ライフサイエンスコーパス: mammalian cell

1 es silencing of H3K27me3-demarcated genes in mammalian cells.

2 scriptional mechanism of relative sensing in mammalian cells.

3 were found to be conserved in Drosophila and mammalian cells.

4 ycle (G1, S, and G2/M)-specific manner using mammalian cells.

5 temporal choreography of DNA replication in mammalian cells.

6 c arrest followed by extensive cell death in mammalian cells.

7 teractions and subcellular proteomes in live mammalian cells.

8 ogression of cytosolic signaling networks in mammalian cells.

9 ould mediate its role in stress responses in mammalian cells.

10 pressed in the plasma membrane of almost all mammalian cells.

11 more rational synthetic construct design in mammalian cells.

12 ool, but is still rarely applied to engineer mammalian cells.

13 hat required their assembly as heteromers in mammalian cells.

14 Escherichia coli and C-to-G transversions in mammalian cells.

15 t protein post-translational modification in mammalian cells.

16 d transferring iron to recipient proteins in mammalian cells.

17 ificant NO(3) (-) conductance of OsPIP1;3 in mammalian cells.

18 an increased focus on biologics produced in mammalian cells.

19 nopus oocytes, and fluorescent microscopy of mammalian cells.

20 t Golgi membranes into stacks and ribbons in mammalian cells.

21 ment dynamics and also regulates adhesion in mammalian cells.

22 hout the genome of budding yeast, as seen in mammalian cells.

23 ed to ribosome profiling, and adapted it for mammalian cells.

24 Red Broccoli to be readily detected in live mammalian cells.

25 roteins with defined sulfation sites in live mammalian cells.

26 T3SS) substrate that induces cytotoxicity to mammalian cells.

27 nt structural and signaling functions within mammalian cells.

28 ls the assembly and organization of actin in mammalian cells.

29 onas rheinhardti and two strains of cultured mammalian cells.

30 r understanding of growth rate regulation in mammalian cells.

31 l below the range in which they are toxic to mammalian cells.

32 nd is involved in the lysosome biogenesis in mammalian cells.

33 -expressing the viral proteins S, M and E in mammalian cells.

34 de range of eukaryotes, including yeasts and mammalian cells.

35 as key sensors of glutamine availability in mammalian cells.

36 present the predominant ribozyme activity in mammalian cells.

37 T54 and the IFT motors were also observed in mammalian cells.

38 ne proteins in their native configuration in mammalian cells.

39 tions (EC50 <500 nM) and low cytotoxicity in mammalian cells.

40 ively packages gRNA in particles produced in mammalian cells.

41 onucleoproteins (RNPs) largely unexplored in mammalian cells.

42 translational outputs and mRNA stability in mammalian cells.

43 X, a marker for DNA double-strand breaks, in mammalian cells.

44 of a large enzyme, CDTa, into the cytosol of mammalian cells.

45 nstrate the broader utility of the method in mammalian cells.

46 d sensor that enables imaging of SAM in live mammalian cells.

47 2'3'-cGAMP to inhibit cGAS-STING immunity in mammalian cells.

48 with beta3, but not with beta2, subunits in mammalian cells.

49 is of modified proteins both in vitro and in mammalian cells.

50 the topology of kinase-signaling networks in mammalian cells.

51 me in the protection of genomic integrity in mammalian cells.

52 meostatic process with multiple functions in mammalian cells.

53 We show that the material is not toxic to mammalian cells.

54 multi-input, multi-output logic circuits in mammalian cells.

55 e that Nudt16 is a novel deNADding enzyme in mammalian cells.

56 wo short-lived ER membrane model proteins in mammalian cells.

57 s receptors to the EHD1 fission machinery in mammalian cells.

58 ted knockdown of wdr48 destabilizes USP46 in mammalian cells.

59 otein-tagged CLR.RAMP complexes expressed in mammalian cells.

60 interest to significant resource loading in mammalian cells.

61 as an expression vector for gene delivery in mammalian cells.

62 As exhibit specific distribution patterns in mammalian cells.

63 ity of small noncoding RNA (sRNA) classes in mammalian cells.

64 coli is fluorescent in vitro but not in live mammalian cells.

65 ndrial and cytosolic/nuclear compartments of mammalian cells.

66 various RNA targets in living bacterial and mammalian cells.

67 o coordinate Fe-S, Fe and ROS homeostasis in mammalian cells.

68 ted RIMS2 and decreased insulin secretion in mammalian cells.

69 itro, but they exhibit lower fluorescence in mammalian cells.

70 DNA double-strand breaks (DSBs) are toxic to mammalian cells.

71 on does not require ERK2 in Dictyostelium or mammalian cells.

72 ication of small molecules and organelles in mammalian cells.

73 progression is conserved between insects and mammalian cells.

74 and Bacillus-yet are relatively non-toxic to mammalian cells.

75 y iron import during active proliferation of mammalian cells.

76 ammatory and other therapeutic activities in mammalian cells.

77 red with loss of replicative ability in most mammalian cells.

78 ntibiotic-resistant bacteria, and neoplastic mammalian cells.

79 omes from unicellular organisms and cultured mammalian cells.

80 truction of customizable genetic programs in mammalian cells.

81 rogeneity on splicing particle biogenesis in mammalian cells.

82 tly regulate the expression of other RBPs in mammalian cells.

83 ides the transport for the otherwise sessile mammalian cells.

84 for the genetic encoding of sulfotyrosine in mammalian cells.

85 route" (MESMER), can accurately assess Mn in mammalian cells.

86 ptors on the membranes and in the cytosol of mammalian cells.

87 eir absence limits proliferative capacity of mammalian cells.

88 e strategy for chemical-genetic profiling in mammalian cells.

89 dated using G protein activity biosensors in mammalian cells.

90 ian cells but not the added reliance seen in mammalian cells.

91 represent a source of genomic instability in mammalian cells(1-4).

92 Among all the tested mammalian cells, 293Ts expressing hACE2 were most effici

93 ed genetic manipulations can be delivered to mammalian cells all at once or extensive engineering of

94 de adenine dinucleotide (NAD)-capped RNAs in mammalian cells and a role for DXO and the Nudix hydrola

95 Intracellular pathogens can thrive within mammalian cells and are inaccessible to many antimicrobi

96 ematically tune protein expression levels in mammalian cells and eventually help to optimize recombin

97 s alleviates TDP-43-mediated cytotoxicity in mammalian cells and fly neurons.

98 tGCN4) and compared the protein expressed in mammalian cells and in Escherichia coli using in vitro a

99 targeting approach for optogenetic tools in mammalian cells and in vivo in zebrafish to specifically

100 herapeutic monoclonal antibodies produced in mammalian cells and is considered an important critical

101 annel (PAC) is active across a wide range of mammalian cells and is involved in acid-induced cell dea

102 , which combine high effective brightness in mammalian cells and monomeric state, perform well in bot

103 zation and was validated by sensitization of mammalian cells and neurons by visible-light photoactiva

104 ct profiling of protein expression in single mammalian cells and other trace samples.

105 , polar SNO-OCTs are rapidly internalized by mammalian cells and remain functional in the cytosol for

106 PC-1/PC-2 complex in the plasma membrane of mammalian cells and show that it functions as an outward

107 ght into the coupling of strain between soft mammalian cells and synthetic LCs, and hint at new metho

108 escent fluorogenic aptamer that functions in mammalian cells and that can be readily developed into r

109 are ubiquitously and abundantly expressed in mammalian cells and tissues.

110 on 38,538 genomically integrated targets in mammalian cells and used the resulting outcomes to train

111 tional regulation of CRISPR/Cas9 activity in mammalian cells and zebrafish embryos using photochemica

112 ns has been realized in bacteria, yeast, and mammalian cells, and recently, in multicellular organism

113 membrane association of VAMP2 SNARE motif in mammalian cells, and the structural change of VAMP2 upon

114 kindlins can oligomerize (self-associate) in mammalian cells, and we propose that this self-associati

115 ling store-operated Ca(2+) entry, typical of mammalian cells; and (iv) the Thg-sensitive Ca(2+) pool

116 Nevertheless, the molecular mechanisms in mammalian cells are not well understood.

117 A major family of NAD(+) consumers in mammalian cells are poly-ADP-ribose-polymerases (PARPs).

118 Mammalian cells are soft, and correct functioning requir

119 -Glo reagent can be conveniently produced in mammalian cells as a secreted protein that retains the f

120 Protein kinase Cbeta (PKCbeta) expressed in mammalian cells as two splice variants, PKCbetaI and PKC

121 ore process and regulation of ferroptosis in mammalian cells, as well as its therapeutic implications

122 The mammalian cell-autonomous circadian clock is built aroun

123 provides multiple levels of interfacing with mammalian cell biology.

124 glycoprotein is critical for virus egress in mammalian cells, but not in tick cells.

125 at are targeted by PTMs during infections of mammalian cells by bacterial pathogens.

126 turnover, we established a genetic screen in mammalian cells by combining a fluorescent protein-based

127 We report activation of TETs in mammalian cells by incorporation of genetically encoded

128 reliable regulation of protein expression in mammalian cells by introducing defined RNA hairpins, ter

129 m-negative bacterial pathogens interact with mammalian cells by using type III secretion systems (T3S

130 We demonstrate that mammalian cells can incorporate uracil analogs and chara

131 propagation of bat influenza H18N11 virus in mammalian cells can result in mammal-adapting mutations

132 The viscoelastic properties of mammalian cells can vary with biological state, such as

133 Genetic screens in mammalian cells commonly focus on loss-of-function appro

134 onstrate that transiently expressed genes in mammalian cells compete for limited transcriptional and

135 Experiments on select receptors in mammalian cells confirmed our yeast-based observations,

136 ly 6 h and requires basic molecular biology, mammalian cell culture and fluorescence microscopy skill

137 a purified yield of 214 mg/l in unoptimized, mammalian cell culture and, in contrast to a stabilized

138 Mammalian cell culture models are widely used to study c

139 se experiments were confounded by the use of mammalian cell culture systems supplemented with fetal b

140 patients with suspected rickettsioses using mammalian cell culture systems.

141 mal cilia formation in zebrafish embryos and mammalian cell culture, arguing that ciliary defects are

142 In the present study, using mammalian cell cultures and a PD mouse model, along with

143 ptor was expressed at high yield in Expi293F mammalian cell cultures, solubilized and purified in Fac

144 diated cassette exchange (RMCE) reactions in mammalian cell cultures.

145 e importance of E2F transcription factors in mammalian cell cycle regulation, we investigated the rol

146 ol progression at the G1/S transition of the mammalian cell cycle.

147 ylation, ubiquitination and transcription in mammalian cell cycle.

148 ded DNA from viral or bacterial infection in mammalian cells, cyclic dinucleotide activation of STING

149 In mammalian cells, despite the presence of the RAD52 prote

150 Mammalian cells developed two main migration modes.

151 ion that is a known target of solenopsins in mammalian cells-did not prevent swelling and vacuolizati

152 In mammalian cells, distinct H3K4 methylation states are cr

153 ic intermediate filaments to be expressed in mammalian cells during embryogenesis, but its role in ce

154 1A rapidly (within ~10 s) phase-separates in mammalian cells during hyperosmotic stress and dissolves

155 In mammalian cells, eight cytoplasmic aminoacyl-tRNA synthe

156 Mammalian cells exhibit remarkable diversity in cell siz

157 We report superior stability of the mammalian cell-expressed receptor compared to its E. col

158 ned with electron cryo-tomography, to intact mammalian cells expressing YFP-rhTRIM5alpha and found th

159 We show, using mammalian cell expression and a single-molecule assay, t

160 In mammalian cells, expression of MGAT4D-L causes the subst

161 In mammalian cells, extracellular protons act as orthosteri

162 els with the 'super-enhancers' that regulate mammalian cell fate.

163 genome-wide C*G to T*A edits are observed in mammalian cells following transfection of mRNA encoding

164 existence of an autophagic mechanism used by mammalian cells for the direct transfer of LD components

165 How mammalian cells form such a nucleus remains incompletely

166 the disassembly of a collided polysome in a mammalian cell-free system.

167 haride head groups, glucose and galactose in mammalian cells, gives rise to an analytical challenge i

168 e wild, this is less apparent for studies of mammalian cells growing outside the organism.

169 implicate a function of macropinocytosis in mammalian cell growth beyond Ras-transformed tumor cells

170 In mammalian cells, >25% of synthesized proteins are export

171 ical effect of CAP on cancer cells and other mammalian cells has been based solely on the chemical fa

172 decades of study, the full scope of RNAi in mammalian cells has remained obscure.

173 larity between those and host nucleic acids, mammalian cells have been able to evolve powerful innate

174 Mammalian cells have the ability to incorporate thymidin

175 existing multiplex assay methods in cultured mammalian cells hinder the breadth, speed and scale of t

176 In mammalian cells, human HIPK2 proteins accumulate posttra

177 wiftly decrease after bacterial infection in mammalian cells, implying a role in the host response.

178 ps phosphorylation in both Dictyostelium and mammalian cells, implying that phosphorylation modulates

179 aracterizing mechanical properties of single mammalian cells in a population and thus cell-to-cell va

180 but not WDR-20, promotes USP-46 abundance in mammalian cells in culture and in C. elegans neurons in

181 d CdiA-CT domain to promote toxicity against mammalian cells in culture and lethality during mouse ba

182 e assay to monitor dynamic FAO activities of mammalian cells in physiologically relevant settings.

183 R-that reorganizes the actin cytoskeleton of mammalian cells in response to calcium influx.

184 y infection of the labeled mutant virions in mammalian cells in the presence of NAbs.

185 cted protein-ultrastructure relationships in mammalian cells including intranuclear vesicles containi

186 e key results on how phages traverse through mammalian cells - including uptake, distribution, and in

187 cussed mechanisms employed in both yeast and mammalian cells, including the various machineries that

188 pharmacological inhibition of glycolysis in mammalian cells induces ciliary translocation of Smo-a k

189 e implications of the growing field of phage-mammalian cell interactions for phage therapy.

190 the predicted phenotypic changes in biofilm, mammalian cell invasion, and antibiotic tolerance.

191 Our data support that HR at bulky adducts in mammalian cells involves post-replicative gap repair and

192 Clathrin-mediated endocytosis (CME) in mammalian cells is driven by resilient machinery that in

193 This homeostatic mechanism in mammalian cells is driven by the transcription factor NR

194 cal pathway of eicosanoid production in most mammalian cells is initiated by phospholipase A(2)-media

195 The current knowledge on FAO regulators in mammalian cells is limited and sometimes controversial.

196 Carotenoid absorption by mammalian cells is not correlated with initial carotenoi

197 gineering, the design of genetic networks in mammalian cells is still painstakingly slow and fraught

198 Most NAD(+) in mammalian cells is synthesized via the NAD(+) salvage pa

199 s regulates the expansion of non-transformed mammalian cells is unknown.

200 agy, the major cellular recycling pathway in mammalian cells, is a promising strategy for the treatme

201 In mammalian cells, kinetochore-fibers connect chromosomes

202 The key to a healthy mammalian cell lies in properly functioning proteolytic

203 d via PKA, we expressed THIK-1 channels in a mammalian cell line (CHO cells) and used the phosphodies

204 iveness of our system to transport different mammalian cell lines (H460, H1299, A549, HEK293T and HS6

205 ng) that increased the virus titers in three mammalian cell lines (i.e., Madin-Darby canine kidney, M

206 ally generated bat influenza H18N11 virus in mammalian cell lines and animal models revealed that thi

207 d targeting and siRNA knockdown of ZNF263 in mammalian cell lines and human primary cells led to dram

208 We use mammalian cell lines and proband-derived fibroblasts to

209 ested the transduction efficiency in several mammalian cell lines expressing SARS-CoV-2 receptor hACE

210 To apply this system to various mammalian cell lines including cancer cells containing m

211 ation dosage over two orders of magnitude in mammalian cell lines of hamster and human origin was con

212 kinase IIIbeta [PI(4)KIIIbeta], in different mammalian cell lines prevented PI(4)P generation and led

213 een, typically performed in invertebrates or mammalian cell lines, has been instrumental in discoveri

214 Forward genetic screens in mammalian cell lines, such as RNAi and CRISPR-Cas9 scree

215 In mammalian cell lines, the endosomal sorting complex requ

216 types of multiplex genetic assays in various mammalian cell lines.

217 layed as importantly no cytotoxicity in four mammalian cell lines.

218 nnervation and do not express in recombinant mammalian cell lines.

219 mployed to degrade RNA in yeast, plants, and mammalian cell lines.

220 The compounds presented mild toxicity toward mammalian cell lines.

221 Ribose concentration was measured for mammalian cell lysate and serum, which led to estimates

222 to detect multiple Dhb-modified proteins in mammalian cell lysates, including histone H3, a previous

223 tro solutions and in complex environments of mammalian cell lysates, where relative amounts of free r

224 ility to capture the endogenous protein from mammalian cell lysates.

225 oitinase ABC, capable of being secreted from mammalian cells (mChABC), to examine the repercussions o

226 Cholesterol is an essential component of mammalian cell membranes, constituting up to 50% of plas

227 ptor 2 (HER2/ERBB2) in vesicles derived from mammalian cell membranes.

228 In mammalian cells, mitochondrial dysfunction triggers the

229 very pipeline using nematode, zebrafish, and mammalian cell models.

230 ane androgen receptor in various teleost and mammalian cell models.

231 Mammalian cell morphology has been linked to the viscoel

232 on are widely accepted as a prerequisite for mammalian cell motility, which precludes swimming.

233 In mammalian cells, much of signal transduction is mediated

234 Here we report that, in mammalian cells, NF2's lipid-binding ability is critical

235 ulation of CRISPR interference or editing in mammalian cells, none of the reported methods enable con

236 rol of CRISPR-Cas systems in prokaryotic and mammalian cells, organisms and ecosystems.

237 Mammalian cells present a fingerprint of their proteome

238 exhibited similar structural folding to the mammalian cell produced bNAbs, but non-sulfated versions

239 9-12], but it is unclear how this relates to mammalian cell proliferation in vivo.

240 ing sequence-specific genomic integration in mammalian cells, recombining donor plasmids bearing the

241 cholesterol in the plasma membranes (PM) of mammalian cells-referred to as the accessible cholestero

242 However, how mammalian cells regulate NS levels and pathway flux rema

243 transporters responsible for their uptake in mammalian cells remain poorly characterized.

244 Mammalian cells reorganize their proteomes in response t

245 the functions of sizable genomic segments in mammalian cells represent important goals of biomedical

246 Mammalian cells respond to insufficient oxygen through t

247 A critical question is how mammalian cells sense oxygen levels to coordinate divers

248 To understand how mammalian cells sense the presence and regulate the repa

249 ensity analysis of CaMKII-alpha expressed in mammalian cells shows that activation of CaMKII-alpha re

250 Although some genes that affect mammalian cell size have been identified, the molecular

251 Mammalian cells stably maintain high levels of DNA methy

252 ve inhibition of cyclic AMP (cAMP) levels in mammalian cells, suggesting coupling to G(alphaz).

253 llin like 1 (Pxl1) also localizes to SFSS in mammalian cells, suggesting that the strain sensing mech

254 otes stem cell functions in post-development mammalian cells; suppression of TAZ activity reduces or

255 Interestingly, in mammalian cells, TALPID3 and ANKRD26 also play a conserv

256 clade viruses replicated to higher levels in mammalian cells than pandemic clade.

257 owed in both Xenopus laevis egg extracts and mammalian cells that a conserved cysteine residue within

258 he ability to modulate the physiology of the mammalian cells that can harbor intracellular bacteria.

259 on of an antibody library in a population of mammalian cells that express the target polypeptide with

260 live cell imaging of nascent polypeptides in mammalian cells, that puromycylated nascent polypeptides

261 we use the endogenous electrophile sensor of mammalian cells, the KEAP1-NRF2 pathway, to discover cys

262 In mammalian cells, the Tip20 homologue RINT1 associates wi

263 olling glucose-derived metabolic pathways in mammalian cells, themselves hijacked by C. trachomatis t

264 aphy, diffusivity, and packing order in live mammalian cells through a synergy of single-molecule and

265 mitochondrial networks and nuclear pores in mammalian cells to amyloid-beta plaques and dendrites in

266 of the pathways involved in the response of mammalian cells to baculovirus infection will improve th

267 Engineering mammalian cells to carry out sophisticated and customiza

268 ion pathway conserved between C. elegans and mammalian cells to enable the transcription factor HSF1

269 tic effects and toxicities of antibiotics in mammalian cells to guide new applications in both cellul

270 s system allows anoxia-resistant animals and mammalian cells to initiate anaerobic glycolysis and sur

271 Epigenetic machinery permits mammalian cells to integrate environmental signals(2); h

272 This regulation allows mammalian cells to respond rapidly to changes in extrace

273 Efficient heterodimerization in mammalian cell transient transfections was observed, but

274 ng 24 Broccoli aptamers to be imaged in live mammalian cells treated with BI.

275 e cell targeting is challenging because most mammalian cell types lack a single surface marker that d

276 holesterol from the PM to the ER in multiple mammalian cell types.

277 neurons and astrocytes and in multiple other mammalian cell types.

278 velopmental and homeostatic pathways in most mammalian cell types.

279 petitive behavior studies have extended into mammalian cell types.

280 Mammalian cells typically start the cell-cycle entry pro

281 n of endogenous carbon monoxide (CO) in live mammalian cells under normoxic and hypoxic conditions.

282 ynamic response of amino acids metabolism in mammalian cells upon activation of the protein kinase R

283 fluorescence activation in stably transduced mammalian cells upon DENV-2/ZIKV infection.

284 combinant proteins and their distribution in mammalian cells using fluorescence imaging.

285 cGAS-STING pathway is a major mechanism that mammalian cells utilize to detect cytoplasmic dsDNA from

286 Lysine fatty acylation in mammalian cells was discovered nearly three decades ago,

287 taining proteins bind N6mA-containing RNA in mammalian cells, we investigated whether mammalian YTH d

288 For use in mammalian cells, we replaced AID with rat APOBEC1 (APOBE

289 In contrast to mammalian cells, we report 5hmC-like levels in the P. fa

290 he targets and effects of this drug class in mammalian cells, we used a genome-wide shRNA screen in K

291 er phiC31 integrase functions efficiently in mammalian cells when co-nucleofected as a purified prote

292 cterial membranes with greater affinity over mammalian cells when compared to poly-l-lysine and poly-

293 and logical control over gene expression in mammalian cells, which has the potential to revolutionis

294 t the single-virion level directly on living mammalian cells, which offers new perspectives to better

295 in vivo in a genome-wide manner, we treated mammalian cells with aminoglycosides and performed ribos

296 d protein species in the plasma membranes of mammalian cells with approximately 100 nm-lateral resolu

297 The glycocalyx regulates the interaction of mammalian cells with extracellular molecules, such as cy

298 and quantification of DSB repair outcomes in mammalian cells with high precision.

299 igenetic regulators of cellular processes in mammalian cells, with their misregulation leading to var

300 ting guide RNAs (pegRNAs), can edit bases in mammalian cells without donor DNA or double-strand break