ライフサイエンスコーパス: mature

1 thereby indicating that the Phase II is more mature.

2 that are subsequently stabilized as tissues mature.

3 t before becoming quiescent and functionally mature.

4 iscussion and ongoing revisions as the field matures.

5 Whether or not p53 is directly involved in mature adipocyte metabolic regulation remains unclear.

6 moxifen-inducible genetic lineage tracing of mature adipocytes and single-cell RNA sequencing reveale

7 ToM, and when is the developmental onset of mature adult ToM?

8 peak area predominantly from fat at 56 days, mature after 270 days to be more yellow, rubbery and smo

9 Quantitative proteomic comparison of mature alpha-smooth muscle actin (alpha-SMA)+ myofibrobl

10 ally, we show wild-type Tcrb alleles produce mature alphabeta T cells that express upstream Vbeta pep

11 ectrophoresis-mass spectrometry (CE-MS) is a mature analytical tool for the efficient profiling of (h

12 y demethylated in CD56(dim) NK cells as they mature and acquire KIR.

13 hydroxylation, resulting in the formation of mature and bioactive CLE40 in planta.

14 ed genetic labeling to identify and map both mature and developing CNS neurons that express choline a

15 se binding and structural studies to compare mature and inferred-germline Ab binding to envelope prot

16 Whole-plant harvests of mature and juvenile tropical deciduous trees, evergreen

17 the reappearing B cell pool revealed a less mature and more activated phenotype: 1) reappearing B ce

18 g RNAs, and less abundant tRNA fragments and mature and pre-miRNAs.

19 eling only), assuming Cameroon will become a mature and saturated LPG market by 2100 (73% adoption, b

20 In melanocytes, melanosomes mature and traffic to dendritic tips, where they are tra

21 The field of TIS has matured and resulted in studies of hundreds of species t

22 gradually shortened and defined them as they matured, and they returned to the breeding grounds progr

23 possibly standardize methods for producing, maturing, and mechanically interrogating iPSC-derived ca

24 articularly strong up-regulation in sexually mature animals, after feeding, and in specific lunar pha

25 g structural changes for parent and affinity-matured antibodies bound to ARG2, with a large reorienta

26 elopment of nanocrystalline YAG:Ce is not as mature as for these other materials.

27 alyze the three-dimensional structure of the mature ASFV particle.

28 ed glycolysis pathway, which is required for mature AT1 cell differentiation.

29 ge-gated sodium channel isoform expressed in mature axon initial segments and nodes, making it critic

30 acquires frequent inactivating mutations in mature B cell malignancies, especially in the MYD88(L265

31 IgD(dim)IgM(dim)CD21(neg)) at the expense of mature B cells (IgD(+)IgM(+)CD21(+)).

32 s in mice leads to the prolonged survival of mature B cells and expanded B cell compartments in secon

33 The exchange of mature B cells between blood and bone marrow is sensitiv

34 s in 8% of cases the translocation occurs in mature B cells mediated by activation-induced cytidine d

35 ther factors appear to influence the fate of mature B cells responding to antigen in vivo.

36 blocks by expressing bnAbs conditionally in mature B cells.

37 n early life determines the clonality of the mature B-1 B cell repertoire and ensuing antibody respon

38 Mantle cell lymphoma (MCL) is a mature B-cell neoplasm initially driven by CCND1 rearran

39 younger than 18 years of age with high-risk, mature B-cell non-Hodgkin's lymphoma (stage III with an

40 and adolescents with high-grade, high-risk, mature B-cell non-Hodgkin's lymphoma and was associated

41 lls can differentiate in culture to generate mature basal and luminal cell types, including ER+ cells

42 tantial advances have been made in producing mature beta-cells from human pluripotent stem cells that

43 ert surfaces, which is particularly true for mature biofilm assemblages.

44 een shown to be necessary and sufficient for mature biofilm formation and catheter infection.

45 n (PJI) largely depends on the presence of a mature biofilm.

46 blood neutrophil subsets arise from distinct maturing bone marrow neutrophil subsets.

47 73 premature- and 89 mature-born adults aged 25-27 years underwent single-she

48 t, the expression and function of uPA in the mature brain are poorly understood.

49 ought to focus on the global geometry of the mature brain by studying its most distinctive feature, t

50 he PHOSPHO1 transcript is highly enriched in mature brown adipose tissue (BAT) and is further induced

51 a proliferative state in the fetus to a more mature but quiescent state after birth.

52 s, and the underlying mechanisms are already mature by adolescence.

53 ts suggest that motoneuron properties do not mature by cell autonomous mechanisms alone, but also dep

54 e virus-like particles can be converted into mature capsid-like particles by the simple addition of v

55 at Myc-driven transcription is re-engaged in mature cardiomyocytes by elevating levels of the positiv

56 aturation and leveraging them to create more mature cardiomyocytes for research and regenerative medi

57 d IFN-gamma led to a significant increase in mature CD27(-) CD11b(+) NK cells as well as a significan

58 mal promoters are densely methylated in less mature CD56(bright) NK cells and are progressively demet

59 turation, concomitant with Mxd1 induction in mature cDC1s.

60 equence of fate decisions that leads to each mature cell type in a tissue or organism.

61 enitor cells with their capacity to generate mature cell types.

62 erial cell wall enzymes cooperate to build a mature cell wall.

63 oles that neuronal and glial progenitors and mature cells play in CNS angiogenesis and neurovascular

64 inter-block AGB variability was observed in mature classes as a result of variations in palm leaning

65 echnology-agnostic cost model developed from mature CO(2) capture technologies, costs of CCS are calc

66 aintenance of the transducing stereocilia in mature cochlear hair cells.

67 Lower percentage of mature collagen fibers was observed in DBG/HV (P <=0.05)

68 in community structure can thus propagate to mature communities, conditioning their functional repert

69 In developing his mature concept of hebephrenic dementia praecox (DP) in h

70 Our study indicates that mature coniferous trees assimilated nitrate as efficient

71 d thymic Treg [tTreg] cells) or derived from mature conventional CD4(+) T cells that underwent TGF-be

72 ocessed by Cas12a itself to release multiple mature crRNAs.

73 se-1 resulted in the cellular release of the mature cytokines IL-1beta and IL-18 and induction of pyr

74 uster of dendritic cells (DCs) that we name 'mature DCs enriched in immunoregulatory molecules' (mreg

75 nal differentiation of early stage DCTs into mature DCTs, and impairment of their terminal differenti

76 importantly, soil nitrogen (N) increased in mature deciduous forests through time but decreased in o

77 specimens indicates that they are skeletally mature despite their small size, thus representing adult

78 ly extracted high yield and quality RNA from mature, developing, and germinated seeds, leaves, and ro

79 y diphtheria toxin-based ablation of >50% of mature DG granule cells (GCs) or by prolonged brain-spec

80 Homogeneous populations of mature differentiated primary cell types can display var

81 pened the intrinsic membrane excitability of mature DYN neurons, and reduced their action potential d

82 of the elastic fibres (oxytalan, elaunin and mature elastic fibres) in 20 cases.

83 , electrodialysis (ED), despite being a more mature electro-driven technology, has yet to be extensiv

84 dults, implying continued essential roles in mature endocrine cell function.

85 In mature endosomes, RAB7 directly interacts with TRAF6 E3

86 We determined that in mice, mature eosinophils are transiently recruited to the lung

87 Mature erythrocytes, immature erythroid cells, and phago

88 (EPO) provides the major survival signal to maturing erythroid precursors (EPs) and is essential for

89 The latter were enabled by a long, mature exit tunnel that partially offset the general the

90 In animals that were 1-10 days more mature, exposure to the same patterns led to a developme

91 , causing a torsional stress that breaks the mature F-pilus at the cell surface.

92 lower than the subnanomolar affinity of the mature Fabs.

93 However, for grasses, which mature faster, the relationships between persistence str

94 From the six first maturing females, five all homozygous clonal lines were

95 icroscope images shows that the formation of mature fibrils of VEALYL correlates with the appearance

96 ted in the formation of unusually stable and mature focal adhesions that resisted disassembly induced

97 oskeletal protein vinculin, they do not form mature focal adhesions.

98 recapitulated embryonic HF development, and mature follicles produced hair co-occurring with epithel

99 ely limits the glycosylation of NCSTN to its mature form and impairs the integrity of the gamma-secre

100 ient macrophages had increased levels of the mature form of IL-1alpha and exhibited pro-inflammatory

101 recursors of granzymes and perforin to their mature form.

102 is predominantly a 129-amino acid truncated mature frataxin (79-207) in which the N-terminal lysine

103 m mass spectrometry, we have discovered that mature frataxin in mouse heart (77%), brain (86%), and l

104 electron microscopic morphology as the fish mature from the juvenile to the adult form.

105 n to be affected in schizophrenia (SCZ) when matured-from induced pluripotent stem cells (iPSCs) deri

106 ly metalated forms of SOD, namely, the fully mature functional Cu,Zn state and the E,Zn-SOD state in

107 equirements for the generation of terminally mature functional innate effector cells can be elucidate

108 PV upregulation supports the acquisition of mature GABAergic phenotype necessary to sustain adult PF

109 tions confirm that XLSSC 122 is a remarkably mature galaxy cluster with both evolved stellar populati

110 We select three genes, not expressed in mature gametocytes, to develop as biomarkers.

111 hable from equilibrium in the most thermally mature gases.

112 temporal dynamics of lighting for a rendered mature Glycine max (soybean) canopy to review the relati

113 The mature GNNQQNY fibers did not exert significant oxidativ

114 ct the abundance of (1,3;1,4)-beta-glucan in mature grain.

115 4% reduction of the total starch in mature grains.

116 lt-born DG granule cells, which compete with mature granule cells for synaptic integration.

117 oxetine, increases D1 receptor expression in mature granule cells in the dentate gyrus.

118 Ethylene initiates ripening of mature green fruit, upregulates RIN expression and other

119 ted via Polycomb-mediated silencing as discs mature (Harris et al., 2016).

120 t active synaptic remodeling by microglia in mature healthy brains is rarely directly observed.

121 Three types of mature hemocytes have been characterized in the lymph gl

122 opoietic organ comprised of prohemocytes and mature hemocytes, has been a valuable model for understa

123 le to acute and/or latent HSV-1 infection in mature hippocampal neurons, a region of the brain severe

124 of MGE-derived interneurons was preserved in mature hippocampus despite early elimination of AMPARs,

125 eurogenesis and increased gliogenesis in the mature hippocampus.

126 Mature hiPSC-CMs showed rod-shaped morphology, highly or

127 odic provision of a specific nutrient by the mature host: each night the symbionts catabolize chitin

128 m human stem cells allow differentiating and mature human retinal cells to be studied in unprecedente

129 s, NSG-SGM3 mice supported the population of mature human tissue-resident mast cells and basophils.

130 nt of a novel OoC that integrates functional mature human white adipocytes.

131 Mature IHCs of Myo7a-DeltaC mice degenerate over time, g

132 Caspase-1 activation mediated release of mature IL-1beta and IL-18 in response to canonical stimu

133 Although precursors are found in blood, mature ILC2s can enter the circulation after small intes

134 d levels of 36 blood cell traits (platelets, mature/immature red cells, and myeloid/lymphoid/compound

135 the primary cells cultured for 12 d to form mature in vitro crypts.

136 Inf-cDC2s matured in response to cell-intrinsic Toll-like receptor

137 re inferred to have originated and initially matured in the thymus before emigration from the thymus

138 Cell types in organoids matured in vitro to a stable "developed" state at a rate

139 pper or lower jaw of a large, osteologically mature individual.

140 ric scaling laws as trees; (2) juveniles and mature individuals do not follow the same allocation pat

141 n of Caspase-1 and the subsequent release of mature interleukin-1beta and interleukin-18.

142 at leptotene, but only ~2.3% of these sites mature into chiasmata.

143 ells tend to aggregate into nodules that may mature into tertiary lymphoid organs.

144 into the tumor microenvironment, where they mature into tumor-associated macrophages (TAMs) that pro

145 Upon gastrulation, this conformation matured into conventional A/B compartments.

146 which following P2Y2 purinoceptor activation matured into GABAergic neurons.

147 etween iPSC lines and yielded functional and mature iPSC-RGCs.

148 pes and Vibrio fischeri As the juvenile host matures, it develops complex daily rhythms characterized

149 he capacity of the immune system to affinity-mature large numbers of Env-specific B cell lineages sim

150 The frontolateral gray matter matured latest (right, 2.3 years; left, 2.4 years).

151 he nighttime O(2) consumption rate (R(N)) in mature leaves of Arabidopsis (Arabidopsis thaliana).

152 oid blast cells unable to differentiate into mature leukocytes.

153 address the following knowledge gaps: (1) Do mature lianas comply with the APT scaling laws or do the

154 It was found that: (1) mature lianas followed the same allometric scaling laws

155 follow the same allocation patterns; and (3) mature lianas had shallowest coarse roots and evergreen

156 It was demonstrated that: (1) mature lianas invested proportionally similar biomass to

157 ing oncogenic KRAS had reduced expression of mature lineage identity genes.

158 PI4KIIalpha is recruited to maturing lipopolysaccharide (LPS)-containing phagosomes

159 We surmise that mature locomotor modules may derive by combining the mul

160 during embryogenesis and continuing even as matured lymphocytes are primed and educated in adult tis

161 tic stem cell function or the development of mature lymphoid or myeloid lineages.

162 Mature mAbs, UCA mAbs, and mature monovalent Fabs bound

163 g strategy to promote HC regeneration in the mature mammalian cochlea.

164 3D printing technology has become a mature manufacturing technique, widely used for its adva

165 e impact of drier soils on convection within mature MCSs.

166 Woody species are inherently slow maturing, meaning that seeders are confined to infrequen

167 lative contribution of adult-born (abGC) and mature (mGC) granule cells to epileptiform network event

168 o interact with and induce ubiquitination of mature MHCII.

169 ayers in the 1990s, a total number of $2656$ mature microRNAs have been publicly described for Homo s

170 ated within the MIR17HG gene and encodes six mature microRNAs.

171 9b-1, pre-miR-199a-1 and pre-miR-199a-2) and mature (miR-19b-3p, miR-199a-3p) miRNAs was found.

172 he same way, CARP9 appeared to interact with mature miRNA, but not with primary miRNA, positioning it

173 iRNA by Dicer and other components generates mature miRNA.

174 hts potential changes in the distribution of mature miRNAs from the same precursor.

175 little conservation across species, whereas mature miRNAs were more likely to be conserved.

176 In such a complex, CARP9 stabilizes AGO1 and mature miRNAs, allowing the proper loading of miRNAs in

177 otation tool (miEAA) for human precursor and mature miRNAs.

178 Mature mAbs, UCA mAbs, and mature monovalent Fabs bound to MuSK and demonstrated pa

179 sed whether knockdown of Disc1 (Disc1-KD) in mature mouse astrocytes of the prefrontal cortex (PFC) o

180 structure of the transducing stereocilia in mature mouse cochlear hair cells.

181 Mature mouse frataxin (78-207) only contributes 7-15% to

182 ly, suggesting that selective recognition of mature mRNA is facilitated by the simultaneous sensing o

183 idth of the muscle cell both at birth and in mature muscle.

184 itional depletion also led to a reduction of mature mycolic acid production and accumulation of inter

185 characterized by the excessive production of mature myeloid cells and arise from the acquisition of s

186 d innate immunity, induced via modulation of mature myeloid cells or their bone marrow progenitors, m

187 The mature naive B cell repertoire consists of three well-de

188 Mature naive B cells expressing BCRs of the IgM and IgD

189 re: 10.1 +/- 1.9%, after: 58.8 +/- 5.2%) and mature naive phenotypes (before: 45.5 +/- 3.1%, after: 2

190 infusion in mice, we found that an affinity matured nanobody antagonist has comparable antihypertens

191 nt, but is also extensively expressed in the mature nervous system, particularly in the hippocampus,

192 Whereas PV-evoked currents in mature neurons exhibit hallmark fast rise and decay phas

193 Both young and mature neurons migrate into compartments containing astr

194 Ablation of Tet3 in adult mature neurons resulted in increased anxiety-like behavi

195 t brain, little is known about their role in mature neurons.

196 physiological changes to become functional, mature neurons.

197 culture derived a mixture of Tbr1 and Ctip2 mature neurons.

198 showed myeloid hyperplasia with predominant mature neutrophils, and decreased progenitor cells and l

199 umber and complexity of doublecortin-labeled maturing newborn neurons in the dentate gyrus subgranula

200 mpaired in preclinical and clinical AD while mature NGF degradation is enhanced.

201 ORC2-deficient NK cells belongs to the least mature NK cluster.

202 je cells expressing the adult-onset mutation matured normally and did not degenerate during cerebella

203 its dependence on POM121, and a reduction of mature NPCs in Torsin-deficient cells lead us to conclud

204 We conclude that, in homeostasis mature OC derive predominantly from BM-resident OCP, whe

205 Our study suggests that mature OLG surrounding demyelinated lesions are not pass

206 e we show that in response to demyelination, mature oligodendrocytes (OLG) bordering the lesion expre

207 allosum and external capsule, and decline of mature oligodendrocytes and oligodendrocyte precursor ce

208 roversial, we show that sheath generation by mature oligodendrocytes is not only possible but also in

209 Mature oocytes are transcriptionally quiescent and posse

210 ergoes monthly structural changes to release mature oocytes.

211 production in the fat body and Vg uptake by maturing oocytes, is of great importance for the success

212 Here, we isolated two cDNAs from mature or imbibed cucumber seeds with high sequence simi

213 cyte- and platelet-rich fibrin (L-PRF), on a mature oral multispecies biofilm on a rough titanium sur

214 ite mice with conditional deletion of Nf1 in mature osteoblasts (Nf1(fl/fl);Dmp1-Cre) and Mekk2(-/-)

215 suggesting independence of EPO signaling in mature osteoblasts, osteoclasts, and adipocytes.

216 a exhibits similar growth characteristics in mature osteoclasts compared to the primary target cell,

217 ific changes in connectivity to attain their mature pattern of synaptic divergence.

218 n mice that B/B therapy selectively depleted mature PC producing donor-specific antibodies (DSA) and

219 It represents a new and comprehensive mature peptide collection.

220 I is polymerized and cross-linked to produce mature peptidoglycan.

221 The three mature peripheral blood neutrophil subsets arise from di

222 ) NKT cells were found in all tissues, had a mature phenotype and, distinct from other NKT cells, exp

223 Myom2-RFP(+) PSC-CMs exhibited more mature phenotypes than RFP(-) cells in morphology, funct

224 c composition in solution in the presence of mature phototrophic biofilm in a rotating annular biorea

225 As kernels continued to mature, pigment coverage across the pericarp progressive

226 ession and activity of NMDA receptors in the mature PL-PFC.

227 lease causes seedling lethality and inhibits mature plant growth.

228 transcript levels from seedlings to predict mature plant traits, we found that transcript and geneti

229 st renewable routes that are bioavailable to mature plants.

230 Our results support a model in which mature pneumococcal peptidoglycan is synthesized by thre

231 t which podocalyxin is ablated (immature vs. mature podocytes) has a profound effect on the urinary p

232 rochromatic silencing in both bicellular and mature pollen.

233 es the core shell, and it is composed of the mature products derived from the ASFV polyproteins pp220

234 s and introduced 24 new residues forming the mature protein, alpha1(Lys374Serfs)*(25) Cell surface ex

235 once the epithelial cells differentiate into mature proximal and distal tubules, whereas expression o

236 ocytes and present the current approaches to mature PSC-derived cardiomyocytes.

237 eflect this study's focus on relatively late-maturing psychological processes, particularly the appra

238 s the differentiation of PT progenitors into mature PT cells by regulating the expression of genes as

239 ponents in secreted microvesicles, including mature PV virions; positive-sense genomic and negative-s

240 The affinity-matured rabbit mAb was then humanized by complementarity

241 The mature red blood cell (RBC) lacks a nucleus and organell

242 In contrast, slower maturing regions, such as the PFC, have been suggested t

243 biogenesis and secretion of SGs, but how SGs mature remains poorly understood.

244 diagnostic algorithms and the publication of mature results from various large clinical trials, the E

245 The mature retrovirus capsid consists of a variably curved l

246 We hypothesize a scenario where levels of mature RNA species or editing in the single T. cruzi mit

247 RNA-capsid binding sites genome-wide within mature RNA virus particles, we have developed a Next-Gen

248 this is partially compensated for by longer mature root cells.

249 GNAI3, another member of the mature row 1 complex, accumulated at mutant row 1 tips a

250 addition, proteins normally concentrated at mature row 2 tips were also distributed differently in t

251 In support of this model, we find that only mature S. mansoni eggs are shed into the feces of mice a

252 tructure of BRIL in complex with an affinity-matured sAB (BAG2) that bound to all systems tested deli

253 Here we show that YAP/TAZ are required for mature SCs to restore peripheral myelination, but not to

254 ition of bee communities between primary and mature secondary (>100 years old) fire-maintained forest

255 MoLCs can be matured, secrete IL-12p70 and TNF-alpha, and stimulate p

256 consume highly digestible foods, wean early, mature slowly, and exhibit high lifelong investments in

257 r lineage-tracing models to confirm that the mature SMC can give rise to a hyperproliferative cell wh

258 elongation and abnormal head morphologies in mature spermatozoa.

259 ediated by accumulation and stabilization of mature SREBP2.

260 e to the native fold for RNase P to bind and mature SRP RNA co-transcriptionally.

261 gh-frequency stimulation that disappeared at mature stages.

262 ination activity of CK1delta establishes the mature state of a neuron by promoting the expression of

263 in fiber development that disappeared in the mature stem.

264 Image-based profiling is a maturing strategy by which the rich information present

265 tured cells do not necessarily generalize to mature synapses under physiological conditions.

266 The availability of such mature systems has significantly advanced the developmen

267 tional, as judged by its capacity to support mature T cell development in vivo after transplantation

268 A/C helps distinguish normal from neoplastic mature T cells, and VAMP-7 recapitulates light-cytometri

269 V-2) strain has the unique ability to infect mature T cells.

270 (>18 years) with newly diagnosed, untreated mature T-cell or NK lymphomas (WHO 2001 or 2008 classifi

271 In total, 1695 patients with mature T-cell or NK lymphomas were enrolled between Oct

272 ance as tissue-resident populations, whereas mature, terminally differentiated subsets mediate immuno

273 eal a mechanism of TGF-beta activation where mature TGF-beta signals within the confines of L-TGF-bet

274 Additionally, RNase AM was found to mature the 5' end of 16S rRNA, a reaction previously att

275 to physically reshape and remodel, and thus mature, the 60S subunit of the ribosome.

276 As they mature, there are increasing reports of combined heart-l

277 As these technologies continue to mature, there is a need to achieve efficient, safe, nont

278 hat human and mouse fetal MCs phenotypically mature through pregnancy and can be sensitized by matern

279 f ageing, whereas the function of individual mature thymic epithelial cells is compromised only modes

280 el of the device became polarized and formed mature tight junctions, that the permeability of the cho

281 ere conditionally and selectively ablated in mature, transgenic mice where the human diphtheria toxin

282 We conducted an in situ whole mature tree nitrogen-15 ((15) N) labeling experiment ((1

283 ine (Pinus sylvestris L.) forests in Sweden, mature trees in ~2015 had longer needles with shorter li

284 reveal that forced overexpression of GILZ in mature Tregs inhibits their suppressive function.

285 anscription factor not normally expressed in mature Tregs, and ex vivo data reveal that forced overex

286 protein-coding genes, abundant full-length, mature tRNAs and other structured small non-coding RNAs,

287 vascular permeability was induced by pooled mature tryptases but not alpha- or beta-tryptase homotet

288 The fraction of perfused mature tumor microvessels was increased in EpsilonC-beta

289 wo systems for reasoning about others' minds-mature verbal ToM that emerges around 4 y of age, wherea

290 that PfClpP oligomerizes as a zymogen and is matured via transautocatalysis.

291 bound to all three viral particle forms-the mature virion, A-particle, and empty particle-and show t

292 in genes encoding protein components of the mature virion, namely, A26L, G6R, and A14.5L, achieved 7

293 that each Fab can simultaneously occupy the mature virion.

294 broad protective epitopes but only bind the mature virion.

295 tious enveloped virions termed intracellular mature virions and extracellular virions (EV).

296 ted by membrane-fusion points, through which mature virions are transported.

297 though viral RNA was detected within spores, mature virions were not observed.

298 roteins (E and prM in immature virus or M in mature virus).

299 However, Smad4 loss of function in all mature VSNs only compromises correct glomeruli formation

300 3 and Pt x tZHD14 were further grown to form mature xylem in the greenhouse.