ライフサイエンスコーパス: matrix vesicle

1 genic differentiation, release of calcifying matrix vesicles).

2 aphy are agglomerations of smaller calcified matrix vesicles.

3 V-, VI- and alkaline phosphatase-containing matrix vesicles.

4 on of hydroxyapatite inside membrane-limited matrix vesicles.

5 ed protein known to mediate Ca2+ influx into matrix vesicles.

6 of dentin mineralization was associated with matrix vesicles.

7 eotide pyrophosphatase activity in cells and matrix vesicles.

8 eedles of hydroxyapatite in conjunction with matrix vesicles.

9 We propose that, unlike bone-derived matrix vesicles, a large population of EVs implicated in

10 of mineralization-competent cell fragments (matrix vesicles and apoptotic bodies).

11 Annexin V is a major component of matrix vesicles and has a role in mediating the influx o

12 n qualitatively modulate their production of matrix vesicles and only when induced to initiate minera

13 hemical cross-linking analysis revealed that matrix vesicles and phosphatidylserine-rich liposomes in

14 V-, VI- and alkaline phosphatase-containing matrix vesicles, and the initiation of mineralization by

15 s made even more intriguing by the fact that matrix vesicles are also present in nonmineralizing tiss

16 Matrix vesicles are lipid bilayer-enclosed structures th

17 oteins, and these spheres are unlikely to be matrix vesicles as reported for collagen calcification i

18 tion on collagen fibrils and the presence of matrix vesicles, as has been described in calcified vasc

19 the production and release of annexin V-rich matrix vesicles by mineralizing chondrocytes were accomp

20 ultures showed the presence of extracellular matrix vesicles, calcifying collagen fibrils, and nodula

21 ice reflects the lack of ANK activity in the matrix vesicle compartment.

22 The nucleational core of matrix vesicles contains a complex (CPLX) of phosphatidy

23 Since the lipid composition of matrix vesicles differs from that of the plasma membrane

24 Microcalcifications appear to derive from matrix vesicles enriched in calcium-binding proteins tha

25 Vascular calcification initiates with matrix vesicle formation and mineralization following a

26 Matrix vesicles have a critical role in the initiation o

27 The phosphatidylserine-rich membrane of matrix vesicles in vivo may thus offer an ideal speciali

28 Interestingly, only matrix vesicles isolated from RA-treated cells that cont

29 ated by PHOSPHO1 and likely does not rely on matrix vesicle-mediated initiation of mineralization.

30 concert to generate phosphocholine from the matrix vesicle membrane during skeletal mineralization.

31 cilitate crystal growth after rupture of the matrix vesicle membrane; it may also offer a smooth tran

32 pathological mineralization are initiated by matrix vesicles, membrane-enclosed particles released fr

33 mal otoconial and otolith formation based on matrix vesicle mineralization in bone which we believe t

34 Matrix vesicles (MV) are lipid bilayer-enclosed nanoscal

35 While previous studies revealed that matrix vesicles (MV) contain a nucleational core (NC) th

36 Matrix vesicles (MV) play a key role in the initiation o

37 nexins II, V, and VI are major components of matrix vesicles (MV), i.e. particles that have the criti

38 rocytes release plasma membrane (PM) derived matrix vesicles (MV), which are the site of initial hydr

39 , and the mineralizing potential of released matrix vesicles (MV).

40 d growth in the interior of membrane-limited matrix vesicles (MVs) and by propagating the crystals on

41 Matrix vesicles (MVs) are involved in de novo mineral fo

42 tes that calcification by isolated mammalian matrix vesicles (MVs) can be initiated by ATP.

43 Matrix vesicles (MVs) in the growth plate bind to cartil

44 Inorganic phosphate (Pi) accumulation within matrix vesicles (MVs) is a fundamental stage in the prec

45 mally occurs within the lumen of TNSALP-rich matrix vesicles (MVs) of growth cartilage, bone, and den

46 rystals were initiated, as is normal, within matrix vesicles (MVs) of the growth plate and bone of TN

47 calcification and the subsequent release of matrix vesicles (MVs), precursors of microcalcification.

48 Matrix vesicles (MVs), secreted by vascular smooth muscl

49 Matrix vesicles (MVs), structures that accumulate Ca2+ d

50 nd in association with meniscal cell-derived matrix vesicles (MVs).

51 A6) are quantitatively major proteins of the matrix vesicle nucleational core that is responsible for

52 hment of annexin V-mediated Ca2+ influx into matrix vesicles or liposomes.

53 Thus, we tested the novel hypothesis that matrix vesicles produced and released by mineralizing ce

54 The regulation of matrix vesicle production is poorly understood but is th

55 ation, will release mineralization-competent matrix vesicles rich in annexin V and alkaline phosphata

56 mice and that NPP1 but not ANK localizes to matrix vesicles, suggesting that failure of ANK deficien

57 eralizing chondrocytes produced and released matrix vesicles that exhibited similar round shape, smoo

58 cholesterol is an integral component of the matrix vesicles that nucleate calcium mineral, we examin

59 of vascular calcification are not known, but matrix vesicles, the nucleation sites for calcium crysta

60 c bodies with (45)Ca demonstrated that, like matrix vesicles, they can concentrate calcium.

61 Isolated matrix vesicles were incubated in synthetic cartilage ly

62 ondrocytes released mineralization-competent matrix vesicles, which contained significantly higher am

63 In addition, lack of AnxA6 in matrix vesicles, which initiate the mineralization proce