ライフサイエンスコーパス: mammary gland

1 x10 has multiple functions in the developing mammary gland.

2 s to match the requirements of the lactating mammary gland.

3 s necessary for long-term maintenance of the mammary gland.

4 regulating the postnatal development of the mammary gland.

5 is during development and postnatally in the mammary gland.

6 ng E. coli vaccine-induced protection of the mammary gland.

7 hormonal action on critical targets like the mammary gland.

8 n of polar lipids is highly regulated in the mammary gland.

9 ent, and secretory function in the lactating mammary gland.

10 me and bacterial load in cows with a healthy mammary gland.

11 IgA in the serum, gut, feces, and lactating mammary gland.

12 partment in an intact and normally developed mammary gland.

13 nal epithelial cell populations in the adult mammary gland.

14 of primary organotypic cultures of the mouse mammary gland.

15 ve during functional maturation of the adult mammary gland.

16 e growth in size of the primary tumor in the mammary gland.

17 ipocyte fate determination in the developing mammary gland.

18 ciated appendages such as hair, eye, and the mammary gland.

19 de range of lineages, including those of the mammary gland.

20 uce multipotency during tumorigenesis in the mammary gland.

21 nd pathways regulated by progesterone in the mammary gland.

22 the ErbB2 oncogenic signaling pathway in the mammary gland.

23 s on effects on progenitor cell pools in the mammary gland.

24 ose stroma and fibrous capsule of the virgin mammary gland.

25 rement of VANGL family members in the murine mammary gland.

26 lar mechanisms of PRMT overexpression in the mammary gland.

27 umen formation, and stem cell biology of the mammary gland.

28 (bMECs) are the main cells of the dairy cow mammary gland.

29 and molecular clock gene expression in mouse mammary glands.

30 except for Glutathione Peroxidase), brain or mammary glands.

31 rganized epithelial compartment within their mammary glands.

32 already operational before the appearance of mammary glands.

33 d ability to generate mammospheres in normal mammary glands.

34 orphological alterations in nulliparous mice mammary glands.

35 patient breast tumors compared with healthy mammary glands.

36 tion is the disruption of apical polarity in mammary glands.

37 a key role for MMP14 and MMP15 in regulating mammary gland adipocyte differentiation.

38 umented, and immune responses protecting the mammary gland against E. coli are not completely underst

39 vestigate the role of super-enhancers in the mammary gland, an organ characterized by exceptional gen

40 autophagy and cell death in both the normal mammary gland and BC cells.

41 ed significant myeloid infiltration into the mammary gland and breast tumor.

42 ion model, P. zopfii GT-II replicated in the mammary gland and caused severe inflammation with infilt

43 levated serotonin concentrations in both the mammary gland and circulation compared to controls.

44 tions of the parameters compared with normal mammary gland and demonstrated the areas of significant

45 benzo-a-pyrene (BaP) metabolism in the mouse mammary gland and develop a circadian in vitro model for

46 gly, this signature is present in the normal mammary gland and is progressively lost in patients with

47 r tissue-specific promoters of the pancreas, mammary gland and other secretory tissues, as well as an

48 vide new insights into the role of SEMA3B in mammary gland and provides a new branch of GATA3 signali

49 rowth-hormone concentrations that may affect mammary gland and pubertal development.We evaluated the

50 AP2C/AP-2gamma influences development of the mammary gland and regulates patterns of gene expression

51 t, WAP-Cre x Tph1 (FL/FL) dams had decreased mammary gland and serum serotonin concentrations compare

52 ) on mammary cell fate in the pre-neoplastic mammary gland and show that the cell of origin of PIK3CA

53 V-PyMT mice redirects SmgGDS splicing in the mammary gland and slows tumorigenesis in this aggressive

54 ntly transduce progenitor cells of the adult mammary gland and use that as a platform to functionally

55 exposure influences BaP metabolism in mouse mammary glands and describe an in vitro model that can b

56 Dams were euthanized on d10 postpartum and mammary glands and duodenal tissue were harvested.

57 l three PRMTs induced hyper-branching of the mammary glands and increased Ki-67 staining.

58 report that Fgf20 is expressed in embryonic mammary glands and is regulated by the Eda pathway.

59 ecific binding of (64)Cu-DOTA-alendronate in mammary glands and mammary tumors.

60 IF4E govern its biologic output in lactating mammary glands and that eIF4E overexpression in the cont

61 l division and apicobasal polarity in normal mammary glands and to establish a protumorigenic program

62 the different cell types that constitute the mammary gland, and discuss how these cell types arise an

63 EMT in vivo, in developing mouse embryos and mammary gland, and in vitro, in cultured 3D cell aggrega

64 in untreated human breast carcinomas, normal mammary gland, and peripheral blood.

65 ermal organs, such as teeth, hair follicles, mammary glands, and salivary glands.

66 transporter ZnT2 is critical for appropriate mammary gland architecture, and ZnT2 deletion is associa

67 Tissue-resident macrophages in the mammary gland are found in close association with epithe

68 The ducts and acini of the human mammary gland are prototypical heterogeneous and dynamic

69 eration, but not normal proliferation of the mammary gland associated with pregnancy or other normal

70 cells that initially appear in the embryonic mammary gland at around E17.5 coincident with the segreg

71 (V) chains are an abundant product of normal mammary gland basal cells, and that alpha3(V) ablation i

72 al organs such as teeth, hair follicles, and mammary glands begin their development as placodes.

73 in regulating bone marrow, skin, muscle, and mammary gland biology is emerging, but the role of adipo

74 ted in breast cancer however its function in mammary gland biology is unknown.

75 reast biology is key to the understanding of mammary gland biology.

76 to genes influencing the reproductive tract, mammary glands, bone, brain, fat differentiation, pituit

77 y that SHARPIN regulates the normal invasive mammary gland branching morphogenesis in an epithelial c

78 properties of stem cells that participate in mammary gland branching morphogenesis remain contested.

79 in the thymus, stomach, adrenal medulla, and mammary gland but not in other organs typically sensitiv

80 n linked to ductal development in the virgin mammary gland, but less is known regarding the effects o

81 uctal epithelial branching in the developing mammary gland by regulating macrophage dynamics.

82 thermore, during the life of the female, the mammary gland can undergo many rounds of expansion and p

83 This work uses a novel mouse mammary gland cancer model to show that tumors initiated

84 isplay convergent co-option by placental and mammary gland cell types to optimize offspring success.

85 nt in cells with a high Ca(2+) load, such as mammary gland cells during lactation, or in cells with a

86 We show that in MCF-7 mammary gland cells, AGO1 associates with transcriptiona

87 effect and the mechanism of low-dose BPA in mammary gland cells.

88 served that Robo1 ablation in the developing mammary gland compromised actin stress fiber assembly an

89 mutation carriers and BRCA1-deficient mouse mammary glands contain an abnormal population of mammary

90 reconstruction of epithelial tissues such as mammary gland, cornea and the hair follicle.

91 ow-dose effects include persistent delays in mammary gland development (perfluorooctanoic acid; PFOA)

92 -1 (mCripto-1) expression that occurs during mammary gland development and a stage-specific function

93 LBH is expressed during mammary gland development and aberrantly overexpressed i

94 ry tumors which were associated with delayed mammary gland development and alterations in mammary miR

95 conserved signaling pathways between normal mammary gland development and breast cancer.

96 h receptors and ligands contribute to normal mammary gland development and breast tumor progression.

97 The p53 family member, p63, is critical for mammary gland development and contains transactivation d

98 unctions are restricted to prolactin-induced mammary gland development and function.

99 HER2 signaling pathway; however, its role in mammary gland development and HER2-induced tumor initiat

100 y proliferative luminal subset necessary for mammary gland development and homeostasis.

101 Myoepithelial cells play key roles in normal mammary gland development and in limiting pre-invasive t

102 onstrate that VANGL2 is necessary for normal mammary gland development and indicate differential func

103 ta reveals that TET2 plays a pivotal role in mammary gland development and luminal lineage commitment

104 have revealed its specific roles in pubertal mammary gland development and potential contributions to

105 in the adipose stroma, and are important for mammary gland development and tissue homeostasis.

106 riments was tested in two studies related to mammary gland development and tumorigenesis.

107 e factors are enriched for genes integral to mammary gland development as well as epithelial cell bio

108 Mammary gland development begins with the appearance of

109 gly, WAP-Int3/Rbpj knockout mice have normal mammary gland development but still developed mammary tu

110 ly unknown mechanism controlling the rate of mammary gland development during puberty and highlights

111 e studies showed that it is not required for mammary gland development during puberty, it is not clea

112 n SOD1, whether SOD1 is essential for normal mammary gland development has never been determined.

113 nal cell phenotype during carcinogenesis and mammary gland development have remained elusive.

114 ed and these mice exhibited an inhibition of mammary gland development in early ages with a specific

115 not alter puberty in male and female rats or mammary gland development in female rats.

116 Mmp14 and Mmp15 targeting on early postnatal mammary gland development in mice.

117 se environmental chemical exposure on normal mammary gland development in rats to motivate and evalua

118 his Review, we outline the various stages of mammary gland development in the mouse, with a particula

119 the roles that these proteinases play during mammary gland development in vivo remain undefined.

120 function of Xbp1 in epithelial cells during mammary gland development is unknown.

121 a novel mechanism for Cripto-1 regulation of mammary gland development through direct effects on prog

122 Here, we examined the role of SHARPIN in mammary gland development, a process strongly regulated

123 be used to study the hormonal regulation of mammary gland development, and to test newly synthesized

124 federal testing programs, including altered mammary gland development, Her2 activation, progesterone

125 In mammary gland development, mathematical modeling has bee

126 During mouse mammary gland development, the estrogen growth factor re

127 that should further understanding of normal mammary gland development, the molecular mechanism of ho

128 rse their litters due to frank impairment of mammary gland development.

129 lts provide a global, unbiased view of adult mammary gland development.

130 showed that estrogens directly altered fetal mammary gland development.

131 licate FOXC1 as a new important regulator of mammary gland development.

132 emokines, is differentially expressed during mammary gland development.

133 show that Ackr2(-/-) mice display precocious mammary gland development.

134 RA1-dependent transcription programme during mammary gland development.

135 ental processes, including those involved in mammary gland development.

136 action between BRCA1 and COBRA1 during mouse mammary gland development.

137 aling pathway and of the p53-p21 axis during mammary gland development.

138 nt stem/progenitor cells contribute to adult mammary gland development.

139 onogenic luminal progenitors is required for mammary gland development.

140 cific function of mCripto-1 signaling during mammary gland development.

141 cks proliferation and differentiation during mammary gland development.

142 ary gland tumorigenesis as well as in normal mammary gland development.

143 During puberty, the mouse mammary gland develops into a highly branched epithelial

144 uss how we discovered that integrins control mammary gland differentiation and explore the role of in

145 se that the unique biology of the postpartum mammary gland drives tumor progression.

146 ell polarity and lumen formation, as well as mammary gland duct diameter and branching.

147 epithelial cell polarity is fundamental for mammary gland duct morphogenesis during mammalian develo

148 Serotonin is a homeostatic regulator of the mammary gland during lactation.

149 expressing a hyperactive STAT5 mutant in the mammary gland during postlactational remodeling.

150 P-Cre transgene, commonly used to target the mammary gland during pregnancy, induces metastatic pineo

151 for developmental changes that occur in the mammary gland during pregnancy, lactation, and involutio

152 activated myofibroblasts, counterpart normal mammary gland endothelial cells (NEC) showed little chan

153 In genetic studies in normal mammary gland epithelial and carcinoma cells, GARP expre

154 t has minimal or less effect on normal human mammary gland epithelial cells (HMECs) and estrogen rece

155 aureus- and Escherichia coli-infected bovine mammary gland epithelial cells.

156 mapping of accessible chromatin in the mouse mammary gland epithelial EpH4 cell line and its Ras-tran

157 The mammary gland epithelium consists of differentiated lumi

158 dates resulted in the hyper-proliferation of mammary gland epithelium.

159 tem cells (MSCs) injected into contralateral mammary gland, evidenced by the lack of tumor growth at

160 keratin-8-positive cells of the adult mouse mammary gland evokes cell dedifferentiation into a multi

161 The mammary gland experiences substantial remodeling and reg

162 We demonstrate here that the developing mammary gland expresses high levels of inflammatory CC-c

163 The mammary gland extracellular matrix (ECM) is comprised of

164 into wild-type stroma, fully repopulate the mammary gland fat pad, undergo unperturbed ductal outgro

165 tent activator of early involution, into the mammary gland fat pads of lactating mice increased ZnT2

166 We find TMEM165 is crucial in the lactating mammary gland for normal biosynthesis of lactose and for

167 Analyses showed that susceptible mammary glands from E-R72 (R72 x MMTV-Erbb2/Neu) mice de

168 imal models show milk-derived miRNAs reflect mammary gland function during lactation.

169 onstrate that Cdc42 plays essential roles in mammary gland function post pregnancy, where it helps to

170 robe the specific role of Cdc42 during adult mammary gland function.

171 porter SLC30A2/ZnT2 plays a critical role in mammary gland function; ZnT2-null mice have profound def

172 potential candidate genes for milk traits or mammary gland functions include ERCC6, TONSL, NPAS2, ACE

173 accessory organs such as hair follicles and mammary glands has proved elusive, a likely consequence

174 ntracellular domain (designated Int3) in the mammary gland have two phenotypes exhibited with 100% pe

175 ases basal levels of autophagy in the normal mammary gland, highlighting the potential of vitamin D a

176 essing EMT-associated genes in normal murine mammary gland homeostasis and human breast cancer still

177 uggest that Zpo2 plays a significant role in mammary gland homeostasis and that deregulation of Zpo2

178 ssociation with stemness, contributes to the mammary gland homeostasis, evolution of early neoplastic

179 pithelial cell differentiation and maintains mammary gland homeostasis.

180 flat facial appearance, skeletal anomalies, mammary gland hypoplasia, and reduced growth.

181 To improve our knowledge of mammary gland immune protection, cows immunized either i

182 The objective was to test whether goat's mammary gland immune response to E. coli lipopolysacchar

183 bnormal development or function of the mouse mammary gland in the Wasf3 null mice and brain developme

184 enitor cells able to reconstitute a complete mammary gland in vivo.

185 s are enriched for cells that can regenerate mammary glands in secondary transplants.

186 As a result, lactating mammary glands in these mice produce less milk protein,

187 oviral expression of ZnT2 in lactating mouse mammary glands in vivo increased Zn in lysosomes and mit

188 heir morphologic symmetry, left versus right mammary glands in wild-type mice have baseline differenc

189 Fgf20 deficiency does not impede mammary gland induction, but compromises mammary bud gro

190 tivity was significantly higher in milk from mammary glands infected with RS-PCR banding type 1 (RSP

191 iomarkers and possible treatments for bovine mammary gland inflammation.

192 the human long noncoding RNA LINK-A in mouse mammary glands initiates metastatic mammary gland tumors

193 t ZnT2-mediated Zn transport is critical for mammary gland involution in mice.

194 cterized by dynamic tissue remodeling in the mammary gland involving ductal elongation, resolution in

195 The mammary gland is a highly vascularized tissue capable of

196 The mammary gland is a unique tissue and the defining featur

197 The female mammary gland is a very dynamic organ that undergoes con

198 Branching morphogenesis in the mammary gland is achieved by the migration of epithelial

199 The innervation of the mammary gland is controlled by brain-derived neurotrophi

200 her analysis of the function of TAp63 in the mammary gland is critical for improved diagnosis and pat

201 th stable barcodes, we found that each mouse mammary gland is generated from a defined number of ~120

202 An important feature of the mammary gland is its ability to undergo profound morphol

203 An important feature of the mammary gland is its ability to undergo repeated morphol

204 hows that precise sensory innervation of the mammary gland is regulated by the balance between trophi

205 The development of the mammary gland is unique: the final stages of development

206 eus-induced mastitis, an inflammation of the mammary gland, is unclear.

207 Here, we show that, in mouse mammary gland, kidney, and human prostate, these feature

208 In mouse models, PELP1 overexpression in the mammary gland leads to premalignant lesions and eventual

209 phospho-mimicking EZH2 mutant EZH2(T416D) in mammary glands leads to tumors with TNBC phenotype.

210 Branching organs, including the salivary and mammary glands, lung, and kidney, arise as epithelial bu

211 multipotent SCs, only unipotent SCs mediate mammary gland (MG) development and adult tissue remodeli

212 Indeed, postnatal mammary gland (MG) development is controlled locally by

213 al sites, but its role in the defense of the mammary gland (MG) has seldom been investigated, althoug

214 , an improper glucose supply often threatens mammary gland (MG) health.

215 e phenotype of the ventral prostate (VP) and mammary gland (MG) in ERbeta(crispr-/-) mice was similar

216 trolled variables across tumor and non-tumor mammary gland microvasculature with and without applicat

217 m and progenitor cell subpopulations driving mammary gland morphogenesis and homoeostasis are poorly

218 nuclear function of Gal-1 in the context of mammary gland morphogenesis and in cancer progression.

219 Mammary gland morphogenesis depends on a tight balance b

220 s role in epithelial tissue organization and mammary gland morphogenesis in vivo has not been investi

221 In a three-dimensional (3D) model of mammary gland morphogenesis, sEV treatment induced hallm

222 The mammary gland niche must support its associated stem cel

223 In the human mammary gland, Numb is a tumor suppressor and regulates

224 Preventive infusion of antibiotics in the mammary gland of cows consumes 11 tons/year of medically

225 cal to prevent new infections in the healthy mammary gland of cows.

226 peculate that secreted sphingomyelins in the mammary gland of mammals with a naturally low incidence

227 The mammary gland of Numb-knockout mice displays an expansio

228 on in the brain, but p53 upregulation in the mammary gland of polymorphic mice compared to that of wi

229 expression of the ErbB2DeltaEx16 variant in mammary gland of transgenic mice results in the rapid de

230 The mammary gland of VDR KO mice shows a florid phenotype re

231 evaluated after the administration of LPS in mammary glands of dairy goats under thermal-neutral (TN;

232 ession of these proteins was evident also in mammary glands of mice subjected to gamma-irradiation an

233 which were orthotopically injected into the mammary glands of mice.

234 ll population significantly in preneoplastic mammary glands of MMTV-Her2 mice which showed a putative

235 In mammary glands of Orai1 knockout mice, these contraction

236 a, PKM2, and aromatase were increased in the mammary glands of p53 null versus wild-type mice.

237 At 3 days post lactational involution, the mammary glands of Snai2-deficient mice exhibited lower l

238 Histologically, the mammary glands of the lactating knockout mice were disti

239 ulated) were differentially expressed in the mammary glands of the two groups.

240 gical, cellular, and molecular milieu of the mammary gland offers insights into the drivers of breast

241 d in tissues that are softer than the normal mammary gland or the primary breast tumor, such as bone

242 helial, stromal and systemic roles in murine mammary gland organogenesis, yet specific functions rema

243 d the testing of estrogen's direct effect on mammary gland organogenesis.

244 ressure build up in epithelial domes, murine mammary gland organoids embedded in hydrogel, and lumen

245 central transcription factor that regulates mammary gland physiology and a key driver in breast canc

246 inal and basal epithelial cells of the adult mammary gland proliferate and differentiate resulting in

247 greater reliance on HDR in the proliferating mammary gland, rather than a specific dependence on BRCA

248 E2f3a levels are elevated in TAMs from PyMT mammary glands relative to controls, suggesting a differ

249 Postnatal development of the mammary gland relies on the maintenance of oriented cell

250 mpaired apoptosis and a significant delay in mammary gland remodeling.

251 Unexpectedly, both Mmp14(-/-) and Mmp15(-/-) mammary glands retain the ability to generate intact duc

252 The lactating mammary gland secretes milk lipid by this mechanism, and

253 The majority of human BRCA1(mut/+) mammary glands showed marked lobular expression of nucle

254 pression is elevated in mammary tumours, and mammary gland-specific DNMT1 deletion protects mice from

255 Using a novel mammary gland-specific JAK1 knockout model, we demonstra

256 Thus, SHARPIN is required in mammary gland stroma during development.

257 intaining homeostasis within the nulliparous mammary gland stroma.

258 Moreover, Sharpin(cpdm) mammary gland stromal fibroblasts demonstrated defects i

259 n of neoplastic cells within the duct of the mammary gland that have not invaded into the surrounding

260 e subpopulation within the mouse nulliparous mammary gland that is characterized by the expression of

261 iosis promoted early inflammation within the mammary gland that was sustained during HR(+) mammary tu

262 In the normal mammary gland, the basal epithelium is known to be bipot

263 In the mammary gland, the identity and characteristics of quies

264 In the lactating mammary gland, the plasma membrane calcium ATPase2 (PMCA

265 for the unique regenerative capacity of the mammary gland throughout adult life.

266 The mammary gland thus provides an excellent model for study

267 tions of this theory on datasets of pubertal mammary gland tips and embryonic kidney tips, as well as

268 RCA-/-, p53-/- breast tumor tissue or normal mammary gland tissue with methyl-tert-butyl ether (MTBE)

269 ling during the transformation of the normal mammary gland to breast cancer hinders the development o

270 revealed a shift from high triglycerides in mammary gland to high phospholipid levels in tumors.

271 The pH of milk changes from the mother's mammary gland to the infant's digestive tract.

272 dherin-expressing mammary cell line from the mammary gland to the lung depends on reduced E-cadherin

273 transferases (PRMT) are directly involved in mammary gland transformation and tumor progression.

274 investigated the impact of dietary sugar on mammary gland tumor development in multiple mouse models

275 In mammary gland tumor models, Angpt2(443) differentially a

276 The roles of TFAP2C in mammary gland tumorigenesis and in pathways critical to

277 his study to investigate the role of SOD1 in mammary gland tumorigenesis as well as in normal mammary

278 ting elevated levels of these three PRMTs in mammary gland tumorigenesis, albeit with variable degree

279 the possible roles of PRMT overexpression in mammary gland tumorigenesis, we generated Cre-activated

280 te the interactions between CSCs and CAFs in mammary gland tumors driven by combined activation of Wn

281 e PLC components, Rb and p53, and sensitized mammary gland tumors to immune checkpoint blockers.

282 in mouse mammary glands initiates metastatic mammary gland tumors, which phenotypically resemble huma

283 The mammary gland undergoes cycles of growth and regeneratio

284 The mammary gland undergoes fast cell proliferation during e

285 The mammary gland undergoes significant proliferative stages

286 ingly, C17orf99 expression is induced in the mammary gland upon the onset of lactation, and a C17orf9

287 her BPA showed effects on the developing rat mammary gland using new quantitative and established sem

288 d in animal organs such as the lung, kidney, mammary gland, vasculature, etc.

289 ost importantly, the activity of cSrc in the mammary gland was reduced during early lactation in the

290 ty and plasticity on cell positioning in the mammary gland, we reconstituted its self-organization fr

291 Mammary glands were analyzed for tumor number and immuno

292 Mammary glands were evaluated for myoepithelium integrit

293 e developed an ex vivo culture method of the mammary gland where the direct action of estrogens can b

294 regulation of branching morphogenesis in the mammary gland, whereby stromal ACKR2 modulates levels of

295 t as well as epigenetic reprogramming in the mammary gland, which can affect cell fate decisions in p

296 on of Semaphorin family members in the mouse mammary gland, which signal through PlexinA4.

297 rogen-induced tumor suppressor in the normal mammary gland with decreased expression in breast cancer

298 mbryonic and adult development of the murine mammary gland with high levels of expression in mammary

299 uction of PIK3CA(H1047R) expression in mouse mammary glands with constitutive expression of activated

300 in (PTHrP) in their developing epidermis and mammary glands] with those from wild type, we show that