), namely pentafluorophenyl 4-maleimidobe

201 g-term exposure to serum whereas the N-alkyl maleimide MMAE ADC lost potency over time.

202 mine-sensitivity of thioesters and selective maleimide-modification of cysteines, termed acyl-PEG exc

203 te antigens, Globo-H, GM2, STn, TF and Tn-to maleimide-modified carrier protein KLH.

204 n tetrazole-oligonucleotide conjugates and a maleimide-modified dye worked quantitatively.

205 acilitates the site-specific attachment of a maleimide-modified gold nanoparticle to the enzyme, whic

206 Specifically, maleimide-modified HA (MaHA) macromers were crosslinked

207 pathway in [2+2] cycloaddition reactions of maleimide moieties.

208 The probe 1.Tb, possessing a maleimide moiety, as its sulfhydryl acceptor, was poorly

209 ls-Alder reaction between dithienylfuran and maleimide monomers to generate a photoresponsive diaryle

210 s prepared with the anticancer drug N-phenyl maleimide monomethyl-auristatin-E (MMAE) maintained high

211 The maleimide motif is widely used for the selective chemica

212 ed trypsin digestion and reactivity with PEG-maleimides (MPEG) to study Ca(2+)-induced conformational

213 rivative N-[2-(4-(18)F-fluorobenzamido)ethyl]maleimide-neurotensin ((18)F-FBEM-NT).

214 hey differ in the nature of the group on the maleimide nitrogen atom and of the substituents on the a

215 with a 4-(dimethylamino)phenyl group on the maleimide nitrogen atom undergo retro-cycloaddition upon

216 )W(5)C] pHLIC was conjugated to bifunctional maleimide-NO2A and radiolabeled with (64)Cu (half-life,

217 most often used iodoacetamide on peptides or maleimide on the antibody trastuzumab, and high cysteine

218 orresponding alkenyl boronic derivatives and maleimides or maleic anhydride is described.

219 an orthogonally protected thiol, a protected maleimide, or an alkyne.

220 In contrast, maleimide-PEG2-biotin reactivity of Cys148 is unaffected

221 mately 29 A), impermeant hydrophilic reagent maleimide-PEG2-biotin.

222 In reactions with maleic anhydride or maleimides, phenoxyacetic acid produced chromenedione de

223 ore was achieved by application of a [5 + 2] maleimide photocycloaddition.

224 ), thiol-acetamide (SA), penicillamine-thiol-maleimide (PM) or penicillamine-thiol-thiol (PS).

225 y of these mutants with progressively larger maleimide-polyethylene glycol derivatives (MPEG) was mea

226 ery of lysine dendrons and poly(ethylene-alt-maleimide) polymer backbone interact with CNCs.

227 ties and reaction intermediates from the PEG-maleimide polymers throughout the conjugation process.

228 porating a basic amino group adjacent to the maleimide, positioned to provide intramolecular catalysi

229 al evaluation of benzofuran-3-yl-(indol-3-yl)maleimides, potent GSK-3beta inhibitors.

230 lternative to the routinely used p-phenylene maleimide (pPDM) for APD detection, allowing for fast an

231 strategy, which combines the CuAAC and thiol-maleimide processes, could become more widely adopted in

232 The resultant protein-maleimide products can be cleaved to regenerate the unmo

233 d-group modification with fluorescent BODIPY-maleimide provided a dye-labeled pOEG-BODIPY conjugate w

234 1,1-cyclization of N-methoxy benzamides with maleimides providing isoindolinone spirosuccinimides thr

235 MPyP pretreatment were labeled with biotin-N-maleimide, purified with streptavidin-agarose, and resol

236 alkyne-azide cycloaddition (CuAAC) and thiol-maleimide reactions is reported.

237 recognition sequences by amidation or thiol-maleimide reactions.

238 ed cysteine to a series of novel hydrophilic maleimide reagents increases with increasing volume of t

239 red efflux by covalent labelling with bulky maleimide reagents.

240 Maleimides remain the reagents of choice for the prepara

241 K cells, and stimulation with PMA or N-ethyl-maleimide resulted in the shedding of FcgammaRIIIA/CD16A

242 The reactions of aryloxyacetic acids with maleimides resulted in a cascade process in which a pyrr

243 ulation of functional groups attached to the maleimide ring-head nitrogen.

244 r para (M(p)) or meta (M(m)) relative to the maleimide ring.

245 The resulting maleimide scaffold was optimized to subnanomolar potency

246 junction by cleaving SNAREs (soluble N-ethyl maleimide sensitive factor attachment protein receptors)

247 r that can directly regulate soluble N-ethyl-maleimide sensitive fusion protein attachment protein re

248 hospholipase D implicated in soluble N-ethyl-maleimide sensitive fusion protein attachment protein re

249 Soluble N-ethyl-maleimide sensitive fusion protein attachment protein re

250 es fusion by both ATL and ER-soluble N-ethyl-maleimide-sensitive factor adaptor protein receptors.

251 in 2 (VAMP2) is an essential soluble N-ethyl maleimide-sensitive factor attachment protein receptor (

252 +) exchange regulatory factor-1) and N-ethyl-maleimide-sensitive factor-regulated exocytosis.

253 Unlike soluble N-ethyl-maleimide-sensitive fusion attachment protein receptors

254 n, a component of the SNARE (soluble N-ethyl-maleimide-sensitive fusion protein attachment receptor)

255 25C channels labeled with Alexa Fluor 488 C5-maleimide showed a change in the emission of the fluores

256 Thiol modification with polyethylene glycol-maleimide showed disulfide bond formation at the active

257 of Phe615Cys mutant AcrB with fluorescein-5-maleimide showed that presumed groove-binders competed a

258 eas the analogous ADCs prepared with N-alkyl maleimides showed 35-67% deconjugation under the same co

259 ne peptide through a thiol-thiol (SS), thiol-maleimide (SM), thiol-vinylsulfone (SV), thiol-acetamide

260 NHS ester-labeling of lysines, the cysteine-maleimide strategy resulted in far less background in fl

261 m active chromogenic Alexa Fluor 350 (AF350) maleimide tag.

262 is a robust alternative to the conventional maleimide technique; the reaction is irreversible and us

263 ct (L126C) was expressed and modified with 4-maleimide TEMPO for electron paramagnetic resonance (EPR

264 yethylene glycol (PEG) functionalized with a maleimide terminal group for protein conjugation.

265 ered with a Cys site for bioconjugation with maleimide-terminated chromophores, which include synthet

266 ands underwent successful cycloaddition with maleimide-terminated fluorescence dyes and a polymeric r

267 ing agents, and blocked by pretreatment with maleimide that alkylates cysteines.

268 1,3-dipolar cycloaddition reactions with two maleimides that differ in the relative position of their

269 eadily functionalizable 5-alkoxyoxazoles and maleimides that readily react together under mild and ea

270 triple bonds, which can be an alternative to maleimides, the most commonly used reagents to link thio

271 nance energy transfer signal between CPT and maleimide thioether bond is monitored to visualize the d

272 olecules are connected by a reduction-labile maleimide thioether bond.

273 Using an improved maleimide-thiol based Michael Addition during (water-in-

274 the subsequent (bio-) functionalization via maleimide-thiol chemistry.

275 zed with a maleimide linker (Au102_C6MI) for maleimide-thiol conjugation to nanocapsid cysteines.

276 80 Ab (Fab'-bearing) onto the NP surface via maleimide/thiol group-mediated covalent bonding improves

277 ting reactions in plasma: elimination of the maleimide through a retro-Michael reaction, which result

278 can rapidly react with dienophiles, such as maleimides, through a conventional Diels-Alder reaction.

279 P of Synechocystis with tetramethylrhodamine-maleimide (TMR) and obtained a photoactive OCP-TMR compl

280 ive fluorescent probe tetramethylrhodamine-6-maleimide (TMRM).

281 e-specific fluorescence labeling with pyrene maleimide to gain insight into the structure and conform

282 in the aza-Michael addition of arylamines to maleimide to obtain aminopyrrolidine-2,5-dione derivativ

283 an be simply addressed using 3,4-substituted maleimides to bridge and thus functionalize disulfide bo

284 f various 2H-pyran-2-ones with N-substituted maleimides toward isoindole derivatives through the reac

285 Second-generation maleimide-toxin conjugates, which include bioorthogonal

286 thyl mercaptan) with N-allyl and N-propargyl maleimide under both base-initiated and radical-mediated

287 Using structure-guided design, pyrene maleimide was attached to pairs of Cys residues separate

288 mbrane-impermeant reagent polyethyleneglycol maleimide was determined.

289 In this paper, synthesis of polysubstituted maleimides was described via cascade reaction of isocyan

290 Set designated NSC 19630 [1-(propoxymethyl)-maleimide] was identified that inhibited WRN helicase ac

291 hysical studies, the triplet energies of the maleimides were estimated.

292 Atropisomeric maleimides were synthesized and employed for stereospeci

293 We conceived of a new class of maleimide which would address some of these limitations

294 MdtC were covalently modified by fluorescein maleimide, which acted as a substrate and presumably pro

295 little affected by pretreatment with biotin maleimide, which cannot reach the cytoplasmic surface.

296 Benzophenone-4-maleimide, which normally forms intramolecular cross-lin

297 ermally robust [4+2] cycloaddition adduct of maleimide with anthracene.

298 e grown from a [4+2] cycloaddition adduct of maleimide with furan containing two polymerization initi

299 ies, exploiting the quantitative reaction of maleimide with l-cysteine, and the subsequent determinat

300 This study describes novel azaindolyl-maleimides with significant inhibition of PKs, such as V