ライフサイエンスコーパス: matricellular protein

1 trix macromolecules (such as fibronectin and matricellular proteins).

2 the production of tenascin C, a pro-invasive matricellular protein.

3 and rich in cysteine), or osteonectin, is a matricellular protein.

4 ciated with an increased expression of Cyr61 matricellular protein.

5 e CCN family of proteins, is a cysteine-rich matricellular protein.

6 Thrombospondin1 (TSP1) is a multifunctional matricellular protein.

7 C-2 is a novel member of the SPARC family of matricellular proteins.

8 macrophage activation through inhibition of matricellular proteins.

9 ed ECM network consisting of de novo-induced matricellular proteins.

10 otensin axis, matrix metalloproteinases, and matricellular proteins.

11 r matrix components, such as fibronectin and matricellular proteins.

12 ysiologic significance of this action of the matricellular proteins?

13 CCN6 is a secreted cysteine-rich matricellular protein (36.9 kDa) that exerts growth-inhi

14 small leucin-rich repeat proteoglycans, and matricellular proteins affecting both the composition an

15 l Communication Network factor 4, a secreted matricellular protein, alters the tumor microenvironment

16 CCN1 is a matricellular protein and a member of the CCN family of

17 In PDAC patient biopsies, higher matricellular protein and activated STAT3 were associate

18 ed, cooperative interaction between the CCN1 matricellular protein and canonical TGF-beta1/SMAD3 sign

19 Hevin is a matricellular protein and the result of a gene duplicati

20 tuates secretion of structural collagens and matricellular proteins and markedly increases MMP2 secre

21 lecular signature composed of an ensemble of matricellular proteins and remodeling enzymes they provi

22 include Thrombospondin 2 (THBS2), encoding a matricellular protein, and cellular proteins, GAS1, CASR

23 ediators of extracellular matrix remodeling, matricellular proteins, and cardiac integrins compared w

24 ls of extracellular matrix genes, integrins, matricellular proteins, and growth factors, when compare

25 Given that matricellular proteins are expressed in response to inju

26 Matricellular proteins are extracellular matrix proteins

27 Matricellular proteins are induced in fibrotic condition

28 The thrombospondin (Thbs) family of secreted matricellular proteins are stress- and injury-induced me

29 bospondin-1 (TSP-1), a potent proatherogenic matricellular protein, as a putative link between hyperg

30 ed protein acidic and rich in cysteine) is a matricellular protein associated with the extracellular

31 ated that NELL1 loss skews the expression of matricellular proteins associated with reduced FAK signa

32 Periostin, an extracellular matrix and matricellular protein, binds to several types of integri

33 Here, we show that ependyma-derived matricellular protein CCN1 (cellular communication netwo

34 Expression of the matricellular protein CCN1 (CYR61) is associated with in

35 Previous studies showed that the matricellular protein CCN1 (CYR61) is induced during hep

36 The matricellular protein CCN1 (CYR61) regulates multiple ce

37 The matricellular protein CCN1 (formerly named CYR61) regula

38 The matricellular protein CCN1 enhances TGF-beta1/SMAD3-depe

39 The matricellular protein CCN1 is induced in endothelial cel

40 is LRA functional adaptation is the secreted matricellular protein CCN1.

41 Here we show that the matricellular protein CCN1/CYR61 can unmask the cytotoxi

42 Here we show that the matricellular protein CCN1/CYR61 coordinately regulates

43 titative mass spectrometry, we find that the matricellular protein CCN1/CYR61 is highly regulated by

44 ecently provided the first evidence that the matricellular protein CCN3 (official symbol NOV) functio

45 re, we determined that the expression of the matricellular protein CCN3 is strongly reduced in rodent

46 ght to interact with BMP-2: collagen IIA and matricellular protein CCN3.

47 The matricellular protein CCN5/WISP-2 represents a promising

48 e combined effects of the fibroblast-derived matricellular proteins CD5L (CD5 antigen-like), SPARC (s

49 The matricellular protein connective tissue growth factor (C

50 The matricellular protein, connective tissue growth factor (

51 The three matricellular proteins considered here might each prefer

52 Thrombospondin 2 (TSP2) is a matricellular protein controlling the apoptosis-prolifer

53 cytes with keratinocytes upregulates CCN3, a matricellular protein critical to maintenance of normal

54 everal microarray databases suggest that the matricellular protein Cyr61 is highly induced by LPA.

55 tion by these agonists and revealed that the matricellular protein cysteine-rich 61 (Cyr61/CCN1) is s

56 lammatory mediator cyclooxygenase 2, and the matricellular protein cysteine-rich angiogenic inducer 6

57 ediated pathways, neurohumoral cascades, and matricellular proteins deposited in the provisional matr

58 , acidic and rich in cysteine (SPARC) family matricellular protein, during invasive phases of prostat

59 ster analysis, we identified a subset of six matricellular proteins (eg, osteopontin and plasminogen

60 Periostin is a matricellular protein essential for tissue integrity and

61 ive tissue growth factor (CTGF or CCN2) is a matricellular protein expressed by multiple cell types i

62 Members of the CCN matricellular protein family are crucial in various biol

63 Mechanistically, CA19-9 modification of the matricellular protein fibulin-3 increased its interactio

64 duction by reporting a novel function of the matricellular protein Fibulin-5 (Fbln5).

65 vel downstream target Sparc, which encodes a matricellular protein found in PDAC stroma that has been

66 lcium-binding proteins (SMOCs) are conserved matricellular proteins found in organisms from Caenorhab

67 ests that CYR61 (now named CCN1), a secreted matricellular protein, has a role in the pathogenesis of

68 ne), although primarily known as a secreted, matricellular protein, has also been identified in uroth

69 Periostin, a matricellular protein, has an important role during reep

70 Periostin (PN), a novel fasciclin-related matricellular protein, has been implicated in cardiac de

71 ervations suggest an important role for this matricellular protein in the local regulation of inflamm

72 d by the excess deposition of structural and matricellular proteins in the extracellular space, under

73 Furthermore, a role for matricellular proteins in the regulation skin blood flow

74 d SPARC, two homologs of the SPARC family of matricellular proteins, in the foreign body response.

75 pression project pinpoints POSTN, encoding a matricellular protein involved in bone formation and bon

76 CCN1 is a matricellular protein involved in normal vascular develo

77 Previously, we showed that periostin, a matricellular protein involved in tissue repair, is mark

78 th factor (CTGF) is a cysteine-rich secreted matricellular protein involved in wound healing and tiss

79 , a secreted extracellular matrix-associated matricellular protein, is elevated in dermal fibroblasts

80 eport that expression of Sparcl1, a secreted matricellular protein, is upregulated in pulmonary capil

81 bospondin-1 (TSP) is a transiently expressed matricellular protein known to promote chemotaxis of leu

82 Thrombospondin-1 (TSP1) is a multifunctional matricellular protein known to promote progression of ch

83 ein acidic and rich in cysteine (SPARC) is a matricellular protein known to regulate extracellular ma

84 During tissue remodeling, matricellular proteins (MCP) are secreted into the ECM.

85 Matricellular proteins mediate pleiotropic effects durin

86 m, we have uncovered a critical role for the matricellular protein Mindin (SPON2) in fibrogenesis.

87 Deposition of matricellular proteins modulates growth factor signaling

88 Here we identify the matricellular protein Nephroblastoma Overexpressed (Nov,

89 Here we show that CCN6 (WISP3), a secreted matricellular protein of the CCN (CYR61/CTGF/NOV) family

90 Here we show that CCN1, a matricellular protein of the CCN (CYR61/CTGF/NOV) family

91 r CCN1 (cysteine-rich 61, CYR61), a secreted matricellular protein of the CCN family, is a ligand of

92 CN3 (NOV, nephroblastoma overexpressed) is a matricellular protein of the CCN family, which also incl

93 CCN3 (NOV) is a matricellular protein of the CCN family, which also incl

94 Cysteine-rich 61 (CCN1) is a matricellular protein of which expression is up-regulate

95 ndly decreased gene expression of a group of matricellular proteins, of which periostin was prominent

96 SPARC is a matricellular protein often associated with fibrosis.

97 The matricellular protein osteopontin (OPN, Spp-1) is widely

98 are the first to show that induction of the matricellular protein osteopontin facilitates DMBA/TPA-i

99 hat Wnt-1 strongly induced the expression of matricellular protein osteopontin, and modestly enhanced

100 The matricellular protein periostin can distinguish CAF subt

101 The matricellular protein periostin has been associated with

102 -and the quantification of its levels of the matricellular protein periostin, which cannot be accurat

103 cretion of profibrotic proteins, such as the matricellular protein periostin.

104 Periostin (Postn) is a matricellular protein preferentially expressed by osteoc

105 Connective tissue growth factor (CTGF) is a matricellular protein presumed to be involved in the pat

106 ADAMTSL2 is a matricellular protein previously shown to interact with

107 lved in extracellular matrix remodeling, and matricellular protein-protein and protein-cholangiocarci

108 ers of fibrinolysis, endothelial activation, matricellular protein release, and tissue damage and wit

109 , fibrinolysis, endothelial cell activation, matricellular protein release, and tissue damage were me

110 ered the role of thrombospondin-1 (TSP-1), a matricellular protein released in abundance from activat

111 otein 61 (Cyr61) is a dynamically expressed, matricellular protein required for proper angiogenesis a

112 secreted cysteine-rich and integrin-binding matricellular protein required for proper cardiovascular

113 factor 1 (CCN1) is a dynamically expressed, matricellular protein required for vascular development

114 y, we demonstrate that the presence of these matricellular proteins results in significantly stiffer

115 ckout sarcoma cells on wild-type OS-enriched matricellular proteins reversed the phenotypic and signa

116 The matricellular protein secreted protein acidic and rich i

117 Here, we provide evidence that the matricellular protein secreted protein acidic and rich i

118 le of which was the evolutionarily conserved matricellular protein Secreted Protein Acidic and Rich i

119 Here, we found that the matricellular protein, secreted protein acidic and rich

120 Matricellular proteins, secreted macromolecules that int

121 Club cell Pdcd5 knockdown reduces matricellular protein secretion, inhibiting fibroblast p

122 and rich in cysteine)/BM 40/osteonectin is a matricellular protein shown to function as a counteradhe

123 The matricellular protein SMOC (Secreted Modular Calcium bin

124 r-activation of the small GTPase Ran and the matricellular protein SMOC-2 that has important conseque

125 ient with a loss-of-function of the secreted matricellular protein SMOC2 (SPARC related modular calci

126 Arntl2 partner and functionally validate the matricellular protein Smoc2 as a pro-metastatic secreted

127 We tested if like other matricellular proteins SMOC2 was required for regenerati

128 The matricellular protein SPARC (secreted protein acidic and

129 observed in the presence and absence of the matricellular protein SPARC (secreted protein, acidic an

130 This study identifies the stromal-derived matricellular protein SPARC as a novel regulator of isle

131 We show that the matricellular protein SPARC contributes to the BM stroma

132 ggers miR29-b-mediated downregulation of the matricellular protein SPARC in the nearby stroma.

133 The matricellular protein SPARC is expressed at high levels

134 The gene encoding the matricellular protein SPARCL1 was most strongly upregula

135 Matricellular proteins such as SPARC, thrombospondin 1 a

136 Whereas major matricellular proteins, such as osteopontin, tenascin or

137 In addition, interstitial deposition of the matricellular protein tenascin, a marker of active remod

138 ficantly, we found that the TGF-beta-induced matricellular protein (TGFBI) was similarly biphasically

139 SPARC, a matricellular protein that affects cellular adhesion and

140 rowth factor (CCN2, also known as CTGF) is a matricellular protein that appears to play an important

141 Fibulin-5 (Fbln5) is a matricellular protein that blocks fibronectin-integrin i

142 We show that CCN1 (also known as CYR61), a matricellular protein that dampens and resolves liver fi

143 Thrombospondin-1 (TSP1) is a matricellular protein that differentially promotes the a

144 Thrombospondin-1 (TSP1) is a matricellular protein that displays both pro- and anti-a

145 CCN1 is a matricellular protein that has been implicated in angiog

146 Thrombospondin 1 (TSP-1) is a matricellular protein that inhibits angiogenesis and cau

147 d Protein, Acidic and Rich in Cysteine) is a matricellular protein that inhibits mesangial cell proli

148 reported that fibulin-5, an integrin-binding matricellular protein that is essential for elastic fibe

149 CCN1 (CYR61) is a matricellular protein that is highly expressed at sites

150 SPARC is a matricellular protein that is highly expressed in remode

151 ed connective tissue growth factor (CTGF), a matricellular protein that is highly expressed in the br

152 ein acidic and rich in cysteine (SPARC) is a matricellular protein that is important for the regulati

153 SPARC is a matricellular protein that is involved in both pancreati

154 Connective tissue growth factor (CCN2) is a matricellular protein that is up-regulated in many fibro

155 Follistatin-like 1 (FSTL1) is a matricellular protein that is upregulated during develop

156 Connective tissue growth factor (CTGF) is a matricellular protein that mediates cell-matrix interact

157 d protein, acidic and rich in cysteine) is a matricellular protein that modulates cell adhesion and p

158 protein acidic rich in cysteine (SPARC) is a matricellular protein that modulates the activity of gro

159 (osteonectin) (SPARC) gene, which encodes a matricellular protein that participates in normal tissue

160 ue growth factor (CTGF/CCN2) is an inducible matricellular protein that plays a major role in fibropr

161 CCN3 is a matricellular protein that promotes oligodendrocyte prog

162 ytes with keratinocytes up-regulated CCN3, a matricellular protein that we subsequently found to be c

163 They comprise a diverse group of matricellular proteins that confer antiadhesive properti

164 e 1 (SC1) is a member of the SPARC family of matricellular proteins that has been implicated in the r

165 Thrombospondin-1 (TSP1) and TSP2 are matricellular proteins that have been shown to regulate

166 1) is a member of the CCN family of secreted matricellular proteins that includes connective tissue g

167 The matricellular protein thrombospondin (TSP) stimulates st

168 to test the hypothesis that the prototypical matricellular protein thrombospondin (TSP)-1, a potent a

169 We hypothesized that the matricellular protein thrombospondin (TSP)-1, a potent i

170 The matricellular protein thrombospondin 1 (TSP1) regulates

171 The matricellular protein thrombospondin 2 (TSP2) regulates

172 undertook a systematic study focused on the matricellular protein Thrombospondin-1 (THBS1) to uncove

173 We tested the hypothesis that the matricellular protein thrombospondin-1 (TSP1), through b

174 We reported previously that the matricellular protein thrombospondin-1 is upregulated in

175 ere found to contain excessive levels of the matricellular protein thrombospondin-2 (TSP2) and geneti

176 Because levels of the matricellular protein thrombospondin-4 (TSP4) rapidly ri

177 The matricellular protein, thrombospondin-1 (TSP-1), is prom

178 The matricellular protein, thrombospondin-2 (TSP-2), has bee

179 -adhesion is induced by the highly regulated matricellular proteins TSP1 and 2, tenascin-C, and SPARC

180 e we show that CCN1 (CYR61) and CCN2 (CTGF), matricellular proteins upregulated at sites of inflammat

181 ng Protein-2 (Smoc-2) is a broadly-expressed matricellular protein which contributes to mitogenesis v

182 naling pathway protein 1 (WISP1), a secreted matricellular protein whose expression is elevated in se

183 in 1 (SMOC1) is an osteonectin/SPARC-related matricellular protein, whose expression is regulated by

184 , we find a key role in this process for the matricellular protein WISP1 (CCN4).

185 We recently noted that the matricellular protein WISP1 contributes to sepsis induce

186 the expression of thrombospondin 2 (TSP2), a matricellular protein with a demonstrated role in respon

187 Tenascin-C (TNC) is a highly conserved matricellular protein with a distinct expression pattern

188 Thrombospondin 2 (TSP2), a matricellular protein with a primary role in modulating

189 otein acidic and rich in cysteine (SPARC), a matricellular protein with counteradhesive properties, i

190 Periostin is considered to be a matricellular protein with expression typically confined

191 orted that Olfactomedin-like 3 (Olfml3) is a matricellular protein with proangiogenic properties.

192 Osteopontin (OPN) is a matricellular protein with proinflammatory and profibrot

193 Periostin is a matricellular protein with roles in tissue repair follow

194 linearization is controlled by two secreted matricellular proteins with antagonistic functions.