ライフサイエンスコーパス: maternal mRNA

1 of Cad mRNA, and that are not represented in maternal mRNA.

2 he translation of the FGF receptor-1 (XFGFR) maternal mRNA.

3 ted by a translation-independent role of its maternal mRNA.

4 e by precise control of the stability of the maternal mRNA.

5 ine-rich motif required for stability of the maternal mRNA.

6 polyadenylation of an early class of Xenopus maternal mRNAs.

7 nd MAP kinase activities, and recruitment of maternal mRNAs.

8 st approach to study the function of dormant maternal mRNAs.

9 lyadenylation-induced translation of dormant maternal mRNAs.

10 e unmasking, translation, and degradation of maternal mRNAs.

11 n the localization and on-site expression of maternal mRNAs.

12 terile mutants for defects in translation of maternal mRNAs.

13 onic divisions rely on translation of stored maternal mRNAs.

14 illustrated to control different futures of maternal mRNAs.

15 bryo, accounting for 59% of all destabilized maternal mRNAs.

16 f and binding partners direct degradation of maternal mRNAs.

17 scription and the degradation of a subset of maternal mRNAs.

18 were annotated as germline mRNAs and many as maternal mRNAs.

19 oocyte maturation with translation of stored maternal mRNAs.

20 timing of polyadenylation and translation of maternal mRNAs.

21 ments in the 3' untranslated region (UTR) of maternal mRNAs.

22 translational activation of specific dormant maternal mRNAs.

23 -binding proteins and translationally masked maternal mRNAs.

24 e differentiation to repress glp-1 and other maternal mRNAs.

25 2, but did not affect maintenance of several maternal mRNAs.

26 specification depends on the inheritance of maternal mRNAs [1-3], cortical rotation to generate a do

27 skin as the key factor for the repression of maternal mRNA, a second mechanism must exist, since mask

28 Maternal mRNAs accumulate during egg growth and must be

29 cortex embryos, indicating that the block in maternal mRNA activation is specific to a class of mRNAs

30 Using the localized maternal mRNA An2 as a target, we have shown that chimer

31 ryos decelerates the decay of m(6)A-modified maternal mRNAs and impedes zygotic genome activation.

32 nce of transcription and instead relies upon maternal mRNAs and proteins deposited in the egg during

33 Maternal mRNAs and proteins loaded into the egg during o

34 After fertilization in animals, maternal mRNAs and proteins regulate development until t

35 During the development of Xenopus laevis, maternal mRNAs and proteins stored in the egg direct ear

36 pid mitotic divisions that are controlled by maternal mRNAs and proteins that accumulate during oogen

37 is a unique quiescent cell, prepackaged with maternal mRNAs and proteins that have functions in early

38 Knockdown of Ago2 stabilizes one set of maternal mRNAs and reduces zygotic transcripts of anothe

39 We find that repressed maternal mRNAs and their regulators localize to P body-l

40 tes, LIMP is translated in the ookinete from maternal mRNA, and later in the sporozoite.

41 is, selective recruitment and degradation of maternal mRNA, and pronuclear development.

42 cortical granule exocytosis, recruitment of maternal mRNAs, and cell cycle resumption.

43 cortical granule exocytosis, recruitment of maternal mRNAs, and cell cycle resumption.

44 anslational regulators and a specific set of maternal mRNAs, and prevents those mRNAs from being degr

45 During the maternal-to-zygotic transition, maternal mRNAs are cleared by multiple distinct but inte

46 mental progression during which thousands of maternal mRNAs are cleared by post-transcriptional mecha

47 he maternal-to-zygotic transition (MZT) when maternal mRNAs are degraded and zygotic transcription be

48 e maternal-to-zygotic transition (MZT), when maternal mRNAs are destroyed, high-level zygotic transcr

49 In oocytes, nontranslated maternal mRNAs are packaged by protein into messenger ri

50 Finally, we demonstrate that maternal mRNAs are required for different modes of zygot

51 How certain maternal mRNAs are selected for translation instead of d

52 In eggs, maternal mRNAs are stored and selectively activated duri

53 Although some maternal mRNAs are targeted for degradation by microRNAs

54 maturation in Xenopus, previously quiescent maternal mRNAs are translationally activated at specific

55 During early metazoan development, certain maternal mRNAs are translationally activated by elongati

56 volved in OET and identified novel motifs in maternal mRNAs associated with transcript stability.

57 s mechanism may involve the translation of a maternal mRNA at the time of the MBT, as suggested previ

58 tages revealed that Hnrnpa1 dissociates from maternal mRNAs at ZGA and instead regulates the nuclear

59 These results suggest that binding of intact maternal mRNA by MSY2 is required for its cytoplasmic re

60 These proteins govern expression from maternal mRNAs by an unknown mechanism.

61 Xenopus, translational activation of stored maternal mRNAs by cytoplasmic polyadenylation requires b

62 ewly-transcribed (zygotic) and pre-existing (maternal) mRNA can be distinguished.

63 Codon composition shapes maternal mRNA clearance during the maternal-to-zygotic t

64 d maternally driven mechanism that regulates maternal mRNA clearance during zebrafish MZT, highlighti

65 n and plakoglobin directly, by depleting the maternal mRNAs coding for each of them in developing Xen

66 We propose that the 3'UTR of maternal mRNAs contains a combinatorial code that determ

67 trophoblast outgrowth in vitro, reflecting a maternal mRNA contribution, which has been shown to pers

68 These results reveal a previously unknown maternal mRNA control system that is specific to late st

69 sumption, and degradation and recruitment of maternal mRNAs; cortical granule exocytosis, however, di

70 ding site suggesting that the translation of maternal mRNAs could be either limited by or independent

71 Maternal mRNA COVID-19 vaccination (1 or more doses) dur

72 The study team previously showed that maternal mRNA COVID-19 vaccination during pregnancy conf

73 ation-based cohort study in Ontario, Canada, maternal mRNA COVID-19 vaccination during pregnancy was

74 In this study, maternal mRNA COVID-19 vaccination, including booster do

75 the poly(A)-dependent recruitment of several maternal mRNAs (cyclin B1, c-Mos, D7, and B9) during mei

76 Recent evidence has shown that one maternal mRNA, cyclin B1, is concentrated on mitotic spi

77 A dominant inhibitory form of Musashi blocks maternal mRNA cytoplasmic polyadenylation and meiotic ce

78 , a reader of N(6)- methylation, facilitates maternal mRNA decay, introducing an additional facet of

79 s spatially and temporally with the onset of maternal mRNA degradation.

80 miR-430 is crucial for the clearance of maternal mRNA during maternal zygotic transition in embr

81 n the translational activation of a specific maternal mRNA during oocyte maturation.

82 ial process that controls the translation of maternal mRNAs during early development and depends on t

83 cilitates the deadenylation and clearance of maternal mRNAs during early embryogenesis.

84 e required to trigger the destabilization of maternal mRNAs during egg activation.

85 our findings for translational regulation of maternal mRNAs during embryogenesis and for the activati

86 discuss mechanisms that control the fate of maternal mRNAs during late oogenesis and after fertiliza

87 constitutive translation of a large group of maternal mRNAs during maturation.

88 regulating the stability and translation of maternal mRNAs during mouse oogenesis.

89 RNA-binding proteins regulates expression of maternal mRNAs during oogenesis, the oocyte to embryo tr

90 and represses the expression of thousands of maternal mRNAs during the Drosophila MZT.

91 to pathways controlling rapid degradation of maternal mRNAs during the maternal-to-zygotic transition

92 nylation controls the translation of several maternal mRNAs during Xenopus oocyte maturation and requ

93 The SpCOUP-TF mRNA, the first sea urchin maternal mRNA encoding a transcription factor that is sp

94 Here, we show that the maternal mRNA encoding the cell-fate regulatory protein

95 of the oocytes; prevented the recruitment of maternal mRNAs encoding cyclin B1, c-Mos, D7, and B9; an

96 nesis, in which RBPs control expression from maternal mRNAs encoding key cell fate determinants.

97 requires the correct temporal translation of maternal mRNAs encoding key regulatory proteins.

98 f the zygotic epigenome that is regulated by maternal mRNA expression and provide new insights into t

99 mily member 1b (eIF4E1b) is the regulator of maternal mRNA expression that ensures subsequent reprogr

100 h the use of Drosophila lines that express a maternal mRNA for the yeast transcription factor GAL4.

101 ts are occurring, including transcription of maternal mRNAs for storage in the mature egg, global tra

102 monstrate that DAZL regulates translation of maternal mRNAs, functioning both as the translational re

103 Translational control of maternal mRNAs generates spatial and temporal patterns o

104 The asymmetric localization of four maternal mRNAs - gurken, bicoid, oskar and nanos - in th

105 bifunctional 3' UTR sequence that maintains maternal mRNA in a dormant state in oocytes and activate

106 ygotic microRNAs coordinate the clearance of maternal mRNA in animals to facilitate developmental tra

107 ment for IBEs in the regulation of localized maternal mRNAs in D. melanogaster and X. laevis.

108 Translational regulation of maternal mRNAs in distinct temporal and spatial patterns

109 sults support a role for MSY2 in stabilizing maternal mRNAs in growing oocytes, a process essential t

110 and is a trans-acting factor for the TCS in maternal mRNAs in immature Xenopus oocytes.

111 sates that independently enrich and regulate maternal mRNAs in the germline founder cells.

112 ation of the stability and/or translation of maternal mRNAs in the mouse oocyte.

113 The translational activation of several maternal mRNAs in Xenopus laevis is dependent on cytopla

114 yadenylation and translational activation of maternal mRNAs in Xenopus laevis.

115 prominent example of this is localization of maternal mRNAs in Xenopus oocytes, a process requiring r

116 ducts accumulate that promote degradation of maternal mRNAs, including string and twine; and (4) cons

117 ng - using reciprocal crosses - to determine maternal mRNA inheritance and the regulatory architectur

118 Early metazoan development is programmed by maternal mRNAs inherited by the egg at the time of ferti

119 Although translational regulation of maternal mRNA is important for proper development of the

120 We show that Nasonia otd maternal mRNA is localized at both poles of the embryo,

121 FGF receptor-1 (XFGFR) maternal mRNA is present in immature oocytes, but the pr

122 Degradation of maternal mRNA is thought to be essential to undergo the

123 Translational recruitment of maternal mRNAs is an essential process in early metazoan

124 Translation of maternal mRNAs is detected before transcription of zygot

125 and demonstrated that active translation of maternal mRNAs is essential for maternal-to-zygotic tran

126 (m(6)A) modified, and the clearance of these maternal mRNAs is facilitated by an m(6)A-binding protei

127 s between 0.5 and 1.0 microM, recruitment of maternal mRNAs is only partially stimulated at injected

128 and invertebrates, the expression of several maternal mRNAs is regulated by cytoplasmic polyadenylati

129 nopus development, the expression of several maternal mRNAs is regulated by cytoplasmic polyadenylati

130 The translation of many maternal mRNAs is regulated by dynamic changes in poly(A

131 The translation of specific maternal mRNAs is regulated during early development.

132 The translational regulation of maternal mRNAs is the primary mechanism by which stage-s

133 wever, where and how mammalian oocytes store maternal mRNAs is unclear.

134 ng proteins modulates poly(A) tail length of maternal mRNAs, leading to asymmetric expression of a ce

135 y also suggest that mechanisms that regulate maternal mRNAs, like TCE-mediated repression, may functi

136 Inherited as a maternal mRNA localized only in vegetal cells, VegT acti

137 GFbeta superfamily member, is expressed as a maternal mRNA localized to prospective endoderm, and mat

138 vel observations: first, XPACE4 is stored as maternal mRNA localized to the mitochondrial cloud and v

139 nt studies have documented the importance of maternal mRNA (MmRNA) and its correct recruitment for de

140 The maternal mRNA nos-2 is maintained in germ granules, but

141 ount for the range of temporal inductions of maternal mRNAs observed during Xenopus oocyte maturation

142 ion and translational activation of multiple maternal mRNAs occur in a CPE- and CPEB-independent mann

143 equires that the translation of pre-existing maternal mRNAs occur in a strict temporal order.

144 equired both to recruit and also to maintain maternal mRNAs on polyribosomes.

145 lates polyadenylation-induced translation of maternal mRNA once it is phosphorylated on Ser 174 or Th

146 Precise elimination of maternal mRNAs plays a critical role during the maternal

147 thus revealing a differential regulation of maternal mRNA polyadenylation by the MAPK and MPF signal

148 ake an unexpectedly high contribution to the maternal mRNA pool, which persists in cleavage stage emb

149 Our work revealed different profiles of maternal mRNA post-transcriptional regulation prior to z

150 xclusively on translation and degradation of maternal mRNAs rather than transcription.

151 nalyse this model with a spatial gradient of maternal mRNA, rather than being fixed at only the anter

152 is CDC6, which is synthesized from a dormant maternal mRNA recruited during oocyte maturation, and a

153 RNA-binding proteins are major effectors of maternal mRNA regulation.

154 ivate the cis-linked gene loci to synthesize maternal mRNAs required for early embryogenesis.

155 Translation of a variety of maternal mRNAs requires either the maintenance or cytopl

156 Issues to be resolved in current maternal mRNA research are described, and future researc

157 ated decay is a conserved mechanism to shape maternal mRNA stability by affecting deadenylation rate

158 ins that are important for the regulation of maternal mRNA stability.

159 presence of related proteins in P-bodies and maternal mRNA storage granules suggests this mechanism i

160 ols mitochondrial distribution and regulates maternal mRNA storage, translation, and decay to ensure

161 Maternal mRNAs stored in the MARDO were translationally

162 this transition requires degradation of two maternal mRNAs, string and twine, which encode Cdc25 pho

163 Unlike maternal mRNAs such as bicoid and oskar that are localiz

164 We find that maternal mRNAs targeted by Upf1-Nos are hypoadenylated a

165 Bicoid ( bcd ) mRNA is a Drosophila maternal mRNA that is translationally activated by cytop

166 s likely to be coupled to the degradation of maternal mRNA that occurs at that stage.

167 dies have also allowed us to define a set of maternal mRNAs that are deadenylated shortly after ferti

168 ogen activator (tPA, Plat) mRNAs are dormant maternal mRNAs that are recruited during oocyte maturati

169 denylation and translational inactivation of maternal mRNAS that lack cytoplasmic polyadenylation ele

170 es that the normal pattern of degradation of maternal mRNAs that occurs during oocyte maturation is d

171 and translational recruitment/repression of maternal mRNAs that occurs in early development is not f

172 mplex, was essential for m(6)A deposition on maternal mRNAs that undergo decay after zygotic genome a

173 ree major events: the removal of a subset of maternal mRNAs, the initiation of zygotic transcription,

174 on of poly(A) tail length and translation of maternal mRNAs through sequence-specific association wit

175 ssive ribonucleoprotein particles containing maternal mRNA to facilitate translational activation.

176 embryos, Bicc1 binds and represses specific maternal mRNAs to control anterior-posterior cell fates.

177 s the cytoplasmic polyadenylation of certain maternal mRNAs to permit or enhance their translation.

178 tly influence posttranscriptional control of maternal mRNAs to promote germ cell specification in the

179 entifying the targeted degradation of stored maternal mRNA transcripts including sirtuin 1 and ubiqui

180 st in kinase activity links development with maternal mRNA translation and ensures irreversibility of

181 Drosophila, the PNG kinase complex regulates maternal mRNA translation at the oocyte-to-embryo transi

182 ome-wide analysis reveals a global switch in maternal mRNA translation coinciding with oocyte re-entr

183 necessary to establish the temporal order of maternal mRNA translation during Xenopus meiotic cell cy

184 lyadenylation is a key mechanism controlling maternal mRNA translation in early development.

185 ealed insights into the critical function of maternal mRNA translation in MZT.

186 ag/RNA-Seq approach to explore the timing of maternal mRNA translation in quiescent oocytes as well a

187 and restore transcriptional competency when maternal mRNA translation is blocked, whereas inhibition

188 Our findings suggest that the timing of maternal mRNA translation is controlled through signal t

189 The maturation-dependent stimulation of maternal mRNA translation is correlated with increases i

190 A strict temporal order of maternal mRNA translation is essential for meiotic cell

191 n requires the strict temporal regulation of maternal mRNA translation.

192 regulatory elements to control the timing of maternal mRNA translational activation during oocyte mat

193 CGE), cytoplasmic segregation, cleavages and maternal mRNA translocation, in transcriptionally quiesc

194 l role for Zfp36l2 may have implications for maternal mRNA turnover in normal embryogenesis, and conc

195 ped techniques, Liu et al. showed that human maternal mRNAs undergo global poly(A) tail-mediated remo

196 translation and subcellular localization of maternal mRNAs underlies establishment of the antero-pos

197 s rely on post-transcriptional regulation of maternal mRNAs until zygotic genome activation (ZGA).

198 AF1 participate in repression and control of maternal mRNAs using Xenopus laevis oocytes.

199 In this population-based cohort study, maternal mRNA vaccination was associated with a lower ri

200 rarchy in the cytoplasmic polyadenylation of maternal mRNAs, we ablated c-mos mRNA with an antisense

201 ) in the 3' untranslated region (UTR) of the maternal mRNA, Wee1, mediates translational repression i

202 proteins before ZGA was surprising, because maternal mRNAs were found to be fully spliced.

203 Previously recruited maternal mRNAs were removed from polyribosomes following

204 Xenopus oocytes accumulate maternal mRNAs which are then recruited to ribosomes dur

205 iffusion of Bcd protein after translation of maternal mRNA, which serves as a strictly localized sour

206 The restricted spatiotemporal translation of maternal mRNAs, which is crucial for correct cell fate s

207 t is important to define the contribution of maternal mRNA while developing zebrafish models of dystr

208 arrest of female meiosis, degrading certain maternal mRNAs while initiating the translation of other

209 In a screen for maternal mRNAs whose stability is regulated by this cort

210 Consistent with regulating maternal mRNAs, Zar2 was present throughout oogenesis, a