ライフサイエンスコーパス: master

1 ofluidic device fabricated from a 3D printed master.

2 ons of behavioral automation as participants mastered a dual n-back task.

3 ding challenges the idea that the ability to master abstract magnitude concepts across domains is uni

4 Mastering activation of surface lattice oxygen and ident

5 They directly promote the expression of master adipogenic transcription factors peroxisome proli

6 ying the constitutive activation of the NRF2 master antioxidant response in Neoaves (~95% of bird spe

7 lance and motor control were performed in 30 masters athletes (16 male) aged 44-83 years.

8 Evidence suggests masters athletes are more successful at motor unit remod

9 Masters athletes exhibit age-related declines in neuromu

10 Masters athletes maintain high levels of activity into o

11 n older age, which may be more successful in masters athletes.

12 MCs, beyond their classic role as master cells of allergic reactions, play a role in other

13 ons within the suprachiasmatic nucleus (SCN) master circadian clock have the ability of encoding affe

14 t of that circuit is conveyed to the brain's master circadian clock.

15 In mammals, the master clock in the brain's suprachiasmatic nuclei has l

16 visualize molecular rhythms in subtypes of master clock neurons to test principles of cell identity

17 Here, we report that deletion of the master clock protein BMAL1 in mice robustly increases ex

18 d" property gated by specific neurons of the master clock to favor subsequent alertness prior to dawn

19 lian rest-activity cycle is controlled by a "master clock" in the suprachiasmatic nucleus (SCN) of th

20 s at many downregulated genes (including the master coactivators Ppargc1a, Ppargc1b, and their downst

21 versity of visual organs are initiated by a 'master control gene' called Pax6, which is both necessar

22 ranscription factor EB (TFEB) functions as a master controller of lysosomal biogenesis and function d

23 Deletion or substitution of this 'master controller' prevents aggregation at pH 7.5 in vit

24 The results highlight the importance of a master-controller sequence motif that controls both alph

25 Together these master curves yield a trajectory universal to particles

26 area per lipid and collapse onto respective master curves.

27 its respective characteristic times onto two master curves.

28 One potential reason is that the master donor virus (MDV), on which all LAIVs are based,

29 These results highlight MUC1-C as a master effector of lineage plasticity driving progressio

30 CD8+ T cells are master effectors of antitumor immunity, and their presen

31 tegy to effectively impair the function of a master EMT-transcriptional factor.

32 ZEB1, a master epithelial-to-mesenchymal transition-inducing tra

33 Their modeling largely rests on the master equation (ME) approach introduced in 1975 by Herm

34 M) for site energies while employing Pauli's master equation approach to model hopping between locali

35 Here we develop a master equation describing the stochastic dynamics of th

36 We also show that any master equation implementing a function can be decompose

37 e current traces were fitted to parametrized master equations.

38 lions of bond formation processes have to be mastered exclusively in two dimensions within 3D crystal

39 hat express the transcription factor Tp63, a master gene for the development of epidermis and its app

40 mponents that interact with the pluripotency master gene Oct4.

41 osphorylation, inhibits the up-regulation of master genes involved in the control of osteogenesis, an

42 [adenohypophysis (ADH)] of the pituitary, a master gland controlling growth, metabolism, and reprodu

43 target repressed by NFAT5, which opposes the master IFN-I inducer IRF3 by binding to an evolutionaril

44 Snail, master inducer of EMT, requires HOTAIR to recruit EZH2 o

45 ations, and oral microbiome, whereby several master inflammatory pathways constitute the complicated

46 ch hybridizes the power of molecularly based master interventional protocols with the breadth of real

47 m has been the target of multiple studies to master its potential use as a therapeutic agent.

48 pected immediate early gene Fos and Stk11, a master kinase of the AMP-related kinase pathway with imp

49 sing expression of liver kinase B1 (LKB1), a master kinase of the AMPK subfamily, via CpG island meth

50 Cyclin B:CDK1 is the master kinase regulator of mitosis.

51 simulations, and analytical modeling with a master kinetic equation to show that cluster sizes and c

52 ercolation, as predicted by solutions to the master kinetic equation.

53 of Schools and Programs of Public Health for masters-level trainees, no equivalent currently exists f

54 lop an RNAi-RbcS tobacco (Nicotiana tabacum) master-line, tobRrDeltaS, for producing homogenous plant

55 factor-kappaB ligand (RANKL) constitutes the master mediator of osteoclastogenesis, while its pharmac

56 We show that mammals utilize equivalent master meiotic regulators (Stra8, Mybl1, Dazl) to regula

57 ansposons and host defense are controlled by master meiotic regulators.

58 Signaling by the master metabolic regulator AMP-activated protein kinase

59 Our analysis pinpoints a small number of master metabolic regulator genes, balancing the relative

60 d that RALY binds the promoter region of the master metabolic regulator Srebp2 and show that it direc

61 n can be modulated by sirtuin 1 (SIRT1), the master metabolic sensor of the cell, belonging to the cl

62 a recent analogy, an interaction between the master mitotic regulator cyclin B1 and the spindle check

63 tiplexed primers and probes and formulated a master mix composed of enzymes and proteins produced in-

64 We demonstrate that PMX is a master modulator of merozoite invasion and direct matura

65 TBX1 interacts with RUNX2, a master molecule of osteoblastogenesis and a regulator of

66 In the present study we show that the master myogenic regulatory factor, MYOD1, is a positive

67 troduces a new clinical trial construct, the Master Observational Trial (MOT), which hybridizes the p

68 The master observational trial bridges the gap between inter

69 is, these jacks-of-all-trades should be the masters of none.

70 alism produce 'jacks-of-all-trades' that are masters of none.

71 most important member of the network is the master operon, flhDC, which encodes the FlhD4C2 protein.

72 The suprachiasmatic nucleus (SCN) acts as a master pacemaker driving circadian behavior and physiolo

73 The National LPG Master Plan (Master Plan) was developed for scaling up t

74 ds: a) short-term (2017-2030): Comparing the Master Plan 58% target with a counterfactual LPG adoptio

75 Successful implementation of the Master Plan could have significant positive impacts on p

76 For 2100, a cooling impact from the Master Plan leading to market saturation (73%) was estim

77 By 2030, successful implementation of the Master Plan was estimated to avert about 28,000 (minimum

78 l impacts of this planned LPG expansion (the Master Plan) on population health and climate change mit

79 The National LPG Master Plan (Master Plan) was developed for scaling up the LPG sector

80 ding quantitative performance comparisons as master plots.

81 hesized a water-soluble and functionalizable master polydiacetylene, namely poly(deca-4,6-diynedioic

82 They act as master post-transcriptional regulators that control most

83 Master protein kinases and transcription factors mediate

84 The Lung Cancer Master Protocol (Lung-MAP; S1400) is a completed biomark

85 -MAP; S1400) is a completed biomarker-driven master protocol designed to address an unmet need for be

86 therapies and was the first biomarker-driven master protocol initiated with the US National Cancer In

87 This study utilized a Master Protocol to generate diagnostic performance data

88 hysician's direction under the auspices of a master protocol.

89 Master protocols allow better efficiency in data collect

90 In Vibrio harveyi, the master quorum sensing transcription factor LuxR directly

91 Extracellular enzymes are master recyclers of organic matter, and to predict their

92 Real-world data/master registry trials may also provide massive, clinica

93 Gene network inference and master regulator analysis (MRA) have been widely adopted

94 a major phosphatase to stabilize a metabolic master regulator and drive anabolism.

95 For example, Oct4, a master regulator and inducer of stem cell pluripotency,

96 of Pbx1, Fgf8, Dusp6, Vangl2, the hair-cell master regulator Atoh1 and a cascade of Atoh1's downstre

97 also show how coding change in a pleiotropic master regulator could have small, quantitative effects

98 rentiation through stabilizing the erythroid master regulator erythroid Kruppel-like factor (EKLF, al

99 the transactivation of myocardin (MYOCD), a master regulator for SMC-specific gene transcription by

100 in independent cohorts, we identified (1) a master regulator gene common to asthma across severity a

101 Comparative analysis of the master regulator genes followed by validation testing in

102 The identified master regulator genes of asthma provide a novel path fo

103 C23, TMEM231, CAPS, PTPRC, and FYB); and (3) master regulator genes of mild/moderate persistent asthm

104 asthma across severity and ages (FOXJ1); (2) master regulator genes of severe persistent asthma in ch

105 beyond gene signatures of asthma to identify master regulator genes that causally regulate genes asso

106 red (R) light-regulated genes, including the master regulator HY5.

107 Our data demonstrate that the promoter of a master regulator is primed for rapid activation while re

108 prophage in the essentiality of SOS response master regulator LexA, which is otherwise not essential

109 aling factors nor involvement of the RNAPIII master regulator Maf1.

110 Cep55 protein is regarded as the master regulator of abscission, because it recruits ESCR

111 as deleted in the presence or absence of the master regulator of antioxidant defense nuclear factor e

112 Transcription factor EB (TFEB), a master regulator of autophagy and lysosome biogenesis, i

113 In summary, our data identify p62 as a master regulator of BAT function in that it controls the

114 Catabolite control protein A (CcpA) is a master regulator of carbon source utilization and contri

115 eostasis, analogous to SOX9's dual role as a master regulator of cartilage and an important regulator

116 yperactivation of mTOR Complex 1 (mTORC1), a master regulator of cell growth and metabolism.

117 s that the retrotrapezoid nucleus (RTN) is a master regulator of central chemoreception, in particula

118 uitination of polo-like kinase 4 (PLK4), the master regulator of centrosome duplication.

119 Although Nrf2 has been recognized as a master regulator of cytoprotection, its functional signi

120 2 signaling pathway has been considered as a master regulator of cytoprotective genes, and exists in

121 status of (yet another) DNA damage factor to master regulator of double-strand break (DSB) repair pat

122 irectly represses the expression of T-bet, a master regulator of effector T cell function.

123 Nrf2 is a master regulator of endogenous cellular defences, govern

124 le of AMP-activated protein kinase (AMPK), a master regulator of energy metabolism, in response to ZI

125 n tumor suppressor, but its sibling p63 is a master regulator of epidermis development and a key onco

126 AKT/GSK3beta to stabilize Snail1 protein, a master regulator of epithelial-mesenchymal transition (E

127 TGF-beta is a master regulator of fibrosis, driving the differentiatio

128 We identify the master regulator of floral fate, LEAFY (LFY) as a target

129 as a direct transcriptional repressor of the master regulator of growth, Myc.

130 ngineer porcine embryos deficient in ETV2, a master regulator of hematoendothelial lineages(3-7).

131 GPRASP2 promote the degradation of CXCR4, a master regulator of HSC function during transplantation.

132 Mechanistic studies identified MPL, the master regulator of HSC identity(5), as a bona fide ERAD

133 s accomplished through the activation of the master regulator of inflammation, dual-specificity phosp

134 ocyte nuclear factor 4alpha (HNF4alpha) is a master regulator of liver function and a tumor suppresso

135 Thus, Notch2 is a master regulator of Ly6C(hi) monocyte cell fate and infl

136 The master regulator of lymphatic development, Prox1, bound

137 show that transcription factor EB (TFEB), a master regulator of lysosomal biogenesis and autophagy(4

138 Transcription Factor EB (TFEB), a master regulator of lysosomal biogenesis and autophagy,

139 ylation of transcription factor EB (TFEB), a master regulator of lysosomal biogenesis and autophagy.

140 e that the transcription factor EB (TFEB), a master regulator of lysosomal biogenesis, plays an essen

141 lcineurin, which in turn activates TFEB, the master regulator of lysosomal biogenesis.

142 ion of the transcription factor EB (TFEB), a master regulator of lysosomal functions and autophagy.

143 CDK1 substitutes for inhibited mTORC1 as the master regulator of macroautophagy during mitosis, uncou

144 finger transcription factor proposed to be a master regulator of male courtship and mating behavior a

145 lts highlight an unexpected repurposing of a master regulator of male-specific sexual behavior to con

146 NA hypomethylation permits CTCF binding, the master regulator of mammalian chromatin structure, which

147 C), which includes the kinase Aurora B, is a master regulator of meiotic and mitotic processes that e

148 Thus, autophagy destroys a master regulator of meiotic gene expression to enable ir

149 act that the transcription factor ATOH1 is a master regulator of Merkel cell development, its role in

150 xploring functional links to PGC-1alpha, the master regulator of mitochondrial biogenesis, we searche

151 ator of transcription 3 (STAT3) protein is a master regulator of most key hallmarks and enablers of c

152 ogen receptor (AR) transcription factor is a master regulator of normal glandular homeostasis in the

153 biotic and abiotic stress responses and is a master regulator of plant-environmental interactions.

154 directly activates the expression of mvfR, a master regulator of pqs system, and subsequently promote

155 se (PERK) branch of the UPR functions as the master regulator of protein translation in ER-stressed c

156 entified the c-Maf transcription factor as a master regulator of protumoral TAM polarization.

157 ce the stability of the PLETHORA2 protein, a master regulator of root stem cells.

158 n of the transcriptional coactivator NPR1, a master regulator of SA signaling.

159 thaliana) ORESARA1 (ORE1), the developmental master regulator of senescence, as a direct CPK1 phospho

160 The transcription factor TRA-1 is the master regulator of somatic sexual differentiation in th

161 ) signaling and induces expression of Bmi-1 (master regulator of stem cell self-renewal) in dental pu

162 Evidence indicates that Hsf1, a master regulator of stress response, mediates B2 RNA pro

163 We found that hepcidin, the master regulator of systemic iron homeostasis, is requir

164 tory relationship between NOTCH and FOXN1, a master regulator of TEC differentiation.

165 uclear long noncoding RNA (lncRNA) H19X as a master regulator of TGF-beta-driven tissue fibrosis.

166 abolic reprogramming and upregulates NRF2, a master regulator of the antioxidant network.

167 in vitro, MCs hindered activation of cMET, a master regulator of the basal program, and simultaneousl

168 o tumor growth, indicating that it acts as a master regulator of the CAF state.

169 ATM kinase is a tumor suppressor and a master regulator of the DNA damage response.

170 ATR functions as a master regulator of the DNA-damage response.

171 determined that gene repression requires the master regulator of the epidermal differentiation progra

172 n endoplasmic reticulum (ER) chaperone, is a master regulator of the ER stress.

173 am, divergent from its canonical role as the master regulator of the heat shock response, leading to

174 In eukaryotes, HSF1 is the master regulator of the heat shock transcriptional respo

175 The transcription factor NF-kB is a master regulator of the innate immune response and plays

176 osed transcriptional repression on WRKY33, a master regulator of the JA/ET signalling pathway.

177 rough loss- and gain-of-function of CIITA, a master regulator of the MHCII pathway.

178 de-of-action of NIN-LIKE PROTEIN 7 (NLP7), a master regulator of the nitrogen signaling pathway in pl

179 meristem, and they strongly support AP2 as a master regulator of this process.

180 The Hippo pathway is a master regulator of tissue homeostasis and organ size.

181 ipper (bZIP) transcription factor, acts as a master regulator of transcription to promote photomorpho

182 tivator (PGC)-1alpha, has been proposed as a master regulator of tumor oxidative phosphorylation.

183 tv2 functions as an evolutionarily conserved master regulator of vasculogenesis.

184 ense, which has two orthologs of AtVND7, the master regulator of vessel formation.

185 sequence of the prfA gene, which encodes the master regulator of virulence genes, has been previously

186 We used overexpression of microRNA156, the master regulator of VPC, to modulate the timing of VPC i

187 ost complex layer of the wall and may be the master regulator of wall physiology and pathobiology.

188 ctive-specific transcript (Xist) gene is the master regulator of X chromosome inactivation in mammals

189 nd X inactive specific transcript (XIST)-the master regulator of XCI-which are silenced after entry i

190 tes EMT through the up-regulation of the EMT master regulator Slug, a process that is dependent on bo

191 -MS/MS revealed that FloR is a physiological master regulator that operates through subordinate pleio

192 ifferences in C. elegans are governed by the master regulator tra-1, whose activity is controlled by

193 s of gene regulatory networks (GRNs) yielded master regulator transcription factors associated with W

194 omotes xylem differentiation through a known master regulator VASCULAR-RELATED NAC-DOMAIN6 (VND6).

195 Here, we demonstrate that HPSE is a master regulator where, in addition to directly enabling

196 In this context, the expression of the "master regulator" is necessary and sufficient to activat

197 kinases CDK9, CDK12, and CDK13, invoking a "master regulator" role in transcription.

198 mice deficient for NF-E2 (the thrombopoietic master regulator), the absence of membrane budding corre

199 s such as WEE1, together with the cell cycle master regulator, CDK7.

200 hase entry by inhibiting the activity of the master regulator, CtrA.

201 a member of the CCR4-NOT complex, which is a master regulator, orchestrating gene expression, RNA dea

202 SPAK kinase (STK39) is the CCC master regulator, which stimulates NKCC1 ionic influx an

203 and transcriptional upregulation of TET2, a master-regulator of cytosine modification status.

204 missense mutation in hilD, that encodes the master-regulator of the Salmonella Pathogenicity Island

205 Moreover, both MA-TAM master regulators and their target genes are significant

206 s (eQTL) analysis detects hotspots harboring master regulators controlling important fruit quality tr

207 iptional response to CYP2J2 silencing; these master regulators have been implicated in aberrant cardi

208 miRNAs) are small noncoding RNAs that act as master regulators in many biological processes.

209 itization and replication of high-confidence master regulators of AD-associated networks, including t

210 t body of work posits matrix constituents as master regulators of autophagy and angiogenesis and prov

211 function of transcription factors acting as master regulators of cell fate as well as activation or

212 Rho guanosine triphosphatases (GTPases) are master regulators of cell shape and cell movement [1].

213 esicles (EVs) of endosomal origin, emerge as master regulators of cell-to-cell signaling in physiolog

214 rring and regenerative phenotypes to uncover master regulators of fibrosis.

215 2-cyclin-dependent kinase (Cdk)1, one of the master regulators of G2/M cell cycle progression in U. m

216 RNA-binding proteins (RBPs) function as master regulators of gene expression.

217 these enzymes and transcription factors are master regulators of hundreds of genes and proteins that

218 vated the NF-kappaB complex along with other master regulators of inflammation.

219 nnate lymphoid cells (ILC3s) have emerged as master regulators of intestinal health and tissue homeos

220 sponsive transcription factors TFEB and TFE3-master regulators of lysosomal biogenesis and autophagy-

221 ch complex that recruit meiotic HORMADs, the master regulators of meiotic recombination.

222 However, the potential of master regulators of metabolism to control innate immuni

223 Canonical plant phytochromes are master regulators of photomorphogenesis and the shade av

224 fy this complex as a hub for repressing both master regulators of reproductive development and endoge

225 MTA1, CAMTA2, and CAMTA3 (CAMTA123) serve as master regulators of salicylic acid (SA)-mediated immuni

226 Rafts have been strongly implicated as master regulators of signal transduction in cancer, wher

227 miRNAs are master regulators of signaling pathways critically invol

228 Integration of ChIP-seq and RNA-seq data for master regulators of the Hippo pathway across normal hum

229 ival endpoints in ccRCC were identified, and master regulators of the transition from the normal to d

230 ate that EBV latent antigens can function as master regulators of this multisubunit repressor complex

231 nd SOX2 are hypothesized to be co-repressive master regulators of tracheoesophageal fates, this is un

232 Nevertheless, master regulators or, more precisely, lineage-defining t

233 etastatic hallmark, but detecting underlying master regulators that drive pathological gene expressio

234 Wilms tumor 1 (WT1) and beta-catenin are two master regulators that play opposing roles in podocyte b

235 The identified master regulators were statistically inferred to causall

236 ilizes these codes to predict CIGs and their master regulators with high accuracy.

237 dentify mild/moderate asthma genes and their master regulators.

238 ork to uncover CIGs and further define their master regulators.

239 ds to identify severe asthma genes and their master regulators.

240 ovel therapeutic strategies targeting these 'master' regulators for better patient outcome.

241 s a childhood cancer that expresses myogenic master regulatory factor MYOD but fails to differentiate

242 ual differentiation is controlled by diverse master regulatory factors across the animal kingdom.

243 Mastering relational concepts and applying them to diffe

244 he signaling molecule c-di-GMP binds BldD, a master repressor, to control initiation of development.

245 The RNase Regnase-1 is a master RNA regulator in macrophages and T cells that deg

246 additional graduate degree, most commonly a master's degree (7 of 23) and doctor of philosophy (7 of

247 h non-coders programming skills on a blended Master's degree module for a Health Informatics programm

248 y with next-generation sequencing (NGS) in a master screening protocol.

249 h NGS and selected immunohistochemistry in a master screening protocol.

250 to 13.5, p = 0.011) and angiogenesis (total master segments length, group difference: 549; 95% CI: 1

251 genomes from plants inoculated with a cloned master sequence revealed naturally occurring variants, a

252 e also report an excellent candidate for the master sex-determination gene: a translocated copy of Am

253 alternative pre-mRNA splicing of xol-1, the master sex-determination switch gene that triggers male

254 Master splicing regulator MBNL1 shapes large transcripto

255 assessing stability of each block through a Master Stability Function.

256 ressor protein is a transcription factor and master stress response mediator, and it is subject to re

257 Language processing involves the ability to master supra-regular grammars, that go beyond the level

258 strument based on a 5-point Likert scale (5="master surgeon" and 1="surgeon-in-training").

259 te that nSMase2 acts, at least in part, as a master switch in the TNF-alpha mediated inflammatory res

260 threonine-protein kinase 1), which acts as a master switch that controls whether the cell undergoes N

261 Here, we report identification of a master switch to enable this control for PLCbeta enzymes

262 s such as insulin and glucagon, the cellular master switches 5' AMP-activated protein kinase and mTOR

263 n and nutrient levels as important metabolic master switches in neuroblastoma cells and identified cr

264 lization dynamics of the key regulators that master the two intertwined and transient transcription w

265 he reader with the key elements allowing for mastering the conjugation of Ab to AuNP and rationalizin

266 Mastering the connection between surface features and co

267 logical machines readily reveals that Nature masters the full gamut of chemical interactions to compo

268 take on new challenges and figure out how to master them.

269 icting productive transcription by RNAPII at master transcription factor (MITF)-regulated endolysosom

270 lls caused by ectopic expression of Prox1, a master transcription factor for lymphatic specification.

271 type signals that regulate expression of the master transcription factor for meiotic entry, IME1.

272 g) instability, characterized by loss of the master transcription factor Foxp3 and acquisition of pro

273 lectin CLEC16A is located next to CIITA, the master transcription factor of HLA class II (HLA-II), at

274 id-related orphan receptor (ROR)-gammat, the master transcription factor of the Th17 subset of CD4(+)

275 the activation-dependent upregulation of the master transcription factor PLZF did not require CD28-co

276 muscle progenitors that inducibly express a master transcription factor, Pax7, we systematically cha

277 ls on the androgen receptor (AR), a prostate master transcription factor.

278 ancers that are co-bound by lineage-specific master transcription factors (MTFs) and signaling transc

279 e discovery of CD4(+) T cell subset-defining master transcription factors and framing of the Th1/Th2

280 P and SphK2 in regulating hypoxia-responsive master transcription factors hypoxia-inducible factor (H

281 ls through epigenetic repression of stemness master transcription factors NANOG and OCT4.

282 pulations, PADI4 downregulated expression of master transcription factors of stemness, NANOG and OCT4

283 teins that tightly control the expression of master transcription factors, effectors, and supportive

284 n cell types, e.g., by induced expression of master transcription factors, holds great promise for ce

285 ne that regulates plant growth, in which the master transcriptionactivator EIN3 (Ethylene Insensitive

286 antibiotics, and motility are controlled by master transcriptional and post-transcriptional regulato

287 tion gene family protein that functions as a master transcriptional corepressor in hematopoiesis.

288 nscriptionally induced by RIPENING INHIBITOR master transcriptional factor, as well as by PHY-mediate

289 the flagellar C ring with the action of the master transcriptional regulator FlrA (named FleQ in oth

290 ch as tumor necrosis factor-alpha (TNF), the master transcriptional regulator nuclear factor (NF)-kap

291 Furthermore, WRINKLED1, a master transcriptional regulator of FAS, positively regu

292 e show that transcription factor EB (TFEB)-a master transcriptional regulator of lysosomal biogenesis

293 synthesis, and ELONGATED HYPOCOTYL5 (HY5), a master transcriptional regulator of photomorphogenesis.

294 ndent on downregulation of expression of the master transcriptional regulator, neuron restrictive sil

295 ken together, our findings reveal Foxp1 as a master transcriptional repressor of brown/beige adipocyt

296 The master tumor suppressor p53 controls transcription of a

297 presentative DWV variants, including the two master variants of DWV-type A and B-was used.

298 AtxA, the master virulence gene regulator of Bacillus anthracis, i

299 ed cells of different types fall on the same master volume-area curve.

300 Pregnane X receptor (PXR) is a master xenobiotic-sensing transcription factor and a val