ライフサイエンスコーパス: massively

1 SF signaling, surfactant-exposed macrophages massively accumulated cholesterol ester-rich lipid-dropl

2 n mice, monocyte-derived macrophages (MoMFs) massively accumulated in injured liver within 12-24 hour

3 Furthermore, we reveal that PSTVd infection massively activates genes involved in plant immune respo

4 ls, and H3K27me2 peaks were colocalized with massively amplified DTC transposons (CACTA family) in eu

5 gambiae Y consists almost entirely of a few massively amplified, tandemly arrayed repeats, some of w

6 amino acids within this surface renders cGAS massively and constitutively active against self-DNA.

7 We found that all lineages of mangroves massively and convergently reduce TE loads in comparison

8 nd Thailand and show that these cells expand massively and express phenotypes indicative of overwhelm

9 However, NF-kappaB factors also massively bind to gene bodies.

10 is of a prospective, observational cohort of massively bleeding patients.

11 nduced activation of the PI3K/Akt pathway is massively compromised in SPPL2a(-/-) B cells and identif

12 scribe a novel biclustering algorithm called Massively Correlated Biclustering (MCbiclust) that selec

13 Our finding that massively deleted sequences rarely succeed in integratin

14 ones analogously to what is observed in vivo Massively deleted viral sequences formed more frequently

15 seed maturation and reserves such as oil are massively deposited in the enlarging embryo.

16 lated the growth of lesions, which exhibited massively dilated glands with a flattened layer of strom

17 This disease manifested as a massively dilated urinary bladder, or megabladder, with

18 iratory syndrome coronavirus 2) pandemic has massively distorted our health care systems and caused c

19 Thus, chronic HCV infection massively disturbs the B-cell compartment even in patien

20 to synthesize single genes but ultimately to massively edit or write from scratch entire genomes.

21 promises a heterogeneous platform to deliver massively enhanced potential based on silicon technology

22 High-frequency mutations are found to be massively enriched in microbial colonies compared with w

23 vels in cells dividing at a high rate but is massively evicted in cells undergoing their last cell cy

24 the CD8(+) TCR repertoire response against a massively exhausted lymphocytic choriomeningitis virus (

25 and organismal biology are clearly poised to massively expand.

26 chromosome loss events, suggesting that the massively expanded and fragmented mitochondrial genomes

27 (Crotalus) species revealed the SVMP family massively expanded from a single, deeply conserved adam2

28 hilic lifestyle of this sea ice alga include massively expanded gene families involved in unsaturated

29 cortices in mice becomes predominant in the massively expanded human lateral nucleus.

30 The GIMAP gene family is massively expanded in fish genomes and may also play a c

31 increase in hot extremes because irrigation massively expanded throughout the 20[Formula: see text]

32 udy that gammadelta T cells specifically and massively expanded upon activation with Plasmodium falci

33 SNP data from unrelated individuals, termed massively expedited genome-wide heritability analysis (M

34 NIPP1-deficient keratinocytes massively expressed proinflammatory chemokines and immun

35 at C. bicolor flowers make MVT de novo via a massively expressed THI4 and that thiamin is not involve

36 The massively generated H(2)O(2) triggers in situ transforma

37 Here we show that this lysine is massively hyperacetylated in peripheral neutrophils.

38 lly, our model calls for new experiments for massively identifying the odorant-receptor dissociation

39 e, the recovery of the exocrine pancreas was massively impaired in Postn-deficient mice.

40 p at the alpha-benzylic position is known to massively improve the anti-HIV-1 activity of these compo

41 how that affinity purification of antibodies massively improved the detection rate.

42 Receptor-like kinases expanded massively in land plants, and leucine-rich repeat recept

43 Single-cell RNA-sequencing has grown massively in scale since its inception, presenting subst

44 Ultimately, the goal is to massively increase opportunities for people with MNS dis

45 ing from 1,000 to 10,000 mutations per cell; massively increasing the variance both within and betwee

46 t much of it took place comparatively early, massively independently, and with lineage-specific rates

47 sion yeast fbp1 gene, whose transcription is massively induced upon glucose starvation.

48 their underestimated capability to repair a massively injured, nonfunctional DG.

49 The mammalian visual cortex massively innervates the brainstem, a phylogenetically o

50 l-investigated cytotoxic anticancer effects, massively interact with the cancer-immune interface and

51 These blood vessels were massively invaded by bacteria, which adhered to and form

52 of inferences that can be made from existing massively large exome-sequencing datasets.

53 A continuing challenge in the analysis of massively large sequencing data sets is quantifying and

54 u hybridization (FISH) analysis revealed two massively large variants of 45S rDNA and their correspon

55 ows us to introduce a scalable algorithm for massively large-scale networks.

56 tigate the function of such RNAs, methods to massively map the genomic interacting sites of multiple

57 d environmental factors contributing to the "massively multifactorial system networks" which go awry

58 le microfluidic single-bead trapping permits massively multiplexed fluorescence detection and quantif

59 libraries and reading the barcodes out using massively multiplexed fluorescence in situ hybridization

60 dy evaluated the analytical performance of a massively multiplexed polymerase chain reaction assay th

61 ce of a single-nucleotide polymorphism-based massively multiplexed polymerase chain reaction assay to

62 Here, we present a massively multiplexed yeast two-hybrid method, CrY2H-seq

63 RNA quantification at transcriptome scale by massively multiplexing single-molecule FISH measurements

64 tagging sequencing (scNT-seq), a method for massively parallel analysis of newly transcribed and pre

65 dual tracer injections into HVC) to reveal a massively parallel and in some cases topographic pattern

66 We describe a massively parallel approach for designing, manufacturing

67 A new study uses a massively parallel approach, deep mutational scanning, t

68 tate, but has not yet been combined with the massively parallel approaches needed to tackle the compl

69 When tested through the RNA on a massively parallel array (RNA-MaP) experimental platform

70 elogram array of multi-optical probes with a massively parallel array size of 200 x 140.

71 The development of massively parallel assays allows the characterization of

72 6-well analytical approach will facilitate a massively parallel assessment of the PDC interfacial int

73 e we use microfluidic chemical gradients and massively parallel automated tracking to study the behav

74 This massively parallel biophysical assay unveiled shifts in

75 processing unit processor markets, enabling massively parallel computations that are not yet fully e

76 Despite the development of massively parallel computing hardware including inexpens

77 we use a combination of machine learning and massively parallel computing to predict the effects of p

78 target recognition and binding, we develop a massively parallel CRISPR interference (CRISPRi) assay t

79 Here we developed massively parallel CRISPR-Cpf1/Cas12a crRNA array profil

80 otocols (with freeware) capable of accurate, massively parallel de novo assembly of high quality DNA

81 nergy harvesting and scavenging displays and massively parallel display-to-display data communication

82 e chromatin immunoprecipitation coupled with massively parallel DNA sequencing (ChIP-seq) and coimmun

83 e chromatin immunoprecipitation coupled with massively parallel DNA sequencing (ChIP-seq) and RNA-seq

84 Chromatin immunoprecipitation with massively parallel DNA sequencing (ChIP-seq) has greatly

85 ssessed by chromatin immunoprecipitation and massively parallel DNA sequencing (ChIP-seq).

86 Chromatin immunoprecipitation followed by massively parallel DNA sequencing showed that genes invo

87 d by 5'-to-3' exonuclease treatment and then massively parallel DNA sequencing) to GATA1 and TAL1 to

88 q (chromatin immunoprecipitation followed by massively parallel DNA sequencing).

89 Here, we assess the performance of a massively parallel droplet-based method for mapping tran

90 We describe a massively parallel experimental approach to quantify how

91 ication of interactions, ultimately enabling massively parallel experimentation for the investigation

92 aturing field of silicon photonics, enabling massively parallel fabrication of photonic structures.

93 This enables a massively parallel frequency-modulated engine(16,17) for

94 Our approach should enable massively parallel functional analysis of a wide range o

95 We develop a massively parallel functional assay termed Dro-seq (Dros

96 Sequencing-based, massively parallel genetic assays have revolutionized ou

97 genetic perturbations can be implemented in massively parallel genetic screens to evaluate the funct

98 led characterization of metagenomics through massively parallel genomic DNA sequencing.

99 adays possible with the rapid development of massively parallel Graphics Processing Unit, i.e. the GP

100 ndom 5' UTRs and assayed their activity in a massively parallel growth selection experiment.

101 of many-body quantum chemistry methods onto massively parallel high-performance computing (HPC) plat

102 In this review, we describe several massively parallel high-throughput DNA sequencing techno

103 Massively parallel high-throughput sequencing technology

104 A) using a shape-memory polymer that enables massively parallel histological analysis of 3D cultures

105 Furthermore, PenSeq enables the massively parallel identification of presence/absence va

106 The brain is capable of massively parallel information processing while consumin

107 Here we combine in vitro selection with a massively parallel kinetic assay to map a fitness landsc

108 onstrate a DNA storage system that relies on massively parallel light-directed synthesis, which is co

109 whole-transcriptome or genomic analysis in a massively parallel manner with minimal reagent use.

110 Using a massively parallel method to quantify protein-DNA intera

111 The approach used massively parallel microfluidics to generate libraries o

112 arise due to somatic mutation and performed massively parallel mRNA sequencing on affected tissue fr

113 systematically mutating 245 HOT loci with a massively parallel mutagenesis assay, we localized regul

114 CRISPR-Cas9 gene editing in combination with massively parallel oligomer synthesis can enable trackab

115 microlens arrays, is proposed to generate a massively parallel optical probe array for integration i

116 hroughput gigapixel confocal imaging using a massively parallel optical probe array with single direc

117 h single pores is kinetically analysed using massively parallel optical readout with transparent sili

118 Massively parallel or second-generation sequencing-based

119 Using a massively parallel origin selection assay coupled with a

120 Massively parallel phenotyping assays have provided unpr

121 This protocol provides a massively parallel pipeline to achieve high stringency a

122 Seq-nuclease digestion and deep sequencing-a massively parallel platform that measures the cleavage k

123 Expansion of these approaches into massively parallel platforms establishes the ability to

124 and scene recognition traditionally focus on massively parallel processing of low-level features, wit

125 nefit from the computational capabilities of massively parallel processors.

126 Cellular barcoding of 3' mRNAs enabled massively parallel profiling of single-cell gene express

127 A-sequencing (dscRNA-seq) has enabled rapid, massively parallel profiling of transcriptomes.

128 owing to their ability to perform rapid and massively parallel reactions in minute fluid volumes.

129 monkey, we observe very different dynamics: massively parallel recordings of 155 single-neuron spiki

130 veloped and applied a novel lentivirus-based massively parallel reporter assay (lentiMPRA) to directl

131 cis-regulation in mouse ESCs, we assayed two massively parallel reporter assay (MPRA) libraries compo

132 To address this challenge, we adapted the massively parallel reporter assay (MPRA) to identify var

133 We designed and executed a massively parallel reporter assay (MPRA) to investigate

134 We employ a massively parallel reporter assay (MPRA) to simultaneous

135 matic interrogation of the HLA-G locus using massively parallel reporter assay (MPRA) uncovered a pre

136 In the massively parallel reporter assay (MPRA), short barcodes

137 tested elements show silencer activity using massively parallel reporter assay (MPRA).

138 this hypothesis in 116 regions analyzed by a Massively Parallel Reporter Assay and observed enrichmen

139 ysis of available cross-population eQTLs and massively parallel reporter assay data show that RAs com

140 Here, we used a massively parallel reporter assay to measure the cis-reg

141 By using a massively parallel reporter assay, we identified cis-reg

142 nding sites in primary mouse T cells using a massively parallel reporter assay.

143 teoarthritis for regulatory activity using a massively parallel reporter assay.

144 Massively parallel reporter assays (MPRA) enable systema

145 question using computational approaches and massively parallel reporter assays (MPRA) surveying hund

146 Using chromatin interaction sequencing, massively parallel reporter assays (MPRA), and transgeni

147 hroughput reporter assay experiments such as massively parallel reporter assays (MPRAs) and similar m

148 Massively parallel reporter assays (MPRAs) are an especi

149 Massively parallel reporter assays (MPRAs) can measure t

150 Massively parallel reporter assays (MPRAs) can simultane

151 y from p53-bound sequences using a series of massively parallel reporter assays (MPRAs) coupled with

152 Massively parallel reporter assays (MPRAs) enable nucleo

153 Massively parallel reporter assays (MPRAs) functionally

154 To address this issue, massively parallel reporter assays (MPRAs) have emerged,

155 Here, we used massively parallel reporter assays (MPRAs) involving 32,

156 Using massively parallel reporter assays (MPRAs) to test the a

157 oach featuring conditional genetic analysis, massively parallel reporter assays (MPRAs), traditional

158 Here we introduce UTR-seq, a combination of massively parallel reporter assays and regression models

159 ulatory code embedded in 5' UTRs, we devised massively parallel reporter assays from a synthetic mess

160 The application of massively parallel reporter assays in human induced plur

161 and the inferred specificity of TRUB1 using massively parallel reporter assays in which we monitored

162 m saturation mutagenesis in conjunction with massively parallel reporter assays on 20 disease-associa

163 However, Massively Parallel Reporter Assays reveal that few SNVs

164 Here, we use massively parallel reporter assays to directly measure t

165 We used massively parallel reporter assays to perform functional

166 on blood lipid-associated loci, we performed massively parallel reporter assays to screen candidate f

167 introduce a new method, Reg-Seq, that links massively parallel reporter assays with mass spectrometr

168 regulatory sequences using in vivo methods (massively parallel reporter assays) to formulate quantit

169 t (MAVEs), such as deep mutational scans and massively parallel reporter assays, test thousands of se

170 Massively parallel RNA sequencing (RNA-seq) has rapidly

171 We performed massively parallel RNA sequencing in GCs and matched nor

172 olve their functional status, we performed a massively parallel screen in human cells to identify los

173 Here, we created a platform for the massively parallel screening of barcoded combinatorial g

174 n of Cas13d guide RNAs (gRNAs), we conducted massively parallel screens targeting messenger RNAs (mRN

175 Seq-Well S(3) ("Second-Strand Synthesis"), a massively parallel scRNA-seq protocol that uses a random

176 itro DNA affinity purification combined with massively parallel sequencing (IDAP-Seq) to identify gen

177 Accurate massively parallel sequencing (MPS) of genetic variants

178 Massively parallel sequencing (MPS) technologies includi

179 Purpose Massively parallel sequencing allows simultaneous testin

180 high throughput molecular techniques such as massively parallel sequencing and phylogenetic microarra

181 (351) of infant and young SD decedents using massively parallel sequencing at <$600 per sample.

182 isplays clonal DNA methylation patterns from massively parallel sequencing data aligned using Bismark

183 RtN!) was developed to categorize reads from massively parallel sequencing data not based on the expe

184 ame feasible with the recent availability of massively parallel sequencing for detection of all codin

185 ssment and Counseling (Family CARE Project), Massively Parallel Sequencing for Familial Colon Cancer

186 As massively parallel sequencing has emerged as a leading t

187 ns of individual genomic cleavage events via massively parallel sequencing has enabled in vivo DNase

188 Massively parallel sequencing has not previously been le

189 Massively parallel sequencing has permitted an unprecede

190 Massively parallel sequencing has revealed many de novo

191 Short-read massively parallel sequencing has revolutionized our abi

192 olecular barcoding and can be applied to any massively parallel sequencing instrument.

193 Variant interpretation in the era of massively parallel sequencing is challenging.

194 Massively parallel sequencing is increasingly used to in

195 Genomic analysis by massively parallel sequencing of 504 cancer genes was pe

196 We employed massively parallel sequencing of all X-chromosome exons

197 methylation results from targeted amplicon, massively parallel sequencing of bisulfite converted DNA

198 The use of massively parallel sequencing of maternal cfDNA for non-

199 Patients who underwent targeted massively parallel sequencing of primary ECs between 201

200 mation was recovered perfectly from a single massively parallel sequencing run.

201 In this study, a massively parallel sequencing technique that is based on

202 Massively parallel sequencing technologies are useful fo

203 Use of chromosomal microarray and massively parallel sequencing technologies has revealed

204 ver the past decade, the decreasing costs of massively parallel sequencing technologies have facilita

205 Massively parallel sequencing technologies provide great

206 enomics has grown rapidly with the advent of massively parallel sequencing technologies, allowing for

207 Massively parallel sequencing technology coupled with sa

208 Massively parallel sequencing technology has made signif

209 We used massively parallel sequencing technology to decode the g

210 We used massively parallel sequencing to examine tumor samples c

211 sociated with chemotherapy exposure, we used massively parallel sequencing to quantitate mutations in

212 the past 15 years, technology, particularly massively parallel sequencing, and bioinformatics advanc

213 mented includes targeted genomic enrichment, massively parallel sequencing, bioinformatic analysis, a

214 With the advent of massively parallel sequencing, considerable work has gon

215 With the emergence of massively parallel sequencing, genomewide expression dat

216 Similarly, massively parallel sequencing-based analyses have identi

217 BROCA Agilent cancer risk panel followed by massively parallel sequencing.

218 e sensitivity of detecting such mutations by massively parallel sequencing.

219 Our massively parallel simulations of RBC flow in real-size

220 ormed using the large-scale Atomic/Molecular Massively Parallel Simulator (LAMMPS) with a reactive fo

221 mulator LAMMPS (Large-scale Atomic/Molecular Massively Parallel Simulator), which we extended with Ib

222 A massively parallel single particle sensing method based

223 oglia gene targeting model, we first applied massively parallel single-cell analyses to compare micro

224 Here we combine massively parallel single-cell analysis, single-molecule

225 Massively parallel single-cell and single-nucleus RNA se

226 iring of CRISPR/Cas9-based gene editing with massively parallel single-cell readouts now enables larg

227 To address these challenges, we used massively parallel single-cell RNA profiling and optimiz

228 an integrated pipeline for index sorting and massively parallel single-cell RNA sequencing (MARS-seq2

229 Here we perform massively parallel single-cell RNA sequencing (scRNA-seq

230 Recent advances such as massively parallel single-cell RNA sequencing and sophis

231 Massively parallel single-cell RNA sequencing can precis

232 Seq-Well, a portable, low-cost platform for massively parallel single-cell RNA-seq.

233 Recent development of massively parallel single-cell RNA-sequencing (scRNA-seq

234 n of a systematic allelic series (SAS) using massively parallel single-nucleotide mutagenesis with re

235 Here, we develop DroNc-seq: massively parallel sNuc-seq with droplet technology.

236 s an effective and efficient tool to analyze massively parallel spike data for temporal sequences of

237 oduced a method for visualization of SSEs in massively parallel spike trains, based on an intersectio

238 hed disease-causing exonic mutations using a massively parallel splicing assay (MaPSy), which showed

239 Massively parallel strand-specific sequencing of RNA (ss

240 ap in the pipeline for automated analysis of massively parallel targeted proteomics data sets.

241 Massively parallel technologies targeting RNA, proteins,

242 Massively parallel trapping of more than 100,000 micropa

243 enetic alterations that underpin SPCRP using massively parallel whole-exome and targeted sequencing.

244 Massively parallel whole-genome sequencing (WGS) data ha

245 droplets-based platform that performs rapid, massively parallel, bottom-up construction and screening

246 rates that can be directly implemented with massively parallel, compact, low-latency and low-power n

247 genitor cell-derived osteoblasts employing a massively parallel, high resolution Capture C based meth

248 Our approach enables massively parallel, high-resolution recording of lineage

249 Here, we report a massively parallel, multigene-profiling nanoplatform to

250 Massively parallel, quantitative measurements of biomole

251 STR-selective primers enable massively parallel, targeted sequencing of large STR set

252 ensing interfaces and as the transducer in a massively parallel, wide field, single molecule detectio

253 Here we report an approach integrating massively-parallel reporter assays (MPRA) with cell-type

254 tify promising detection strategies based on massively-parallel sequencing.

255 plification-free molecular diagnostics using massively paralleled and hierarchically cascaded nanoflu

256 However, an alternative massively parallelized configuration, capable of interro

257 In the last years, applications based on massively parallelized RNA sequencing (RNA-seq) have bec

258 of a membrane-less microfiltration system by massively parallelizing inertial microfluidics to achiev

259 lar input patterns in the olfactory bulb are massively perturbed and olfactory behaviors are altered.

260 ty to detect carbamazepine, an antiepileptic massively prescribed and persistent in water, which had

261 The massively produced (1)O2 can compromise the integrity of

262 DCS cells can be massively produced from Lgr5(+) colon stem cells in vitr

263 f human innate and adaptive immunity and are massively produced from plasmacytoid dendritic cells (pD

264 ch syndrome protein Homology 2 (WH2) domain, massively promoted the formation of F-actin-rich membran

265 nd that approximately 4% of the samples have massively rearranged chromosomes, many of which are asso

266 with predominant apoptosis, macrophages were massively recruited into Mtz/NTR-damaged livers.

267 a hallmark of glioblastoma (GBM), TAMCs are massively recruited to reach up to 50% of the brain tumo

268 parable measures for information flow in the massively recurrent networks of the rest of the brain ha

269 presentation and T-cell costimulation, which massively reduced T-cell subset skewing and exhaustion.

270 a fast and efficient filtering strategy for massively reducing the computational burden of pairwise

271 artner defense system is activated and olive massively releases the arsenal of defense.

272 d cells) becomes highly up-regulated and can massively reorganize the bacterial chromosome.

273 hromatin accessibility revealed that fasting massively reorganizes liver chromatin, exposing numerous

274 ng RNA-genome interactions), a technology to massively reveal native RNA-chromatin interactions from

275 pping RNA interactome in vivo) technology to massively reveal RNA-RNA interactions from unperturbed c

276 It is designed to be massively scalable to hundreds of taxa and thousands of

277 human pathogen that, under KdgR regulation, massively secrete enzymes such as pectinases that degrad

278 s, whereas the ORF2g and ORF2c proteins were massively secreted glycoproteins not associated with inf

279 lecular markers, and their use has increased massively since the inception of Next Generation Sequenc

280 on therefore appears to have also unlocked a massively successful evolutionary trajectory.

281 Coleoptera (beetles) is a massively successful order of insects, distinguished by

282 First, using massively systematic transcript end readout, MASTER, we

283 sition to lasting quiescence as they develop massively thickened circumferential F-actin bands at the

284 infection when host populations are expanded massively through fungiculture.

285 ts phenotypically resembling PKD that expand massively to 1-centimetre diameters.

286 Exploratory subgroups included massively transfused and severe TBI patients.

287 inistration of blood component ratios in the massively transfused nontrauma demographic.

288 Among 601 massively transfused nontrauma patients, cardiothoracic

289 Massively transfused nontrauma patients.

290 paucity of comprehensive descriptions of the massively transfused patients and their outcomes.

291 Also, 50% of massively transfused patients in hemorrhagic shock demon

292 atient characteristics, and the mortality of massively transfused patients.

293 e associated with lower 24-hour mortality in massively transfused pediatric trauma patients.

294 ot observed in this analysis of a nontrauma, massively transfused population.

295 73.5% blunt mechanism, 47% severe TBI, 20.5% massively transfused.

296 Although epigenetically silenced, B2s become massively up-regulated during thermal and other types of

297 ast, exclusive removal of non-CG methylation massively up-regulated transposons and genes.

298 allenge, Rac1(P29S)-harboring melanoma cells massively upregulate lamellipodia formation by dendritic

299 SARS-CoV-2-infected lung tissues show a massively upregulated innate immune response with signat

300 erium oxide (CeO(2)) nanoparticles (NPs) are massively used as abrasives in the chemical and mechanic