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1 ngle-agent therapy in relapsed or refractory mantle cell lymphoma.
2 ents with indolent non-Hodgkin's lymphoma or mantle cell lymphoma.
3 VcR-CVAD produced high ORR and CR rates in mantle cell lymphoma.
4 in the clinic to treat multiple myeloma and mantle cell lymphoma.
5 , used for treatment of multiple myeloma and mantle cell lymphoma.
6 elapsing and refractory multiple myeloma and mantle cell lymphoma.
7 formed the treatment of multiple myeloma and mantle cell lymphoma.
8 ma, B-cell chronic lymphocytic leukemia, and mantle cell lymphoma.
9 refractory chronic lymphocytic leukaemia and mantle cell lymphoma.
10 nhibitor PD0332991 in patients with relapsed mantle cell lymphoma.
11 ody) in patients with relapsed or refractory mantle cell lymphoma.
12 s to evaluate this regimen in follicular and mantle cell lymphoma.
13 ent of patients with relapsed and refractory mantle cell lymphoma.
14 e-agent antitumour activity in patients with mantle cell lymphoma.
15 treatment of multiple myeloma and recurring mantle cell lymphoma.
16 for the therapy of multiple myeloma (MM) and mantle cell lymphoma.
17 acytic lymphoma, marginal zone lymphoma, and mantle cell lymphoma.
18 te for the treatment of multiple myeloma and mantle cell lymphoma.
19 as clinical activity in multiple myeloma and mantle cell lymphoma.
20 se for the treatment of multiple myeloma and mantle cell lymphoma.
21 remission (PR) in a patient with refractory mantle cell lymphoma.
22 brutinib in patients with previously treated mantle cell lymphoma.
23 e kinase is a clinically validated target in mantle cell lymphoma.
24 specific tumors, such as Kaposi sarcoma and mantle cell lymphoma.
25 file in patients with relapsed or refractory mantle cell lymphoma.
26 had follicular lymphoma, and one patient had mantle cell lymphoma.
27 ab and idelalisib in relapsed follicular and mantle cell lymphoma.
28 n particular refractory multiple myeloma and mantle cell lymphoma.
29 ated in patients with relapsed or refractory mantle cell lymphoma.
30 ngle-group studies in relapsed or refractory mantle cell lymphoma.
31 efit in patients with relapsed or refractory mantle-cell lymphoma.
32 atio for ibrutinib in relapsed or refractory mantle-cell lymphoma.
33 ersus temsirolimus in relapsed or refractory mantle-cell lymphoma.
34 rituximab was active as initial therapy for mantle-cell lymphoma.
35 ibody, are active in patients with recurrent mantle-cell lymphoma.
36 ially approved for the treatment of relapsed mantle-cell lymphoma.
37 ve outcomes in patients with newly diagnosed mantle-cell lymphoma.
38 tients with chronic lymphocytic leukemia and mantle-cell lymphoma.
39 : Burkitt lymphoma, follicular lymphoma, and mantle-cell lymphoma.
40 atment option for patients with indolent and mantle-cell lymphoma.
41 l types of non-Hodgkin's lymphoma, including mantle-cell lymphoma.
42 in 111 patients with relapsed or refractory mantle-cell lymphoma.
43 gle-agent efficacy in relapsed or refractory mantle-cell lymphoma.
44 tuximab is effective for older patients with mantle-cell lymphoma.
45 R-CHOP in patients with previously untreated mantle-cell lymphoma.
46 clinical trial of adoptive immunotherapy for mantle-cell lymphoma.
47 rity of patients with relapsed or refractory mantle-cell lymphoma.
48 imus in patients with relapsed or refractory mantle-cell lymphoma.
49 -X19 in patients with relapsed or refractory mantle-cell lymphoma.
50 vity in patients with relapsed or refractory mantle-cell lymphoma.
51 n patients with relapsed indolent B-cell and mantle cell lymphomas.
52 detectable nuclear LEF1 expression, as were mantle cell lymphoma (0 of 5), marginal zone lymphoma (0
53 mide and rituximab in patients with relapsed mantle cell lymphoma (A051201) and relapsed follicular l
54 patients had intermediate-risk or high-risk mantle-cell lymphoma according to clinical prognostic fa
55 f 56 unclustered IgH-CCND1 translocations in mantle cell lymphoma across the ~ 344-kb bcl-1 breakpoin
56 a randomised, phase 2 study of patients with mantle cell lymphoma aged 18 years or older at 67 clinic
57 ve B-cell non-Hodgkin's lymphomas, including mantle cell lymphoma and diffuse large B-cell lymphoma,
58 he BCL-2 targeting drug ABT-199 in models of mantle cell lymphoma and double-hit lymphoma evolves fro
59 , and Sept 30, 2014, 11 patients (three with mantle cell lymphoma and eight with follicular lymphoma)
61 by nonstereotyped FL BCRs and by the Igs of mantle cell lymphoma and multiple myeloma and suggest th
62 nhibitor of the UPS, bortezomib, in treating mantle cell lymphoma and multiple myeloma has demonstrat
64 rash (two [67%] of three) for patients with mantle cell lymphoma and neutropenia (five [63%] of eigh
65 complex 1 (mTORC1) inhibitors, are active in mantle cell lymphoma and other lymphoid neoplasms, but r
67 alignant B cells isolated from patients with mantle cell lymphoma and Waldenstrom macroglobulinemia.
69 seven of 15 with indolent NHL, and two with mantle-cell lymphoma) and seven of nine patients treated
70 phoma, 78% in marginal zone lymphoma, 67% in mantle cell lymphoma, and 30% in diffuse large B-cell ly
71 0) triggered synergistic cytotoxicity in MM, mantle cell lymphoma, and Burkitt lymphoma cell lines.
72 s efficiently lysed primary B-cell leukemia, mantle cell lymphoma, and multiple myeloma in vitro.
73 vity of temsirolimus in lymphomas other than mantle cell lymphoma, and supports further evaluation of
74 tment of chronic lymphocytic leukemia (CLL), mantle cell lymphoma, and Waldenstrom macroglobulinemia.
76 this review is to update recent advances in mantle cell lymphoma biology with prognostic and potenti
77 2 trials have shown single-agent activity in mantle-cell lymphoma, breast cancer, liposarcoma, and te
78 than R-CHOP in patients with newly diagnosed mantle-cell lymphoma but at the cost of increased hemato
79 ycin (mTOR) pathway is a validated target in mantle cell lymphoma, but has not been extensively evalu
80 fferentiated embryonic stem cells, B-CLL and mantle cell lymphoma, but not in major adult tissues apa
83 s in human chronic lymphocytic leukaemia and mantle cell lymphoma cell lines, and patients treated wi
87 othesised that adding rituximab could target mantle cell lymphoma cells associated with redistributio
88 ent-derived acute lymphoblastic leukemia and mantle cell lymphoma cells, whereas the IgG1 analogue wa
91 nrolled patients with relapsed or refractory mantle-cell lymphoma confirmed by central pathology in 2
93 l lymphocytic lymphoma, plasma cell myeloma, mantle cell lymphoma, diffuse large B-cell lymphoma, ALK
94 ular lymphoma, chronic lymphocytic leukemia, mantle cell lymphoma, diffuse large B-cell lymphoma, and
95 in a host of B-cell malignancies, including mantle cell lymphoma, diffuse large B-cell lymphoma, Wal
97 e B-cell lymphoma, Richter's transformation, mantle cell lymphoma, follicular lymphoma, and chronic l
98 ls for patients with relapsed and refractory mantle cell lymphoma following prior failed Bruton's tyr
99 ed for the treatment of multiple myeloma and mantle cell lymphoma; however, in other hematologic mali
100 r treatment of relapsed multiple myeloma and mantle cell lymphoma) in dy(3K)/dy(3K) mice and in conge
101 ed specific recognition of primary B-CLL and mantle cell lymphoma, including rare drug effluxing chem
103 tatus > 16%, lactate dehydrogenase > 1N 38%, Mantle Cell Lymphoma International Prognostic Index (low
105 ased on the clinical factors included in the Mantle Cell Lymphoma International Prognostic Index (MIP
106 is associated with clinical characteristics (Mantle Cell Lymphoma International Prognostic Index [MIP
107 be shorter for patients presenting with high Mantle Cell Lymphoma International Prognostic Index or l
109 imilar model was created with miR-615-3p and Mantle Cell Lymphoma International Prognostic Index scor
110 I of 2, and 49% with IPI of 3 to 5), as were Mantle Cell Lymphoma International Prognostic Index scor
111 variable analysis, these risk groups and the Mantle Cell Lymphoma International Prognostic Index were
112 ostic value of miR-29 is comparable with the Mantle Cell Lymphoma International Prognostic Index.
113 ignificantly different OS independent of the Mantle Cell Lymphoma International Prognostic Index.
114 tratified by previous therapy and simplified mantle-cell lymphoma international prognostic index scor
123 or bortezomib-resistant, relapsed/refractory mantle-cell lymphoma, lenalidomide has demonstrated effi
124 aluating this compound in four proliferating mantle cell lymphoma lines (Jeko-1, Granta 519, Mino, an
125 of B-cell acute lymphocytic leukemia (ALL), mantle cell lymphoma, marginal zone lymphoma and Sezary
126 ollicular lymphoma (FL) (16.3% [43 of 263]), mantle cell lymphoma (MCL) (6.8% [18 of 263]), and diffu
127 large B-cell lymphoma (DLBCL) (10% [n = 9]), mantle cell lymphoma (MCL) (8% [n = 7]), and mycosis fun
131 ignancy that may be hard to distinguish from mantle cell lymphoma (MCL) and chronic lymphocytic leuke
132 broad panel of lymphoma cell lines including mantle cell lymphoma (MCL) and diffuse large B-cell lymp
133 ate the therapeutic efficacy of atiprimod on mantle cell lymphoma (MCL) and elucidate the mechanism b
134 CLL), T-prolymphocytic leukemia (T-PLL), and mantle cell lymphoma (MCL) and is associated with defect
135 nti-CD74 IgG)] show enhanced cytotoxicity in mantle cell lymphoma (MCL) and other lymphoma/leukemia c
136 ouse model, we demonstrated that adhesion of mantle cell lymphoma (MCL) and other non-Hodgkin lymphom
137 monstrated in tumors derived from Granta-519 mantle cell lymphoma (MCL) and Raji Burkitt lymphoma (BL
140 Y-box 11 (SOX11) expression is specific for mantle cell lymphoma (MCL) as compared with other non-Ho
141 tivation of the translocated CCND1 allele in mantle cell lymphoma (MCL) because of its relocalization
142 et al describe recurrent NOTCH1 mutations in mantle cell lymphoma (MCL) by next-generation sequencing
146 hibits enhanced antiproliferative effects on mantle cell lymphoma (MCL) cells in vitro by degrading B
147 with the tumor microenvironment account for mantle cell lymphoma (MCL) cells survival in lymphoid or
151 e randomized, open-label, phase III European Mantle Cell Lymphoma (MCL) Elderly trial (ClinicalTrials
155 blood-brain barrier and has activity against mantle cell lymphoma (MCL) in the central nervous system
156 cell leukemia (HCL) cases, 15% (5 of 34) of mantle cell lymphoma (MCL) in the leukemic phase, and 16
157 interrogate signaling pathways activated in mantle cell lymphoma (MCL) in vivo, we contrasted gene e
178 ion signature of tumor proliferation rate in mantle cell lymphoma (MCL) is an overriding molecular pr
181 t failure (TTF) and overall survival (OS) in mantle cell lymphoma (MCL) is based on the clinical fact
188 entral nervous system (CNS) dissemination in mantle cell lymphoma (MCL) is low and occurs late in the
191 ed CD19+/CD20+/CD45+ human lymphoma cells in mantle cell lymphoma (MCL) JeKo-1 model, while the same
194 ase (PI3K) pathway activation contributes to mantle cell lymphoma (MCL) pathogenesis, but early-phase
195 as identified a number of novel mutations in mantle cell lymphoma (MCL) patients including mutations
196 matic gene copy number alterations (CNAs) in mantle cell lymphoma (MCL) patients treated first line w
197 , display remarkable activity in a subset of mantle cell lymphoma (MCL) patients, but the drug resist
198 spite recent advances in lymphoma treatment, mantle cell lymphoma (MCL) remains incurable, and we are
200 There is consensus that young patients with mantle cell lymphoma (MCL) should receive intensive immu
201 is study, we define the genetic landscape of mantle cell lymphoma (MCL) through exome sequencing of 5
202 cently reported the application of RNAseq to mantle cell lymphoma (MCL) transcriptomes revealing recu
205 opoiesis in serial samples from persons with mantle cell lymphoma (MCL) undergoing frontline treatmen
207 rosine kinase, is approved for patients with mantle cell lymphoma (MCL) who have received one prior t
208 ent study, we analyzed telomere length in 73 mantle cell lymphoma (MCL), 55 chronic lymphocytic leuke
209 thesized that 8-NH(2)-Ado would be active in mantle cell lymphoma (MCL), a hematological malignancy c
211 randomized trials have compared therapies in mantle cell lymphoma (MCL), and the role of aggressive i
212 SOX11 is usually highly expressed in typical mantle cell lymphoma (MCL), but it is absent in the more
213 nt in chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL), but the extent of internaliz
214 lymphoma (FL), and (3) other NHL, including mantle cell lymphoma (MCL), marginal zone lymphoma (MZL)
216 is clinically approved for the treatment of mantle cell lymphoma (MCL), only limited effects of this
217 Despite unprecedented clinical activity in mantle cell lymphoma (MCL), primary and acquired resista
218 ediated effects of interleukin-21 (IL-21) in mantle cell lymphoma (MCL), providing a preclinical rati
219 advances in the therapy for newly diagnosed mantle cell lymphoma (MCL), relapsed MCL continues to ha
221 r understanding about antigen involvement in mantle cell lymphoma (MCL), we analyzed the expression l
223 mong 45 patients with relapsed or refractory mantle cell lymphoma (MCL), with manageable tolerability
243 s active in patients with previously treated mantle cell lymphoma (MCL); however, nearly half of all
244 oxidative stress-mediated drug resistance in mantle cell lymphoma (MCL); however, the biological func
245 mall lymphocytic lymphoma (CLL/SLL; n = 15), mantle cell lymphoma (MCL; n = 15), low-grade follicular
247 co purified DNA methylation signatures of 82 mantle cell lymphomas (MCL) in comparison with cell subp
255 rabine, and rituximab (FFR) in patients with mantle-cell lymphoma (MCL), indolent B-cell non-Hodgkin'
256 have improved the outcome for patients with mantle-cell lymphoma (MCL), most eventually relapse and
257 ctory diffuse large B-cell lymphoma (DLBCL), mantle-cell lymphoma (MCL), transformed follicular lymph
259 attempt to improve outcome in patients with mantle-cell lymphoma (MCL); however, the importance of i
263 sk chronic lymphocytic leukemia (n = 22) and mantle-cell lymphoma (n = 13) received a total lymphoid
266 dge, the clinical features of ocular adnexal mantle-cell lymphoma (OA-MCL) have not previously been e
267 a dramatically regressed, and a patient with mantle cell lymphoma obtained an ongoing partial remissi
268 y high-risk chronic lymphocytic leukaemia or mantle cell lymphoma often do not derive durable benefit
269 patients with diffuse large B-cell lymphoma, mantle-cell lymphoma, or follicular lymphoma were enroll
271 t trials with these agents were conducted in mantle cell lymphoma, pancreatic neuroendocrine tumors a
272 tumor biopsies were reviewed by the European Mantle Cell Lymphoma Pathology Panel to determine Ki-67
274 One hundred sixty untreated, stage II-IV mantle cell lymphoma patients <66 years received rituxim
275 patients were 73% and 47%, respectively; for mantle-cell lymphoma patients, they were 69% and 53%, re
276 large B-cell lymphoma, follicular lymphoma, mantle cell lymphoma, peripheral T-cell lymphoma, and no
278 small molecule inhibitor (HDACi) in CLL and mantle cell lymphoma restored the expression of the BTK-
279 stochemical analysis of a cohort of 33 human mantle cell lymphomas shows that elevated expression of
280 igned patients 60 years of age or older with mantle-cell lymphoma, stage II to IV, who were not eligi
281 rapeutic agent for multiple myeloma (MM) and mantle cell lymphoma, suppresses proteosomal degradation
282 nd potentially therapeutic implications, and mantle cell lymphoma treatment approaches and new agents
283 chronic lymphocytic leukaemia or 560 mg for mantle cell lymphoma) until disease progression or unacc
284 iven to patients with relapsed or refractory mantle cell lymphoma, until disease progression or unacc
285 mphocytic leukemia, follicular lymphoma, and mantle cell lymphoma were 5%-10% higher per 5-year incre
287 16, 124 patients with relapsed or refractory mantle cell lymphoma were enrolled and all patients rece
288 ed or refractory indolent B-cell lymphoma or mantle cell lymphoma were treated with autologous T cell
291 ents with histologically documented relapsed mantle cell lymphoma who had not received previous lenal
292 , USA, and other countries for patients with mantle cell lymphoma who received one previous therapy.
293 e I/II trial (NCT00490529) for patients with mantle cell lymphoma who, having achieved remission afte
295 mly assigned 487 adults with newly diagnosed mantle-cell lymphoma who were ineligible or not consider
296 al, and overall survival among patients with mantle-cell lymphoma who were younger than 66 years of a
297 nts with relapsed or refractory indolent and mantle cell lymphoma with adequate organ function were t
298 een reported in patients with follicular and mantle-cell lymphoma with the combination of bendamustin
299 refractory chronic lymphocytic leukaemia and mantle cell lymphoma, with a recommended phase 2 dose of
300 refractory chronic lymphocytic leukaemia or mantle cell lymphoma, with an Eastern Cooperative Oncolo