ライフサイエンスコーパス: maternal

1 n telomere attrition from 4 to 18 months and maternal ACEs was examined as a predictor of infant scor

2 Higher maternal ACEs were associated with shorter infant TL acr

3 The maternal AChR-Ab positive plasmas reduced fetal AChR cur

4 A vaccine to prevent maternal acquisition of human cytomegalovirus (HCMV) dur

5 lying mechanisms relate more to differential maternal adaptation in early pregnancy than fetal geneti

6 ; 1.10)] suggesting no specific influence of maternal adiposity as such.

7 Maternal adiposity was associated with increased amounts

8 of prenatal immune activation often involve maternal administration of agents that activate toll-lik

9 Sensitivity, specificity, preterm delivery, maternal adverse effects, congenital birth defects, chil

10 Maternal adverse events from treatment were infrequent a

11 Maternal age <20 years (hazard ratio [HR]: 2.40; 95% con

12 ducted for parity (nulliparous/multiparous), maternal age (<35/>=35 years), and body mass index (BMI)

13 odds of preterm birth, which increased with maternal age (1.80 [1.16-2.79] in 20-29 years, 2.19 [1.2

14 Maternal age at birth, maternal level of education, hous

15 sk of adverse mental health included younger maternal age at cancer diagnosis, low socioeconomic stat

16 eatures of female meiosis, for instance, the maternal age effect on PSSC.

17 semi-captive Asian elephants to investigate maternal age effects on several offspring life-history t

18 ernal effects on early life survival such as maternal age may act through their influence on infant b

19 rican-American women and in women with older maternal age, hypertensive disorders of pregnancy, and m

20 age, ethnicity, deprivation) and maternity (maternal age, maternal smoking, sex-gestation-specific b

21 disease during pregnancy is rising as older maternal age, obesity, diabetes mellitus and hypertensio

22 st regression was carried out, adjusting for maternal age, smoking, parity, ethnicity, neonate sex, a

23 gistic regression, adjusting for parity, and maternal age.

24 g to pre-pregnancy body mass index (BMI) and maternal age.

25 eproductive decline associated with advanced maternal age.

26 Significant biases for maternal alleles were detected on 5 (of 12) chromosomes

27 To better understand the effects of maternal allocation on offspring survival and growth, we

28 aternal features when assessing variation in maternal allocation.

29 ovision in routine clinical settings such as maternal and child health facilities might contribute to

30 Women and girls older than 15 years seeking maternal and child health services who tested HIV negati

31 n explaining the ramifications of smoking on maternal and child health was effective and feasible in

32 Pooled data analysis in the field of maternal and child nutrition rarely incorporates data fr

33 omic metrics globally, including progress in maternal and child nutrition.

34 ates of childhood wasting in the short term, maternal and child undernutrition rates are also likely

35 ation were anesthetized with isofluorane and maternal and fetal catheters and flow probes were implan

36 elevates inflammatory cytokine levels in the maternal and fetal compartments and causes behavioral ch

37 mechanisms and the relative contributions of maternal and fetal genetic effects behind these observed

38 However, maternal and fetal genetic factors and the molecular mec

39 sought to describe clinical characteristics, maternal and fetal outcomes, and cardiovascular readmiss

40 Maternal and infant RSV titers were strongly correlated.

41 al outcomes were also collected according to maternal and neonatal medical records.

42 Although maternal and neonatal mitochondrial bioenergetics were p

43 Maternal and newborn characteristics (health care settin

44 imed to assess the validity of indicators of maternal and newborn health-care coverage around the tim

45 dings provide new and important evidence for maternal and paediatric influenza immunisation, and shou

46 iciency virus (HIV) occurs in the setting of maternal and passively acquired antibodies, providing a

47 l Holocaust exposure or associated with both maternal and paternal age at Holocaust exposure were in

48 ts after controlling for gestational age and maternal and paternal BMIs.

49 Furthermore, maternal and paternal effects on offspring survival were

50 changes of shared DEGs associated with both maternal and paternal Holocaust exposure or associated w

51 pregnancies worldwide and causes significant maternal and perinatal morbidity and mortality.

52 Maternal and perinatal outcomes were also collected acco

53 utating the morpholino binding sites in both maternal and zygotic genes can ascertain the specificity

54 Low agonist doses did not cause maternal anemia but still adversely affected the embryo,

55 The concept that exposure in utero to maternal anti-brain antibodies contributes to the develo

56 f macrophage Toll-like receptor signaling in maternal anti-SSA/Ro-mediated congenital heart block (CH

57 e protection from infection, but gestational maternal antibodies have not yet been characterized in d

58 There is evidence that maternal antibodies provide some protection from infecti

59 er age 24 months, possibly indicating waning maternal antibodies.

60 binding resulted in enhanced accumulation of maternal antibody in the fetus.

61 transmission has dramatically decreased with maternal antiretroviral therapy, breast milk transmissio

62 cularly in attenuating the risk conferred by maternal asthma on childhood asthma or recurrent wheeze

63 first time that ASD-specific antigen-induced maternal autoantibodies produced alterations in a conste

64 t there has been limited research focused on maternal bacterial infection.

65 Both sex and maternal BCG vaccination status influenced the effect of

66 ugh maternal responses to pregnancy, altered maternal behavior, epigenetic modifications, or a combin

67 that help link the calls to a discriminative maternal behavioral response.

68 ges are essential for adequate expression of maternal behaviour, thereby ensuring proper development

69 L) plays a crucial role in pregnancy-induced maternal beta-cell proliferation.

70 ividuals of both reciprocal crosses, whereas maternal biases were largely absent in low-fitness indiv

71 gh levels of soluble CORIN were confirmed in maternal blood from preeclamptic pregnancies compared wi

72 eding during pregnancy significantly reduces maternal blood TG levels.

73 (THg) concentrations in eggs increased with maternal blood THg concentrations; however, the proporti

74 Maternal blood, saliva, and cervicovaginal wash (CVW) sa

75 le iron isotopic enrichment were measured in maternal blood, umbilical cord blood, and placental tiss

76 exane sulfonate, and perfluoroundecanoate in maternal blood.

77 unseling about LHON should be offered to all maternal bloodline relatives, females and males of all a

78 Overall, maternal BMI, along with maternal socioeconomic status a

79 typic and the GRS associations may depend on maternal BMI, being weaker among mothers with overweight

80 PUFA-enriched 'Western' diets can reprogram maternal bodily metabolism with maternal nutrient supply

81 Maternal body mass index and gestational weight gain pre

82 Maternal burden of pre-pregnancy hypertension has nearly

83 a terminalis (BNST) of lactating mice during maternal care and analysed locomotor activity and anxiet

84 hoid cells (dILCs) interact with surrounding maternal cells and invading fetal extravillous trophobla

85 At the immediate level, changes in several maternal characteristics predicted modest stunting reduc

86 r age, socioeconomic position and infant and maternal characteristics.

87 ce of the transplanted uterus, the fetus and maternal circulation might provide valuable novel insigh

88 We hypothesized that STEV profiles in maternal circulation would be altered under conditions o

89 al bioenergetics were positively correlated, maternal CM only had a small effect on mitochondrial den

90 Here, we report that maternal contribution of histone H3.3 assembly complexes

91 loped risk prediction models specific to the maternal critical care population.

92 The maternal cumulative prevalence of infant mortality (mIM)

93 valence of under 5 mortality (mU5M), and the maternal cumulative prevalence of offspring mortality (m

94 ve prevalence of infant mortality (mIM), the maternal cumulative prevalence of under 5 mortality (mU5

95 Comprehensive maternal data collected during three study visits were a

96 There was one maternal death attributed to underlying disease and no n

97 dditional child deaths and 56 700 additional maternal deaths.

98 Maternal decisions, such as where to build a nest or whe

99 Maternal DeltagD-2 immunization provided significant pro

100 We determined the association between maternal depression and stress symptom trajectories and

101 In ascidian zygotes, maternal determinants (mRNAs) are first transported to t

102 In summary, maternal DHCR7 heterozygosity, combined with offspring D

103 Maternal diabetes can lead to pregnancy complications an

104 th BW, suggesting an opportunity to modulate maternal diet and improve long-term offspring cardiometa

105 The impact of maternal diet during pregnancy on child neurodevelopment

106 t Quality Score (PDQS; range: 0-42) assessed maternal diet quality based on consumption of 21 healthy

107 s for newborn epigenetic aging, specifically maternal dietary macronutrient intake, and whether epige

108 Maternal dolutegravir was described by a two-compartment

109 Additivity and maternal dominance accounted for approximately 42 and 25

110 f the Dorsal gradient is highly sensitive to maternal dorsal dosage.

111 a demonstrate an interactive pathway between maternal early-life adversity and infant TL that predict

112 d with antenatal exposure to smoking, higher maternal education levels, and wheezing at age 36-72 mon

113 elihood of early presentation; thus, focused maternal education may promote earlier detection and pre

114 for mid-childhood body mass index z scores, maternal education, smoking in pregnancy, and prenatal p

115 e from 5%-15% for 4+ ACEs and 1%-19% for low maternal education.

116 leles are eliminated via a dominantly-acting maternal effect combined with slower-acting standard neg

117 able to evaluate the fitness consequences of maternal effect senescence across species with diverse a

118 ic function, tbx5a, and one gene with strong maternal effect, ctnnb2.

119 frequency, while survival due to second-site maternal-effect suppressors occur at a ~10(-5) frequency

120 enetic effects in OCD are overestimated when maternal effects are not modeled.

121 We speculate that similar maternal effects might explain the missing heritability

122 This finding suggests that maternal effects on early life survival such as maternal

123 ch occurs when double fertilization precedes maternal (egg cell) genome loss.

124 The Ser/Thr protein kinase MELK (maternal embryonic leucine zipper kinase) has been consi

125 ent experienced by reproducing females (i.e. maternal environment).

126 n the length of gestation, neurogenesis, the maternal environment, and key features associated with m

127 (+/- 6.00%) of the phenotypic variance, the maternal environmental variance was significant for T1D

128 Maternal exercise (ME) during pregnancy has been shown t

129 pened tuning for pup vocalizations following maternal experience.

130 kely than females to develop psychosis after maternal exposure to any bacterial infection during preg

131 AD that emerged in early life as a result of maternal exposure to DEP.

132 could reduce the risk of PTD associated with maternal exposure to PM in ambient air during pregnancy.

133 In this study, we sequenced two maternal (factor H and C3) and one fetal (CD46) compleme

134 hereas late transient rhinitis may relate to maternal factors and early respiratory infections indepe

135 s specified by inductive signals rather than maternal factors, and support the existence of zygotical

136 ectrometry and identified 134 metabolites in maternal fasting plasma at 26-28 weeks of gestation.

137 light the importance of considering multiple maternal features when assessing variation in maternal a

138 protect against infection while leaving the maternal-fetal barrier intact.

139 s described to respond to IL-15 at the early maternal-fetal interface have been NK cells.

140 Modeling maternal-fetal transport in FcgammaR/FcRn humanized mice

141 development scores were not associated with maternal fructose and SSB + J consumption at 6 postnatal

142 Passively acquired maternal GBS-specific antibodies protect newborns from e

143 A study of maternal gene expression changes between different deliv

144 dy is to investigate the association between maternal gestational weight gain (GWG) and preterm birth

145 Maternal gestational weight gain was self-reported in 20

146 We used self-reported grand-maternal gestational weight gain, diet, physical activit

147 A positive association between maternal glycemia and neonatal AA was observed across th

148 Together, our findings show that the maternal gut microbiome promotes fetal thalamocortical a

149 'Dysbiosis' of the maternal gut microbiome, in response to challenges such

150 We hypothesized that maternal H. pylori status affects the maternal intestina

151 e infant fecal microbiota is affected by the maternal H. pylori status only in infants born vaginally

152 In 78 mother-infant dyads, maternal hair was sampled postnatally, and infants under

153 eristics (health care setting and timeframe; maternal health factors; child's size factors; child's f

154 mothers should be explored to reduce adverse maternal health outcomes.

155 Universal screening and convenient access to maternal health services for NICU mothers should be expl

156 n pregnancy outcomes, fetal development, and maternal health.

157 of this study was to quantify the effect of maternal heat exposure during early-mid gestation, when

158 cluding parity, interpregnancy interval, and maternal height.

159 o iron homeostasis, we mimicked the range of maternal hepcidin activity by administering a hepcidin p

160 To establish how essential maternal hepcidin suppression is for embryo iron homeost

161 ounteract pregnancy-dependent suppression of maternal hepcidin.

162 the dietary undersupply was combined with a maternal heterozygous variant in Haao, which alone does

163 Higher levels of maternal high-sensitivity C-reactive protein and glycopr

164 as associated with male gender, paternal and maternal history of atopy, eczema, and house dust mite s

165 These findings suggest that maternal HIV infection is independently associated with

166 We evaluated the impact of maternal HIV infection on the burden of RSV among mother

167 e at baseline (room air); phase II, 6-minute maternal hyperoxia with 100% oxygen; and phase III, 5.6-

168 Maternal hypertension is associated with adverse pregnan

169 e through pregnancy and can be sensitized by maternal IgE.

170 Maternal immune activation (MIA) disrupts the central in

171 Experimental animal models demonstrate that maternal immune activation (MIA) elevates inflammatory c

172 Maternal immune activation (MIA) is a proposed risk fact

173 The timing of maternal immune activation (MIA) may present distinct sc

174 Here we utilized a mouse model of maternal immune activation (MIA) with the viral mimic Po

175 Further, we highlight the role of maternal immune activation, or uncontrolled inflammation

176 ate an association between activation of the maternal immune system during pregnancy and increased ri

177 infants who were born at least 28 days after maternal immunisation.

178 arly RSV will require passive protection via maternal immunization in pregnancy.

179 We previously showed that maternal immunization with a replication-defective HSV v

180 In this study, we evaluated the efficacy of maternal immunization with an experimental trivalent (gC

181 The current study tested the hypothesis that maternal immunization with DeltagD-2 would protect neona

182 a murine model of nHSV, we demonstrated that maternal immunization with the trivalent vaccine protect

183 t during the next hour as it is patterned by maternal inductive signals and zygotic gene products.

184 (neurologic and/or hearing loss) following a maternal infection in the first trimester were, respecti

185 t of infants enrolled in a clinical trial of maternal influenza vaccination, we estimate incidence of

186 The placenta participates in maternal insulin sensitivity changes during pregnancy; h

187 Maternal intakes of saturated fat [6.2 wk epigenetic age

188 d that maternal H. pylori status affects the maternal intestinal microbiota of both mother and newbor

189 om disparities in the quality of diet-driven maternal investments, particularly key fatty acids.

190 The suppressed neuroinflammation by maternal LB supplementation was associated with reduced

191 Maternal LB supplementation, carried out by giving Lacto

192 associated with nonsignificant increases in maternal lead and with significant increases in cord blo

193 Maternal age at birth, maternal level of education, household income, as well a

194 we aimed to explore regional differences in maternal lifestyle during pregnancy related to congenita

195 hese results indicate that early gestational maternal lipid levels influence the CB lipidome and its

196 intended to explore the associations between maternal lipid profile and small-for-gestational-age neo

197 We classified dynamic changes in the maternal lipidome during pregnancy and identified lipids

198 metabolism in pregnancy delivers PUFAs from maternal liver to the developing fetus.

199 me elapsed between the first day of the last maternal menstrual period and the time at imaging) using

200 tifying the operative dimensions of positive maternal mental health in relation to specific outcomes.

201 We suggest that the inclusion of positive maternal mental health provides the potential for a more

202 e translation, stability, or localization of maternal messenger RNAs required for patterning decision

203 Vertical transmission of maternal microbes is a major route for establishing the

204 nditions indicative of the least exposure to maternal microbiome (ie no labour, short interval betwee

205 In mice, the maternal microbiome influences fetal immune development

206 Metabolomic profiling revealed that the maternal microbiome regulates numerous small molecules i

207 Maternal micronutrient deficits during preconception and

208 ns of milk micronutrient concentrations with maternal micronutrient intakes, status, and milk volume.

209 al AA was observed across the whole range of maternal mid-gestation glucose concentrations.

210 are indeed able to suppress both zygotic and maternal morphant phenotypes.

211 pregnancy is associated with a high risk of maternal mortality and pregnancy loss.

212 Regional variations in maternal mortality rates may relate to the availability

213 cross a region may be associated with higher maternal mortality rates.

214 per 1,000 live births and the intra-hospital maternal mortality ratio was 36.2 per 100,000 live birth

215 We find no significant improvement in maternal mortality when birthing mothers share race with

216 birth attendants are important for reducing maternal mortality.

217 ag/RNA-Seq approach to explore the timing of maternal mRNA translation in quiescent oocytes as well a

218 re, normal protein diet is indispensable for maternal musculoskeletal health during the reproductive

219 We found that the resulting maternal mutant Dot1l(mat-/+) offspring displayed normal

220 lar mechanism for detrimental effects of low maternal n-3 PUFA intake on hippocampal development in m

221 We demonstrate here that low maternal n-3 PUFA intake worsens MIA-induced early gut d

222 ht into neurodevelopmental defects caused by maternal n-3 PUFAs dietary deficiency.

223 d with iron isotope partitioning between the maternal, neonatal, and placental compartments were iden

224 Maternal non-transmitted GRS was not associated with chi

225 an reprogram maternal bodily metabolism with maternal nutrient supply precipitating the body-wide imp

226 defecation (13%), parental education (10%), maternal nutrition (5%), economic improvement (4%), and

227 Notably, maternal nutrition and postnatal leptin surge have a pro

228 igration and remittances, food security, and maternal nutrition as key drivers of stunting decline.

229 dies of both rodents and non-human primates, maternal obesity also predicts a preference for palatabl

230 egies for preventing the negative effects of maternal obesity on offspring development and adult heal

231 Here, we used a mouse model of maternal obesity to investigate the importance of early

232 Maternal obesity was established by prepregnant HF (ppHF

233 rowth, and the choice of genetic instrument (maternal or fetal) will greatly influence the interpreta

234 Selective maternal or paternal germline recombination is showcased

235 therapy during the second trimester improves maternal oral health but fails to reduce the risk of pre

236 Maternal outcome measures were glycaemic control, weight

237 tial modification of the association between maternal particulate matter (PM) exposure and preterm de

238 Maternal Pb and PS exposures were carried out in F0 mice

239 rapine to lopinavir/ritonavir (International Maternal Pediatric Adolescent Acquired Immunodeficiency

240 Trajectories of maternal perceived stress and depression were based on s

241 In October 2012 a maternal pertussis vaccination program was introduced in

242 The progeny of plants relies on maternal photosynthesis, via food reserves in the seed,

243 NRDE-3 with small RNAs that normally effect maternal piRNAs, which prevents precocious nuclear trans

244 ncy obesity mediates the association between maternal place of birth and severe pre-eclampsia in the

245 ity as a mediator in the association between maternal place of birth and the development of severe pr

246 Second trimester maternal plasma alpha-T concentration was 3-fold higher

247 s the first to report a profile of fetal and maternal plasma FA concentrations in a baboon model of g

248 We measured maternal plasma phospholipid FA concentration at preconc

249 Maternal pre-postnatal psychosocial distress increases t

250 pose of this study was to describe trends in maternal pre-pregnancy hypertension among women in rural

251 nsive neurons in TeA impairs auditory-driven maternal preference in a pup-retrieval assay.

252 ethoxazole [TMP-SMX]) and abstracted data on maternal, pregnancy, and fetal/neonatal outcomes.

253 tropy and mean diffusivity and analyzed with maternal prenatal depressive symptoms as well as child b

254 Maternal prenatal stress exposure (PNSE) increases risk

255 In addition, the association between maternal prepregnancy BMI and HMO composition was assess

256 optimizing the neonate's microbiome through maternal probiotic supplementation can improve offspring

257 Maternal progesterone administration altered fetal pitui

258 nked to population-specific variation in the maternal provisioning of lipids to offspring, with a pos

259 fold changes of shared DEGs associated with maternal PTSD and paternal PTSD were in opposite directi

260 Maternal receipt of 3-drug antiretroviral therapy compar

261 ere not predominantly organized around close maternal relatives.

262 ed methods for measuring temperament such as maternal report.

263 Preterm birth and LBW were assessed using maternal reports from ALSWH data between 2003 and 2015.

264 results reveal a local role for CEPR1 in the maternal reproductive tissue in determining seed size an

265 ies in trauma, cancer, congenital anomalies, maternal/reproductive health, aging, and infection were

266 ee crucial epigenetic reprogramming windows: maternal reprogramming at fertilization, embryonic stem

267 Maternal resilience (positivity accounting for stress) w

268 y through salient emotional expressions, and maternal responses to infant signals are critical for in

269 Lineage effects may occur through maternal responses to pregnancy, altered maternal behavi

270 ith no exposure, while controlling for known maternal risk factors.

271 Infant outcomes after maternal SARS-CoV-2 infection are not well-described.

272 ear model evaluated the interactions between maternal SDB and offspring growth and adiposity measurem

273 We performed similar analyses with maternal second trimester tocopherol isoform levels.

274 pective cohort, five PFAS were quantified in maternal serum (median 27 wk of gestation).

275 me regulates numerous small molecules in the maternal serum and the brains of fetal offspring.

276 entrations of PFOS and PFOA were measured in maternal serum/plasma during pregnancy, or in breast mil

277 the rabbit model for CDH, the combination of maternal sildenafil and TO has a complementary effect on

278 Interestingly, the loss of maternal SMCHD1 does not alter germline DNA methylation

279 Maternal smoking may induce such long-term effects throu

280 y, deprivation) and maternity (maternal age, maternal smoking, sex-gestation-specific birth weight ce

281 ay provide a biomarker for fetal exposure to maternal smoking.

282 that interfering with ZNF274 binding at the maternal SNORD116 locus is a potential therapeutic strat

283 Overall, maternal BMI, along with maternal socioeconomic status and lifestyle factors in t

284 Here, we explore the utility of the maternal spindle transfer (MST) technique as a reproduct

285 potentially extreme case of conflict between maternal survival and adequate provisioning of offspring

286 onal duration (p = 1.8 x 10-4) and increased maternal systolic BP during pregnancy (p = 2.2 x 10-2).

287 IPT exposure and adverse pregnancy outcomes, maternal TB, all-cause mortality, and liver injury durin

288 Although recent studies suggest that maternal Tdap vaccination is effective at preventing inf

289 is 100% dominant and cannot be repressed by maternal tetracycline.

290 their eggs differed among bird taxa and with maternal THg exposure.

291 Most RCTs found that supplementation reduced maternal thyroglobulin and in 3 RCTs, it prevented or di

292 , it prevented or diminished the increase in maternal thyroid volume during pregnancy.

293 CEPR1 controls yield and seed size from the maternal tissue.

294 The shift from maternal to embryonic control is a critical developmenta

295 hundreds of dual-initiation promoters during maternal to zygotic transition.

296 ippocampal cingulum, was not associated with maternal unpredictability.

297 gist for abnormalities, such as infection or maternal vascular malperfusion, can provide important in

298 Maternal viremia predicts fetal infection and neonatal o

299 In this cohort, maternal ZIKV exposure was not associated with increased

300 Despite this, maternal zygotic single and double mutants were viable a