ライフサイエンスコーパス: malfunction

1 se of the lower rate of reoperation for pump malfunction.

2 ruption of the slit diaphragm and nephrocyte malfunction.

3 slationally fold and function or misfold and malfunction.

4 genes that may avert harm from mitochondrial malfunction.

5 dent CIED dose did not correlate with device malfunction.

6 ochondrial Ca2+ overload, dysmorphology, and malfunction.

7 clei and disrupted lamina and die of cardiac malfunction.

8 in vivo, which is associated with proteasome malfunction.

9 c glomerular disease and consecutive nephron malfunction.

10 tion between the SMC loss and cardiovascular malfunction.

11 he occurrence of shocks, and possible device malfunction.

12 n ways that might affect biological function/malfunction.

13 dromes associated with WBSCR22 (human Bud23) malfunction.

14 ory stimuli associated with tissue damage or malfunction.

15 ecific genes, probably contributing to their malfunction.

16 time to first infection, bleeding, or device malfunction.

17 isease caused by Rab and vesicle trafficking malfunction.

18 d how its principles may be used to mitigate malfunction.

19 posite of surrogate events of lead or device malfunction.

20 ioversion and on the risk of lead and device malfunction.

21 ations that result in sensory hair cell (HC) malfunction.

22 strate maldevelopment and varying degrees of malfunction.

23 ained even when 20 per cent of the particles malfunction.

24 n, and 2 hearts were declined due to machine malfunction.

25 ophthalmate-a marker of gamma-glutamyl cycle malfunction.

26 rders associated with performance monitoring malfunctions.

27 day and night vision as well as some visual malfunctions.

28 self in an array of non-lethal physiological malfunctions.

29 even before denervation, contributing to NMJ malfunctions.

30 tal night blindness, are linked to rhodopsin malfunctions.

31 nd treating diseases caused by TLR signaling malfunctions.

32 ion and reagent evaporation, which can cause malfunctions.

33 real networks and their dynamic response to malfunctions.

34 P=0.46); and 1 pacemaker in the study group malfunctioned.

35 s 0.39, respectively; P<0.01) and peripheral malfunctions (2.32 versus 1.78 for the HM II and HVAD, r

36 nfection (18%), pocket infection (32%), lead malfunction (30%), and other (device upgrade, venous occ

37 ed of difficult lead placement (18.4%), lead malfunction (9.8%), infection (1.4%), lead displacement

38 plication to real-time evaluation of cardiac malfunction accompanied by changes in intracellular pH l

39 d to the growing evidence that immune system malfunction after allergic disease or immunosuppression

40 ein in cancer and almost all cancers exhibit malfunction along the p53 pathway.

41 and initiate protective responses and, upon malfunction, also jointly contribute to disease.

42 Among the mutations that cause PRC2 malfunction, an I363M LOF mutation of EED has been ident

43 Strikingly, both telomere malfunction and activin A expression in epithelial cells

44 cases including breakage of a catheter, pump malfunction and arachnoid adhesions.

45 lted in lower risks of hemodialysis catheter malfunction and catheter-related bacteremia compared wit

46 s of the mutations, which might reveal their malfunction and contribution to disease.

47 ation, pancreatitis, vulvar pain, chest tube malfunction and conversion to open splenectomy); all wer

48 ypic defects were accompanied by significant malfunction and damage of the photosynthetic machinery.

49 he body and can progress to a state of organ malfunction and death.

50 c retinal remodeling as a consequence of rod malfunction and degeneration.

51 protein condensates is generally related to malfunction and disease, one case where the liquid-to-so

52 rations in FA are often associated with cell malfunction and disease.

53 ose dysfunction could contribute to neuronal malfunction and diseases of the nervous system including

54 Despite the link between Drp1 malfunction and human disease, the molecular details of

55 Given the lack of correlation between CIED malfunction and incident dose observed up to 5.4 Gy, inv

56 This includes aspects of barrier malfunction and inflammation as well as the interaction

57 aired lysosomal acidification, mitochondrial malfunction and inflammation in vivo.

58 otic tissue remodelling often leads to organ malfunction and is commonly associated with high morbidi

59 from astrocytes, contribute to motor neuron malfunction and loss.

60 lecular mechanisms of Abeta-induced synaptic malfunction and may offer new mechanism-based therapeuti

61 unction specifically after dialysis, thyroid malfunction and muscle damage.

62 reeing with both hypotheses of mitochondrial malfunction and neuroinflammation.

63 Telomere malfunction and other types of DNA damage induce an acti

64 is central to an understanding of function, malfunction and therapeutic modulation of biological sys

65 The malfunction and/or aberrant expression of ion channels m

66 previous work has advocated that operational malfunctions and abnormal process conditions explain the

67 previously uncharacterized basis of circuit malfunction, and a possible underlying cause of neurolog

68 Mutation, malfunction, and dysregulation of HATs are associated wi

69 ological diseases in which there is also BBB malfunction, and highlighting current disease-modifying

70 uirements for development, susceptibility to malfunction, and how its principles may be used to mitig

71 k traffic and noise pollution, accidents and malfunctions, and psychosocial stress associated with co

72 eficiency anaemia and zinc deficiency immune malfunction are a risk.

73 ellular surface expression and physiological malfunction are believed to be pathologically implicated

74 PFC malfunctions are a common denominator in several neurops

75 Its malfunctions are implicated in many hereditary and degen

76 ding portends a public under-reaction to the malfunctioning artificial intelligence components of aut

77 cause of CSD and implies primary basal NHE3 malfunction as a predisposition for IBD in a subset of p

78 ic basis of reproductive disorders and other malfunctions associated with defective prolactin regulat

79 s with HVAD were 90% free of a pump-specific malfunction at 3 years compared with 56% for the HM II (

80 cardiovascular mortality, stroke, and device malfunction at 30 days was 86.6%.

81 cing psychiatry requires understanding brain malfunction at a microscopic scale, where neurons and sy

82 substitute a sensory organ: they bypass the malfunctioning auditory periphery of profoundly-deaf peo

83 ne emissions may be attributed to proteasome malfunction based on three observations: leaves with TPS

84 n occur at many levels, with transcriptional malfunction being a major cause.

85 ly, we discovered that hepatocytes displayed malfunctioning beta-oxidation, reflected by increased ac

86 and control pathological states caused by a malfunctioning blood coagulation system.

87 makes it particularly catastrophic when they malfunction, both during development and for tissue home

88 new opportunities to access and interrogate malfunctioning brain circuits and to test the therapeuti

89 investigate the molecular mechanisms of tau malfunction, but current models show little and inconsis

90 e multi-organ inflammation and immune system malfunction, but how SHARPIN regulates T cell responses

91 It follows, therefore, that PTP malfunction can actively contribute to a host of human d

92 advances in our understanding of how circuit malfunction can lead to brain disorders and outlines the

93 the pacemaker activity in the heart, and its malfunction can result in heart disorders.

94 Catheter malfunctions can be avoided by using proper surgical tec

95 Their malfunctions cause numerous diseases including neuronal

96 potential target for cancer therapy and its malfunction causes a degenerative disease.

97 rstitial tissue fluid balance, and lymphatic malfunction causes edema.

98 Integrin malfunction causes severe disease patterns characterized

99 Myosin-5B malfunction causes the congenital enteropathy microvillu

100 Its malfunction causes the severe ciliopathy Bardet-Biedl sy

101 riminating between different RNAs, and whose malfunctioning causes serious autoimmune diseases.

102 ates a proapoptotic program to eliminate the malfunctioning cells from the organism.

103 ocytes have abnormal cell cycle profiles and malfunctioning cilia.

104 e have recently surged among patients with a malfunctioning cobalt-alloy hip prosthesis.

105 d more pronounced kidney fibrosis and kidney malfunction compared with wild-type mice.

106 In settings with network malfunction, consumers of tap water versus POU-treated w

107 ad extraction: 152 with CDI and 10 with lead malfunction (control group).

108 s-induced maladaptive behaviors and synaptic malfunctions converge on the regulation of PV+ IN activi

109 d ADAR2 catalyze this modification and their malfunction correlates with disease.

110 We provide evidence that chromaffin cell malfunction derives from altered Cav1.2 channel gating.

111 We provide evidence that CC malfunction derives from the altered Cav1.2 channel gati

112 nel cells that monitor for tissue stress and malfunction-deviations from optimal homeostasis-and that

113 stroke or reoperation to replace or remove a malfunctioning device at 2 years (relative risk, 0.84; 9

114 stroke or reoperation to replace or remove a malfunctioning device.

115 stroke or reoperation to replace or remove a malfunctioning device.

116 ith a reference group of extraction for lead malfunction), diabetes mellitus (HR, 1.71; 95% CI, 1.25-

117 channel) contributes to nodose ganglia (NG) malfunction, disrupting gastrointestinal function in dia

118 water consumption is associated with GII in malfunctioning distribution networks.

119 ected data were reviewed for all LVAD device malfunctions (DMs) occurring in rotary LVADs implanted a

120 ad to aberrant mRNAs leading to synthesis of malfunctioning DNA repair proteins.

121 troke or reoperation to replace the pump for malfunction), driven by a reduced need for reoperations.

122 hysiological blood glucose levels, and their malfunction drives diabetes development.

123 pathology in parallel suggests that synaptic malfunction due to Abeta oligomers rather than plaque pa

124 ildhood brain tumor, can arise from cellular malfunctions during hindbrain development.

125 Here, we analyze several distinct malfunctions during mitosis and cytokinesis that lead to

126 some types of monogenic diabetes linked with malfunctioning endoplasmic-reticulum (ER), the beta-cell

127 age concentration, likely from vehicles with malfunctioning engine coolant systems.

128 wise avoidable operating conditions, such as malfunctioning equipment.

129 rainstem irregularities rather than cortical malfunctions for early vocalizations/babbling.

130 Lysosomal malfunction has been implicated in several pathologies,

131 ed with the tryptophan/indole pathway, whose malfunctioning has been linked to pathologies including

132 rts of left ventricular assist device (LVAD) malfunction have focused on pump thrombosis.

133 abnormalities of head movements stem from a malfunctioning head neural integrator, either intrinsica

134 tools have been optimized to interrogate the malfunctioning hippocampal circuit, and by applying thes

135 HR = 1.6; 95% CI, 1.2-2.2; P = .002) and CVC malfunction (HR = 2.0; 95% CI, 1.6-2.4; P < .001).

136 patients undergoing removal of an unused or malfunctioning ICD lead had slightly higher in-hospital

137 of conditions that arise as a consequence of malfunctioning immune responses.

138 ght our understanding of the consequences of malfunctioning immunity on neurodevelopment and will dis

139 sm spectrum disorder, are the consequence of malfunctioning immunity.

140 Patients with an unused or malfunctioning implantable cardioverter-defibrillator (I

141 safety and the ability to respond to device malfunction in a timely fashion, improving outcomes.

142 ect common age-associated diseases when they malfunction in aging.

143 h hinders the deciphering of the hippocampal malfunction in animal models and the translation to crit

144 ol the processes of life in health and their malfunction in disease, making their characterization an

145 s process by CM mutants could underlie their malfunction in disease.

146 tion is critical for gene regulation and can malfunction in diseases like cancer.

147 ble the understanding of how those complexes malfunction in human diseases.

148 In addition, considerable liver malfunction in NPC disease is common.

149 ed change thinking about the nature of brain malfunction in psychiatric disorders and during aging, a

150 bility, reflect underlying dysregulation and malfunction in specific neural circuits.

151 ion can also be induced by tissue stress and malfunction in the absence of infection or overt tissue

152 Malfunction in the crosstalk between these components mi

153 f IL-17RA expression, which implies a severe malfunction in the IL-17 signaling pathway, conferring s

154 The unmasking of silent lead malfunction in the internal cardioversion group suggests

155 n LTP and provide insights into how retromer malfunction in the mature brain may contribute to sympto

156 ly-relevant hour-long state of neurovascular malfunction in the wake of CSDs.

157 A malfunction in this system can lead to an inadequate hos

158 etic patterns correlate with effector T cell malfunction in tumours(1-4), but the cause of this link

159 bolism, differentiation, cell cycle, and its malfunctioning in aging and conditions such as cancer, n

160 ncoding proteins that are often misfolded or malfunctioning in neuronal populations subserving overt

161 Innate immunity of LOAD patients is malfunctioning in phagocytosis and degradation of Abeta

162 sodium ions in cellular processes and their malfunctions in brain in vivo.

163 Patients with PCD experience malfunctions in cilia motility, which can result in infl

164 clinical alert for a wide range of metabolic malfunctions in medicine.

165 oodstream infections (CLABSIs), and catheter malfunctions in PICCs and TLs, and risk factors of CVC-r

166 (BBS) is a genetic disorder characterized by malfunctions in primary cilia resulting from mutations t

167 Malfunctions in regulatory pathways that control cell si

168 zed by insulin resistance, which arises from malfunctions in the intracellular insulin signaling netw

169 In-depth understanding of how SAC silencing malfunctions in these cases is yet missing, but is belie

170 ntative hits for impact on multiple alphaSyn malfunctions in vitro and in cells including aggregation

171 Their absence or malfunction is associated with a growing number of human

172 Its malfunction is associated with severe liver disease.

173 siological well-being, whereas mitochondrial malfunction is associated with various pathologies and r

174 The cardinal manifestation of lymphatic malfunction is lymphedema.

175 Device malfunction is much broader than pump failure alone and

176 involved in key metabolic processes and its malfunction is related to several diseases.

177 rebrain structures may contribute to network malfunction leading to progressive neuropsychiatric symp

178 peptide (Abeta) is responsible for synaptic malfunctions leading to cognitive deficits ranging from

179 BBSome malfunction leads to Bardet-Biedl syndrome, a ciliopathy

180 that remethylate homocysteine; hence, their malfunction leads to hyperhomocysteinemia.

181 symptomatic pulmonary oedema, and the device malfunctioning, leaking, or dislodging.

182 sible for many cellular functions, and their malfunction manifests itself in several human diseases.

183 ecognizing and correcting the early signs of malfunctioning mitochondria is of critical importance fo

184 To minimize oxidative damage to the cell, malfunctioning mitochondria need to be removed by mitoph

185 were identified as likely mechanisms of the malfunctioning mutants.

186 patients were excluded because of manometer malfunction (n=2), inability to access effusion due to p

187 Malfunctioning neurotransmitter systems, such as glutama

188 Many varieties of autoregulatory malfunction occur within the cardiovascular system; thus

189 orary CIEDs, all cases of single-event upset malfunction occurred in the setting of notable neutron p

190 , particularly inappropriate shocks and lead malfunction, occurred in 91 patients (41%) at 17 +/- 5 y

191 vide a molecular basis for understanding how malfunction occurs whereby mutations shift the ADP-bound

192 Autophagy malfunctioning occurs in multiple human disorders, makin

193 maintaining glucose homeostasis; the loss or malfunction of beta cells results in diabetes mellitus.

194 link to ID in humans are predicted to cause malfunction of beta-catenin pathways, including mutation

195 n of the LAMTOR complex which results in the malfunction of both ERK and mTOR signal pathways.

196 of CD4(+) T cells is often accompanied by a malfunction of CD8(+) T cells that are persistently acti

197 A plethora of evidence indicates that malfunction of cell death can lead to inflammation, auto

198 de the first structural insight into how the malfunction of centriole proteins results in human disea

199 Malfunction of CIED attributable to RT occurred during 1

200 Malfunction of CIED, characterized as single-event upset

201 othesized that PAI-1 mediates post-traumatic malfunction of coagulation, with inhibition or genetic d

202 ctural insights into the molecular basis for malfunction of disease-associated XPA missense mutations

203 om water-electrolyte imbalance partly due to malfunction of ENaC regulation.

204 Malfunction of GABA(B) receptor has been implicated in s

205 Pathological malfunction of GPR52 signalling occurs primarily through

206 wer levels of protein carbonyls (PC) causing malfunction of hepatic and renal tissues, when compared

207 atory network and consider examples in which malfunction of its components leads to system failure an

208 n to promote oxidative stress leading to the malfunction of multiple proteins, including cytochrome c

209 Malfunction of mutant AIPL1 proteins triggers a severe f

210 Malfunction of NMDARs has been implicated in a variety o

211 pressant effects that can compensate for the malfunction of other brain circuits that results in depr

212 ifferent stages of lung involvement (L), and malfunction of peripheral organs such as the kidney, liv

213 ing to localized cell responses and systemic malfunction of phloem.

214 This reaction is mainly caused by malfunction of photosystem I and oxidative damage induce

215 Emerging evidence has shown that loss or malfunction of primary cilia or ciliary proteins in bone

216 acy to enable insights into the function and malfunction of proteins, especially in cases for which n

217 Absence, loss and malfunction of Schwann cells or their myelin sheaths lea

218 pies for brain disorders associated with the malfunction of Slack channels.

219 Malfunction of such a repression mechanism at the molecu

220 provide the first direct demonstration of a malfunction of the astrocytic thalamic GAT-1 transporter

221 Malfunction of the cystic fibrosis transmembrane conduct

222 urbance may lead to a large-scale systematic malfunction of the entire road network at a critical poi

223 Sudden cardiac arrest is a malfunction of the heart's electrical system, typically

224 ants, therefore, appears to be the result of malfunction of the influx/efflux systems due to modifica

225 ficit in alcoholism causally associated with malfunction of the medial prefrontal cortex (mPFC), but

226 the testis, irrespective of cause, leads to malfunction of the somatic (Leydig, Sertoli) cells and c

227 necessary for cellular resistance to chronic malfunction of the UPR(MT) Given the increasingly recogn

228 ress urinary incontinence mainly suffer from malfunction of the urethra closure mechanism.

229 not identified, and it is not known whether malfunction of these cells may contribute to bone loss i

230 cation, however, comes greater potential for malfunction of these intricate processes.

231 these genes are expressed in podocytes, and malfunction of these proteins leads to a universal end p

232 cancers could exert their properties through malfunction of these Trr/MLL3/MLL4-specific (Trrific) en

233 We hypothesize that malfunction of this quorum-sensing mechanism may lead to

234 cell differentiation and maturation and that malfunction of this switch during sepsis promotes MDSC e

235 and MLL4 exert their properties through the malfunction of Trr/MLL3/MLL4-dependent enhancers.

236 mages may be affected by the wearing down or malfunctioning of equipment.

237 Malfunctioning of one of these hydrolases can lead to a

238 epilepsies and is generally associated with malfunctioning of the hippocampal formation.

239 Malfunctioning of the system caused all other adverse ev

240 Rather, they induce a toxic malfunctioning of their target biosynthetic machinery in

241 These findings suggest that the malfunctioning of these cellular processes in both midgu

242 Malfunctioning of these channels has been implicated in

243 Malfunctioning of these complexes in humans is associate

244 Malfunctioning of this machinery renders virions incapab

245 and further insights into peculiarities and malfunctions of neonatal immunity are needed.

246 Malfunctions of quality control systems are linked to ag

247 Malfunctions of selenoproteins lead to various human dis

248 Possible malfunctions of the ICD were found in 3% of all patients

249 tral nervous system (CNS) are underpinned by malfunctions of the immune system, including disorders i

250 e dystrophy caused by PRPH2 mutations and/or malfunctions of the LE.SIGNIFICANCE STATEMENT Peripherin

251 have various roles in homeostasis, signaling malfunctions of these receptors can cause disease.

252 Malfunctions of this channel are known to cause heredita

253 easily seen themselves, the effects of their malfunction on the brain can be tracked with detailed br

254 py is a means of delivering genes to replace malfunctioning ones, to kill cancer cells, or to correct

255 sorders are being discovered to be linked to malfunction or deficits of INs, this review will cover h

256 rol group than in the study group had device malfunction or device failure requiring replacement (16.

257 from disabling stroke or device removal for malfunction or failure.

258 from disabling stroke or device removal for malfunction or failure.

259 Improper setup can result in equipment malfunction or may cause serious damage to instruments d

260 Equipment malfunction or operation error was reported in all study

261 5-1.692), reimplantation for device upgrade, malfunction, or manufacturer advisory (OR, 1.354; 95% CI

262 ortant in detecting disease or physiological malfunction, or tracking disease progression.

263 nce of catheter-related VTE, CLABSI, and CVC malfunction over TLs.

264 Angle was the only risk factor for catheter malfunction (P < 0.001).

265 Our data show that SCN malfunctioning plays an important role in the disturbanc

266 exert only mild structural effects led to a malfunctioning pol II enzyme, thereby inducing a dominan

267 of modulatory capacity, possibly reflecting malfunctioning precision in GABAAergic neurotransmission

268 ere not advantageous with regard to catheter malfunction prevention as compared to open tip catheters

269 There were no pump exchanges, pump malfunctions, pump thrombosis, or hemolysis events.

270 d be the result of a chromosomal segregation malfunction resulting in the development of nodules.

271 ndrial component of folate metabolism, whose malfunction results in accumulation of glycine and dimin

272 ntrol of inflammation and healing, and their malfunction results in cardiometabolic disorders.

273 aining glucose homeostasis; their absence or malfunction results in diabetes mellitus.

274 slation at its peak efficiency by preventing malfunctioning ribosomes from active duty in translation

275 ata suggest that the inhibitory effects of a malfunctioning SCN on cognition require preservation of

276 y to precisely intervene with the underlying malfunctioning signalling pathway using endogenous subst

277 g therapeutic target for age-dependent brain malfunction.SIGNIFICANCE STATEMENT We found that local r

278 y included analysis of infection rates, line malfunctions, temporary hospitalization, neurological ev

279 nto the origins and nature of reward circuit malfunction that may set the stage for addiction.

280 lationship between the two systems and their malfunction that may underlie some neurological diseases

281 s a diagnostic feature of WD linked to liver malfunction; the mechanism behind urinary copper elevati

282 Recent studies suggest that enhancer malfunction through point mutations in either regulatory

283 tinosin deficiency, is characterized by cell malfunction, tissue failure, and progressive renal injur

284 ite a plethora of evidence linking G protein malfunction to human disease.

285 memory deficits and the underlying synaptic malfunction triggered by the accumulation of amyloid bet

286 ling metabolism, growth, and aging and whose malfunctioning underlies diabetes, some cancers, and neu

287 show that a mechanistic understanding of the malfunctions underpinning disease progression will prove

288 of abnormal process conditions (for example, malfunctions upstream of the point of emissions; equipme

289 ead until extraction is indicated because of malfunction versus an aggressive management strategy of

290 Freedom from lead malfunction was 97% at 5 years (from implantation) and 9

291 r disabling stroke, but reoperation for pump malfunction was less frequent in the centrifugal-flow pu

292 A higher rate of pump-specific malfunctions was discovered in those implanted with an H

293 To understand how cells deal with ribosome malfunction, we introduced mutations in the Expansion Se

294 Cumulative rates of malfunction were examined for the main components of eac

295 Three cases of pre-existing silent lead malfunction were unmasked by internal shock, resulting i

296 No delayed malfunctions were directly attributed to RT.

297 findings suggest that RBC in trauma patients malfunctions, which may explain organ damage and constit

298 s studies of severe diseases caused by miRNA malfunction, will benefit from the proposed computationa

299 ored against the early stages of AD synaptic malfunction with the goal of attenuating further synapti

300 gy and acquired or innate immunity and their malfunctioning with age.