ライフサイエンスコーパス: matricellular

1 scribe a clot Treg population that forms the matricellular acid- and cysteine-rich protein SPARC (sec

2 Periostin, a matricellular adapter protein highly expressed by period

3 d and uninfected devices, and these included matricellular and inflammatory proteins.

4 The matricellular angiogenesis inhibitor, thrombospondin (TS

5 Mice that lack the matricellular angiogenesis inhibitor, thrombospondin-2 (

6 GF and NOV) family of proteins is a group of matricellular biomolecules involved in both physiologica

7 lting from cardiomyocyte-TrkA recognition by matricellular connective tissue growth factor (CTGF/CCN2

8 eft ventricular size and function, including matricellular (e.g. SPON1, MFAP4), senescence-associated

9 These included several proteoglycans and matricellular ECM proteins composed of common repetitive

10 stimulating synthesis of both structural and matricellular ECM proteins.

11 epithelial STAT3 activity and develop stiff, matricellular-enriched fibrosis associated with high epi

12 tion and reduced synthesis of structural and matricellular extracellular matrix proteins.

13 ing promotes tumor progression by increasing matricellular fibrosis and tissue tension.

14 he findings implicate epithelial tension and matricellular fibrosis in the aggressiveness of SMAD4 mu

15 r lesion formation, we examined whether this matricellular gene cluster was also coordinately regulat

16 nectin, collagen IV, collagen VI, myocilin), matricellular genes (connective tissue growth factor [CT

17 TGF-B-induced transcriptional activation of matricellular genes.

18 Human thrombospondin 1 (hTSP-1) is a matricellular glycoprotein facilitating bacterial adhere

19 f angiogenesis is thrombospondin-1 (TSP1), a matricellular glycoprotein known to influence adhesion,

20 The matricellular glycoprotein SPARC (secreted protein acidi

21 The matricellular glycoprotein SPARC (secreted protein acidi

22 e (SPARC) is an extracellular Ca(2+)-binding matricellular glycoprotein that associates with cell pop

23 in, acidic and rich in cysteine (SPARC) is a matricellular glycoprotein that is capable of inhibiting

24 d Protein Acidic and Rich in Cysteine), is a matricellular glycoprotein that is produced by tumor and

25 The human matricellular glycoprotein thrombospondin-1 (hTSP-1) is

26 hibition of some angiogenic responses by the matricellular glycoprotein thrombospondin-1 and is there

27 e necessary for some T cell responses to the matricellular glycoprotein thrombospondin-1.

28 Tenascin C (TNC) is a matricellular glycoprotein whose expression in adult tis

29 Thrombospondin (TSP)-1 is a matricellular glycoprotein with immunoregulatory propert

30 at SPARC/osteonectin, a small ECM-associated matricellular glycoprotein, can induce MMP-2 activation

31 Thrombospondin-2 (TSP2), a matricellular glycoprotein, has been shown to negatively

32 tential role for thrombospondin-2 (TSP-2), a matricellular glycoprotein, in the regulation of primary

33 SPARC, a 32-kDa matricellular glycoprotein, mediates interactions betwee

34 ted protein, acidic and rich in cysteine), a matricellular glycoprotein, modulates the interaction of

35 ich in cysteine (SPARC) is a multifunctional matricellular glycoprotein.

36 pondins (Thbs) are a family of five secreted matricellular glycoproteins in vertebrates that broadly

37 interaction of Streptococcus pneumoniae with matricellular hTSP-1.

38 CCN1 (CYR61) is a matricellular inducer of angiogenesis essential for succ

39 f Eomes-dependent genes encode intercellular/matricellular interaction and cytoskeletal components, l

40 ed as a cell scaffold to study the effect of matricellular interactions in vitro.

41 Periostin (POSTN), a secretory matricellular matrix protein, plays a multitude of biolo

42 ealing in skin fibroblasts and establish its matricellular mode of action through integrin receptors.

43 uch as CCN1, an immediate-early gene-encoded matricellular molecule critical for vascular development

44 The majority of prioritized proteins were of matricellular origin.

45 Interferons blunted the protective matricellular programs and contractile function of borde

46 CCN6 is a secreted cysteine-rich matricellular protein (36.9 kDa) that exerts growth-inhi

47 ficantly, we found that the TGF-beta-induced matricellular protein (TGFBI) was similarly biphasically

48 CCN1 is a matricellular protein and a member of the CCN family of

49 In PDAC patient biopsies, higher matricellular protein and activated STAT3 were associate

50 ed, cooperative interaction between the CCN1 matricellular protein and canonical TGF-beta1/SMAD3 sign

51 Hevin is a matricellular protein and the result of a gene duplicati

52 ed protein acidic and rich in cysteine) is a matricellular protein associated with the extracellular

53 Here, we show that ependyma-derived matricellular protein CCN1 (cellular communication netwo

54 Expression of the matricellular protein CCN1 (CYR61) is associated with in

55 Previous studies showed that the matricellular protein CCN1 (CYR61) is induced during hep

56 The matricellular protein CCN1 (CYR61) regulates multiple ce

57 The matricellular protein CCN1 (formerly named CYR61) regula

58 The matricellular protein CCN1 enhances TGF-beta1/SMAD3-depe

59 The matricellular protein CCN1 is induced in endothelial cel

60 is LRA functional adaptation is the secreted matricellular protein CCN1.

61 Here we show that the matricellular protein CCN1/CYR61 can unmask the cytotoxi

62 Here we show that the matricellular protein CCN1/CYR61 coordinately regulates

63 titative mass spectrometry, we find that the matricellular protein CCN1/CYR61 is highly regulated by

64 ecently provided the first evidence that the matricellular protein CCN3 (official symbol NOV) functio

65 re, we determined that the expression of the matricellular protein CCN3 is strongly reduced in rodent

66 ght to interact with BMP-2: collagen IIA and matricellular protein CCN3.

67 The matricellular protein CCN5/WISP-2 represents a promising

68 The matricellular protein connective tissue growth factor (C

69 Thrombospondin 2 (TSP2) is a matricellular protein controlling the apoptosis-prolifer

70 cytes with keratinocytes upregulates CCN3, a matricellular protein critical to maintenance of normal

71 everal microarray databases suggest that the matricellular protein Cyr61 is highly induced by LPA.

72 tion by these agonists and revealed that the matricellular protein cysteine-rich 61 (Cyr61/CCN1) is s

73 lammatory mediator cyclooxygenase 2, and the matricellular protein cysteine-rich angiogenic inducer 6

74 Periostin is a matricellular protein essential for tissue integrity and

75 ive tissue growth factor (CTGF or CCN2) is a matricellular protein expressed by multiple cell types i

76 Members of the CCN matricellular protein family are crucial in various biol

77 Mechanistically, CA19-9 modification of the matricellular protein fibulin-3 increased its interactio

78 duction by reporting a novel function of the matricellular protein Fibulin-5 (Fbln5).

79 vel downstream target Sparc, which encodes a matricellular protein found in PDAC stroma that has been

80 ervations suggest an important role for this matricellular protein in the local regulation of inflamm

81 pression project pinpoints POSTN, encoding a matricellular protein involved in bone formation and bon

82 CCN1 is a matricellular protein involved in normal vascular develo

83 Previously, we showed that periostin, a matricellular protein involved in tissue repair, is mark

84 th factor (CTGF) is a cysteine-rich secreted matricellular protein involved in wound healing and tiss

85 bospondin-1 (TSP) is a transiently expressed matricellular protein known to promote chemotaxis of leu

86 Thrombospondin-1 (TSP1) is a multifunctional matricellular protein known to promote progression of ch

87 ein acidic and rich in cysteine (SPARC) is a matricellular protein known to regulate extracellular ma

88 m, we have uncovered a critical role for the matricellular protein Mindin (SPON2) in fibrogenesis.

89 Here we identify the matricellular protein Nephroblastoma Overexpressed (Nov,

90 Here we show that CCN6 (WISP3), a secreted matricellular protein of the CCN (CYR61/CTGF/NOV) family

91 Here we show that CCN1, a matricellular protein of the CCN (CYR61/CTGF/NOV) family

92 r CCN1 (cysteine-rich 61, CYR61), a secreted matricellular protein of the CCN family, is a ligand of

93 CN3 (NOV, nephroblastoma overexpressed) is a matricellular protein of the CCN family, which also incl

94 CCN3 (NOV) is a matricellular protein of the CCN family, which also incl

95 Cysteine-rich 61 (CCN1) is a matricellular protein of which expression is up-regulate

96 SPARC is a matricellular protein often associated with fibrosis.

97 The matricellular protein osteopontin (OPN, Spp-1) is widely

98 are the first to show that induction of the matricellular protein osteopontin facilitates DMBA/TPA-i

99 hat Wnt-1 strongly induced the expression of matricellular protein osteopontin, and modestly enhanced

100 The matricellular protein periostin can distinguish CAF subt

101 The matricellular protein periostin has been associated with

102 -and the quantification of its levels of the matricellular protein periostin, which cannot be accurat

103 cretion of profibrotic proteins, such as the matricellular protein periostin.

104 Periostin (Postn) is a matricellular protein preferentially expressed by osteoc

105 Connective tissue growth factor (CTGF) is a matricellular protein presumed to be involved in the pat

106 ADAMTSL2 is a matricellular protein previously shown to interact with

107 ers of fibrinolysis, endothelial activation, matricellular protein release, and tissue damage and wit

108 , fibrinolysis, endothelial cell activation, matricellular protein release, and tissue damage were me

109 ered the role of thrombospondin-1 (TSP-1), a matricellular protein released in abundance from activat

110 otein 61 (Cyr61) is a dynamically expressed, matricellular protein required for proper angiogenesis a

111 secreted cysteine-rich and integrin-binding matricellular protein required for proper cardiovascular

112 factor 1 (CCN1) is a dynamically expressed, matricellular protein required for vascular development

113 The matricellular protein secreted protein acidic and rich i

114 Here, we provide evidence that the matricellular protein secreted protein acidic and rich i

115 le of which was the evolutionarily conserved matricellular protein Secreted Protein Acidic and Rich i

116 Club cell Pdcd5 knockdown reduces matricellular protein secretion, inhibiting fibroblast p

117 and rich in cysteine)/BM 40/osteonectin is a matricellular protein shown to function as a counteradhe

118 The matricellular protein SMOC (Secreted Modular Calcium bin

119 r-activation of the small GTPase Ran and the matricellular protein SMOC-2 that has important conseque

120 ient with a loss-of-function of the secreted matricellular protein SMOC2 (SPARC related modular calci

121 Arntl2 partner and functionally validate the matricellular protein Smoc2 as a pro-metastatic secreted

122 The matricellular protein SPARC (secreted protein acidic and

123 observed in the presence and absence of the matricellular protein SPARC (secreted protein, acidic an

124 This study identifies the stromal-derived matricellular protein SPARC as a novel regulator of isle

125 We show that the matricellular protein SPARC contributes to the BM stroma

126 ggers miR29-b-mediated downregulation of the matricellular protein SPARC in the nearby stroma.

127 The matricellular protein SPARC is expressed at high levels

128 The gene encoding the matricellular protein SPARCL1 was most strongly upregula

129 In addition, interstitial deposition of the matricellular protein tenascin, a marker of active remod

130 SPARC, a matricellular protein that affects cellular adhesion and

131 rowth factor (CCN2, also known as CTGF) is a matricellular protein that appears to play an important

132 Fibulin-5 (Fbln5) is a matricellular protein that blocks fibronectin-integrin i

133 We show that CCN1 (also known as CYR61), a matricellular protein that dampens and resolves liver fi

134 Thrombospondin-1 (TSP1) is a matricellular protein that differentially promotes the a

135 Thrombospondin-1 (TSP1) is a matricellular protein that displays both pro- and anti-a

136 CCN1 is a matricellular protein that has been implicated in angiog

137 Thrombospondin 1 (TSP-1) is a matricellular protein that inhibits angiogenesis and cau

138 d Protein, Acidic and Rich in Cysteine) is a matricellular protein that inhibits mesangial cell proli

139 reported that fibulin-5, an integrin-binding matricellular protein that is essential for elastic fibe

140 CCN1 (CYR61) is a matricellular protein that is highly expressed at sites

141 SPARC is a matricellular protein that is highly expressed in remode

142 ed connective tissue growth factor (CTGF), a matricellular protein that is highly expressed in the br

143 ein acidic and rich in cysteine (SPARC) is a matricellular protein that is important for the regulati

144 SPARC is a matricellular protein that is involved in both pancreati

145 Connective tissue growth factor (CCN2) is a matricellular protein that is up-regulated in many fibro

146 Follistatin-like 1 (FSTL1) is a matricellular protein that is upregulated during develop

147 Connective tissue growth factor (CTGF) is a matricellular protein that mediates cell-matrix interact

148 d protein, acidic and rich in cysteine) is a matricellular protein that modulates cell adhesion and p

149 protein acidic rich in cysteine (SPARC) is a matricellular protein that modulates the activity of gro

150 (osteonectin) (SPARC) gene, which encodes a matricellular protein that participates in normal tissue

151 ue growth factor (CTGF/CCN2) is an inducible matricellular protein that plays a major role in fibropr

152 CCN3 is a matricellular protein that promotes oligodendrocyte prog

153 ytes with keratinocytes up-regulated CCN3, a matricellular protein that we subsequently found to be c

154 The matricellular protein thrombospondin (TSP) stimulates st

155 to test the hypothesis that the prototypical matricellular protein thrombospondin (TSP)-1, a potent a

156 We hypothesized that the matricellular protein thrombospondin (TSP)-1, a potent i

157 The matricellular protein thrombospondin 1 (TSP1) regulates

158 The matricellular protein thrombospondin 2 (TSP2) regulates

159 undertook a systematic study focused on the matricellular protein Thrombospondin-1 (THBS1) to uncove

160 We tested the hypothesis that the matricellular protein thrombospondin-1 (TSP1), through b

161 We reported previously that the matricellular protein thrombospondin-1 is upregulated in

162 ere found to contain excessive levels of the matricellular protein thrombospondin-2 (TSP2) and geneti

163 Because levels of the matricellular protein thrombospondin-4 (TSP4) rapidly ri

164 ng Protein-2 (Smoc-2) is a broadly-expressed matricellular protein which contributes to mitogenesis v

165 naling pathway protein 1 (WISP1), a secreted matricellular protein whose expression is elevated in se

166 , we find a key role in this process for the matricellular protein WISP1 (CCN4).

167 We recently noted that the matricellular protein WISP1 contributes to sepsis induce

168 the expression of thrombospondin 2 (TSP2), a matricellular protein with a demonstrated role in respon

169 Tenascin-C (TNC) is a highly conserved matricellular protein with a distinct expression pattern

170 Thrombospondin 2 (TSP2), a matricellular protein with a primary role in modulating

171 otein acidic and rich in cysteine (SPARC), a matricellular protein with counteradhesive properties, i

172 Periostin is considered to be a matricellular protein with expression typically confined

173 orted that Olfactomedin-like 3 (Olfml3) is a matricellular protein with proangiogenic properties.

174 Osteopontin (OPN) is a matricellular protein with proinflammatory and profibrot

175 Periostin is a matricellular protein with roles in tissue repair follow

176 l Communication Network factor 4, a secreted matricellular protein, alters the tumor microenvironment

177 include Thrombospondin 2 (THBS2), encoding a matricellular protein, and cellular proteins, GAS1, CASR

178 bospondin-1 (TSP-1), a potent proatherogenic matricellular protein, as a putative link between hyperg

179 Periostin, an extracellular matrix and matricellular protein, binds to several types of integri

180 The matricellular protein, connective tissue growth factor (

181 , acidic and rich in cysteine (SPARC) family matricellular protein, during invasive phases of prostat

182 ests that CYR61 (now named CCN1), a secreted matricellular protein, has a role in the pathogenesis of

183 ne), although primarily known as a secreted, matricellular protein, has also been identified in uroth

184 Periostin, a matricellular protein, has an important role during reep

185 Periostin (PN), a novel fasciclin-related matricellular protein, has been implicated in cardiac de

186 , a secreted extracellular matrix-associated matricellular protein, is elevated in dermal fibroblasts

187 eport that expression of Sparcl1, a secreted matricellular protein, is upregulated in pulmonary capil

188 Here, we found that the matricellular protein, secreted protein acidic and rich

189 The matricellular protein, thrombospondin-1 (TSP-1), is prom

190 The matricellular protein, thrombospondin-2 (TSP-2), has bee

191 in 1 (SMOC1) is an osteonectin/SPARC-related matricellular protein, whose expression is regulated by

192 lved in extracellular matrix remodeling, and matricellular protein-protein and protein-cholangiocarci

193 the production of tenascin C, a pro-invasive matricellular protein.

194 and rich in cysteine), or osteonectin, is a matricellular protein.

195 e CCN family of proteins, is a cysteine-rich matricellular protein.

196 ciated with an increased expression of Cyr61 matricellular protein.

197 Thrombospondin1 (TSP1) is a multifunctional matricellular protein.

198 ster analysis, we identified a subset of six matricellular proteins (eg, osteopontin and plasminogen

199 During tissue remodeling, matricellular proteins (MCP) are secreted into the ECM.

200 small leucin-rich repeat proteoglycans, and matricellular proteins affecting both the composition an

201 tuates secretion of structural collagens and matricellular proteins and markedly increases MMP2 secre

202 lecular signature composed of an ensemble of matricellular proteins and remodeling enzymes they provi

203 Given that matricellular proteins are expressed in response to inju

204 Matricellular proteins are extracellular matrix proteins

205 Matricellular proteins are induced in fibrotic condition

206 The thrombospondin (Thbs) family of secreted matricellular proteins are stress- and injury-induced me

207 ated that NELL1 loss skews the expression of matricellular proteins associated with reduced FAK signa

208 e combined effects of the fibroblast-derived matricellular proteins CD5L (CD5 antigen-like), SPARC (s

209 The three matricellular proteins considered here might each prefer

210 ediated pathways, neurohumoral cascades, and matricellular proteins deposited in the provisional matr

211 lcium-binding proteins (SMOCs) are conserved matricellular proteins found in organisms from Caenorhab

212 d by the excess deposition of structural and matricellular proteins in the extracellular space, under

213 Furthermore, a role for matricellular proteins in the regulation skin blood flow

214 Matricellular proteins mediate pleiotropic effects durin

215 Deposition of matricellular proteins modulates growth factor signaling

216 y, we demonstrate that the presence of these matricellular proteins results in significantly stiffer

217 ckout sarcoma cells on wild-type OS-enriched matricellular proteins reversed the phenotypic and signa

218 We tested if like other matricellular proteins SMOC2 was required for regenerati

219 Matricellular proteins such as SPARC, thrombospondin 1 a

220 They comprise a diverse group of matricellular proteins that confer antiadhesive properti

221 e 1 (SC1) is a member of the SPARC family of matricellular proteins that has been implicated in the r

222 Thrombospondin-1 (TSP1) and TSP2 are matricellular proteins that have been shown to regulate

223 1) is a member of the CCN family of secreted matricellular proteins that includes connective tissue g

224 -adhesion is induced by the highly regulated matricellular proteins TSP1 and 2, tenascin-C, and SPARC

225 e we show that CCN1 (CYR61) and CCN2 (CTGF), matricellular proteins upregulated at sites of inflammat

226 linearization is controlled by two secreted matricellular proteins with antagonistic functions.

227 trix macromolecules (such as fibronectin and matricellular proteins).

228 ediators of extracellular matrix remodeling, matricellular proteins, and cardiac integrins compared w

229 ls of extracellular matrix genes, integrins, matricellular proteins, and growth factors, when compare

230 d SPARC, two homologs of the SPARC family of matricellular proteins, in the foreign body response.

231 ndly decreased gene expression of a group of matricellular proteins, of which periostin was prominent

232 Matricellular proteins, secreted macromolecules that int

233 Whereas major matricellular proteins, such as osteopontin, tenascin or

234 r matrix components, such as fibronectin and matricellular proteins.

235 C-2 is a novel member of the SPARC family of matricellular proteins.

236 macrophage activation through inhibition of matricellular proteins.

237 ed ECM network consisting of de novo-induced matricellular proteins.

238 otensin axis, matrix metalloproteinases, and matricellular proteins.

239 ysiologic significance of this action of the matricellular proteins?

240 We previously found that matricellular proteoglycan fibromodulin is one such fact

241 incubation (8 h) of UCB CD34+ cells with the matricellular regulator Nov (CCN3) increases the frequen

242 rograms and circulating osteopontin (OPN), a matricellular regulator of arteriosclerosis.

243 The matricellular secreted protein connective tissue growth

244 Matricellular Secreted Protein, Acidic and Rich in Cyste

245 Ab) that is directed against the pleiotropic matricellular signaling protein connective tissue growth

246 The matricellular SPARC family member hevin (SPARC-like 1/SP

247 r to the classical PspC molecule, with human matricellular thrombospondin-1 (hTSP-1).