ライフサイエンスコーパス: maternally

1 most eukaryotes, mitochondria are inherited maternally.

2 n the paternal genome and may be transmitted maternally.

3 mese infants have extensive exposure to NTS, maternally acquired antibodies appear to play a protecti

4 By 52 weeks of age, the majority of maternally acquired antibodies had waned and vaccine Env

5 egy aimed at mothers-to-be, thereby boosting maternally acquired antibodies of infants, and their hou

6 Antibody dynamics, the role of maternally acquired antibodies, and NTS seroincidence ra

7 The kinetics of enhancing activity by maternally acquired DENV antibodies was determined in se

8 Maternally acquired DENV-3 NAbs disappeared in >90% of t

9 is and bacteremia, but little is known about maternally acquired immunity and natural exposure in inf

10 high DNA-lactia and lower GA, regardless of maternally acquired neutralizing antibody levels.

11 Maternally acquired RSV antibodies were associated with

12 ntal transport, suggesting Fc engineering of maternally administered antibody to enhance only FcRn bi

13 a complete lack of genetic structure in both maternally and biparentally inherited markers.

14 ing trios to investigate differences between maternally and paternally derived DNMs and study the und

15 Here, we assess maternally and paternally derived protection in a monarc

16 genes were enriched for coexpressed pairs of maternally and paternally expressed genes, showed accele

17 F1R causes down-regulated expression of both maternally and paternally expressed imprinted genes and

18 imprinting rely on an asymmetry between the maternally and paternally inherited alleles at a locus t

19 f-origin specific differential expression of maternally and paternally inherited alleles.

20 between reciprocally imprinted genes on the maternally and paternally inherited chromosomes.

21 DNA result in maternally inherited diseases; maternally and somatically acquired mutations also accum

22 , fish lacking both Cnrip1a and Cnrip1b both maternally and zygotically are viable and fertile and no

23 rative transcriptome analysis identified 807 maternally biased expressed genes (MBGs) and 581 paterna

24 The role of maternally contributed and zygotically transcribed genes

25 ough the structure of the synapse is normal, maternally contributed CaMKII does not localize to synap

26 ogical role of the nematode mir-35 family of maternally contributed essential microRNAs.

27 Maternally contributed microRNAs may therefore play impo

28 ion repression to its biological role in the maternally controlled stages of vertebrate embryogenesis

29 ygote and embryo development being primarily maternally controlled, and subsequent steps being govern

30 ons in population size were observed between maternally density-stressed and density-unstressed offsp

31 Here, we characterize the maternally deposited and zygotically expressed small RNA

32 at which Drosophila embryos synthesize DNA, maternally deposited dNTPs can generate less than half o

33 To test if maternally deposited DOT1L is required for embryo develo

34 ranscriptome, we previously found that three maternally deposited Drosophila RNA-binding proteins (ME

35 A second maternally deposited factor, Zelda (Zld), is uniformly d

36 dispensable for embryonic development, while maternally deposited gdf3 is required for mesendoderm fo

37 piwil2 is a gonad-specific and maternally deposited gene in Nile tilapia eggs which is

38 ternal to zygotic transition (MZT), in which maternally deposited messenger RNAs are degraded while z

39 cific 3' end nontemplate oligoadenylation of maternally deposited microRNAs that is conserved between

40 cer activity in downregulating the levels of maternally deposited mRNAs to fine-tune the expression o

41 fertilization, development is controlled by maternally deposited products, and it is not until later

42 early development, animal embryos depend on maternally deposited RNA until zygotic genes become tran

43 ion of the zygotic genome and degradation of maternally deposited RNA.

44 bundant piRNA resulted in failure to degrade maternally deposited transcripts in the zygote and devel

45 ed microRNAs, target a significant number of maternally deposited transcripts.

46 istance alleles in the early embryo and that maternally-deposited Cas9 alone can power germline drive

47 ing demonstrated that she is a carrier for a maternally derived 5T/12TG variant.

48 Similarly, the presence of maternally derived anti-brain autoantibodies found in 20

49 Similarly, the presence of maternally derived anti-brain autoantibodies found in ~2

50 However, if maternally derived antibodies adversely affect the immun

51 which could partly offset the early loss of maternally derived antibodies in infants born to predomi

52 munization to passively protect infants with maternally derived antibodies, a multivalent vaccine mig

53 8 weeks of age correlated with a decrease in maternally derived antibodies.

54 Maternally derived copy number gains of human chromosome

55 that some genome regions show enrichment for maternally derived DNMs.

56 Through manipulation of maternally derived EGF and alteration of the earliest gu

57 Thus, maternally derived EGF, and potentially other EGFR ligan

58 sbred to generate homozygous NOS3(-/-) (KO), maternally derived heterozygous NOS3(+/-) (KOM: mother w

59 onset defects can be maternally rescued, and maternally derived HIRA-1 protein can be detected in hir

60 the transfer of helminth antigens but rather maternally derived IFN-gamma during the acute phase of i

61 sure was associated with a faster decline of maternally derived immunoglobulin G antibody to both the

62 e, when the IgA antibodies are predominantly maternally derived in breast-fed children.

63 Whereas approximately 10% were maternally derived in the first few weeks after weaning,

64 the transmission of this food preference: a maternally derived NPF locus is necessary for this pheno

65 s to offspring, many studies have focused on maternally derived protection.

66 Maternally derived RSV-specific antibodies play a role i

67 Differentiation of the maternally derived seed coat epidermal cells into mucila

68 fertilization products are surrounded by the maternally derived seed coat, whose development prior to

69 osperm, which is in turn enclosed within the maternally derived seed coat.

70 d collected at delivery); however, at birth, maternally derived serotype-specific antibody concentrat

71 wed as a single unified dynamic system where maternally derived size-dependent information interprete

72 s represent the first evidence of a role for maternally derived WNT regulators during this period and

73 months later to distinguish between passive (maternally derived) and active (induced by secondary tra

74 his relative resistance has been ascribed to maternally-derived anti-parasite immunoglobulin G; howev

75 rgenerational consequences via, for example, maternally-derived steroids in eggs.

76 igated how predation risk affects a suite of maternally-derived steroids in threespine stickleback eg

77 We demonstrate that maternally-derived, cord-blood anti-PfSEA-1 antibodies p

78 Here we assess the role of maternally directed learning of migratory habitats, or m

79 ndent RNA decay as a previously unidentified maternally driven mechanism that regulates maternal mRNA

80 Most human aneuploidies originate maternally, due in part to the presence of highly string

81 evealed two temporal degradation programs: a maternally encoded early-onset program and a late-onset

82 Depletion of these maternally-encoded transcripts frequently results in fai

83 To test this, we maternally exposed developing mice in utero to gestation

84 We assessed the effects of CAR on maternally exposed Dhcr7(+/-) and wild-type mouse offspr

85 AR elevated toxic oxysterols in the brain of maternally exposed Dhcr7(+/-) offspring to levels approa

86 and oxysterols were measured in the brain of maternally exposed offspring at various time points usin

87 model where WT and Dhcr7(+/)(-) embryos were maternally exposed to ARI or vehicle (VEH) from E12 to E

88 Xenopus development, gtpbp2 transcripts are maternally expressed and localized to the egg animal pol

89 NAs, including miR-127, are processed from a maternally expressed antisense Rtl1 transcript (Rtl1as)

90 In this study, we demonstrate that lncRNA maternally expressed gene 3 (Meg3) interacts with the RN

91 Maternally expressed gene 3 (MEG3) is an imprinted gene

92 The long non-coding RNA (lncRNA) Maternally Expressed Gene 3 (Meg3) is encoded within the

93 Among them, the lncRNA maternally expressed gene 3 (Meg3) was found to be mostl

94 CTC-binding factor (CTCF) recruitment to the maternally expressed gene 3 differentially methylated re

95 essed genes (PEGs), while endosperm-specific maternally expressed genes (endo-MEGs) were associated w

96 In the rice endosperm, we identified 162 maternally expressed genes (MEGs) and 95 paternally expr

97 However, only approximately 14% of maternally expressed genes (MEGs) and approximately 29%

98 The majority of maternally expressed genes (MEGs) were shared among all

99 gulates imprinted expression of a cluster of maternally expressed genes on human chromosome 11p15.5.

100 ic expression of Kcnq1ot1 and suppression of maternally expressed genes.

101 vated in the hybrid, demonstrating that also maternally expressed imprinted genes are perturbed durin

102 at the Ido1 and Ido2 genes are imprinted and maternally expressed in mouse placentas.

103 show that AGL36-like genes are imprinted and maternally expressed in seeds of Arabidopsis species and

104 otein-coding genes (DLK1, RTL1 and DIO3) and maternally expressed lncRNAs (MEG3/GTL2, RTL1as and MEG8

105 These data suggest maternally expressed miRNAs antagonize paternally driven

106 ced neuron (iN) culture system, we show that maternally expressed miRNAs from the miR-379/410 cluster

107 In addition, 35 maternally expressed non-coding RNAs exhibited the same

108 A group of maternally expressed NRPD1-siRNA loci targets endosperm-

109 nal knockout (cKO) of Smc5 demonstrated that maternally expressed SMC5 protein is essential for early

110 ext]), and lower expression of h19 imprinted maternally expressed transcript (H19) ([Formula: see tex

111 the AS-IC exhibit reduced expression of the maternally expressed UBE3A gene and biallelic expression

112 eurogenetic disorder caused by deficiency of maternally expressed ubiquitin-protein ligase E3A (UBE3A

113 Furthermore, we show that the maternally expressed zebrafish Kinesin-1 Kif5Ba is a bin

114 essed from the maternally inherited allele ("maternally expressed") to explore the molecular and cell

115 Here, we uncover and characterize a novel, maternally expressed, TRIM28-interacting KRAB zinc-finge

116 e imprinted Dlk1-Meg3 gene locus and is only maternally expressed.

117 th respect to perturbations to the dosage of maternally-expressed dorsal mRNA.

118 studies reveal that both genes are required maternally for egg laying, mitotic progression in early

119 Maternally heritable symbionts are common in arthropods

120 uid from each sac showed that the twins were maternally identical but chimerically shared 78% of thei

121 ents with mutations (W100G and R102X) in the maternally imprinted epsilon-sarcoglycan (SGCE) gene and

122 maternal insulin sensitivity, including the maternally imprinted gene DLGAP2.

123 Mkrn3, the maternally imprinted gene encoding the makorin RING-fing

124 Herein we show that the maternally imprinted gene Zac1 is a critical regulator o

125 eural lineage progression, we focused on the maternally imprinted gene Zac1.

126 associated with decreased expression of the maternally imprinted genes Mest, Sfrp2, and Dlk1, which

127 For instance, transcripts for the maternally imprinted MEST and PLAGL1, were high in oocyt

128 ifically, Alb/AEG-1/c-Myc mice overexpressed maternally imprinted noncoding RNAs (ncRNAs), such as Ri

129 MAGEL2 is a maternally imprinted, paternally expressed gene, located

130 H19 is abundantly expressed maternally in embryonic tissues but is strongly represse

131 Mitochondria are inherited maternally in most animals, but the mechanisms of select

132 e disorder.SIGNIFICANCE STATEMENT People who maternally inherit a deletion or nonfunctional copy of t

133 t period owes to conflict, between a woman's maternally inherited (MI) and paternally inherited (PI)

134 Maternally inherited 15q11-13 chromosomal triplications

135 In members of family 1, a maternally inherited 4-nucleotide deletion was identifie

136 ter of microRNAs (miRNAs) expressed from the maternally inherited allele ("maternally expressed") to

137 UBE3A is only expressed from the maternally inherited allele in mature human neurons due

138 d that Ube3a is primarily expressed from the maternally inherited allele in myelinated large-diameter

139 s multiple non-coding RNAs (ncRNAs) from the maternally inherited allele, including the largest miRNA

140 The maternally inherited alpha-proteobacterium Wolbachia has

141 Mitochondrial DNA (mtDNA) mutations are maternally inherited and are associated with a broad ran

142 They are maternally inherited and in humans contain a 16,569-base

143 This microbiome-mediated resistance was maternally inherited and increased over successive gener

144 Mitochondrial disease is maternally inherited and refractory to treatment, but as

145 Wolbachia are intracellular maternally inherited bacteria that can spread through in

146 er's hereditary optic neuropathy (LHON) is a maternally inherited blinding disease characterized by d

147 iparentally inherited nuclear loci and three maternally inherited chloroplast fragments from all dipl

148 ces with blue eggs are distinguished only by maternally inherited components of the genome, which mai

149 ising from loss-of-function mutations in the maternally inherited copy of the UBE3A gene, and is char

150 l disorder caused by loss of function of the maternally inherited copy of UBE3A, an imprinted gene ex

151 e M. pyrifera genotype for two predominantly maternally inherited cytoplasmic markers (COI and rbcLS

152 nd stroke-like episodes) and MIDD syndromes (maternally inherited diabetes and deafness).

153 syndrome, the low mtDNA heteroplasmy causes maternally inherited diabetes with or without deafness (

154 tions in mitochondrial genes as the cause of maternally inherited diseases affecting tissues that rel

155 gh frequencies of pathogenic mtDNA result in maternally inherited diseases; maternally and somaticall

156 ting by assaying hybrid embryos with ablated maternally inherited DNA methylation.

157 Rare maternally inherited duplications at 15q11-13 are observ

158 Approximately 3-5% of ASD cases arise from maternally inherited duplications of 15q11.2-q13.1, term

159 In many arthropods, maternally inherited endosymbiotic bacteria can increase

160 (IIT)-which uses sterilization caused by the maternally inherited endosymbiotic bacteria Wolbachia-is

161 Progress has been made in developing the maternally inherited endosymbiotic bacterium Wolbachia a

162 ited CNVs, specifically for small (<100 kb), maternally inherited events (P = 0.01) that are enriched

163 try between the influences of paternally and maternally inherited gene copies.

164 inherited genes might be inactivated because maternally inherited genes are adapted to function harmo

165 Mitochondrial diseases include a group of maternally inherited genetic disorders caused by mutatio

166 , using the D-loop of mitochondrial DNA as a maternally inherited genetic marker, we address the ques

167 d systems such as Drosophila and Xenopus use maternally inherited germ determinants to specify germ c

168 Specification through maternally inherited germ plasm occurs in many well-char

169 at growth hormone deficiency associated with maternally inherited gingival fibromatosis is an allelic

170 patients with growth hormone deficiency and maternally inherited gingival fibromatosis.

171 However, it may also cause maternally inherited hearing loss in the absence of amin

172 according to extreme geographic structure in maternally inherited host mitochondrial DNA, appeared co

173 Mitochondria are maternally inherited in many organisms.

174 this limitation, since the plastid genome is maternally inherited in most plants, motivating the need

175 The genus Wolbachia is an archetype of maternally inherited intracellular bacteria that infect

176 aoronymphium and its sister species harbor a maternally inherited intracellular bacterial symbiont.

177 drial inhibitors, or in neurons derived from maternally inherited Leigh syndrome (MILS) patient iPS c

178 cluding NRXN2 and CNTNAP2 putatively overlay maternally inherited loss-of-function coding variations

179 Some rare SRS patients carry maternally inherited microduplications spanning the impr

180 ormalities, including the three samples with maternally inherited microduplications.

181 Maternally inherited mitochondrial (mt)DNA mutations can

182 We targeted the maternally inherited mitochondrial DNA (mtDNA), known to

183 plus hundreds to thousands of copies of the maternally inherited mitochondrial DNA (mtDNA).

184 Deleterious CNVs (>400 kb) were maternally inherited more often (up to 64%, p = 10(-15))

185 and is regulated through the translation of maternally inherited mRNAs.

186 Our data thus demonstrate that low levels of maternally inherited mtDNA mutations when present during

187 s in CEP104; one of these subjects harbors a maternally inherited nonsense mutation (c.496C>T [p.Arg1

188 tions that disrupted a gene, 82% were either maternally inherited or de novo (p = 4.3 x 10(-3)).

189 Because cytochrome b is encoded by the maternally inherited parasite mitochondrion, even outcro

190 led from paternally inherited centrioles and maternally inherited pericentriolar material (PCM) [1].

191 tic distances, population structure, and the maternally inherited rbcL gene identified putative hybri

192 ound to be conferred non-canonically through maternally inherited repressive histone modification H3K

193 Maternally inherited RNA and proteins control much of em

194 cal presentations and affected by de novo or maternally inherited single-nucleotide changes.

195 an be rendered asexual by infection with the maternally inherited symbiont Wolbachia.

196 Maternally inherited symbionts are common in arthropods

197 l., 2016) we showed that dormancy levels are maternally inherited through the preferential maternal a

198 Breakpoint sequencing of one maternally inherited translocation involving four chromo

199 ome (AS), which is caused by the loss of the maternally inherited UBE3A allele (encoding ubiquitin pr

200 rogenetic disorder caused by deletion of the maternally inherited UBE3A allele and is characterized b

201 l disorder caused by loss of function of the maternally inherited UBE3A allele.

202 rder caused by a mutation or deletion of the maternally inherited UBE3A allele.

203 analyses identified co-regulated networks in maternally inherited Ube3a deletion offspring enriched i

204 Interpretation of the significance of maternally inherited X chromosome variants in males with

205 rRNA gene of human mitochondrial DNA causes maternally inherited, nonsyndromic deafness, an extreme

206 Wolbachia is maternally inherited, resulting in co-inheritance of mit

207 uclear differentiation, either stochastic or maternally inherited.

208 ing revealed a subset of pri-miRNAs that are maternally inherited.

209 with rearrangements < 6 Mb, unless they were maternally inherited.

210 tinalis to show that levels of buffering are maternally inherited.

211 ased thyroid-stimulating hormone levels when maternally inherited.

212 t by an average of 1.83 cm (-0.31 s.d.) when maternally inherited.

213 irect consequence of delayed turnover of the maternally-inherited transcription factor LIN-15B, a syn

214 a were collected from birth certificates and maternally linked hospital discharge data.

215 s, posits that MBT timing is controlled by a maternally loaded inhibitory factor that is titrated aga

216 In addition to the maternally loaded primary piRNAs, Tribolium embryos prod

217 asmically-transmitted bacteria influence the maternally-loaded components of the egg or early embryo

218 ion mechanism does not involve alteration of maternally-loaded transcripts.

219 reported in this issue of the Journal, is a maternally matched design based on a single interpregnan

220 The maternally methylated KvDMR1 ICR regulates imprinted exp

221 e inseminated or microinjected, yet numerous maternally-nucleated cytasters are found.

222 Thus, maternally obtained GlcN may increase substrates for bio

223 -containing cellular fragments (CCFs) can be maternally or paternally derived and display double-stra

224 that restricts gene expression to either the maternally or paternally inherited allele.

225 fic transcriptome analysis of offspring from maternally or paternally inherited Ube3a deletions revea

226 x-specific genetic maps to classify pairs as maternally or paternally related-e.g., paternal half-sib

227 essed genes (endo-MEGs) were associated with maternally preferred H3K4me3 and H3K36me3 peaks.

228 that many developmental enhancers are marked maternally, prior to exposure to extrinsic signals.

229 Our studies indicate that maternally provided aura (mid1ip1l) acts during the reor

230 Animal embryos depend upon maternally provided factors until zygotic genome activat

231 ing (induction) or by a derived mechanism of maternally provided germ plasm (preformation).

232 Previous work suggests that the pool size of maternally provided histones can alter the timing of zyg

233 We show that maternally provided Plag1 is needed for timely mouse pre

234 vage divisions that are facilitated by large maternally provided pools of nuclear components.

235 the JabbaTrap, a technique for inactivating maternally provided proteins in embryos.

236 n but not its chromodomain and was guided by maternally provided signals.

237 e demonstrate that zygotically expressed and maternally provided transcripts are efficiently targeted

238 ere we report that zebrafish embryos without maternally provided vg1 fail to form endoderm and head a

239 ss spectrometry methods, we demonstrate that maternally provisioned pheromone 7,11-heptacosadiene (7,

240 Accordingly, we propose that SEIP-1 may maternally regulate LD biogenesis and lipid homeostasis

241 ce interval, 1.06-1.44) that was similar for maternally reported asthma.

242 mine the associations of race/ethnicity with maternally reported child AD.

243 is, day-care center attendance, birth order, maternally reported common infections in infancy, and br

244 ASD were at significantly increased odds of maternally reported constipation (adjusted odds ratio [a

245 accination was associated with reductions in maternally reported diarrhea (hazard ratio [HR], 0.89; 9

246 In this large prospective cohort, maternally reported GI symptoms are more common and more

247 the estimates; adjustment for the number of maternally reported infections in the child in 2 large s

248 Birth weight was measured in hospitals or maternally reported, sedentary time was assessed by usin

249 These late-onset defects can be maternally rescued, and maternally derived HIRA-1 protei

250 pqn-80 and xnp-1 abnormalities are also maternally rescued.

251 ession profiling in the medial PFC (mPFC) of maternally separated (MS) pups identified an increased e

252 in fecal transplantation experiments: adult maternally separated rats were subjected to water avoida

253 MAGEL2 is an imprinted, maternally silenced, gene located at 15q11-13, within th

254 s are specified by using germ plasm-that is, maternally specified germ-line determinants (inheritance

255 d in low and high density, and HL and HH for maternally stressed offspring, assigned in low and high

256 d in low and high density, and HL and HH for maternally stressed offspring, assigned in low and high

257 rest is unable to compensate for deficits in maternally supplied rest and uncovers novel temporal req

258 Here we show that in zebrafish, maternally supplied rest regulates expression of target

259 These divisions are dependent on maternally supplied RNAs and proteins including histones

260 n Caenorhabditis elegans is initiated by the maternally supplied SKN-1/Nrf2 bZIP transcription factor

261 to play a role in the efficiency with which maternally supplied substrates are converted into storag

262 Maternally supplied wnt16 is expressed ubiquitously duri

263 to estimate the effectiveness of alternative maternally targeted vaccination strategies (antenatal de

264 ormation to aid consideration of alternative maternally targeted vaccination strategies and can infor

265 prompted a number of countries to implement maternally targeted vaccination strategies to protect vu

266 tern, not detected in other parts of Poland; maternally the individuals are linked to earlier Neolith

267 Mice acquire both IgG and IgA maternally; the former has primarily been implicated in

268 In most species, mitochondria are inherited maternally through mechanisms that are poorly understood

269 is also highly diverse, and transitions from maternally to embryonically expressed elements.

270 the enhancing activity of DENV infection by maternally transferred DENV antibodies occurs at earlier

271 Experimental manipulations of maternally transferred hormones have yielded increasingl

272 rely stored in lipid rich tissue of eels but maternally transferred into gonads and eggs.

273 We therefore studied whether maternally transferred thyroid hormones (THs) exert cont

274 fect, with all ten inherited mutations being maternally transmitted (p=0.00098).

275 Maternally transmitted associations between endosymbioti

276 Numerous arthropods harbor maternally transmitted bacteria that induce the preferen

277 Spiroplasma poulsonii is a maternally transmitted bacterial endosymbiont that is na

278 Male-killing is one strategy used by maternally transmitted bacterial symbionts to boost tran

279 Wolbachia, a maternally transmitted bacterium globally present in art

280 ide new insights into the pathophysiology of maternally transmitted deafness that was manifested by a

281 The triplications arose de novo from maternally transmitted duplications and caused a more se

282 es of linkage between mitochondria and other maternally transmitted genetic elements, including the r

283 ortion, have well-studied parallels in other maternally transmitted genetic elements, such as bacteri

284 mong transmitters (defined as pairs in which maternally transmitted HIV infection occurred by 12 mont

285 stand potential context-dependent effects of maternally transmitted hormones on offspring, and their

286 We report the first case to date of maternally transmitted infantile spinocerebellar ataxia

287 Wolbachia are maternally transmitted intracellular bacteria that invad

288 Surprisingly, we also found that maternally transmitted mtDNA mutations can cause mild pr

289 Here, we dissected a complex maternally transmitted phenotype, reminiscent of comorbi

290 case study, we discuss a recently discovered maternally transmitted sex ratio distortion in an insect

291 the pea aphid (Acyrthosiphon pisum) and its maternally transmitted symbiont, Buchnera aphidicola Usi

292 Tsetse flies (Glossina spp.) house maternally transmitted symbionts that regulate the devel

293 p mutation (c.2386C>T; p.R796X), whereas the maternally transmitted variant predicted a missense subs

294 Wolbachia, which is maternally transmitted, invaded and spread through the p

295 Thus, CI drives maternally-transmitted bacteria to high frequencies in a

296 Maternally-transmitted endosymbiotic bacteria are ubiqui

297 virus-specific T lymphocytes (VSTs) to treat maternally-transmitted, disseminated adenovirus infectio

298 al populations (referred to as LL and LH for maternally unstressed offspring, assigned in low and hig

299 al populations (referred to as LL and LH for maternally unstressed offspring, assigned in low and hig

300 Early Wnt signaling is provided maternally, whereas BMP ligand expression in the zebrafi