ライフサイエンスコーパス: maternal age

1 eproductive decline associated with advanced maternal age.

2 ng's genome increases with both paternal and maternal age.

3 aboratory stocks develop fully regardless of maternal age.

4 fespan and fecundity decline with increasing maternal age.

5 ons per offspring increase with paternal and maternal age.

6 tromeric chromatin decompacts with advancing maternal age.

7 not completely, attenuated by adjustment for maternal age.

8 e performance declines rapidly with advanced maternal age.

9 lowing fertilisation declines with advancing maternal age.

10 nging demographics associated with advancing maternal age.

11 idence in humans increases dramatically with maternal age.

12 e incidence of de novo mutations relating to maternal age.

13 crossover interference levels decreased with maternal age.

14 d adaptive function, as well as paternal and maternal age.

15 for age, sex, study, maternal education, and maternal age.

16 but the risk varied by pre-pregnancy BMI and maternal age.

17 tological malignancies by either paternal or maternal age.

18 hy oocyte aneuploidy increases with advanced maternal age.

19 after adjustment for infant's birth year and maternal age.

20 life survival remained after controlling for maternal age.

21 ht 2.0-2.5 kg, multiple birth and increasing maternal age.

22 ndividuals are jointly classified by age and maternal age.

23 gistic regression, adjusting for parity, and maternal age.

24 lactating women, including those of advanced maternal age.

25 g to pre-pregnancy body mass index (BMI) and maternal age.

26 odds of preterm birth, which increased with maternal age (1.80 [1.16-2.79] in 20-29 years, 2.19 [1.2

27 0.07 standard deviations lower than that for maternal ages 25-29 years (P < 0.001).

28 When compared with maternal ages 25-29 years in between-family models, mate

29 %), paternal education (6%), fertility (6%), maternal age (3%), and wealth accumulation (2%).

30 98 births to AYA cancer survivors (mean [SD] maternal age, 31 [5] years) were included.

31 infants who received active care (mean [SD] maternal age, 32 [6] years), 58 (67%) survived until hos

32 ; oligohydramios; pre-delivery LoS 3-5 days; maternal age 35-39 years; placenta weight 1,000-1,500 g;

33 factor infertility, unexplained infertility, maternal age 38 years or older, low oocyte yield, and 2

34 ry LoS >= 3 days; placental weight >= 600 g; maternal age 40-44 years; >=6 US scans performed in preg

35 e): multiple birth; eclampsia/pre-eclampsia; maternal age 40-44 years; placental weight 600-99 g; oli

36 For example, maternal ages 40-44 years were associated with an offspr

37 elative to young (3-4 months) dams, advanced maternal age (9.5-10 months) compromises growth of both

38 ered the joint association of UTIs and young maternal age, a synergistic effect was observed.

39 d no association with offspring IQ; however, maternal ages above 30 years were inversely associated w

40 052 nmol/L; 95% CI: 0.050, 0.053 nmol/L) and maternal age (adjusted mean difference: -0.018 nmol/L; 9

41 as not only limited to advancing paternal or maternal age alone but also to differences parental age

42 fects are unknown, and it remains unclear if maternal age alters offspring response to therapeutic in

43 Thus, advanced maternal age alters placental phenotype in a sex-specifi

44 Pregnancies in women of advanced maternal age (AMA) are susceptible to fetal growth restr

45 Data for maternal age and at least one outcome were available for

46 The survival submodel included maternal age and cycle length covariates.

47 Adjusting for sample storage time, maternal age and education, and both child asthma and vi

48 Some metabolites were associated with maternal age and education, but no consistent patterns w

49 sted for urinary creatinine and thiocyanate, maternal age and education, ethnicity, and gestational a

50 We evaluated the associations of maternal age and education, type of delivery, sex, and b

51 conditional logistic regression adjusted for maternal age and education.

52 ed using zero-inflated Poisson, adjusted for maternal age and income.

53 countries since 1980, secondary to advanced maternal age and increased reliance on in vitro fertiliz

54 At baseline, adjusting for maternal age and intelligence, plasma ferritin, head cir

55 ly models, the relationship between advanced maternal age and low birth weight or preterm birth is st

56 the pro-rural inequalities are birth weight, maternal age and maternal education.

57 Maternal age and maternal height were associated with a

58 ntake significantly interacted with advanced maternal age and metabolic conditions; combined exposure

59 , breech presentation, history of CS, higher maternal age and multiple birth, consideration may be gi

60 We examined associations between maternal age and offspring birthweight, gestational age

61 nce intervals, adjusted for confounders (eg, maternal age and parity).

62 orn mortality rate among twins, adjusted for maternal age and parity, was 4.6 to 7.2 times higher for

63 bles associated with episiotomy according to maternal age and parity.

64 72-0.91]), and the risk varied by increasing maternal age and pre-pregnancy BMI.

65 Advancing maternal age and preexisting comorbid conditions have co

66 n pre-pregnancy obesity and preterm birth by maternal age and race or ethnicity in a large, multiraci

67 opulation, but the risk differs according to maternal age and race or ethnicity.

68 eflecting the published relationship between maternal age and SCZ risk in offspring by McGrath et al

69 ions that described the relationship between maternal age and SCZ risk in offspring in Denmark.

70 elihood of a successful pregnancy depends on maternal age and the number of previous losses.

71 files (n = 12990) with frequency matching on maternal age and year of delivery.

72 single-year categories of infant birth year, maternal age, and age-specific HPV vaccination coverage

73 wer family income, family functioning score, maternal age, and being in a single-parent family were p

74 Female sex, maternal age, and high maternal educational level were f

75 es and controls matched for gestational age, maternal age, and human immunodeficiency virus status at

76 lies, adjusted for birth year, birth weight, maternal age, and self-reported maternal race/ethnicity.

77 Adjusting for household income, maternal age, and smoking exposure, postconceptual age a

78 sex, age, ethnic origin, parental education, maternal age, and study, to estimate odds ratios (ORs) a

79 es not only with paternal age, but also with maternal age, and that some genome regions show enrichme

80 estic product, unemployment rate, education, maternal age, and underlining temporal trends.

81 he number of incident neonatal infections by maternal age, and we generated separate estimates for ea

82 d to an increase in aneuploidy with advanced maternal age are largely unclear.

83 This study tests if advancing paternal and maternal ages are independently associated with ASD risk

84 ants with reduced activity may contribute to maternal age-associated fertility loss in humans.

85 e sought to examine the relationship between maternal age at birth and prevalence of asthma in a nati

86 me and percent college educated), as well as maternal age at birth and year of birth.

87 Advanced maternal age at birth can have pronounced consequences f

88 To test whether advanced maternal age at birth independently increases the risk o

89 Younger maternal age at birth is associated with increased risk

90 Advanced maternal age at birth is considered a major risk factor

91 c regression models to examine the effect of maternal age at birth on asthma in offspring overall and

92 ge, sex, socioeconomic status, birth weight, maternal age at birth, anisometropia, astigmatism, spher

93 Maternal age at birth, maternal level of education, hous

94 cally widespread source of such variation is maternal age at breeding, which typically has negative e

95 sk of adverse mental health included younger maternal age at cancer diagnosis, low socioeconomic stat

96 e aimed to quantify the relationship between maternal age at childbirth and early childhood developme

97 age, retinopathy of prematurity occurrence, maternal age at childbirth, mother smoking, breastfeedin

98 Moreover, we find evidence that maternal age at conception influences the mutation rate

99 Potential confounding variables; maternal age at conception, maternal education level, pa

100 ression adjusting for potential confounders (maternal age at conception, paternal age at conception,

101 , 7 (63.6%) were female, and the median (SD) maternal age at delivery was 25 (6) years.

102 sociation was not modified by year of birth, maternal age at diabetes onset, or diabetes duration, an

103 the number of heteroplasmies in a child and maternal age at fertilization, likely attributable to oo

104 When both parental Holocaust exposure and maternal age at Holocaust exposure shared DEGs, fold cha

105 gender, gestational age at delivery, parity, maternal age at oral glucose tolerance test (OGTT); Mode

106 Increased maternal age at reproduction is often associated with de

107 We used maternal age at reproduction, brood size and survival ra

108 th the de novo 22q11.2 deletion, the average maternal age at time of conception was 29.5, and this is

109 owed an association between paternal-but not maternal-age at birth and sporadic hematological cancer

110 Male gender, the youngest and oldest maternal age bands, multiple births, and deprivation (In

111 f developmental vulnerability decreased with maternal ages between 15 and 39 years, but the decrease

112 ere not explained by geographic variation in maternal age, birth year, child's sex, community income,

113 adjusting for several potential confounders: maternal age, body mass index (BMI), education, native c

114 llocation of maternal reserves declined with maternal age but the efficiency of mass transfer to pups

115 cation of energy to reproduction varies with maternal age, but additional maternal features may be im

116 a were 5%-10% higher per 5-year increment in maternal age, but no associations were observed for acut

117 tilisation is largely unchanged by advancing maternal age, but subtle changes in Ca(2+) handling occu

118 sk factor for human aneuploidy is increasing maternal age, but the basis of this association remains

119 sed pregnancies matched on propensity score, maternal age, calendar year, and gestational age (based

120 This suggests that maternal age can influence the timing of birth and proce

121 s rising in prevalence secondary to advanced maternal age, cardiovascular risk factors, and the succe

122 d to IPT-exposed women after controlling for maternal age, CD4 count, viral load, antiretroviral regi

123 with IPT-exposed women after controlling for maternal age, CD4 count, viral load, antiretroviral regi

124 log-binomial regression models adjusted for maternal age, comorbidities, parity, whether there was a

125 ed with adjustment for confounders including maternal age, compliance to supplement, and infant sex a

126 son, body mass index, daily milk intake, and maternal age controlled for.

127 y through reduced fertility, particularly at maternal ages corresponding to peak reproductive output.

128 Extremes of maternal age could be associated with disturbed offsprin

129 zard ratios (HRs) with 95% CIs, adjusted for maternal age, country of origin, education level, cohabi

130 tios (aRRs) and 95% CIs, after adjusting for maternal age, country of origin, educational level, coha

131 ratios (HRs) and 95% CIs after adjusting for maternal age, country of origin, educational level, coha

132 To investigate the hypothesis that maternal age directly influences successful parturition,

133 ome estimates were age adjusted based on the maternal age distribution of the EXPECT study.

134 an affect offspring longevity as strongly as maternal age does and that breeding age effects can inte

135 After controlling for maternal age, education level, family income, pre-pregna

136 stational duration, birth weight, sex ratio, maternal age, education, and socioeconomic status.

137 All models were adjusted for maternal age, education, annual household income, census

138 1.11, 6.97; P = 0.029) with adjustments for maternal age, education, ethnicity, monthly household in

139 ignificantly associated with infection were: maternal age, education, marital status and religion; ho

140 sted odds ratio [AOR; adjusting for country, maternal age, education, marital status, neonate weight

141 t neonatal sample collection, preterm birth, maternal age, education, smoking, fish consumption per w

142 ochore fragmentation could contribute to the maternal age effect in mammalian eggs.

143 ffect has implications for understanding the maternal age effect on aneuploidies.

144 eatures of female meiosis, for instance, the maternal age effect on PSSC.

145 orates as oocytes age and contributes to the maternal age effect.

146 cally as women age, a phenomenon termed the "maternal age effect." During meiosis, cohesion between s

147 oduction-line model is not the basis for the maternal-age effect on trisomy.

148 rovide a plausible explanation for the human maternal-age effect, meaning that-45 years after its int

149 Indeed, one of the earliest models of the maternal-age effect--the "production-line model" propose

150 However, the mechanisms of maternal age effects are unknown, and it remains unclear

151 Here, we evaluate maternal age effects on offspring lifespan, reproduction

152 semi-captive Asian elephants to investigate maternal age effects on several offspring life-history t

153 vestigate maternal investment as a source of maternal age effects using the rotifer, Brachionus manja

154 le many laboratory studies have investigated maternal age effects, relatively few studies have been c

155 logistic regression analyses, adjusting for maternal age, ethnicity, birth country and weight, as we

156 Older maternal age, family history of Chagas disease, home con

157 They also decrease with increasing maternal age for late maternal ages, implying that mater

158 No differences in median baseline maternal age, gestation (31 vs 30 weeks), weight, obstet

159 Maternal age, gestational age, prematurity (<37 weeks' g

160 ne dinucleotides (CpGs), with adjustment for maternal age, gravidity, smoking, BMI, child sex, and ge

161 Risk factors for CHD included maternal age >/=40 years (adjusted odds ratio [aOR], 1.4

162 eeks; oligohydramnios; birthweight <2,500 g, maternal age >= 35 and cord prolapse.

163 al weight >= 600 g, eclampsia/pre-eclampsia, maternal age >= 35 and oligohydramnios.

164 years; >=6 US scans performed in pregnancy; maternal age >= 45 and 35-39 years; oligohydramnios; ecl

165 weight 1,000-1,500 g; birthweight < 2,000 g; maternal age >= 45 years; pre-delivery LoS >= 6 days; mo

166 tal status, history of CS, labour analgesia, maternal age >=35 and gestation >40 weeks.

167 ABSTRACT: Advanced maternal age (>/=35 years) is associated with increased

168 iation]), 101 of whom (60%) were of advanced maternal age (>=35 years).

169 Maternal age has a negative effect on offspring lifespan

170 We show that maternal age has a small but significant correlation wit

171 productive success in older females.Advanced maternal age has been associated with lower reproductive

172 line in offspring survival or fertility with maternal age-has been demonstrated in many taxa, includi

173 Advancing paternal and maternal age have both been associated with risk for aut

174 nge in postpartum weight after adjusting for maternal age, height, and energy intake.

175 o adjust for gestational age; fetal sex; and maternal age, height, education, ethnicity, prepregnancy

176 (and 95% confidence intervals) adjusted for maternal age, height, smoking habits, education, and tim

177 rican-American women and in women with older maternal age, hypertensive disorders of pregnancy, and m

178 crease with increasing maternal age for late maternal ages, implying that maternal effect senescence

179 We have found that increasing maternal age in C57BL/6J mice is associated with prolong

180 that the number of crossovers increases with maternal age in humans, but others have found the opposi

181 olute risk of developmental vulnerability by maternal age in Indigenous and non-Indigenous population

182 ied models, the protective effect of younger maternal age in Mexican Americans was seen only in child

183 eal underappreciated roles of DNA damage and maternal age in the genesis of human germline mutations.

184 We substituted AFB for maternal age in these functions, one of which was correc

185 While advancing maternal age increased risk of leukemia and central nerv

186 Among women of advanced maternal age, induction of labor at 39 weeks of gestatio

187 In the present study, we focus on how maternal age influences offspring life-history trajector

188 Maternal age is a risk factor for congenital heart disea

189 Both young and advanced maternal age is associated with adverse birth and child

190 Advanced maternal age is associated with an increased risk of pre

191 rted that SCZ risk associated with increased maternal age is explained by the age of the father and t

192 In Finland, advanced maternal age is not independently associated with the ri

193 , adjusting for gestational age at birth and maternal age, is significantly associated with autism (p

194 is known to occur in oocytes with advancing maternal age, is sufficient to trigger centromere decomp

195 Advanced maternal age led to an increase in sister kinetochore se

196 In multivariable models, older maternal age, longer breastfeeding duration, and later i

197 Maternal age < 20 years was significantly associated wit

198 Maternal age <20 years (hazard ratio [HR]: 2.40; 95% con

199 balance study group assignments according to maternal age (<30 years vs >=30 years), body-mass index

200 ducted for parity (nulliparous/multiparous), maternal age (<35/>=35 years), and body mass index (BMI)

201 After adjustment for maternal age, marital status, race/ethnicity, and educat

202 composition All the results were adjusted by maternal age, maternal BMI and gestational age.

203 ld and maternal factors (ie, sex, ethnicity, maternal age, maternal educational level, and income) (i

204 These findings were not accounted for by maternal age, maternal or parental psychiatric disorders

205 separately for each parent and adjusted for maternal age, maternal prepregnancy body mass index (kil

206 sted for gestational age, sex, birth weight, maternal age, maternal smoking during pregnancy, and com

207 age, ethnicity, deprivation) and maternity (maternal age, maternal smoking, sex-gestation-specific b

208 ernal effects on early life survival such as maternal age may act through their influence on infant b

209 r duration of exclusive breastfeeding, lower maternal age, mother having less than 3 living children,

210 adjusted analysis, at enrollment, increased maternal age, nonwhite ethnicity, and lower maternal qua

211 disease during pregnancy is rising as older maternal age, obesity, diabetes mellitus and hypertensio

212 NHS was independently associated with lower maternal age (odds ratio [OR], 0.87; 95% CI, 0.78-0.94),

213 Evidence of association was convincing for maternal age of 35 years or over (relative risk [RR] 1.3

214 Median maternal age of included women was 26 years (IQR 22-30).

215 l ages 25-29 years in between-family models, maternal ages of 35-39 years and >/=40 years were associ

216 and lifestyle factors (each about 10%), and maternal age older than 35 years (6.7%).

217 The impact of maternal age on congenital heart disease can be modelled

218 ults show evidence of a persistent effect of maternal age on fitness across generations in a long-liv

219 y in the rat assessed the impact of advanced maternal age on placental phenotype in relation to the g

220 from any specific cohort about the effect of maternal age on recombination.

221 pivotal, albeit under-appreciated, impact of maternal age on uterine adaptability to pregnancy as maj

222 .01 for interaction) for parity, but not for maternal age or BMI.

223 besity (OR: 1.56; 95% CI: 1.07, 2.29), older maternal age (OR: 1.05; 95% CI: 1.01, 1.08), insulin GDM

224 V viral load but was associated with younger maternal age (P = .02).

225 with NAFLD in female offspring were younger maternal age (P = 0.02), higher maternal prepregnancy BM

226 affected infant, up to 10 mothers matched on maternal age, parity, and year of infant's birth.

227 rpregnancy interval by country, adjusted for maternal age, parity, decade of delivery, and gestationa

228 No associations were observed for maternal age, parity, delivery mode, or infant sex.

229 After adjustment for maternal age, parity, education, household income, race/

230 D-epidemiology collaboration), hypertension, maternal age, parity, ethnicity.

231 Relative risks were adjusted for maternal age, parity, income quintile, chronic hypertens

232 ratios (ORs) with 95% CIs (fixed effects for maternal age, parity, maternal education, and random eff

233 ation on the type of delivery, birth weight, maternal age, parity, maternal schooling, and maternal s

234 atal seizures, adjusted for maternal height, maternal age, parity, mother's smoking habits, education

235 We adjusted for maternal age, parity, pregnancy conditions, and (for neo

236 ontrolled for gestational age, birth weight, maternal age, parity, prepregnancy body mass index, smok

237 us variable or in quartiles, controlling for maternal age, parity, socio-occupational status, smoking

238 Difference in maternal age, parity, socioeconomic and behavioral chara

239 ght gain, and preterm birth rate, but not in maternal age, parity, socioeconomic or behavioral charac

240 , gestational age, maternal body mass index, maternal age, paternal age, newborn sex, newborn ethnici

241 rns, higher maternal body mass index, higher maternal age, preeclampsia, higher socioeconomic positio

242 Controlling for maternal age, prepregnancy BMI, education level, kilocal

243 In proportional hazards models adjusted for maternal age, prepregnancy body mass index (weight (kg)/

244 (n=66 980) after controlling for changes in maternal age, prepregnancy diabetes mellitus, preterm pr

245 iotic use, and diarrheal history, as well as maternal age, probiotic use, and smoking.

246 After controlling for maternal age, race or ethnic origin, pre-pregnancy BMI,

247 used logistic regression models adjusted for maternal age, race or ethnicity, parity, education level

248 Logistic regression models were adjusted for maternal age, race, education, body mass index, parity,

249 BDILMs adjusted for maternal age, race, education, prepregnancy obesity, ato

250 Associations of paraxanthine (adjusted for maternal age, race, education, smoking, prepregnancy wei

251 The findings were not confounded by maternal age, race, educational level, gestational age a

252 were matched with controls (N = 30) based on maternal age, race, pre-pregnancy body mass index, and g

253 , and WHZ, respectively), adjusting for age; maternal age, race, prepregnancy BMI; parity; smoking du

254 and fetal disproportion or obstructed labor; maternal age, race/ethnicity, and insurance status; and

255 Analyses were adjusted for maternal age, race/ethnicity, education and neighborhood

256 In linear regression analyses adjusted for maternal age, race/ethnicity, education, prenatal fine p

257 S) to control for over 70 confounders (e.g., maternal age, race/ethnicity, indications for gabapentin

258 number of cigarettes consumed, adjusting for maternal age, race/ethnicity, parity, education levels,

259 stic regression evaluated factors, including maternal age, race/ethnicity, substance use, antiretrovi

260 ased risk of this outcome across most of the maternal age range.

261 Older maternal age reduces the probability of success in both

262 cytes remains a pivotal question relevant to maternal age-related aneuploidy.

263 After adjustment, older maternal age remained associated with increased risk of

264 After adjustment, associations with younger maternal age remained for low birthweight (odds ratio [O

265 Maternal age represents one factor that may help to expl

266 matched 2:1 to cases by sex, birth year, and maternal age, self-reported race/ethnicity, and county o

267 major confounders: deprivation, birthweight, maternal age, sex, and multiple birth.

268 al log-Cd concentrations while adjusting for maternal age, sex, smoking history, and educational atta

269 st regression was carried out, adjusting for maternal age, smoking, parity, ethnicity, neonate sex, a

270 nal age at birth, postmenstrual age at scan, maternal age, socioeconomic status, sex, and number of d

271 ubsequent decrease in the twinning rate with maternal age that is observed across human populations.

272 tness of the next generation associated with maternal age, the present study helps increase our under

273 Maternal age, time postpartum, weight, and body mass ind

274 number of socio-demographic factors, namely maternal age, type of residence and maternal education,

275 ; the odds ratio for each 5-year increase in maternal age was 1.06 (95% confidence interval (CI): 1.0

276 and 52% were 13-24 wk postpartum, and median maternal age was 25 y (interquartile range [IQR] 22-28).

277 Median maternal age was 26.5 years (IQR 23.1-30.3).

278 nal age of 38.7 weeks (50.4% were male, mean maternal age was 26.7 years, and mean duration of follow

279 At study entry, median maternal age was 28 y (interquartile range [IQR] 25-31),

280 The mean (SD) maternal age was 28.1 years (5.8 years) and 32.8% of res

281 Mean maternal age was 30 years +/- 6 (age range, 12-49 years)

282 The mean maternal age was 30.7 years, and the mean gestational ag

283 Mean maternal age was 31 years; 32% of the women were from Bl

284 Younger maternal age was also associated with increased risk for

285 Overall, each 5-year increment in maternal age was associated with a 3% increase in incide

286 In Puerto Ricans, older maternal age was associated with decreased odds of asthm

287 ast to European descent populations, younger maternal age was associated with decreased odds of asthm

288 p analyses, the protective effect of younger maternal age was observed only in Mexican Americans (OR

289 regression models stratified by infant sex, maternal age was positively associated with AGD in male

290 , as without birth year adjustment, advanced maternal age was positively associated with IQ.

291 and 39 years, but the decrease in risk with maternal age was significantly steeper in non-Indigenous

292 advancing parental age, especially advancing maternal age, was associated with higher pediatric cance

293 the odds ratios for each 5-year increase in maternal age were 1.05 (95% CI: 1.02, 1.07) and 1.14 (95

294 ounger (</=19 years) and older (>/=35 years) maternal age were associated with lower birthweight, ges

295 Advancing paternal and maternal age were each associated with increased RR of A

296 lationship between SCZ risk in offspring and maternal age when not adjusted for the age of the father

297 m that the recombination rate increases with maternal age, while hotspot usage decreases, with no suc

298 ears to become increasingly deregulated with maternal age, with an increasing fraction of events obse

299 Congenital HSV infection was associated with maternal age younger than 20 years, gestational age less

300 associated with birthweight less than 1 kg, maternal age younger than 25 years, socioeconomically de