ライフサイエンスコーパス: master regulator

1 ate stress response, with PhoR acting as the master regulator.

2 ablished by multifaceted kinase control by a master regulator.

3 dentify mild/moderate asthma genes and their master regulators.

4 ork to uncover CIGs and further define their master regulators.

5 ators and identifies biologically meaningful master regulators.

6 ds to identify severe asthma genes and their master regulators.

7 ion, which has recently been identified as a master regulator affecting many cancer-relevant pathways

8 Gene network inference and master regulator analysis (MRA) have been widely adopted

9 Master regulator analysis revealed SOX2 as a transcripti

10 a well-established network biology approach (master regulator analysis) to combine a transcriptional

11 a major phosphatase to stabilize a metabolic master regulator and drive anabolism.

12 For example, Oct4, a master regulator and inducer of stem cell pluripotency,

13 silico perturbations of the network identify master regulators and destabilizers of its attractors.

14 atasets, our method ensures the existence of master regulators and identifies biologically meaningful

15 Moreover, both MA-TAM master regulators and their target genes are significant

16 auxin is upstream of LBD29 in repressing NAC master regulators, and therefore shed new light on the r

17 as9 validation screening shows 56% of tested master regulators are important for the viability of NTR

18 However, recent studies indicate that the master regulators are often coexpressed.

19 ified hyper-activation of the E2F cell-cycle master regulator as driver of AR indifferent growth, whi

20 of Pbx1, Fgf8, Dusp6, Vangl2, the hair-cell master regulator Atoh1 and a cascade of Atoh1's downstre

21 Conversely, conditional deficiency of the master regulator Bcl6 in CD4(+) T cells resulted in a ma

22 s such as WEE1, together with the cell cycle master regulator, CDK7.

23 nd then performed RNA-sequencing followed by Master Regulator computational analysis.

24 s (eQTL) analysis detects hotspots harboring master regulators controlling important fruit quality tr

25 also show how coding change in a pleiotropic master regulator could have small, quantitative effects

26 hase entry by inhibiting the activity of the master regulator, CtrA.

27 is crucial to induce the degradation of the master regulator cyclin D1.

28 Our work thus establishes Borealin as a master regulator determining the chromosome association

29 Caspofungin hypersusceptibility requires the master regulator Efg1, working in concert with Gcn5.

30 rentiation through stabilizing the erythroid master regulator erythroid Kruppel-like factor (EKLF, al

31 nd that ArcZ and OmrAB repress the flagellar master regulator flhD post-transcriptionally.

32 lagellar motility by acting primarily on the master regulator, FlhD, but also through additional fact

33 the transactivation of myocardin (MYOCD), a master regulator for SMC-specific gene transcription by

34 , which inhibits the expression of ComK, the master regulator for the K-state, and reduces transforma

35 STRIPAK also serves as a master regulator for the STE20 family kinases.

36 ovel therapeutic strategies targeting these 'master' regulators for better patient outcome.

37 tor, YY1, is required for the cell-specific "master regulator" functions of PLZF.

38 in independent cohorts, we identified (1) a master regulator gene common to asthma across severity a

39 The lung lineage master regulator gene, Thyroid Transcription Factor-1 (T

40 or of autophagy, was identified as a hub, or master regulator, gene.

41 Comparative analysis of the master regulator genes followed by validation testing in

42 The identified master regulator genes of asthma provide a novel path fo

43 C23, TMEM231, CAPS, PTPRC, and FYB); and (3) master regulator genes of mild/moderate persistent asthm

44 asthma across severity and ages (FOXJ1); (2) master regulator genes of severe persistent asthma in ch

45 beyond gene signatures of asthma to identify master regulator genes that causally regulate genes asso

46 iptional response to CYP2J2 silencing; these master regulators have been implicated in aberrant cardi

47 own-regulation of SPI-1 genes depends on the master regulator HilD, and altering translational fideli

48 red (R) light-regulated genes, including the master regulator HY5.

49 that may display properties of an oncofetal master regulator in human cancers.

50 Our findings of GATAe as a potential master regulator in the events of growth control and cel

51 In summary, we identify ARID4B as a master regulator in the PTEN-PI3K pathway, thus providin

52 miRNAs) are small noncoding RNAs that act as master regulators in many biological processes.

53 sgenic studies demonstrated LBD29 depends on master regulators in mediating SCW biosynthesis, specifi

54 The common master regulators in rice in response to the infection o

55 ted that 34 upregulated and 12 downregulated master regulators in rice interacting with the fungus pr

56 and variants, including the transcriptional master regulators in the liver and kidney, HNF1A and HNF

57 -specific transcriptional activation by PrCa master-regulators (including androgen receptor) in Posit

58 Systems biology approaches identify numerous master regulators, including 41 kinases and 23 transcrip

59 One of these proteins, p53, is a master regulator involved in a large panel of biological

60 Our data demonstrate that the promoter of a master regulator is primed for rapid activation while re

61 In this context, the expression of the "master regulator" is necessary and sufficient to activat

62 hemokine receptors S1PR1 and CCR7, and their master regulator KLF-2, and reduced chemotaxis toward S1

63 the transcriptional level by repressing the master regulator, ler Our data support a model in which

64 prophage in the essentiality of SOS response master regulator LexA, which is otherwise not essential

65 aling factors nor involvement of the RNAPIII master regulator Maf1.

66 functionally with other organelles, and the master regulator mechanistic target of rapamycin complex

67 this process is largely orchestrated by the master regulator MYC2 and related transcription factors

68 Furthermore, biofilm defects associated with master regulators, namely, biofilm and cell wall regulat

69 Core pluripotency stem cell master regulators (OCT4, SOX2 and NANOG) along with epit

70 synthetic genetic interaction with Hac1, the master regulator of a second proteotoxic stress response

71 ckout tumors identified a role for E2F1 as a master regulator of a suite of pro-metastatic genes, but

72 Cep55 protein is regarded as the master regulator of abscission, because it recruits ESCR

73 can buffer the effective membrane tension-a master regulator of all cell deformations.

74 ription factor 4 (ATF4), the transcriptional master regulator of amino acid metabolism, to supply glu

75 as deleted in the presence or absence of the master regulator of antioxidant defense nuclear factor e

76 It is thought that S256 is the master regulator of AQP2 trafficking and membrane accumu

77 It is thought that serine 256 is the master regulator of AQP2 trafficking, and its phosphoryl

78 , thereby matching many of the criteria of a master regulator of AS in SMCs.

79 n factor EB (TFEB) has recently emerged as a master regulator of autophagosome-lysosome function, con

80 Transcription factor EB (TFEB), a master regulator of autophagy and lysosome biogenesis, i

81 or, Deleted in Colorectal Cancer (DCC), is a master regulator of axonal crossing throughout the neura

82 In summary, our data identify p62 as a master regulator of BAT function in that it controls the

83 osphate-activated protein kinase (AMPK) is a master regulator of bioenergetics crucial for glucose me

84 Catabolite control protein A (CcpA) is a master regulator of carbon source utilization and contri

85 eostasis, analogous to SOX9's dual role as a master regulator of cartilage and an important regulator

86 yperactivation of mTOR Complex 1 (mTORC1), a master regulator of cell growth and metabolism.

87 AMP-activated protein kinase (AMPK), a master regulator of cellular energy homeostasis, partly

88 Thus, ANAC017 is a master regulator of cellular responses with mitochondria

89 s that the retrotrapezoid nucleus (RTN) is a master regulator of central chemoreception, in particula

90 4 (PLK4) is a Ser/Thr protein kinase and the master regulator of centriole duplication, but it may pl

91 uitination of polo-like kinase 4 (PLK4), the master regulator of centrosome duplication.

92 evealed late-phase activation of SREBP2, the master regulator of cholesterol biosynthesis genes.

93 The master regulator of chromosomal replication, DnaA, was f

94 er recent findings(3,4) establish TRAIP as a master regulator of CMG unloading and the response of th

95 Although Nrf2 has been recognized as a master regulator of cytoprotection, its functional signi

96 2 signaling pathway has been considered as a master regulator of cytoprotective genes, and exists in

97 We identify the dopamine transporter as a master regulator of dopamine short-term plasticity, gove

98 status of (yet another) DNA damage factor to master regulator of double-strand break (DSB) repair pat

99 irectly represses the expression of T-bet, a master regulator of effector T cell function.

100 promotes optimal transcription of Wt1 as the master regulator of embryonic EPDCs.

101 ays that regulate the expression of SNAI2, a master regulator of EMT, and provides new insights into

102 Nrf2 is a master regulator of endogenous cellular defences, govern

103 osphate-activated protein kinase (AMPK) is a master regulator of energy homeostasis in eukaryotes.

104 le of AMP-activated protein kinase (AMPK), a master regulator of energy metabolism, in response to ZI

105 n tumor suppressor, but its sibling p63 is a master regulator of epidermis development and a key onco

106 in CRC, and we have characterized it to be a master regulator of epithelial-mesenchymal transition (E

107 AKT/GSK3beta to stabilize Snail1 protein, a master regulator of epithelial-mesenchymal transition (E

108 TGF-beta is a master regulator of fibrosis, driving the differentiatio

109 e show that the transcription factor Ume6, a master regulator of filamentation, inhibits gut coloniza

110 We identify the master regulator of floral fate, LEAFY (LFY) as a target

111 APE1 acts also as a master regulator of gene expression through its redox ac

112 egy to rapidly and reversibly inactivate the master regulator of genome activation in Drosophila, Zel

113 as a direct transcriptional repressor of the master regulator of growth, Myc.

114 ngineer porcine embryos deficient in ETV2, a master regulator of hematoendothelial lineages(3-7).

115 PU.1 is a master regulator of hematopoiesis and promotes myeloid d

116 y the hermaphrodite-specific transcriptional master regulator of hermaphroditic cell identity tra-1,

117 GPRASP2 promote the degradation of CXCR4, a master regulator of HSC function during transplantation.

118 Mechanistic studies identified MPL, the master regulator of HSC identity(5), as a bona fide ERAD

119 ng site for the aryl hydrocarbon receptor, a master regulator of IL-22 production.

120 IL-10 is a master regulator of immune responses, but its cellular s

121 s accomplished through the activation of the master regulator of inflammation, dual-specificity phosp

122 duced by multiple TLR stimuli and acted as a master regulator of inflammatory responses.

123 The master regulator of interferon-mediated antiviral respon

124 Inflammation-inducible cytokines and the master regulator of iron homeostasis, hepcidin, block in

125 Hepcidin is the master regulator of iron metabolism.

126 we discovered that NS2 palmitoylation is the master regulator of its multiple functions, including NS

127 tivate the transcription factor EB (TFEB), a master regulator of lipid metabolism and lysosomal bioge

128 ocyte nuclear factor 4alpha (HNF4alpha) is a master regulator of liver function and a tumor suppresso

129 Thus, Notch2 is a master regulator of Ly6C(hi) monocyte cell fate and infl

130 The master regulator of lymphatic development, Prox1, bound

131 show that transcription factor EB (TFEB), a master regulator of lysosomal biogenesis and autophagy(4

132 Transcription Factor EB (TFEB), a master regulator of lysosomal biogenesis and autophagy,

133 ylation of transcription factor EB (TFEB), a master regulator of lysosomal biogenesis and autophagy.

134 e that the transcription factor EB (TFEB), a master regulator of lysosomal biogenesis, plays an essen

135 N enabled mTORC1-dependent regulation of the master regulator of lysosomal biogenesis, transcription

136 tophagy genes and transcription factor EB, a master regulator of lysosomal biogenesis.

137 lcineurin, which in turn activates TFEB, the master regulator of lysosomal biogenesis.

138 ion of the transcription factor EB (TFEB), a master regulator of lysosomal functions and autophagy.

139 CDK1 substitutes for inhibited mTORC1 as the master regulator of macroautophagy during mitosis, uncou

140 finger transcription factor proposed to be a master regulator of male courtship and mating behavior a

141 lts highlight an unexpected repurposing of a master regulator of male-specific sexual behavior to con

142 NA hypomethylation permits CTCF binding, the master regulator of mammalian chromatin structure, which

143 The circadian clock is a master regulator of mammalian physiology, regulating dai

144 This study thus identifies Gmeb1 as a master regulator of mDA gene expression and function, an

145 C), which includes the kinase Aurora B, is a master regulator of meiotic and mitotic processes that e

146 Thus, autophagy destroys a master regulator of meiotic gene expression to enable ir

147 The MITF transcription factor is a master regulator of melanocyte development and a critica

148 The Na(+)/K(+)-ATPase (NKA) complex is the master regulator of membrane potential and a target for

149 act that the transcription factor ATOH1 is a master regulator of Merkel cell development, its role in

150 AMPK is a highly conserved master regulator of metabolism, which restores energy ba

151 We find that PAX8 is a master regulator of migration with unique downstream tra

152 receptor gamma coactivator (PGC)-1alpha is a master regulator of mitochondrial biogenesis and control

153 tor-gamma coactivator-1alpha (PGC-1alpha), a master regulator of mitochondrial biogenesis, antioxidan

154 xploring functional links to PGC-1alpha, the master regulator of mitochondrial biogenesis, we searche

155 vated receptor gamma coactivator 1alpha, the master regulator of mitochondriogenesis, was also enhanc

156 ator of transcription 3 (STAT3) protein is a master regulator of most key hallmarks and enablers of c

157 ogen receptor (AR) transcription factor is a master regulator of normal glandular homeostasis in the

158 Despite being a master regulator of oligodendrocytes, oligodendrocyte en

159 1) and the nuclear accumulation of NFATc1, a master regulator of osteoclast function, possibly throug

160 tor PHOSPHATE STARVATION RESPONSE1 (PHR1), a master regulator of P sensing and signaling.

161 sis thaliana MADS-box TF PHERES1 (PHE1) is a master regulator of paternally expressed imprinted genes

162 se CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1), a master regulator of plant growth.

163 biotic and abiotic stress responses and is a master regulator of plant-environmental interactions.

164 directly activates the expression of mvfR, a master regulator of pqs system, and subsequently promote

165 se (PERK) branch of the UPR functions as the master regulator of protein translation in ER-stressed c

166 entified the c-Maf transcription factor as a master regulator of protumoral TAM polarization.

167 gy 2 domain-containing protein (p66Shc) is a master regulator of reactive oxygen species (ROS).

168 tion were due to the activation of NRF2, the master regulator of redox stress tolerance.

169 r findings thus demonstrate that ARFRP1 is a master regulator of retrograde-carrier tethering to the

170 The general transcription factor P-TEFb, a master regulator of RNA polymerase (Pol) II elongation,

171 ce the stability of the PLETHORA2 protein, a master regulator of root stem cells.

172 n of the transcriptional coactivator NPR1, a master regulator of SA signaling.

173 thaliana) ORESARA1 (ORE1), the developmental master regulator of senescence, as a direct CPK1 phospho

174 in Plasmodium falciparum using PfAP2-G, the master regulator of sexual conversion, as a marker of co

175 The transcription factor TRA-1 is the master regulator of somatic sexual differentiation in th

176 ) signaling and induces expression of Bmi-1 (master regulator of stem cell self-renewal) in dental pu

177 Evidence indicates that Hsf1, a master regulator of stress response, mediates B2 RNA pro

178 identify the GLI2 transcription factor as a master regulator of subtype inter-conversion.

179 We found that hepcidin, the master regulator of systemic iron homeostasis, is requir

180 tory relationship between NOTCH and FOXN1, a master regulator of TEC differentiation.

181 uclear long noncoding RNA (lncRNA) H19X as a master regulator of TGF-beta-driven tissue fibrosis.

182 abolic reprogramming and upregulates NRF2, a master regulator of the antioxidant network.

183 in vitro, MCs hindered activation of cMET, a master regulator of the basal program, and simultaneousl

184 o tumor growth, indicating that it acts as a master regulator of the CAF state.

185 ng of its core control process, in which the master regulator of the cell cycle, cyclin-dependent kin

186 TOR is a master regulator of the cell's growth and metabolic stat

187 The ATR kinase is a master regulator of the cellular response to DNA replica

188 Together, our study uncovers a master regulator of the cholesterol-biosynthesis program

189 ATM kinase is a tumor suppressor and a master regulator of the DNA damage response.

190 ATR functions as a master regulator of the DNA-damage response.

191 determined that gene repression requires the master regulator of the epidermal differentiation progra

192 n endoplasmic reticulum (ER) chaperone, is a master regulator of the ER stress.

193 egulates flagellar function and besides, the master regulator of the flagellar synthesis signaling pa

194 am, divergent from its canonical role as the master regulator of the heat shock response, leading to

195 In eukaryotes, HSF1 is the master regulator of the heat shock transcriptional respo

196 er (BTB/POZ) transcription factor family and master regulator of the immune cells in the GC reaction.

197 The transcription factor NF-kB is a master regulator of the innate immune response and plays

198 osed transcriptional repression on WRKY33, a master regulator of the JA/ET signalling pathway.

199 rough loss- and gain-of-function of CIITA, a master regulator of the MHCII pathway.

200 de-of-action of NIN-LIKE PROTEIN 7 (NLP7), a master regulator of the nitrogen signaling pathway in pl

201 Our data indicate that TRAIP is a master regulator of the processing of incomplete DNA rep

202 A binding pattern of RELA - a NF-kB subunit, master regulator of the response to infection - under ba

203 meristem, and they strongly support AP2 as a master regulator of this process.

204 The Hippo pathway is a master regulator of tissue homeostasis and organ size.

205 ipper (bZIP) transcription factor, acts as a master regulator of transcription to promote photomorpho

206 tivator (PGC)-1alpha, has been proposed as a master regulator of tumor oxidative phosphorylation.

207 tv2 functions as an evolutionarily conserved master regulator of vasculogenesis.

208 We identify Dead-end1 (Dnd1), a master regulator of vertebrate germline development, as

209 ense, which has two orthologs of AtVND7, the master regulator of vessel formation.

210 sequence of the prfA gene, which encodes the master regulator of virulence genes, has been previously

211 We used overexpression of microRNA156, the master regulator of VPC, to modulate the timing of VPC i

212 ost complex layer of the wall and may be the master regulator of wall physiology and pathobiology.

213 ctive-specific transcript (Xist) gene is the master regulator of X chromosome inactivation in mammals

214 Xist RNA, the master regulator of X chromosome inactivation, acts in c

215 nd X inactive specific transcript (XIST)-the master regulator of XCI-which are silenced after entry i

216 itization and replication of high-confidence master regulators of AD-associated networks, including t

217 t body of work posits matrix constituents as master regulators of autophagy and angiogenesis and prov

218 most vertebrate taxa, are thought to be the master regulators of bone modeling, a process of coordin

219 function of transcription factors acting as master regulators of cell fate as well as activation or

220 ling complexes, mTORC1 and mTORC2, which are master regulators of cell growth, metabolism, survival a

221 Rho guanosine triphosphatases (GTPases) are master regulators of cell shape and cell movement [1].

222 esicles (EVs) of endosomal origin, emerge as master regulators of cell-to-cell signaling in physiolog

223 We show that CTCF and cohesin, which are master regulators of chromatin architecture, display low

224 Polycomb group (PcG) proteins repress master regulators of development and differentiation thr

225 changes within cell lineages, and identified master regulators of differentiation pathways.

226 We identified four possible master regulators of energy metabolism, which all were g

227 rring and regenerative phenotypes to uncover master regulators of fibrosis.

228 2-cyclin-dependent kinase (Cdk)1, one of the master regulators of G2/M cell cycle progression in U. m

229 Transcription factors (TFs) are master regulators of gene expression by binding to speci

230 scription factors (TFs) are dosage-sensitive master regulators of gene expression, with haploinsuffic

231 RNA-binding proteins (RBPs) function as master regulators of gene expression.

232 MicroRNAs (miRNAs) function as master regulators of gene expression.

233 SNF, establishing a relationship between two master regulators of genome organization.

234 Cohesin and CTCF are master regulators of genome topology.

235 these enzymes and transcription factors are master regulators of hundreds of genes and proteins that

236 vated the NF-kappaB complex along with other master regulators of inflammation.

237 nnate lymphoid cells (ILC3s) have emerged as master regulators of intestinal health and tissue homeos

238 sponsive transcription factors TFEB and TFE3-master regulators of lysosomal biogenesis and autophagy-

239 ch complex that recruit meiotic HORMADs, the master regulators of meiotic recombination.

240 However, the potential of master regulators of metabolism to control innate immuni

241 Members of the MYC family of oncogenes are master regulators of mRNA translation.

242 of transcription factors STAT3 and BCL-3 as master regulators of MRP-induced tolerance.

243 molecular identity that makes it one of the master regulators of neural plasticity and excitability.

244 nd show that these transcription factors are master regulators of neuropsychiatric function.

245 n cell homeostasis maintenance as one of the master regulators of oxidative and electrophilic stress

246 on between the activities of AMPK and HIF-1, master regulators of OXPHOS and glycolysis, respectively

247 Canonical plant phytochromes are master regulators of photomorphogenesis and the shade av

248 hat during embryonic development function as master regulators of positional identity.

249 fy this complex as a hub for repressing both master regulators of reproductive development and endoge

250 Plants are master regulators of rhizosphere ecology, secreting a co

251 MTA1, CAMTA2, and CAMTA3 (CAMTA123) serve as master regulators of salicylic acid (SA)-mediated immuni

252 Rafts have been strongly implicated as master regulators of signal transduction in cancer, wher

253 miRNAs are master regulators of signaling pathways critically invol

254 Integration of ChIP-seq and RNA-seq data for master regulators of the Hippo pathway across normal hum

255 novel KSHV regulator.IMPORTANCE Viruses are master regulators of the host gene expression machinery.

256 called switch genes previously suggested as master regulators of the ripening onset in grape berries

257 NEv2, BooleaBayes predicts ELF3 and NR0B1 as master regulators of the subtype, and TCF3 as a master d

258 ival endpoints in ccRCC were identified, and master regulators of the transition from the normal to d

259 Master regulators of the unfolded protein response (UPR)

260 that the small MAF transcription factors are master regulators of the VEGFA transcriptional program a

261 ate that EBV latent antigens can function as master regulators of this multisubunit repressor complex

262 nd SOX2 are hypothesized to be co-repressive master regulators of tracheoesophageal fates, this is un

263 s of genes encoding virulence factors and to master regulators of virulence.

264 and transcriptional upregulation of TET2, a master-regulator of cytosine modification status.

265 missense mutation in hilD, that encodes the master-regulator of the Salmonella Pathogenicity Island

266 Nevertheless, master regulators or, more precisely, lineage-defining t

267 a member of the CCR4-NOT complex, which is a master regulator, orchestrating gene expression, RNA dea

268 d inhibition of the function of the myogenic master regulator PAX7.

269 ide gene expression given gene knockouts and master regulator perturbations.

270 the circadian dependency of the adipogenesis master regulator PPARgamma.

271 genes from promoter P(Q) is inhibited by the master regulator PrgX, further repressed when PrgX is in

272 kinases CDK9, CDK12, and CDK13, invoking a "master regulator" role in transcription.

273 Transcriptional activity of the 2 master regulators sigma B and RpiRc was drastically redu

274 state in which cells express the competence master regulator, SigX (sigma(Chi)), an alternative sigm

275 tes EMT through the up-regulation of the EMT master regulator Slug, a process that is dependent on bo

276 leading to premature stop codons within the master regulator, Spo0A.

277 nd identifies additional GRNs and associated Master Regulators, such as SOX11 and KLF5 in Basal-like

278 r expression at veraison of several ripening master regulators "switch genes" can play a central role

279 network analysis identified miR-508-3p as a master regulator that defines the mesenchymal subtype an

280 and conditional deletion revealed IRF8 as a master regulator that drives the maturation and diversit

281 -MS/MS revealed that FloR is a physiological master regulator that operates through subordinate pleio

282 as aeruginosa, LasR is a quorum sensing (QS) master regulator that senses the concentration of secret

283 he mechanistic Target of Rapamycin (mTOR), a master regulator that when activated promotes cell growt

284 Ras monomeric GTPases are master regulators that direct many of the cytokines know

285 etastatic hallmark, but detecting underlying master regulators that drive pathological gene expressio

286 Wilms tumor 1 (WT1) and beta-catenin are two master regulators that play opposing roles in podocyte b

287 mice deficient for NF-E2 (the thrombopoietic master regulator), the absence of membrane budding corre

288 ifferences in C. elegans are governed by the master regulator tra-1, whose activity is controlled by

289 computational approach for identification of master regulator transcription factor in a genome.

290 s of gene regulatory networks (GRNs) yielded master regulator transcription factors associated with W

291 key distal regulatory regions and associated master regulator transcription factors that can be targe

292 This 'master regulator' transcription factor is at the top of

293 Our work thus illustrates how a master regulator uses two types of BRCT domains to recog

294 omotes xylem differentiation through a known master regulator VASCULAR-RELATED NAC-DOMAIN6 (VND6).

295 The identified master regulators were statistically inferred to causall

296 onably well in validating the existence of a master regulator when the number of subjects in each tre

297 Here, we demonstrate that HPSE is a master regulator where, in addition to directly enabling

298 sphoinositide-dependent-Kinase-1 (PDK1) is a master regulator whereby its PI3-kinase-dependent dysreg

299 SPAK kinase (STK39) is the CCC master regulator, which stimulates NKCC1 ionic influx an

300 ilizes these codes to predict CIGs and their master regulators with high accuracy.