ライフサイエンスコーパス: malformed

1 ricles of Tg737orpk mutant mice are severely malformed.

2 latter 11 valves also had been congenitally malformed.

3 mation is not complete and the male gonad is malformed.

4 erface, and the extra-embryonic tissues were malformed.

5 the cytoplasm, and focal adhesions appeared malformed.

6 and somatic gonadal structures are severely malformed.

7 However, the resulting structures are often malformed.

8 f low numbers of sperm that are immotile and malformed.

9 and the cardiac outflow tracts are short and malformed.

10 e Gle1-FinMajor protein, these particles are malformed.

11 ificantly enlarged, and the meibomian glands malformed.

12 digestive vacuoles (DVs) that are small and malformed.

13 Widespread observations of malformed amphibians across North America have generated

14 heir widespread appearance in the mid-1990s, malformed amphibians have evoked fear, as well as fascin

15 Ribeiroia ondatrae were more likely to have malformed amphibians, but these effects were strongest w

16 The hippocampus was malformed and compressed into the lower hindbrain togeth

17 cted later this century had shells that were malformed and eroded.

18 hen this balance is lost, the vessels can be malformed and fragile, and they can lose arteriovenous d

19 tional TAS1R3 and GNAT3 is compromised, with malformed and immotile sperm.

20 rs was often noted at the border between the malformed and normal cortex.

21 that the sensory cilia of these neurons are malformed and the neurons are nonfunctional in d-plp mut

22 bryos and rapidly induced several additional malformed and uncoordinated blood vessel structures that

23 s of valve replacement surgery, congenitally malformed aortic valves continue to be more common than

24 -2004) had a lower frequency of congenitally malformed aortic valves, a higher frequency of tricuspid

25 neme cargo is either highly efficient at the malformed apical prominence or secretion may also occur

26 fish require lower levels of Tbx5 to produce malformed appendages and display whole-heart rather than

27 newly described BAPN-Associated Target with Malformed Archenteron (BATMAN), identified here.

28 Teratological (malformed) assemblages of fossil plankton that correlate

29 esented with bilateral cleft lip and palate, malformed auricles, and bilateral ectrodactyly of his ha

30 171 pregnancies (43% of prenatally diagnosed malformed babies) were terminated because of suspected a

31 Depletion of TbPLK leads to malformed bilobed structures, which is consistent with a

32 Electron microscopy confirmed malformed blood vessels and wide pericapillary ECM space

33 l, and other intramembranous bones caused by malformed blood vessels that lack a mature vascular smoo

34 en studied extensively, synaptic function in malformed brain regions remains poorly understood.

35 examine inhibitory synaptic function in the malformed brain.

36 that inhibitory systems are enhanced in the malformed brain.

37 equent spontaneous recurrent seizures in the malformed, but not in the normal brain, are associated w

38 tricular septum, and atrial septum) that are malformed by CHD.

39 s each increase the fraction of virions with malformed capsids (from approximately 12% to approximate

40 eduction of granule cell proliferation and a malformed cerebellum.

41 Mutations in the GPR56 gene cause a malformed cerebral cortex in both humans and mice that r

42 brain disorder characterized by an enlarged, malformed cerebral hemisphere, typically causing epileps

43 die perinatally with a markedly enlarged and malformed cerebrum caused by reduced apoptosis during br

44 lly, electrical stimulation of the CC led to malformed chirping movements by crickets, and pharmacolo

45 crocephaly and aberrant heart looping due to malformed cilia.

46 d also results in the increased formation of malformed coccoliths in C. braarudii.

47 mouse knockout of Foxf2 shows shortened and malformed cochleae, in addition to altered shape of hair

48 We performed a population-based case-malformed control study testing signals identified in a

49 ng both nonmalformed controls (OR = 0.3) and malformed controls (OR = 0.2) and for urinary tract defe

50 ng both nonmalformed controls (OR = 0.6) and malformed controls (OR = 0.5).

51 with defects other than those of the cases (malformed controls).

52 ias, we performed logistic regression, using malformed controls.

53 Fourth, malformed cores, typical of integrase-deleted virus, are

54 ated decreased maximum firing frequencies in malformed cortex compared to control FS cells.

55 Cells in malformed cortex identified as having an apical dendrite

56 Most intrinsic properties measured in malformed cortex were unchanged, suggesting that subtype

57 were clearly identified in both control and malformed cortex.

58 induced zebrafish crusher variant results in malformed craniofacial skeleton, kinked pectoral fins an

59 Thus, investigating how malformed craniofacial tissues are naturally corrected i

60 phic Xenopus laevis tadpoles to self-correct malformed craniofacial tissues.

61 osition of adult-born granule cells within a malformed dentate gyrus critically influences their func

62 ar anomaly comprised of aberrant clusters of malformed dermal venule-like channels underlying hyperke

63 us in fetu (FIF) is a rare entity in which a malformed diamniotic monochorionic parasitic fetal twin

64 to wildtype mice: They die at birth due to a malformed diaphragm and they lack metanephric kidneys.

65 fied histologically in Eisenmenger syndrome: malformed, dilated, muscular arteries within alveolar se

66 CXCR4 null mice exhibited small and malformed DRGs.

67 We propose that the protein variants cause malformed enamel because they bind excessively to HAP an

68 no acid variation in amelogenins can lead to malformed enamel.

69 Loss of either gene results in malformed eyes and head capsules due to defects in eye p

70 eages in which these cells reside results in malformed eyes.

71 core), we record not only high abundances of malformed fern spores at the Triassic-Jurassic boundary,

72 396 (55%) malformed fetuses and infants had been correctly identif

73 More than half of all malformed fetuses can be identified prenatally in routin

74 13 is not established, resulting in severely malformed forelimbs lacking all posterior, Shh-regulated

75 The affected mice exhibited malformed glial borders, larger lesions, and impaired re

76 in knock-in human kidney organoids revealed malformed glomeruli with increased apoptosis.

77 ed by neurodegeneration and accumulations of malformed glycogen (Lafora bodies).

78 homozygous for sys-1(q544) possess a grossly malformed gonad and are sterile; in contrast, sys-1(q544

79 In germ unit malformed (gum) mutants, the vegetative nucleus is posit

80 also result in short, fat, and occasionally malformed hairs and bristles.

81 ow a decrease in motility and an increase in malformed heads.

82 ll heart, develops a diminutive and severely malformed heart and multiple developmental defects of th

83 x40(-/-) or Cx43(-/-) mice, and they exhibit malformed hearts with ventricles that are abnormally rot

84 of treatments for patients with congenitally malformed hearts, efforts that span traditional geograph

85 no significant variations between normal and malformed hearts.

86 re its absence leads to the development of a malformed, immotile, non-infectious ookinete with an ext

87 ngly, middle ear structures are enlarged and malformed in a majority of Ednra(fl/fl);Wnt1-Cre embryos

88 In the node, primary cilia were absent or malformed in homozygous mutant and heterozygous embryos,

89 Furthermore, cilia are malformed in mice with PKD with mutations in TgN737Rpw (

90 t to maintain homeostasis, was also severely malformed in mutants.

91 ontaining hippocampal nerve terminals appear malformed in the absence of collagen XIX.

92 The urethra was malformed in the colliculus region and was significantly

93 al complexity; oligodendrocytes are severely malformed in vitro (a relatively simple environment), bu

94 and controls were 429 randomly selected non-malformed infants.

95 However, the small and malformed inner ear at E17.5 exhibits residual and grade

96 all middle ear cavity, short nasal bone, and malformed interface between the nasal bone process and c

97 w that cells deficient in Shk1 function have malformed interphase microtubules and mitotic microtubul

98 certain individuals with NTDs are born with malformed kidneys, and recent studies have discovered VA

99 enetic screens for dominant enhancers of the malformed leg phenotype associated with a mutation in th

100 -lethality, with adult 'escapers' possessing malformed legs.

101 mb skeletal defects, including shortened and malformed limb bones, oligodactyly, and fusion of joints

102 MP inhibitor GM6001 produces either dwarfed, malformed limb regenerates or limb stumps with distal sc

103 Msx2-noggin mutant mice have severely malformed limbs characterized by syndactyly, postaxial p

104 s in the formation of shortened and severely malformed limbs that lack one or more skeletal elements.

105 es resulted from physical obstruction by the malformed mandible and tongue.

106 -/-) neonates have mandibular hypoplasia and malformed mandibular incisors.

107 xilla-maxilla suture, smaller premaxilla and malformed maxilla during midface development.

108 Grem2(-/-) mice have small, malformed maxillary and mandibular incisors, indicating

109 s a quality-control center for mutant and/or malformed membrane proteins.

110 However, the otoliths are malformed, misplaced, lack an organic matrix, and often

111 showed that Prpf31-deficient HSPCs underwent malformed mitosis and M phase arrest during HSPC expansi

112 to aberrant microtubule structure, including malformed mitotic spindles and impaired interphase micro

113 a drastic reduction in astral microtubules, malformed mitotic spindles, defocused spindle poles, and

114 Tumor microvasculature tends to be malformed, more permeable, and more tortuous than vessel

115 beta-deficient gametocytes show a strikingly malformed morphology leading to the death of parasites i

116 layed consistent skeletal defects, including malformed neural and haemal arches, vertebral fractures

117 This was associated with the presence of malformed nodes of Ranvier characterized by an accumulat

118 in dstyk mutants is related to the wavy and malformed notochord sheath formation and abnormal axial

119 Excessive apoptosis occurred in the malformed notochord, causing a significantly reduced num

120 en surveillance or clearance is compromised, malformed NPCs accumulate in a storage of improperly ass

121 -binding protein nucleostemin, and enlarged, malformed nucleoli.

122 less cardiomyocyte invasion and resulted in malformed OFT valves.

123 canals, endolymphatic duct and utricle, are malformed or absent.

124 morphology, lumbar and sacral vertebrae were malformed or completely absent, and no tail vertebrae we

125 Detection of malformed or damaged virions with reduced potency is rat

126 frustrated by kinetic traps corresponding to malformed or incompletely formed capsids.

127 Kinetic trapping in malformed or intermediate structures often impedes a dir

128 to treat proteinopathies (diseases caused by malformed or misfolded proteins) is to restore protein f

129 neurons, one MB pathway, the medial lobe, is malformed or missing.

130 UG1 with RNA interference (RNAi) resulted in malformed or nonexistent outer segments of transfected p

131 hat the deletion of NCKX1 in mice results in malformed outer segment disks, suppressed expression and

132 kout mice, ultrastructural analysis revealed malformed outer segments characterized by whorl-like con

133 heterozygous rds/+ retinas which have short malformed outer segments.

134 Jagged1-deficient mice displayed malformed pancreatic ducts with resulting acinar cell de

135 severe fin fold defect, which also displays malformed pectoral fins.

136 Cryo-EM analysis revealed a malformed peptidyl transferase center in the misassemble

137 1 have been conditionally ablated, including malformed periodontal ligament (PDL) (recently shown to

138 second-site noncomplementation assay for the malformed phenotype.

139 own-regulation was required to induce a wing-malformed phenotype.

140 anomalies, characteristic facial appearance (malformed pinnae, oral clefts), and, less commonly, rena

141 As a result, malformed procollagen-II both accumulates intracellularl

142 of alpha-factor, but instead formed a single malformed projection, which frequently gave rise to a bu

143 eart, Lung, and Blood Institute workshop on "Malformed Protein Structure and Proteostasis in Lung Dis

144 d in normal protein maturation and refolding malformed proteins through the unfolded protein response

145 patterning of the brain, including absent or malformed regions.

146 n addition, the placenta of ABCA1-/- mice is malformed, resulting in severe embryo growth retardation

147 illar projections, and subsequently leads to malformed rhabdomeres.

148 ior and posterior semicircular canals, and a malformed saccule and cochlear duct.

149 tivation in the SAN junction did not cause a malformed SAN at birth, the mutant mice manifested sinus

150 se in the dentin formation rate; (3) a small malformed second molar and an absent third molar; (4) an

151 mice are shorter and wider with delayed and malformed secondary ossification centers and an irregula

152 HB-EGF(-/-) newborns had enlarged and malformed semilunar and atrioventricular heart valves, a

153 dig cell aggregation, ectopic Sertoli cells, malformed seminiferous cords) is not evident until after

154 ent shape, whereas leukemia samples map into malformed shapes that are distinct from healthy bone mar

155 ozygotes thus lack hands and feet except for malformed single digits, whereas heterozygotes lack phal

156 al sinusoids, and macrophage accumulation in malformed sinuses.

157 oggin null mice die at birth with a severely malformed skeleton that is postulated to reflect the act

158 ibit cranial neural tube closure defects and malformed somites and are caudally truncated.

159 organized apical ectoplasmic specialization, malformed spermatids, and marked hyperspermia.

160 otic recombination, increased apoptosis, and malformed spermatozoa.

161 spine plasticity, decreased the presence of malformed spines in diabetes, attenuated neuronal hyperr

162 c neuropathic pain, then (1) the presence of malformed spines should coincide with the development of

163 ed outer whorl organs and reduced numbers of malformed stamens in the double mutant.

164 ls (NCCs) of the pharyngeal arches display a malformed stapes.

165 structures, the ability to remodel existing malformed structures has been less well studied.

166 nd postsynaptic specializations, albeit with malformed synaptic ribbons.

167 The KO mice exhibited small malformed teeth, severe enamel defects, very thin dentin

168 equent pulmonary infections, and missing and malformed teeth.

169 llicle induction, lack sweat glands and have malformed teeth.

170 e, including changes in T cell localization, malformed tertiary lymphoid structure (TLS)-like aggrega

171 Cre;Erk2(fl/fl) mice exhibited cleft palate, malformed tongue, micrognathia and mandibular asymmetry.

172 orming ameloblasts, resulting in eruption of malformed tooth enamel that phenocopies human amelogenes

173 d disordered triad organization with visibly malformed transverse tubules and sarcoplasmic reticulum,

174 ssection), the aortic valve was congenitally malformed (unicuspid or bicuspid) in 58 (98%) of the 59

175 ed to turbulent hemodynamic flow through the malformed valve leading to focal defects in the vessel w

176 ngly suggest that an underlying congenitally malformed valve, at least in men, is more common than a

177 nosis: A total of 504 (54%) had congenitally malformed valves (unicuspid in 46 [unicommissural in 42;

178 e effort is given to repairing even severely malformed valves in pediatric patients.

179 hat, among the 96 patients with congenitally malformed valves, the 38 AR patients had a significantly

180 Knockdown lines of TpSAP1 and 3 displayed malformed valves; which confirmed their roles in frustul

181 Injection of soluble VEGFR-1 results in malformed vascular networks and the absence of large ves

182 ability in tumours is thought to result from malformed vascular walls with leaky cell-to-cell junctio

183 wounds were characterized by an early leaky, malformed vasculature followed by abundant granulation t

184 Curvatures caused by malformed vertebrae (congenital scoliosis (CS)) are appa

185 ax3 deficiency causes foreshortened cochlea, malformed vestibular apparatus, and neural tube defects.

186 Cystic cholangiocyte cilia were short and malformed, whereas in renal cysts they appeared normal.

187 The radius and tibia were malformed, whereas the fibula and ulna remained unminera

188 The dap160 mutant synapse is grossly malformed with abundant, highly ramified, small synaptic

189 ss anatomy of the inner ear is distorted and malformed, with cochlear duct outgrowth and coiling most

190 mals were infected 113 days before producing malformed young, the commonest symptom of reported infec

191 t kernels have an opaque, starchy phenotype, malformed zein protein bodies, and highly increased leve