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1 solone improved the condition of the patient markedly.
3 ed leukocytes during the remission phase was markedly accelerated in CMH-treated mice, as determined
7 with this mAb disrupted immune homeostasis, markedly activated NK and memory phenotype T cells, enha
8 ithin the X-gate and the surrounding regions markedly affect both the channel-open probability and th
9 rosyl-DNA phosphodiesterase 2 (TDP2) did not markedly affect rcDNA deproteination or cccDNA formation
13 rlying the reversal of NAFLD by KD: That is, markedly altered hepatic mitochondrial fluxes and redox
14 since their arrival in Amazonia-humans have markedly altered the landscape, with lasting repercussio
15 e or more ultrastructural layers that differ markedly among the three major dinosaur clades, as do th
16 c >2 SD above historical healthy controls (2 markedly and 3 marginally) but ECGs were otherwise norma
18 nfluence of cognition on overall function is markedly attenuated and differences in mental health are
19 ethnic groups, differences in survival were markedly attenuated and hazard ratios approached 1.0.
21 l of glucose metabolic pathway, resulting in markedly attenuated glucose utilization and fasting hype
22 Whole blood collected from EHS mice showed markedly attenuated inflammatory responses to LPS challe
23 show that loss of the DNA repair protein XPA markedly augments the synthetic lethality between MK2 an
26 species and habitat alteration, often differ markedly between entomologists and plant pathologists.
27 sults show that mutational landscapes differ markedly between normal tissues-perhaps shaped by differ
28 e temporal dynamics of VIP activity differed markedly between novel and familiar images: VIP cells we
31 The case-fatality rate for COVID-19 varies markedly by age, ranging from 0.3 deaths per 1000 cases
34 of discrete TADs, and complex rearrangements markedly change chromatin folding maps in the cancer gen
35 er 2 inhibitors and incretin therapies - has markedly changed the treatment landscape of type 2 diabe
36 and downstream function of the efferocyte is markedly changing the way we think about macrophage immu
38 d clamped to -40 mV, CO(2) / HCO3- exposures markedly decrease E(rev) , producing large transient out
39 he number of cells residing within the TM is markedly decreased and the function of the tissue is com
40 at the levels of synaptotagmin 1 (SYT1) were markedly decreased in CTE and AD compared to normal.
42 CAM-1(+) neutrophils in blood and lungs were markedly decreased in rmCIRP-injected mice or septic mic
44 n and local infiltration of eosinophils, but markedly decreased M2 macrophages and SPEM features, whi
46 inhibition of SphK1 or its genetic deletion markedly decreased the IFN signature, pDC activation, an
47 the Rap1-talin-1 F1 interaction in platelets markedly decreases talin-1-mediated activation of platel
48 ymphoma incidence by enhancing apoptosis and markedly decreasing premalignant B lymphoid cell populat
49 onset of seizures, the recruitment dynamics markedly differed between neuronal subpopulations, with
50 e majority of LMP2A-induced signaling events markedly differed from those induced by BCR stimulation.
51 and B cells among patients with ABMR, which markedly differed from those of patients who did not dev
53 hlights that E2-dependent gene expression is markedly different between WT mice and Het-Met mice.
54 thin the matrix portion of the complex adopt markedly different conformations than in a structure of
55 ndary OH groups of beta-cyclodextrin exhibit markedly different dynamics, suggesting distinct H-bond
56 sed-PD haplotype may be a consequence of the markedly different fitness landscape imposed by domestic
59 NdCCD revealed a tapered active site cavity markedly different from the broad active site observed f
60 ale VAT, and T(reg) cells from male VAT were markedly different from their female counterparts in phe
61 fections and a potential vaccine can lead to markedly different immune landscapes and burdens of crit
62 trast, the tubulointerstitial proteomes were markedly different in IgAN and SAGN, with a lower abunda
63 cle internalization in two cell lines with a markedly different integrin fingerprint: ovarian carcino
64 for two representative cell types that have markedly different migratory modes and physiological pur
68 so positive for alphaSyn aggregates but with markedly different reaction kinetics from MSA; aggregati
69 ods of automated variable selection produced markedly different results; different variables were sel
70 tions showing sequence differences result in markedly different structural motifs upon physiological
73 o influence responses of T and NK cells, was markedly diminished in cells infected with EBNA3A mutant
74 by showing that MFS disulfide bond mutations markedly disrupt normal mechanosensitive calcium binding
76 teration signatures in Chinese patients were markedly distinct from those of Western cohorts: specifi
80 hat local plant and animal diversity dropped markedly during Younger Dryas cooling, but while plant d
82 d lipidomics (1871 biochemicals) revealed 18 markedly elevated biochemicals (>5 sd outliers versus n
83 ine and phosphatidylcholine biosynthesis was markedly elevated in Traf3 (-/-) mouse B cells and decre
84 time of cataract surgery lowered the risk of markedly elevated IOP in the early postoperative period
85 y premature cardiovascular disease caused by markedly elevated levels of low-density lipoprotein (LDL
86 ors (Q-factors) in the thousands to billions markedly enhance light-matter interactions, with applica
88 Finally, we show that sharply resolved DHSs markedly enhance the genetic association and heritabilit
89 y elicited in vaccinated individuals, may be markedly enhanced by altering the lipid composition of t
90 Accordingly, epicardial mapping revealed a markedly enhanced homogeneity in ventricular conduction.
93 ing those redox proteins was associated with markedly enhanced respiration and deregulated TCA cycle
95 omyocyte maturation in postnatal hearts, and markedly enhances cardiomyocyte proliferation and improv
96 KT activation in intestinal epithelial cells markedly enhances tumor invasion and metastasis in Trp53
97 early PDAC progression, showing that obesity markedly enhances tumorigenesis, while genetic or dietar
98 nges, esophageal adenocarcinoma samples were markedly enriched for polyunsaturated phosphatidylglycer
99 d the promoters regulated by these enhancers markedly enriched in G4-capable sequences suggesting G4s
100 a gene in myeloid cells (HIF-2alpha(mye/-) ) markedly exacerbated APAP-induced liver injury (AILI) wi
103 report that knocking out these three factors markedly extends survival in the SOD1(G93A) ALS mouse mo
104 expression of NUC-treated patients differed markedly from IC patients, especially in DC, monocytes a
107 uses, which conserve mitochondria, differing markedly from viruses causing short-term viral diseases,
110 ver, vibriocidal antibody seroconversion was markedly higher among H. pylori seropositives than seron
112 selected gut-associated germinal centres is markedly higher in germ-free than in SPF mice, and winne
113 d in severe illness, with the IL-6:AAT ratio markedly higher in patients requiring ICU admission (P <
115 l mice with augmented Tfr cell responses had markedly higher levels of peanut-specific IgE, revealing
116 the kidney, proximal and distal tubules had markedly higher mtDNA levels compared with cells within
118 e second PDE4B-transgenic mouse line (TG50), markedly higher PDE4B overexpression, resulting in a ~50
119 value of population-based screening (such as markedly higher prevalence of CKD in people with diabete
120 low socially vulnerable county, as well as a markedly higher risk than white patients (all p > 0.05).
121 exonuclease in HeLa cells, where it showed a markedly higher specific activity compared with PLD4.
122 tive in the presence of nuclease and exhibit markedly higher thermal stability than monoclonal antibo
123 calcification, poorly defined margin, and a markedly hypoechoic solid nodule; and benign ultrasonogr
124 failure and early cardiogenic shock seem to markedly impact the prognosis, suggesting a prompt ident
126 removal of select, conserved basic residues markedly impacts both nucleotide-dependent DNA wrapping
128 ce with intact Ncoa4 regulation but showed a markedly impaired ability to lower hepatic ferritin subu
129 in both podocytes and renal tubular cells is markedly impaired in type 2 diabetes, and this deficienc
130 Deletion of Islr in stromal cells in mice markedly impaired intestinal regeneration and suppressed
131 notype in severe COVID-19 pneumonia but also markedly impaired pulmonary perfusion likely caused by p
132 and high CD3(+) or CD8(+) T-cell density had markedly improved disease-specific survival compared wit
135 tron count, La(3+) [B(3) C(3) ](3-) exhibits markedly improved pressure stability and is a semiconduc
136 ss spectrometry (MS)-based technologies have markedly improved the comprehensive proteomic characteri
137 onic treatment of wobbler mice with myriocin markedly improved their wellness scores, grip strength,
138 ) concentration and Ti(3+) formation, which markedly improves the electrocatalytic NRR performance.
140 therapeutic effect of a theranostic agent in markedly improving progression-free survival in patients
141 ligands of PPARgamma and RXR, TETRAC differs markedly in its molecular structure and the PPARgamma-TE
145 archetypal discovery process did not change markedly in the first seven decades of the industry, the
147 nflammatory burden on the brain, but it does markedly increase the cerebral metabolic rate, independe
148 hepatic LCN2 expression and serum LCN2 level markedly increased and correlated with disease severity
149 tioned media from RBP4-activated macrophages markedly increased basal lipolysis and impaired insulin-
151 rose) diet for 16 weeks, GLP-1 secretion was markedly increased but arrhythmic over the 24-h day, whe
152 ivated unfolded protein response and PKR and markedly increased DNA damage and apoptosis caused by dy
154 ral infection, Mx proteins are known to show markedly increased expression via an interferon-responsi
155 r (GHR) from TH cells or in the entire brain markedly increased GH pulse secretion and body growth in
157 ated glycoprotein (MAG) myelin proteins were markedly increased in the cortices of betaOHB-treated ar
162 tor cells from MAM-negative individuals show markedly increased proliferation and higher reticulocyte
163 t-lived cell proteins, but unlike cAMP, also markedly increased proteasomal degradation of long-lived
164 cantly increased NIS at the cell-surface and markedly increased RAI uptake in mouse and human thyroid
165 steatohepatitis and advanced fibrosis are at markedly increased risk of adverse outcomes, including o
167 The development of nGA was associated with a markedly increased risk of progression to GA compared wi
168 e validation cohorts than the PTP model, and markedly increased the area under the receiver-operating
170 ATII RNA at different levels, and levels are markedly increased when cells are infected with HCMV or
172 etion expands the lysosome population, which markedly increases association between mTORC1 and its ly
173 ut manual stimulation, we find that MA at P6 markedly increases c-Fos positive neurons in a number of
175 inflammatory burden on the brain, despite it markedly increasing CMRO(2) , irrespective of arterial p
176 eased the number of viral load tests without markedly increasing the number of months of undetected f
178 mononuclear cells, while its expression was markedly induced in AH livers, not only in mononuclear c
179 imitation, Vitamin K2-upregulated glycolysis markedly induced metabolic stress, along with AMPK activ
183 were we able to inhibit tumor growth, but we markedly inhibited the generation and recruitment of mye
185 ib exerts the most potent antitumor effects, markedly inhibiting cell proliferation, survival, and tu
186 in-resistant, KK mice; and hyperglycemic and markedly insulin-resistant KKAy mice were used for ozone
187 The IL-1 and NLRP3 inflammasome pathways are markedly less responsive to SARS-CoV-2, commensurate wit
189 namics of confined water are resolved with a markedly long rotational coherence, extended beyond 10 p
190 r dissociation product, as compared with the markedly longer recoil (8.7 angstrom) of Br observed fro
191 or all IE subtypes; however, sensitivity was markedly lower for native valve IE than prosthetic valve
192 erase reporter constructs, CYP2B11-H3 showed markedly lower gene expression (over 70%) compared to CY
196 grants arriving after 11 years of age showed markedly lower ORs for myopia and high myopia relative t
197 ecificity remained high, but sensitivity was markedly lower than in HIV uninfected samples; only one
198 rue ileal nitrogen digestibility of zein was markedly lower than WPI (60.2 +/- 4.5% and 91.2 +/- 2.6%
199 (ClC-7) delivery to lysosomes which reverses markedly lowered chloride (Cl(-)) content in PSEN1 KO ly
202 in), germ cells with inactivated Mgat4d were markedly more sensitive to the effects of heat stress, a
205 rfaces on which they are formed, are able to markedly outcompete planktonic-grown cells in the infant
206 amodiaquine (AQ) resistance did not increase markedly over the study period either amongst study chil
209 he current study, we found that miR-200a was markedly overexpressed in both human BC tissues and BBN-
211 eport that CHIP-mediated protein turnover is markedly post-translationally enhanced by direct protein
212 er, the visual function of S- and M-cones is markedly preserved in the KI;Fatp4 (-/-) mice, displayin
213 Rituximab added to standard LMB chemotherapy markedly prolonged event-free survival and overall survi
215 under control of a hypoxia-response element markedly promotes vascular volume and blood flow, increa
216 n outbreak-strain-specific PCR enabled us to markedly redefine the initial picture of the outbreak by
218 c microglia after TBI using CSF1R inhibitors markedly reduce chronic neuroinflammation and associated
221 sening HF or diagnosed with new-onset HF was markedly reduced after lockdown but has not yet impacted
222 deletion in mice, acute ATF6alpha knockdown markedly reduced ATF6-pathway target gene expression und
223 t a rigid IS6-alpha-interaction domain helix markedly reduced basal open probability despite intact b
224 f N-acetylglucosaminyl transferase I (Mgat1) markedly reduced cellularity in the bone marrow and/or s
226 ex that mediates neutrophil oxidative burst, markedly reduced CXCL1-induced NASH and stress kinase ac
227 arse graining, though connectivity was still markedly reduced for this ensemble type with coarse grai
228 n reduced Gp130 palmitoylation and even more markedly reduced Gp130 surface expression, potentially e
230 oplasmy across all cell types but also found markedly reduced heteroplasmy in T cells, a finding cons
233 ymes that phosphorylate sphingoid bases, was markedly reduced in both NPC1 mutant and NPC1 knockout c
234 protein expression and caveolae numbers were markedly reduced in ECs from EphB1-deficient (EphB1(-/-)
235 ebpalpha and C/ebpbeta mRNA and protein were markedly reduced in Src-1/-2 double-deficient (Src-1/-2(
237 SIRT6 protein, but not mRNA, expression was markedly reduced in VSMCs in human and mouse atheroscler
240 ted with suppressed mast cell activation and markedly reduced mast cell infiltration into the small i
242 ion of the MCP1-CCR2 chemoattractant pathway markedly reduced monocytic infiltrates, perineuronal net
244 accelerate decomposition of S-nitrosothiols, markedly reduced NADPH diaphorase staining in tissue sec
245 us, amaurotic pupils, oculo-digital sign and markedly reduced or absent electroretinograms (ERG).
246 ients with anaphylaxis were characterized by markedly reduced PGE(2) levels vis-a-vis healthy subject
247 iant cells (GCs) within the junctional zone, markedly reduced placental serotonin (5-HT) concentratio
251 For example, S180A knock-in mice showed markedly reduced spontaneous tumorigenesis and increased
252 noid-derived epithelial monolayers expressed markedly reduced ST6Gal-I and underwent TNF-induced, cas
259 loading in mice and step aerobics in humans markedly reduced WNT1-inducible signaling pathway protei
266 restin2 mutants acting as dominant-negatives markedly reduces tau-laden neurofibrillary tangles in FT
268 study suggests that education in early life markedly reduces the probability of cognitive impairment
269 inistration of free PEG alone was capable of markedly reducing the APA response to PEG-liposomes for
270 proves detection of high-risk patients while markedly reducing the number of HVPG measurements requir
272 a possible sub-clinical phenotype involving markedly shortened metacarpophalangeal bones with intraf
275 aics, wind, and battery storage have dropped markedly since 2010, however, many recent studies and re
278 he pore reduce scrambling activity and yield markedly smaller autophagosomes, indicating that lipid s
280 Conversely, silencing endogenous KLHL15 markedly stabilizes these DCX domain-containing proteins
282 correlation with CD33rSIGLEC gene number was markedly strengthened by excluding the post-reproductive
286 ted Ca(2+) channel, Orai1, in the brain show markedly stronger seizures in response to the chemoconvu
288 ses sustained accumulation of p53, increases markedly the expression of histone genes and results in
289 fter multiple infections, the epithelium was markedly thickened and bladder capacity was reduced rela
291 uction of interleukin (IL)-1beta and IL-6 is markedly upregulated after heart allotransplantation and
292 olarization, migration, and invasion and are markedly upregulated in GBM and many other infiltrative
293 Inhibitory RNA Transcript (SCIRT), which was markedly upregulated in tumorspheres but colocalized wit
296 mbrane region of cholesterol-rich lipid raft markedly weakens the membrane association of VAMP2 SNARE
298 r cent marrow fat) of wolf-killed elk varied markedly with summer plant productivity, snow water equi
300 fecalith were independently associated with markedly worse outcomes and higher cost in children with