ライフサイエンスコーパス: marked

1 did not improve insulin sensitivity despite marked (~20%) weight loss.

2 D1-G93A mice at 12 weeks was paralleled by a marked ~50% increase in motoneuron volume and a near-nor

3 Rubicon, attenuation of autophagic flux, and marked accumulation of autophagosomes.

4 plete lack of testosterone in XY-KO mice and marked accumulation of progesterone in XX-KO mice.

5 ncing analysis using liver and kidney showed marked activation of gene regulatory pathways associated

6 the probability of detecting an isotopically marked adult at different distances from the larval habi

7 We found marked advance of liver fibrosis (chronic damage), as we

8 Moreover, marked age-related changes occurred in many nonepithelia

9 changes during the late 1800s did not cause marked alteration in average carbon burial, they did lea

10 modulation, only Diclofenac exposure shows a marked alteration of these intracellular parameters, lea

11 and alpha oscillations that are linked with marked alterations in self-referential processing.

12 In some AMD patients, marked alterations in the pattern of AO-IRAF could be se

13 ured abyssal ocean ventilation at the YD and marked an interval of Si cycle reorganisation.

14 Marked antidepressant activity and dose-dependent recept

15 Digital videoscope images were made of the marked areas using only white light and also with only a

16 The marked areas were root planed until no calculus was visi

17 fferent (heterotypic) types of cells, with a marked asymmetry within heterotypic pairs.

18 rare neurological condition that features a marked ataxic gait that progressively worsens over time.

19 ith some hydroxy fatty acids, which deserved marked attention due to their health-promoting activitie

20 g in ESCs reveals hundreds of messenger RNAs marked by 5hmC at sites characterized by a defined uniqu

21 ls exhibit a terminally exhausted phenotype, marked by a loss of self-renewal capacity.

22 The immunodeficiency was marked by a pronounced actin polymerization defect and a

23 The human lineage is marked by a transition in hand use, from locomotion towa

24 88/1989 North Pacific climate shift that was marked by abrupt northeast Pacific warming, declining te

25 spatial context, participants' behavior was marked by an abrupt switch to an exploitation strategy o

26 give rise to the "nude" phenotype, which is marked by athymia.

27 The lymphoid-primed IRF8(hi) pathway, marked by CD123 and BTLA, carried pDC, cDC1, and DC2 tra

28 is beige APC population is proliferative and marked by cell-surface proteins, including PDGFRalpha, S

29 for accurate chromosome segregation and are marked by centromere protein A (CENP-A) nucleosomes.

30 age at onset of CF-related diabetes (CFRD) (marked by clinical diagnosis and treatment initiation) i

31 ymerase II pausing in resting macrophages is marked by co-localization of the negative elongation fac

32 is revealed that, although ductal stem cells marked by cytokeratin K14 and Axin2 undergo a multipoten

33 inflammatory bowel disease (IBD) that may be marked by debilitating symptoms of abdominal pain and ob

34 stem and vocabulary for human regulatory DNA marked by DHSs, and provide a new global perspective on

35 Examination of genomic regions marked by differential chromatin states and associated w

36 t thymic gammadelta T cell subsets were each marked by distinct coexpression profiles of SLAMF1, SLAM

37 ocampal encoding versus retrieval states, as marked by distinct network connectivity between hippocam

38 Diabetes-associated organ fibrosis, marked by elevated cellular senescence, is a growing hea

39 cytokine storm in its severest form has been marked by elevation of IL-6, IL-10, TNF-alpha, and other

40 ity is a prevalent prothrombotic risk factor marked by enhanced fibrin formation and suppressed fibri

41 s more frequent in early S phase, in regions marked by euchromatin.

42 t a +4 stem cell (SC) in the gastric antrum, marked by expression of Cck2r (a GPCR) and Delta-like li

43 conditional knockdown in Hh-receiving cells (marked by Gli1+) during E8 to E10.5, a previously establ

44 4(+) T cells also acquire cytotoxic activity marked by granzyme B (GzmB) expression and the ability t

45 we identified mice with a syndromic disorder marked by growth retardation, diabetes, premature death,

46 composition at bivalently modified promoters marked by H3K4me3 and H3K27me3.

47 4A (KDM4A) demethylates H3K9me3 at promoters marked by H3K4me3 in actively transcribing somatic cells

48 ens centromeres are of similar structure and marked by high abundance of retroelements unlike in vasc

49 eage-negative epithelial progenitors (LNEPs) marked by high H2-K1 expression critical for alveolar re

50 Moreover, their chemical signals were marked by high proportions of octadecanoic acid, oleic a

51 Thrips mitochondrial genomes are marked by high rates of gene rearrangement, duplications

52 hin NKT subsets, however, stage 3 NKT cells, marked by higher NK1.1 expression, were significantly mo

53 We live in a research era marked by impressive new tools powering the scientific m

54 lized countries, the past 50 years have been marked by increasing female labor-force participation.

55 T cell exhaustion is marked by inhibitory molecule upregulation and the devel

56 The history of the Earth has been marked by major ecological transitions, driven by metabo

57 These beige fat progenitors are marked by PDGFRalpha, Sca1, and CD81 and proliferate upo

58 iscovered that formative TF target genes are marked by permissive epigenomic signatures in the naive

59 ron and Classical Ages in the Near East were marked by population expansions carrying cultural transf

60 tatitis frequently progresses to chronicity, marked by recurrent episodes interspersed with asymptoma

61 herapeutically effective only for conditions marked by reduced inhibition, and it is also unclear whe

62 They were marked by relatively high phytoplanktonic productivity a

63 rogram and a fetal gene expression signature marked by Sca1, but upon injury are unable to generate S

64 dent neurogenic precursors or classical glia marked by sox10, plp1a, gfap or s100 Rather, lineage tra

65 n (p = 0.415), but STEV quantitative signal, marked by syncytin-1 specific EVs, was significantly dec

66 was confined to tissues and disease subtypes marked by TDP-43 inclusions.

67 thies including Alzheimer's disease (AD) are marked by the accumulation of aberrantly modified tau pr

68 Upon serum deprivation, a subset of AEs pre-marked by the activity-dependent neuroprotector homeobox

69 Next, it behaves as a stable glass, marked by the appearance of a plateau in the MSD whose m

70 fy a regionally localized pial subpopulation marked by the expression of mu-crystallin.

71 othalamus contains catecholaminergic neurons marked by the expression of tyrosine hydroxylase (TH).

72 Mitotic chromosome reorganization is marked by the general attenuation of transcription on ch

73 unctional types, and the origin of snakes is marked by the highest rates of phenotypic evolution in d

74 Gravettian manufacturers and a discontinuity marked by the Last Glacial Maximum (LGM).

75 A new era was marked by the recent isolation of acid-base free main gr

76 iate allergic immunity and in the dermis are marked by their expression of CD301b.

77 e Tonian and Cryogenian periods, an interval marked by two global glaciations with strong consequent

78 nes all types of mechanosensory neurons with marked cell-class dependence.

79 Furthermore, the marked change in bone points coincides with a change in

80 Paternal and maternal epigenomes undergo marked changes after fertilization(1).

81 E STATEMENT Animal studies consistently show marked changes in action potential waveform during epile

82 There were no marked changes in any of the serum enzymes activities.

83 ransformations during foraging that leads to marked changes in both the motivation to hunt for prey a

84 a surrogate state of depressed CA, leads to marked changes in dynamic CA, that are entirely explaine

85 However, Neu5Gc was not associated with marked changes in infant immune markers, in contrast wit

86 sed strongly until middle age then showed no marked changes in later age periods.

87 hat pulmonary response to hyperoxia involves marked changes in specific subsets of myeloid and lympho

88 Marked changes in TCC protein expression profiles were o

89 Vascular disease is associated with marked changes in the S-sulfhydration of endothelial cel

90 Despite marked changes in this neural circuitry and extinction l

91 Here we observe marked changes of activity cycles in millions of twitter

92 adaptations within the mother(1), including marked changes within the immune system(2).

93 In severe cases with marked chronic inflammation, a cell-fate switch from a t

94 l valve repair with the MitraClip results in marked clinical improvement in some but not all patients

95 on a decrease of pH from 8 to 4, we observed marked conformational changes in the ECD-TMD interface a

96 in a non-western developed setting with less marked confounding by socioeconomic position.

97 upon stacking two twisted sheets of GeSe, in marked contrast to all moire systems studied so far.

98 ame bond length) found in amorphous PCMs, in marked contrast to existing viewpoints.

99 In marked contrast to Fos immunoreactivity, neuroanatomical

100 This is in marked contrast to the minimal phototoxicity required in

101 In marked contrast, activating all ventral tegmental area G

102 In marked contrast, short-chain Vi (9.5 to 42.7 kDa) conjug

103 In marked contrast, those derived from cancer cells correla

104 In marked contrast, very few of these compounds are able to

105 HIV-1 shows marked CpG suppression, and by introducing CpGs into its

106 ty in infected chicken cells, accompanied by marked cytotoxicity, requires the full-length protein.

107 f circadian timekeeping in the brain display marked daily changes in neuronal morphology.

108 phase of the COVID-19 pandemic, there was a marked decline in acute cardiovascular hospitalizations,

109 a transient increase in 3-HIB followed by a marked decrease after bariatric surgery and weight loss.

110 umor and myeloid-derived cells, leading to a marked decrease in kynurenine levels.

111 itinib-treated EpsilonC-betaKO mice showed a marked decrease in microvessel density, and reduced new

112 atures of both events were (1) an abrupt and marked decrease in salinity (from > 30ppt to < 5ppt) due

113 striction protocols in C57BL6 mice promote a marked decrease in the hepatic protein levels of G prote

114 Microdialysis revealed marked decreases in cocaine-induced dopamine and glutama

115 eceptor transcription factors accompanied by marked decreases of both rod- and cone-specific gene exp

116 However, a marked deepening of the redoxcline and a reduced frequen

117 the medial ganglionic eminence (MGE) showed marked deficits in distinct subpopulations of somatostat

118 Marked deficits in glucose availability, or glucoprivati

119 e that RAD50-deficient fibroblasts exhibit a marked delay in mitotic progression that can be rescued

120 Acute lesions showed marked dendritic-cell signatures and a prominent enrichm

121 decreased granularity by flow cytometry and marked depletion of intracytoplasmic granules by light m

122 This marked difference in reactivity reflects the ability of

123 fective for such substrates; presumably, the marked difference is attributable to the lesser crowding

124 RNA-seq identified marked differences among NM, TC-TAM, and IM-TAM.

125 atforms, and these characteristics displayed marked differences between subtypes.

126 tomic, molecular and functional tests reveal marked differences between the fast and slow subpopulati

127 d-expiration and forced inspiration revealed marked differences between the groups.

128 We found marked differences in accuracy and intra- and inter-meth

129 during the social preference test, we reveal marked differences in behavioral dynamics between the st

130 onfailing hearts from brain-dead donors show marked differences in circadian clock gene expression pa

131 r among biomes (geographical units that have marked differences in environment and species compositio

132 ies such as lemon, mandarin and pummelo with marked differences in fruit pigmentation and content of

133 We also detect marked differences in miRNA expression between populatio

134 5.8% ID/g for alphaPECAM mAb vs. scFv), but marked differences in organ residence time, with antibod

135 minal halves bearing the bromodomains convey marked differences in protein stability but do not accou

136 Comparative analysis revealed marked differences in protocol performance.

137 Patients with PSC showed marked differences in the abundance of genes related to

138 However, no marked differences were observed in the lung sound param

139 , unbiased gene expression analyses revealed marked differences, including pathways related to steril

140 ielding due to the bulky P-substituent gives marked different reactivities at the 2- and 7-positions,

141 arameters but also reveal the surprising and marked dominance of the limiting-rate selection process

142 hich is associated with MYC upregulation and marked downregulation of MYC's negative regulator miR-34

143 s, with these features becoming increasingly marked during regression.

144 on of the intramonomeric disulfides triggers marked dynamical heterogeneity, interfacial wettability,

145 ulin and high-dose T. muris infection caused marked dysbiosis, with expansion of the Firmicutes and P

146 that pDC commitment to IFN-I production was marked early on by their downregulation of leukemia inhi

147 These lasting and marked effects of M(1) receptor stimulation reinforce ou

148 tional relevance of DDR1 is supported by its marked elevation in HCC which is inversely associated wi

149 Marked elevation in the brain concentration of N-acetyl-

150 ays, the myocardium of female mice developed marked elevations in free fatty acids, ceramides and dia

151 t 14 days of recovery in females, there were marked elevations in myocardial free fatty acids, cerami

152 C labeling efficiencies (>95%), resulting in marked enhancement of blood residence time of tPA from m

153 ive cells is due to a distal K79 methylation-marked enhancer in the MYC gene bound by AR and DOT1L no

154 A marked enrichment of the transcription factor Runx3 as w

155 ronic, rare allergic disease associated with marked eosinophil accumulation in the esophagus.

156 is a globally re-emerging disease, which has marked European history with a devastating epidemic at t

157 Here we show that carbonate-rich lakes are a marked exception to phosphate-poor natural waters.

158 mitochondrial localization of Drp1, causing marked fragmentation of mitochondria.

159 proliferation, metabolic re-programming and marked gene alteration resembling the remodeling phase o

160 rs related to tissue-specific functions, and marked genes functionally enriched for tissue-specific p

161 iating colocalization of BAHCC1 and H3K27me3-marked genes.

162 derlying the selective targeting to polycomb-marked genomic regions and synovial sarcoma-specific dep

163 Further, results suggest a marked geographic catchment of malaria admission around

164 PC-like WM displayed marked global hypomethylation and selective overexpressi

165 Although not always concomitant with a marked grain size change, backwash deposits are identifi

166 re.On physical examination, the child showed marked head lag and did not reach out to objects.

167 Network modeling revealed marked heterogeneity across participants.

168 Analysis of included studies identified marked heterogeneity in animal models of donor brain dea

169 wed longitudinally to ~100 days demonstrated marked heterogeneity in antibody duration dynamics.

170 These observations revealed a marked heterogeneity of release site properties within i

171 Together, our results reveal the marked heterogeneity of TAM populations in different tum

172 ystems immunology approaches have identified marked heterogeneity within these cells, and much of wha

173 ans with collapse of the glomerular tuft and marked hyperplasia of the parietal epithelial cells (PEC

174 DTBM revealed marked hypoplasia of cerebellar afferent systems in DS,

175 ts experiencing increased appetite exhibited marked immunometabolic dysregulation, with higher insuli

176 tic clearance of tau from the brain; showing marked impaired glymphatic CSF-ISF exchange and tau prot

177 f the new analogues, NBD-14270 (8), showed a marked improvement in cytotoxicity, with 3-fold and 58-f

178 onnaires showed, after a month of therapy, a marked improvement in LI symptoms subjects.

179 APIp exhibited marked improvement in the functional properties in compa

180 stologic disease remission in 3 patients and marked improvement in the other 2.

181 treated with benralizumab, which resulted in marked improvement of asthma symptoms and reduced the pe

182 ere very satisfied and anoscopy demonstrated marked improvement of the hemorrhoids.

183 asonal timing of control measures could make marked improvement on the long-term burden reduction for

184 61 patients, mild in 56, moderate in 19, and marked in 5.

185 each gene-corrected cell and its progeny are marked in a unique way by the integrating vector.

186 Changes were more marked in ISF and suggest that homeostatic mechanisms we

187 ponse, and that this reduction would be most marked in patients with "residual schizophrenia", in who

188 outs for CTI exhibit higher rates of FAS and marked increase in absolute triacylglycerol levels in le

189 ltaneously Isovolumic haemodilution led to a marked increase in brachial artery flow-mediated dilatat

190 Marked increase in central venous pressure during passiv

191 untreated guinea pigs was associated with a marked increase in energy metabolism (glycolysis and mit

192 ity of high-quality patches, but exhibited a marked increase in foraging habitat quality over time th

193 Golgi function and maintenance, we observed marked increase in Golgi fragmentation in primary fibrob

194 Results show a marked increase in HF water use, and depleting groundwat

195 ed in the suppression of Th1 cytokines and a marked increase in lung macrophages displaying an altern

196 a diagnosis of ILD and is associated with a marked increase in mortality.

197 Tumor cell lines exhibited a marked increase in sensitivity to ubidecarenone vs. non-

198 Task engagement elicited a marked increase in the association between glucose consu

199 (surface) Bronsted acid sites and observed a marked increase in the conversion relative to three-dime

200 Fermentation also led to a marked increase of antioxidant activity, with the highes

201 Here, we show that ageing elicits a marked increase of SUMO levels in C. elegans.

202 ssion of costimulatory molecules on B cells, marked increase of Th17 responses and increased recruitm

203 A marked increase of the RPE65 mRNA was also observed in t

204 This combination of medial SMC loss with marked increases in non-SMC aortic cell mass induced exu

205 only very minor decreases in a few targets, marked increases in the abundances of very stable mRNAs,

206 n in average carbon burial, they did lead to marked increases in the spatial variability of carbon bu

207 profiles were similar among groups, whereas marked increases were evident at age 2 and 4(+) years on

208 boring epidermal cells, and hence exhibit no marked induction of autophagy and a milder suppression o

209 We found a marked infiltration of autoreactive CD4 T cells, macroph

210 Marked inflammation and coagulopathy in blood and tissue

211 ourse of hydroxychloroquine, later developed marked inflammatory manifestations with rapid improvemen

212 We observed a marked influence of optical turbulence on particle imagi

213 nt compensation, from adverse impacts of the marked inter-annual climatic variation that occurred dur

214 an previously reported (21/100 000 PY), with marked interethnic variation.

215 MVA-NP+M1 activated a marked interferon gamma-secreting T-cell response to M1

216 There is marked interindividual variability in metabolism and res

217 da bloodstream infection experienced a prior marked intestinal expansion of pathogenic Candida specie

218 same stepwise increase, instead exhibiting a marked jump within the highest decile of racial minority

219 associated with phenotype dominated by MAD, marked leaflet redundancy, and repolarization abnormalit

220 ssociated with male sex, bileaflet prolapse, marked leaflet redundancy, mitral annulus disjunction (M

221 Our findings highlight the links between marked levels of genomic and immune heterogeneity within

222 Our data show evidence of marked levels of tissue repair in the human donor pancre

223 Behaviourally, patients with svPPA manifest marked lexico-semantic impairments including difficultie

224 In the endosperm, siren siRNAs show a marked maternal bias, and siren expression in maternal s

225 of the choroid plexus and ependymal lining, marked meningitis, and 100% mortality within 2 weeks pos

226 Marked mosquito pools with stable isotopes were used to

227 Our findings implicate a marked nonvascular disruption in T1D of several essentia

228 referential affinity to repressed, H2AK119Ub-marked nucleosomes, underlying the selective targeting t

229 widespread response at episode onset, plus a marked offset response specific to DMN regions.

230 food preservatives are their safety limits, marked organoleptic effects and possible contamination b

231 First, we tracked congenically marked OT-I cell populations in recipient mice infected

232 iglycerides with neosynthesized monoenes are marked out for release.

233 In atherosclerotic lesions, apoA-I exhibits marked oxidative modifications at multiple sites, includ

234 ORs for any moderate/marked physician-assessed breast NTE (shrinkage, indurat

235 eta-cell-selective D2R knockout mice exhibit marked postprandial hyperinsulinemia in vivo.

236 autoimmune lymphoproliferative syndrome with marked predisposition to lymphoma.

237 primed chromatin landscape, with bivalently marked primed pluripotency genes.

238 Peanut allergy (PA) is associated with marked quality-of-life (QoL) impairment.

239 In addition, KI mice demonstrated a marked reduction in Cfl2 mRNA levels in various tissues

240 mained steady until the intervention, when a marked reduction in DOT/1,000 patient-days occurred at b

241 which can lead to thrombocytopenia showing a marked reduction in platelet counts, and dengue hemorrha

242 that patients treated with baricitinib had a marked reduction in serum levels of IL-6, IL-1beta, and

243 Further metabolomic analyses revealed a marked reduction in storage lipids and an increase in me

244 We find a marked reduction in the evolutionary diversity of commun

245 e virus infection, the MEG-01 cells showed a marked reduction in the surface expression of platelet m

246 There was a marked reduction in the variation in rates of hazardous

247 synuclein preformed fibrils, and we observed marked reductions in alpha-synuclein aggregation and neu

248 hyla, near elimination of Bacteroidetes, and marked reductions in cecal short-chain fatty acids.

249 elta oscillations throughout the cortex; (b) marked reductions in neural activity (from waking) over

250 overexpressing transgenic mice and confirmed marked reductions in protein translation in 4E-BP1-overe

251 Marked reductions in the chemokine Ccl2 and the pro-infl

252 We find marked regional differences in Southern Ocean overturnin

253 These differentially marked regions showed both losses and gains of 5hmC afte

254 eletion of Alk resulted in thin animals with marked resistance to diet- and leptin-mutation-induced o

255 pretreated mice had little proliferation and marked restoration of urothelial layers, whereas the pho

256 ed signatures of vaccine response as well as marked seasonal differences.

257 IR region, performed at 4 degrees C, lead to marked sensitivity improvements over conventional optoac

258 ic cancer cell line screens and discovered a marked sensitivity of hematological cancer cell lines, i

259 Owing to the marked sexual dimorphism of hepatocellular carcinoma (HC

260 grees C, the microbial community also showed marked shifts in both composition and activity, which mo

261 Microbiome signatures showed marked shifts in taxonomic levels in patients with bacte

262 Variable SI predisposes to marked SI increases after stressful events and may be a

263 eous, and climatic factors may have driven a marked slowdown observed at higher latitudes.

264 increasing the percentage of DMPC leads to a marked slowing of CNTP diffusion.

265 Marked snowmelt across the surrounding periglacial envir

266 munity of Aguada Fenix probably did not have marked social inequality comparable to that of San Loren

267 The gut microbial community exhibited marked spatial variation across populations with the low

268 stem in cancer is now a clinical reality and marked successes have been achieved, most notably throug

269 common psychiatric disorder associated with marked suffering, morbidity, mortality, and cost.

270 Marked systemic elevation in C5a activity was demonstrat

271 CD29 also marked T cells with cytotoxic gene expression from diffe

272 We evaluated resection specimens with marked target fields from 151 consecutive EC patients tr

273 The marked technical variability, high amounts of missing ob

274 nificant Endocardial-epicardial dissociation marked temporal heterogeneity, discordant and transition

275 ated from segmented micrographs and boundary marked tetrahedral meshes which are compatible with simu

276 l than contralateral abnormalities, but less marked than those in patients with hippocampal sclerosis

277 This marked the conversion of iMo to an inflammatory phenotyp

278 e verge of leaving as this commencement also marked the end of the career of D.

279 e culinary fat addition whose FA composition marked the meat.

280 that the earliest ribozymes, whose emergence marked the origin of life, were low in activity but high

281 that its subsequent sequestration induces a marked transition in the conformational ensemble, which

282 ulation of these cells with Ab W6/32 induced marked translocation of YAP to the nucleus.

283 A less marked trend was seen for diabetes (rate ratio, 1.55; 95

284 Marked tumor growth inhibition compared with controls wa

285 mperceptible response of molluscs versus the marked turnover of foraminifera and reef faunas.

286 Ischemia-reperfusion triggered marked unilateral CX3CR1-CCR2 dependent accumulation of

287 In contrast, during NMP, there was marked upregulation OXPHOS genes, but also of a number o

288 In vivo application of secretin induced a marked urinary alkalization, an effect absent in mice la

289 mporary period since 2018; and (3) there was marked variability in allocation of HCV+ hearts at the O

290 tients undergoing PCI treated with MCS, with marked variability in its use and associated outcomes.

291 ons were inappropriate or inconclusive, with marked variation between EDs.

292 The authors report marked variation in buffering capacity, correlated with

293 Despite marked variation in tissue architecture and regenerative

294 There were marked variations in rates of direct discharge to home a

295 oximately half of the heart still allows for marked vulnerability to injury.

296 shed a high-resolution 3D model of molecular marked whole laryngeal cancer by optimizing the currentl

297 Signs of subtle inflammation were marked with cardiorenal, endothelial defects with decrea

298 d new microtubule growth initiated at puncta marked with fz, dsh, Axin, and Rab5.

299 sposase helper plasmid, and creating vectors marked with the D. melanogaster mini-white(+) or polyubi

300 ipt levels, with more than 2000 genes stably marked with this modification throughout asexual develop