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1 ong with low acetylation levels in xylan and mannan.
2 ffinities for C. albicans yeast and purified mannan.
3 years, possess an elaborate cell wall alpha-mannan.
4 ies of glycoside hydrolases that can degrade mannan.
5 mpletely blocked by the addition of EGTA and mannan.
6 SLA enzyme to produce glucomannan instead of mannan.
7 ch showed it to be a phosphorylated branched mannan.
8 ent and GtfB-mediated binding to C. albicans mannan.
9 of preserving the carbohydrate structure of mannan.
10 lf of the phosphomannan attached to N-linked mannans.
11 eta1,6-branched beta1,3-d-glucan and free of mannans.
12 though further studies ruled out cytoplasmic mannans.
13 ed or if mannose receptors were blocked with mannans.
14 cytes mainly via recognition of cell-surface mannans.
15 for the observed accommodation of decorated mannans.
16 esses two loci conferring metabolism of beta-mannans.
17 ans, galactans, arabinogalactan proteins and mannans.
18 tivities of an LM glycan backbone, alpha(1-6)mannans.
19 aginella, pine, spruce, rice and poplar were mannan 2-O- and 3-O-acetyltransferases, whereas the two
20 6 was observed, which was inhibited by yeast mannan (a known CD206 ligand), free mannose, and a block
22 benefits of commensal fungi are mediated by mannans, a highly conserved component of fungal cell wal
26 e is little to no information on how exactly mannan alignment, including the number of mannose units
28 endomannanases) catalyse degradation of beta-mannans, an abundant class of plant polysaccharides.
29 n of FMS contains mainly the backbone of 1,4-mannan and 1,6-alpha-galactan and through the Fucalpha1-
33 te to the EPS matrix structure, while fungal mannan and beta-glucan provide sites for GtfB binding an
39 Thus, differential surface expression of mannan and glucan may influence recognition of C. albica
41 rphogenesis and cell wall components such as mannan and glucan were also upregulated, indicating enha
44 al MOS is being derived from yeast cell wall mannan and is widely used as prebiotic in feed supplemen
47 multiple membrane spans, and their products (mannan and xyloglucan) accumulate in the Golgi lumen.
48 tion by Ig was inhibited by coapplication of mannan and, thus, likely to be mediated by C-type lectin
49 mechanism for binding of dectin-2 to fungal mannans and also to bacterial lipopolysaccharides, capsu
50 ex cell wall consisting of an outer layer of mannans and an inner layer of beta-glucans and chitin.
54 s as immunodominant epitopes in (1-->2)-beta-mannans and to the viability of a glycoconjugate vaccine
56 ayer enriched in mannosylated glycoproteins (mannan) and an inner layer enriched in beta-(1,3)-glucan
57 ve ligands (acetylated BSA [AcBSA], zymosan, mannan, and LPS from Escherichia coli and Salmonella as
59 , the degree of acetylation of xylan, (gluco)mannan, and xyloglucan as well as overall cell wall acet
63 BM families that targeted beta-glucans, beta-mannans, and the pectic polysaccharide homogalacturonan.
65 ing cells by human neutrophils requires anti-mannan antibody, whereas ingestion of glucan-displaying
66 ion with homology modeling of the bound beta-mannan antigen suggested an optimum oligosaccharide for
67 a surface-associated phosphorylated branched mannan (APS) indicated that this locus is also downregul
69 ell wall components chitin and outer chain N-mannans are absent, based on genome content and experime
76 array analysis of Arabidopsis indicated that mannans are present throughout the plant and are especia
81 ays a critical role in the elongation of the mannan backbone of mycobacterial and corynebacterial LM,
83 arides composed of a (1 --> 4)-linked beta-D-mannan backbone substituted with single-unit (1 --> 6)-a
84 tus, this polysaccharide is made of a linear mannan backbone with side chains of galactofuran and is
85 a-mannanase catalyzes endo-hydrolysis of the mannan backbone, a major constituent of woody biomass.
86 addition to alpha(1-->2)Man branching on the mannan backbones of LM and LAM, confirming the involveme
96 nt, the pattern recognition molecules (PRMs) mannan-binding lectin (MBL) and ficolins complexed with
98 In teleost fish, the immune functions of mannan-binding lectin (MBL) associated protein (MAP) and
101 b, CR1 was reported to interact with C1q and mannan-binding lectin (MBL) likely through its C-termina
103 ght to occur via recognition of pathogens by mannan-binding lectin (MBL) or ficolins in complex with
104 t the soluble pattern recognition molecules, mannan-binding lectin (MBL), L-ficolin, and M-ficolin, w
106 ction of an endogenous complement inhibitor, mannan-binding lectin (MBL)-associated protein (MAp)44,
108 found that the C7 rs6876739 CC genotypes and mannan-binding lectin (MBL2) gene polymorphisms of liver
110 way and absence of the LP complement protein mannan-binding lectin abrogates elastase-induced AAA.
111 in pathway (LP) showed that both ficolin and mannan-binding lectin can activate the LP through natura
113 etic deficiency in early complement, IgM, or mannan-binding lectin were characterized in a mesenteric
114 to ischemic Ag providing a binding site for mannan-binding lectin which subsequently leads to activa
115 he lectin activation pathway upon binding of mannan-binding lectin, ficolins, or collectin kidney 1 (
116 and factor H in the alternative pathway and mannan-binding lectin, mannan-binding lectin-associated
117 substrate complex consisting of glycan-bound mannan-binding lectin, MASP-2, and C4 is discussed.
118 to the same areas that stain positively for mannan-binding lectin, which suggests that the complemen
120 n pathway deficiency, a mouse strain lacking mannan-binding lectin-associated serine protease-2 (MASP
121 mediated by direct cleavage of native C3 by mannan-binding lectin-associated serine protease-2 bound
125 lecules leading to the activation of zymogen mannan-binding lectin-associated serine proteases (MASPs
126 H-ficolin is found in plasma associated with mannan-binding lectin-associated serine proteases (MASPs
127 ternative pathway and mannan-binding lectin, mannan-binding lectin-associated serine proteases 1 and
128 In serum, CL-L1 was found in complexes with mannan-binding lectin-associated serine proteases, sugge
129 anism, which is conserved in C1r and also in mannan-binding lectin-associated serine proteases, the s
131 ution of blistering had a similar pattern in mannan-binding lectin-deficient and control mice and was
132 ys in this model, we injected C1q-deficient, mannan-binding lectin-deficient, and factor B-deficient
137 hat C. albicans engages both beta-glucan and mannan-binding receptors on macrophages that act with My
138 cans where inactivation of genes involved in mannan biosynthesis has usually been linked to an attenu
140 t NCgl1505 was involved in core alpha(1-->6) mannan biosynthesis of Cg-LM-A and Cg-LM-B, extending Ac
141 nclude that the MSR protein is important for mannan biosynthesis, and offer some ideas about its role
144 s with antibody specific for DC-SIGN or with mannan but not antibody specific for xCT, a cystine/glut
146 ring studies showed that metabolism of yeast mannan by B. thetaiotaomicron presents a 'selfish' model
147 es and that the masking of primary cell wall mannan by pectin is a potential mechanism for controllin
149 i-encoded proteins that are involved in beta-mannan capturing, importation, de-branching and degradat
150 f the GH130_1 subfamily would be involved in mannan catabolism, whereas the enzymes belonging to the
151 anched mannosyl residues, the alpha-6-linked mannan chain is terminated with an alpha-mannopyranose a
153 onal antibody 3F8 inhibited C3 deposition on mannan-coated plates in MBL2 KI, but not wild-type, mice
154 n vitro, MBL/MASP complexes were captured on mannan-coated plates, and cleavage of a chromogenic thro
155 significant increase in sensitivity to both mannan competition and endoglycosidase H digestion compa
156 ebound to 2G12 was 10-fold more sensitive to mannan competition than gp120 that was not prebound in a
159 softwoods, such as conifers and cycads, are mannans consisting of a 1,4-linked beta-mannopyranosyl m
160 ta, a molecular mechanism for utilization of mannan-containing nutrients by C. polysaccharolyticus is
161 akes them a resource for depolymerization of mannan-containing polysaccharides in the biofuel industr
163 abinan chain attached near the middle of the mannan core is present in mature LAM and allow for an up
164 s of the number of arabinans attached to the mannan core of LM in two other mutants (DeltaembC and De
166 the addition of alpha(1-->2) branches to the mannan core of LM/LAM and that arrest of this branching
167 d exactly one arabinosyl substitution of the mannan core suggestive of the arabinosylation of a linea
168 the LM glycans that consist of an alpha(1,6) mannan core, with and without the complete alpha(1,2) ma
170 T Rv2181 in the dual role of Man capping and mannan-core branching, and in the process generated a ra
171 f mannose receptor (MR) activity on MDM with mannan decreased the association of F. novicida and opso
172 anscriptome sequencing to gain insights into mannan degradation by the thermophilic anaerobic bacteri
177 he CBMs that recognize beta-glucans and beta-mannans, differences in the conformation of conserved ar
180 (zymosan and sheep erythrocytes coated with mannan (E(Man))) revealed that the convertases (ZymM1,C4
182 The most highly up-regulated genes during mannan fermentation occur in a cluster containing severa
183 a phosphatidylinositol anchor followed by a mannan followed by an arabinan that may be capped with v
184 oteins, which synthesize beta-(1-->4)-linked mannans found in the walls of many plant species, and CS
185 Indeed, we found that phosphatidylinositol mannan from M. tuberculosis inhibits macrophage response
186 lar weights (MW) of glycogen from Oyster and mannan from Saccharomyces cerevisiae are determined by s
188 s have the greatest impact on the removal of mannan from tobacco and Physcomitrella cell walls, respe
190 an synthases and support the hypothesis that mannans function in metabolic networks devoted to other
192 ohydrate-binding module directed against the mannan group of hemicellulose cell wall polysaccharides,
196 several genes encoding enzymes for efficient mannan hydrolysis as well as a solute-binding protein (C
197 l glycone binding site more efficiently than mannan-hydrolyzing glycoside hydrolases in related enzym
198 spectra of trehalose, glycogen, glucose, and mannan, i.e., the major carbohydrates present in S. cere
200 gus was inhibited by beta-glucans but not by mannans, implicating a lectin-like activity in recogniti
203 y reduced level of the virulence factor beta-mannan in the glucose transporter null mutants compared
205 mannanase was independent of the context of mannan in tobacco cell walls, a significant proportion o
206 e is known about the acetylation patterns of mannans in bryophytes and seedless vascular plants, and
207 nition of epitopes/ligands, and detection of mannans in primary cell walls can be effectively blocked
208 affects the structure of the fungal N-linked mannan, in line with their predicted functions, and this
209 cifically, high iron decreased the levels of mannans (including phosphomannans) and chitin; and incre
210 nted levels of the storage carbohydrate beta-mannan, increased cell size and increased growth as inse
211 he purified cell wall components zymosan and mannan induced caspase-1 activation and IL-1beta secreti
216 ation constants for Con A-glycogen and Con A-mannan interactions are KA=3.93+/-0.7x10(6) M(-1)/KD=0.2
219 By 28 DAP labeling of hetero-(1-->4)-beta-D-mannan is observed in the walls of the starchy endosperm
220 hestrate the depolymerization of yeast alpha-mannans, it is likely that the two enzymes target the be
221 -glucan to the immune system occurs when the mannan layer is altered or removed in a process called u
223 ated neutrophils with three soluble glucans, mannan, lipopolysaccharide, or a variety of cytokines re
225 veral cell-wall polysaccharides (xyloglucan, mannans, mixed-linkage beta-glucan and xylans); however,
226 ition of a fungal cell wall component, alpha-mannan (Mn), an Mn (sugar) polymer, by the C-type lectin
228 ion in Arabidopsis and konjac is mediated by mannan O-acetyltransferases belonging to the Domain of U
229 cular plants, and the evolutionary origin of mannan O-acetyltransferases in land plants has not yet b
230 es originated in algae, their recruitment as mannan O-acetyltransferases probably occurred in bryophy
231 ESI-MS/MS results showed that the isolated mannan oligomers, MOS-III, MOS-IV, MOS-V and MOS-VI cons
234 , that multivalently and selectively bind to mannan on the C. albicans cell surface to form crosslink
236 rt a model whereby limited cleavage of alpha-mannan on the surface generates large oligosaccharides t
244 narin (beta-1,3-glucan) but not sialic acid, mannan or pustulan mediated Hst 5 binding to C. albicans
245 e MTPs are structurally related to bacterial mannan phosphorylases, they constitute a distinct family
247 rized grass pollen allergoids to nonoxidized mannan (PM) compared with glutaraldehyde-polymerized all
250 ily have previously been shown to synthesise mannan polysaccharides in vitro when heterologously expr
251 rides, we show that molecular recognition of mannan polysaccharides present in intact cell walls is s
255 the glycoside hydrolases encoded by the beta-mannan PUL and involved in the beta-mannan utilization p
258 the conserved fungal components zymosan and mannan require ASC and Cryopyrin for caspase-1 activatio
259 The hydrolysis of polysaccharides containing mannan requires endo-1,4-beta-mannanase and 1,4-beta-man
263 accharide utilization loci, including novel, mannan-specific esterases that are critical to its decon
265 ns and those microbes devoid of cell-surface mannan such as the gram-negative bacterium E. coli.
266 l gold particles was used to label the alpha-mannan sugar in the cell wall of the yeast Saccharomyces
267 This binding was blocked by the addition of mannan, suggesting mannose receptor involvement in the D
268 Ca(2+) and by preincubation of DC-SIGN with mannan, suggesting that C1q binds to DC-SIGN at its prin
269 Blocking experiments with laminarin and mannan supported the conclusion that differences in cell
272 pecific MSR cofactors were indispensable for mannan synthase activity of a coffee CSLA or modulated a
274 Previous studies led to the conclusion that mannan synthase enzymes in several plant species are enc
276 tive GTs have also been implicated in (gluco)mannan synthesis, but their roles have been difficult to
279 n-1, was incorporated into the original beta-mannan tetanus toxoid conjugate providing a tricomponent
280 ive vaccine against Candida albicans, a beta-mannan tetanus toxoid conjugate showed poor immunogenici
281 y the tricomponent vaccine, but not the beta-mannan tetanus toxoid vaccine, showed activation of BMDC
282 e showed that the reducing end region of the mannan that is attached to inositol has 5-7 unbranched a
286 tinct molecular structure of wood xylans and mannans, the multiphase architecture of the hydrogels an
287 s of enzymatic synthesis of MOS from various mannans, their structural characteristics and their pote
288 nd YCW-b-MP1' contained mannoproteins with a mannan to protein ratio of 3.5 and 6.9, respectively.
289 weight (MW) distribution and variability of mannan to protein ratio of purified mannoproteins (MP),
290 and conjugated to the fungal cell wall beta-mannan trisaccharide [beta-(Man)(3)] by novel saccharide
291 oncanavalin A (Con A) and glycogen and Con A-mannan using quartz crystal microbalance (QCM), cost and
292 ein and provides a framework for engineering mannan utilization capabilities for microbial fermentati
295 phenomenon in parenchyma systems, and masked mannan was found to be a feature of cell wall regions at
297 ogy as well as the storage carbohydrate beta-mannan, which is an essential virulence factor for survi
298 s, R. intestinalis shares the available beta-mannan with Bacteroides ovatus, demonstrating that the a
299 o the inner Araf-alpha(1-->5)-Araf unit) and mannan (with fewer 6-Manp residues and more substitution
300 Low-MW YCW-b-MP2' was mainly comprised of mannan, with a ratio of 181, whereas low-MW Agrimos(R)-M