ライフサイエンスコーパス: mannoside

1 olic instability of the O-glycosidic bond (O-mannosides).

2 t installation of the galactose beta-(1-->4) mannoside.

3 ing protein 4 and ER degradation enhancing a-mannoside.

4 contact with distal portions of the branched mannoside.

5 . coli ORN 208, which does not bind to alpha-mannoside.

6 E. coli ORN 178, which is specific for alpha-mannoside.

7 e axial 2-OH group of a (4)C(1) ground state mannoside.

8 harmacokinetic (PK) properties relative to O-mannosides.

9 IGN binds more efficiently to densely packed mannosides.

10 er levels of binding to phosphatidylinositol mannosides.

11 in a novel detergent system employing alkyl mannosides.

12 ations being the addition of O- and N-linked mannosides.

13 d the higher-order phosphatidyl-myo-inositol mannosides.

14 high alpha-selectivities were the norm for C-mannosides.

15 dified allylsilane 29a-c to C(2)OH of methyl mannoside 15 improved matters.

16 Methyl mannoside 16 containing an allyldimethylsilyl ether at C

17 Reaction of the tethered mannosides 27a-c with TMSOTf in the presence of 2,6-DTBM

18 n peptidoglycan (mAGP), phosphatidylinositol mannoside-6 (PIM6) and lipomannan (LM) were identified a

19 the carboxylate substituted biphenyl alpha-d-mannoside 9, affinity and the relevant pharmacokinetic p

20 T2) are able to interact with four different mannoside acetylglucosaminyltransferases (Mgat1, Mgat2,

21 macrophages were treated with alpha-methyl-D-mannoside (alphaMM), a competitor of glycopeptide ligand

22 y gave a mixture of the desired alpha-linked mannoside and an orthoacetate resulting from attack at t

23 the cow CRD in the presence of alpha-methyl mannoside and GlcNAcbeta1-2Man reveal that a range of ol

24 colipids, specifically, phosphatidylinositol mannoside and mannose-capped lipoarabinomannan, were pot

25 ed products such as the phosphatidylinositol mannosides and linear and mature branched lipomannan and

26 ria or by millimolar concentrations of alpha-mannosides and micromolar concentrations of high-mannose

27 Phosphodiester-linked mannosides and the beta-(1,2)-mannose monomer help to di

28 on of higher order phosphatidyl-myo-inositol mannosides and the presence of dimycocerosates, triglyce

29 The stereoselective synthesis of beta-mannosides and the underlying reaction mechanism have be

30 ed IMS(n) analyses of enzymatically produced mannosides and, by comparison with the references, we su

31 ens, lipoarabinomannan, phosphatidylinositol mannoside, and glucose monomycolate.

32 synthetic substrate, 4-umbelliferyl-alpha-D-mannoside, and this activity is inhibited by swainsonine

33 trehalose dimycolates, phosphatidylinositol mannosides, and highly apolar lipids, similar to the Min

34 ion at the hindered anomeric center of alpha-mannosides, and the potential of mannosidase inhibitors

35 This new class of C-mannoside antagonists have significantly increased compo

36 followed by lipomannan, phosphatidylinositol mannoside, arabinosyl-lipoarabinomannan, and dimycolated

37 with Raney nickel, the so-formed 6-thio-beta-mannosides are converted in high yield to the beta-rhamn

38 strategy in which properly protected phospho-mannosides are coupled with a Fmoc protected threonine d

39 The observation that 1-thio-linked mannosides are not well tolerated by the catalytic site

40 On addition of an acceptor alcohol alpha-mannosides are then formed.

41 one- or p-nitrophenol-linked) alpha- or beta-mannosides as substrates indicated that there was no cor

42 ucomannan by cleaving the glycosidic bond of mannosides at the -1 subsite.

43 ing heteromultivalent liposomes copresenting mannosides bearing aromatic aglycones with natural glyca

44 glycans is UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I (Gl

45 the Mgat2 gene encoding UDP-GlcNAc:alpha-6-d-mannoside beta-1,2-N-acetylglucosaminyltransferase II en

46 albicans cell wall expresses beta-1,2-linked mannosides (beta-Mans), promoting its adherence to host

47 lvement of UDP-N-acetylglucosamine:alpha-6-D-mannoside beta1,6-N-acetylglucosaminyltransferase V (MGA

48 Golgi apparatus resident UDP-GlcNAc:alpha3-D-mannoside beta1-2-N-acetylglucosaminyltransferase I acti

49 ylation requires MGAT1 (UDP-GlcNAc:alpha-3-D-mannoside-beta1,2-N-acetylglucosaminyl-transferase I) fu

50 ed to govern the affinity and specificity of mannoside binding, we characterized the FimHL Y48A mutan

51 cross-talk between allosteric sites and the mannoside-binding pocket.

52 ivity toward the simple sugar alpha-methyl d-mannoside but impaired phosphorylation of acid hydrolase

53 es was inhibited by mannose and alpha-methyl mannoside but not by EDTA or arginine.

54 y suppressed in the presence of alpha-methyl-mannoside but not in the presence of mannose 6-phosphate

55 tively depleting intestinal UPEC reservoirs, mannosides could markedly reduce the rate of UTIs and re

56 aried the nature of anchoring/gate keepers d-mannoside, d-mannuronic acid, or sialic acid H-bonding g

57 ibited the synthesis of phosphatidylinositol mannosides, early precursors to LAM.

58 inide component from the corresponding alpha-mannoside employed Deshong's novel azide displacement pr

59 ture-based design and optimization of biaryl mannoside FimH inhibitors.

60 acylglycerol and cholesteryl 6'-O-acyl alpha-mannoside, found in Saccharopolyspora and Candida albica

61 prepared with terminal hydroxyl, methoxy, or mannoside functionality and incorporated into nanocarrie

62 ed, and especially the benzylidene-protected mannosides have gained a lot of attention since the corr

63 The lead mannosides have increased metabolic stability and oral b

64 Conformational analysis of enzyme-catalyzed mannoside hydrolysis has revealed two predominant confor

65 sphere: Conformational analysis of enzymatic mannoside hydrolysis informs strategies for enzyme inhib

66 A key improvement is the use of alpha-methyl-mannoside in the purification buffers to overcome the ag

67 afforded corresponding 2-azido-2-deoxy-beta-mannosides in good yields and excellent anomeric selecti

68 beta-selectivities (1:>10 alpha:beta) and C-mannosides in moderate alpha-selectivities (3:1 alpha:be

69 duced higher order phosphatidyl-myo-inositol mannosides in strains HN885 and HN1554 resulted in their

70 Mannosides in the southern hemisphere: Conformational an

71 s, this enzyme showed a preference for beta -mannosides including 1,4- beta -D-mannooligosaccharides,

72 ns in vivo and in vitro disclosed that alpha-mannosides induce BT3172 expression, which in turn induc

73 ggest that formation of both alpha- and beta-mannosides involve loose S(N)2-like transition-state str

74 and carba-beta-L-gulose from methyl alpha-D-mannoside is described.

75 nsition structure for formation of the alpha-mannoside is significantly looser.

76 Stereoselective synthesis of beta-mannosides is one of the most challenging linkages to ac

77 Two mannoside isomers differentiated Actinomyces israelii an

78 olymers that each display multiple copies of mannoside ligand for DC-SIGN, yet differ in length and s

79 hieve stereocontrolled formation of the beta-mannoside linkage.

80 osidases cleave specific glycosidic bonds of mannoside linkages in glycans and can be used in enzyme-

81 sual enzyme, endo-alpha-mannosidase, cleaves mannoside linkages internally within an N-linked glycan

82 ulosis) which specifically cleaves alpha-1,6-mannoside linkages within LM and LAM, driving its export

83 sule releasing its phosphatidyl-myo-inositol mannoside lipid anchor.

84 evels of mycothiol, but phosphatidylinositol mannoside, lipomannan and lipoarabinomannan levels were

85 nthetic pathway of phosphatidyl-myo-inositol mannoside, lipomannan, and lipoarabinomannan, which are

86 cluding the glycolipids phosphatidylinositol mannoside, lipomannan, and lipoarabinomannan.

87 containing glycolipids: phosphatidylinositol mannosides, lipomannan, and lipoarabinomannan (LAM).

88 nthetic pathway of phosphatidyl-myo-inositol mannosides, lipomannan, and lipoarabinomannan, which are

89 The normal spectrum of phosphatidylinositol mannosides, long presumed precursors of these lipoglycan

90 Oral delivery of BSA bearing 51 molecules of mannoside (Man(51)-BSA) substantially reduced the BSA-in

91 osamine (GlcNAc) residue at the central beta-mannoside of N-glycans.

92 f the binding site for the alpha(1,3)-linked mannoside of the natural substrate.

93 ha(1-2)-, alpha(1-3)-, and alpha(1-6)-linked mannosides of natural high-mannose type N-glycans with s

94 -alpha-D-mannopyr anoside both provide alpha-mannosides on activation with benzenesulfenyl triflate f

95 of brush height and the grafting density of mannosides on the binding of ConA to the brushes was stu

96 nic organisms that display alpha(1-2)-linked mannosides on their cell surfaces suggests a broad defen

97 coproteins and also whole cells that display mannosides on their surface.

98 alpha-Mannoside or beta-galactoside was immobilized on a gold

99 Substitution on the mannoside phenyl ring ortho to the glycosidic bond resul

100 is of the substrate specificity of UhgbMP, a mannoside phosphorylase of the GH130 protein family disc

101 ive site mannose are conserved in both GH130 mannoside phosphorylases and beta-1,2-mannosidases.

102 data demonstrating that phosphatidylinositol mannoside (PIM) specifically stimulated homotypic fusion

103 s cell wall glycolipid, phosphatidylinositol mannoside (PIM), induces homotypic adhesion of human CD4

104 Phosphatidyl-inositol mannosides (PIM) are glycolipids unique to mycobacteria

105 Phosphatidylinositol mannosides (PIM), lipomannan (LM), and lipoarabinomannan

106 Phosphatidyl-myo-inositol mannosides (PIMs) are key glycolipids of the mycobacteri

107 of LAM, lipomannan, and phosphatidylinositol mannosides (PIMs) compared with control strains and led

108 ocessed to give rise to phosphatidylinositol mannosides (PIMs) or lipoarabinomannan.

109 mannosylated with phosphatidyl-myo-inositol mannosides (PIMs), lipomannan, and mannose-capped lipoar

110 he biosynthesis of phosphatidyl-myo-inositol mannosides (PIMs), which are key components of the mycob

111 s of mycobacterial phosphatidyl-myo-inositol mannosides (PIMs).

112 glycolipids called phosphatidyl-myo-inositol mannosides (PIMs).

113 Ms)], glycolipids [phosphatidyl-myo-inositol mannosides (PIMs)], and PIMs associated lipoglycans [lip

114 obably originate in the phosphatidylinositol mannosides (PIMs; PIMans).

115 Using arrays of mannoside-presenting SAMs, inhibitors of bacterial adhes

116 FimH with M4284, a high-affinity inhibitory mannoside, reduces intestinal colonization of geneticall

117 ion after exposure to acidic conditions, and mannoside resulted in only 32% inhibition of uptake by m

118 azole, or 2,4-dinitrophenol 2-deoxy-2-fluoro-mannoside reveal the residues essential for specificity

119 treatment of macrophages with alpha-methyl-D-mannoside significantly reduced the cytokine GM-CSF resp

120 ze the reaction products of Uhgb_MS, a novel mannoside synthase of the GH130 family.

121 enzyme inhibition and inspires solutions to mannoside synthesis.

122 investigated using nanocarriers having 0-75% mannoside-terminated PEG chains in the PEG corona.

123 nanocarrier association is attained with 9% mannoside-terminated PEG chains, increasing uptake more

124 significantly higher in the case of the beta-mannoside than of the beta-xyloside.

125 ed in part through phosphatidyl-myo-inositol mannosides that are present in the cell wall of both rou

126 this promising new class of carbon-linked C-mannosides that show improved pharmacokinetic (PK) prope

127 , through a highly functionalized phenylthio mannoside, the l-gulose donor was prepared by C-5 epimer

128 se all reported FimH antagonists are alpha-d-mannosides, they are also potential ligands of mannose r

129 that the conformational change of the bound mannoside to a high-energy B 2,5 conformation is facilit

130 led unambiguous distortion of the -1 subsite mannoside to an (O)S2 conformation, matching that predic

131 g anti-CD11b receptor blocking antibodies or mannoside to inhibit the uptake of M. tuberculosis by ma

132 We developed a set of mannosides to prevent AIEC attachment to the gut by bloc

133 differ in their ability to recognize various mannosides, utilizing at least two different mechanisms.

134 st potent representative, an indolinylphenyl mannoside, was administered in a mouse model at the low

135 e physical and pharmacokinetic properties of mannosides were assessed for FimH binding affinity based

136 No species degraded these alpha-linked mannosides, while degradation of the beta-linked synthet