ライフサイエンスコーパス: mature DC

1 The elevated production of CCL22 by PGE(2)-matured DC persists after the removal of PGE(2) and is f

2 erent Treg-recruiting abilities, with PGE(2)-matured DC, but not type 1-polarized DC, generated in th

3 not LTB(4) or LTD(4), are superior to PGE(2)-matured DCs in stimulating CD4(+) T-cell responses and i

4 at high surface expression of CCR7 on PGE(2)-matured DCs is associated with their suppressed producti

5 In accordance with these findings, PGE(2)-matured DCs show significantly higher in vitro migratory

6 In contrast to the PGE(2)-matured DCs, DCs matured in the presence of toll-like re

7 IRX-2-matured DC carried a higher density of tumor antigen-der

8 IRX-2-matured DC expressed higher levels (p<0.05) of CD11c, CD

9 IRX-2-matured DC functions were compared with those of conv. m

10 IRX-2-matured DC migrated significantly better towards CCL21,

11 LTC(4)-matured DCs migrate efficiently through layers of extrac

12 des are functionally different and acquire a mature DC phenotype.

13 Transfection with caTLR4 RNA also induced a mature DC phenotype.

14 -DR) by flow cytometry was consistent with a mature DC phenotype, indicating that pulsing with CPD-MA

15 Activated mature DCs enhance B cell activation and differentiation

16 HC-II is significantly greater in activated (mature) DCs than in resting (immature) DCs, but the mole

17 mmatory cytokines produced by TLR-activated, mature DCs are required for reversal of Treg anergy, but

18 both of which are produced by TLR-activated, mature DCs.

19 All mature DCs uniformly expressed comparable levels of HLA-

20 ecific CD8+ CTL when compared with TNF-alpha-matured DCs pulsed with an HLA-A*0201-restricted FMP pep

21 -MA(58-66) Ag was directly loaded on already matured DCs and mDCs(ICOS).

22 Thus, although mature DCs markedly down-regulate their capacity for mac

23 d by unexpectedly high levels of T cells and mature (DC-lysosome-associated membrane glycoprotein pos

24 The combination of follicular B cell and mature DC densities allowed the identification of patien

25 d HLA-DP, DQ, DR) markers in immature DC and mature DC and was associated with down-regulation of bot

26 ptidomes of MUTZ3-derived human immature and mature DC lines and THP1-derived macrophages by liquid c

27 ations were expanded, including immature and mature DC, myeloid (CD11c(+)CD11b(+)CD8a(-)), lymphoid (

28 irus movement to and release at immature and mature DC-T-cell contact sites.

29 immature dendritic cells (DCs; SI, 2.1), and mature DCs (SI, 2.6).

30 s are resistant to stimuli that activate and mature DCs.

31 al venules (HEV) and clusters of T cells and mature DCs, in 7 of 29 cutaneous metastases from melanom

32 l synapse between human resting NK cells and mature DCs.

33 and CD14+ monocyte-derived immature DCs and mature DCs (mDCs) were inhibited by BxCM.

34 h increased numbers of dermal DCs (DDCs) and mature DCs in the lamina propria.

35 Stimulants that expand and mature DCs during imatinib treatment improve antitumor i

36 of HIV-1 mediated by immature DCs (iDCs) and mature DCs (mDCs), using replication-competent and singl

37 on into immature dendritic cells (imDCs) and mature DCs (mDCs).

38 n human monocytes, immature DCs (imDCs), and mature DCs (mDCs).

39 s of ICAMs and their ligands on immature and mature DCs and various types of HIV-1 target cells were

40 Both immature and mature DCs are capable of clathrin-coated pit-mediated u

41 tor FcgammaRIIa is preserved in immature and mature DCs at comparable levels with macrophages.

42 ially found in mature DCs, both immature and mature DCs contained similar amounts of viral RNA, sugge

43 NK cells killed immature and mature DCs independently of NKp46, NKp30, and NKG2D; how

44 slational isoforms expressed in immature and mature DCs probably contribute to the DC maturational st

45 ions, promoted the migration of immature and mature DCs to CCL19 and CCL21, which was associated with

46 required for the chemotaxis of immature and mature DCs to CCL2, CCL19, CCL21, and CXCL12.

47 to block HIV-1 transmission by immature and mature DCs to HIV-1-sensitive cells.

48 Treatment of immature and mature DCs with HIV resulted in potent IL-10 secretion a

49 ns of HIV-1 particles with both immature and mature DCs.

50 ability to be captured by both immature and mature DCs.

51 d DDR1b, were expressed in both immature and mature DCs.

52 entry mechanisms are active in immature and mature DCs.

53 -1 cells is enhanced upon DC maturation, and mature DCs are superior to monocytes for the expansion o

54 sampling for antigen and danger signals, and mature DCs (mDCs), which exhibit enhanced antigen-presen

55 e dendritic cells (DCs) induce tolerance and mature DCs induce inflammatory immune responses.

56 Interestingly, tolerogenic and mature DCs manifested substantially different expression

57 At the level of glycolysis, tolerogenic and mature DCs showed similar glycolytic rates, but glycolyt

58 Ad.DC function with that of immature DCs and matured DCs (mDCs).

59 ptional repressor c-fos in both immature and maturing DCs.

60 Human thymic Proins+ cells appear as mature DC but express CD8alpha, CD20, CD123, and CD14; p

61 how how tumors infiltrated by TLS-associated mature DC generate a specific immune contexture characte

62 grate to lymphoid tissues, where they become mature DCs (mDCs) for effective antigen presentation.

63 ted dying cells promoted monocytes to become mature DCs and cross-present cell-associated Ags for the

64 rather, the bioactivity of IL-12 produced by mature DC depends on IL12p70, IL12p40, and IL12(p40)2 pr

65 block the more robust replication driven by mature DCs.

66 Furthermore, Ags internalized by mature DCs were efficiently presented on MHC class II an

67 LR-induced cross-presentation is mediated by mature DCs, is independent of endosomal acidification, a

68 the production of TNF-alpha and IL-12 p70 by mature DCs.

69 vivo DC maturation step could be replaced by maturing DC in situ by injecting immature DC into sites

70 uppresses the generation of key cytokines by maturing DCs through the activation of ERK-dependent pat

71 in diminished production of IL-23 protein by maturing DCs.

72 Specifically, the hMSCs caused mature DCs type 1 (DC1) to decrease tumor necrosis facto

73 h1 cells but augmented the capacity of CD40L-matured DCs to polarize naive T cells into Th1 cells.

74 both p35 and p40 production by LPS or CD40L-matured DCs.

75 entiation (CD)1a(+) immature DCs and CD83(+) mature DCs.

76 ally, differentiation of Th2 cells by B-cell-matured DCs is dependent on OX-40 ligand.

77 an immunization strategy with peptide-coated mature DC that, in the absence of inflammatory cytokines

78 suggest that under inflammatory conditions, mature DCs may contribute to T cell stimulation without

79 In contrast, mature DCs used for immunotherapy exclusively express iP

80 Compared with conventionally matured DCs, AP1903-activated iMyD88/CD40-DCs had increa

81 Moreover, LCCs also converted mature DCs into cells producing TGF-beta1.

82 A single injection of cytokine-matured DCs led to rapid enhancement of FOXP3(+) Treg's

83 ceived intranodal vaccinations with cytokine-matured DCs loaded with keyhole limpet hemocyanin and MH

84 3 intravenous injections of tolerogenic DCs, mature DCs, or saline.

85 lication proceeded efficiently in LC-derived mature DCs (mDCs).

86 ed intravenous injection of monocyte-derived mature DCs that were loaded with a synthetic NKT cell li

87 arated PBMCs, as well as in monocyte-derived mature DCs.

88 scin1, we characterized bone marrow-derived, mature DCs from fascin1 knockout mice.

89 with IL-3 and CD40L for 72 hours, developed mature DC morphology.

90 own increases adhesion of iDCs that displace mature DCs.

91 In contrast, exposure to IFN-beta during mature DC-mediated primary stimulation of naive Th cells

92 and peptide fragments were unique to either mature DC or activated CD4(+) T cells.

93 glioblastoma to pre-conditioning with either mature DCs or Td unilaterally before bilateral vaccinati

94 zed transcriptional determinants that enable mature DCs to direct these opposing T cell outcomes.

95 ditions, when FRCs are unlikely to encounter mature DCs expressing the PDPN receptor CLEC-2, PDPN end

96 gen-loaded dendritic cells (DCs), especially mature DCs.

97 We demonstrate that beta2-AR agonist-exposed mature DC display a reduced ability to cross-present pro

98 In functional assays, flagellin-matured DCs displayed enhanced T cell stimulatory activi

99 icating that IN may be the preferred ROA for mature DC vaccines.

100 actic activity toward CCL19 (a chemokine for mature DCs) in vitro, and in vivo, Langerhans cells show

101 r alpha (TNF-alpha) are effective agents for maturing DCs; however, they have potential in vivo toxic

102 n, they decreased the density of HLA-DR from mature DCs, the expression of CD80 and CD86 coactivation

103 stered Treg-DC as a discrete population from mature-DC and immature-DC, with 51 and 93 genes that wer

104 Suppression of IL-12p70 production from maturing DCs was not observed in the presence of nicotin

105 capable of differentiating into functional, mature DCs, which can now be reproducibly prepared for i

106 ich is an important property of functionally mature DCs.

107 l studies, we evaluated whether functionally mature DCs could be generated in chimpanzee plasma by go

108 material derived from sonicates of IFN-gamma-matured DC is enriched in small membrane vesicles that c

109 g autologous peptide-pulsed, CD40L/IFN-gamma-matured DCs.

110 c-di-GMP-matured DCs demonstrated enhanced T cell stimulatory act

111 er LPS stimulation, whereas the MHC II(high) mature DCs were found in the draining lymph node.

112 However, mature DCs downregulate MHC II synthesis, which prevents

113 ort the gene expression profiling of hypoxic mature DCs and identify TREM-1 as a novel hypoxia-induci

114 In contrast to immature DCs (iDCs), mature DCs (mDCs) are not permissive for infection with

115 ochemical analysis was performed to identify mature DCs, myeloid DCs (MDCs), and plasmacytoid DCs (PD

116 IFN-matured DCs also activate cytotoxic CD8+ T cells, possib

117 tions with LECs and is required for immature/mature DC discrimination by LECs.

118 Most important, mature DCs from patients with X-HIGM differentiated by c

119 in entry routes (FcgammaRIIa or DC-SIGN) in mature DC broadens target options and suggests additiona

120 increased infectivity of the supernatants in mature DC.

121 -loaded MHCII is expressed at the surface in mature DC.

122 n and whose expression leads to apoptosis in mature DCs.

123 C/EBPalpha deletion in mature DCs did not affect their numbers or function, sug

124 as they exhibit high levels of expression in mature DCs.

125 ion, suggesting a unique role for fascin1 in mature DCs.

126 f whole viruses were preferentially found in mature DCs, both immature and mature DCs contained simil

127 megalovirus promoter (hIE-CMVp) is higher in mature DCs than in immature DCs and is further increased

128 was associated with a transient increase in mature DCs, but not MDSCs.

129 GM-CSF treatment caused an increase in mature DCs, first identified after 2 weeks of treatment,

130 optotic GR-A isoform was the main isoform in mature DCs.

131 ciated with changes in cross-presentation in mature DCs.

132 bits CCR7 expression and MMP-9 production in mature DCs and reduces their migratory capacity.

133 ediated uptake of virus can occur readily in mature DCs.

134 cgammaRIIb expression is patently reduced in mature DCs, an effect that is modulated by treatment wit

135 nt of CD169-dependent HIV-1 sequestration in mature DCs.

136 the 3 inducible immunoproteasome subunits in mature DCs, we found that such DCs expressed increased i

137 ed, and is enriched at the immune synapse in mature DCs.

138 induces stable Treg-attracting properties in maturing DC, mediated by CCL22.

139 d STAT6 pathways are distinctly regulated in maturing DC.

140 n the impact of PGE(2) on CCR7 expression in maturing DCs and demonstrate a novel mechanism of regula

141 the expression of apoptotic-related genes in maturing DCs has not been determined.

142 ession kinetics of Bcl-2 but not Bcl-x(L) in maturing DCs.

143 o induced cyclooxygenase-2 protein levels in maturing DCs and significantly augmented endogenous PGE2

144 lar CD83+/CCR7+/CD25+ LN-homing phenotype in maturing DCs.

145 Second, DD blocked Stat3 phosphorylation in maturing DCs.

146 osure to COX-2-overexpressing glioma induced mature DCs to overexpress IL-10 and decreased IL-12p70 p

147 THD-modulated MSCs from ITP patients induced mature DCs to become tolerogenic DCs, whereas unmodulate

148 nderstand how IAV interacts with and infects mature DCs.

149 ciated with a higher density of infiltrating mature DC and effector memory T-cell subsets, suggesting

150 l(-/-) DC maturation results in insufficient mature DCs that require microbial activation to restore

151 he life cycle of LC is their activation into mature DC in response to various stimuli, including epic

152 t, unlike immature DCs, did not develop into mature DCs expressing CCR7 and high levels of MHC II, ev

153 iDC) and declines as iDCs differentiate into mature DCs (mDCs).

154 recursors readily able to differentiate into mature DCs once the Notch signal is stopped (eg, after c

155 -alpha (IFN-alpha) and to differentiate into mature DCs.

156 5 (RANTES), where their differentiation into mature DCs is impaired by tumor-derived interleukin-10.

157 expression levels upon differentiation into mature DCs.

158 immature DCs and their differentiation into mature DCs.

159 d IL-6, and the differentiation of mDCs into mature DCs.

160 persistent differentiation of monocytes into mature DCs that expressed IL-12 and stimulated T cell pr

161 DCs) and intratumoral injection of Ag-loaded mature DCs delayed the tolerization of tumor-infiltratin

162 Tumor cell-loaded mature DCs induced a strong CD8(+) T cell response that

163 Greater HIV(NL4-3) uptake by fully LPS-matured DC resulted in higher viral transmission to targ

164 the rolling or capturing of immature and LPS-matured DCs to the CNS microvascular endothelium, inhibi

165 aptors allowed maximal T cell priming by LPS-matured DCs, with MyD88 playing a larger role than TRIF.

166 nificantly inhibited IL-12p70 release by LPS-matured DCs.

167 rophage inflammatory protein 3beta, like LPS-matured DCs.

168 Immature but not LPS-matured DCs efficiently migrated across the wall of infl

169 However, unlike LPS-matured DCs, galectin-1-treated MDDCs did not produce th

170 owing the failure of L-Sel(-/-) LRLN to make matured DCs.

171 a higher IL12p70/IL-10 ratio than conv. mix-matured DC (p<0.05 for all).

172 ctions were compared with those of conv. mix-matured DC.

173 LMP2, TAP1, TAP2 and tapasin than conv. mix-matured DC.

174 r targets (p<0.05) compared to the conv. mix-matured DC.

175 Unlike cytokine mixture-matured DC which induce predominantly nonproliferative e

176 Moreover, mature DC density correlated with expression of genes re

177 Moreover, mature DCs from patients with systemic lupus erythematos

178 Moreover, mature DCs pretreated with E(2) stimulated T cells bette

179 Moreover, mature DCs were at least 10 times more susceptible than

180 uster of dendritic cells (DCs) that we name 'mature DCs enriched in immunoregulatory molecules' (mreg

181 ells (iDCs) to migrate, but not neutrophils, mature DCs, or unstimulated monocytes.

182 phenotype or potent immunogenicity of normal mature DCs.

183 ne marrow (BM)-derived immature DCs, but not mature DCs, can inhibit BCR-induced proliferation of B c

184 ly, supplementation of immature DCs, but not mature DCs, enhanced tumor growth.

185 Morphologically, fascin1-null mature DCs are flatter and fail to disassemble podosomes

186 In this work we examined the ability of mature DC presenting a high vs low level of peptide to g

187 he current data, showing that the ability of mature DC to interact with Treg cells is predetermined a

188 It also decreased the ability of mature DC to present Ag to T cells and secrete IL-12 as

189 We found that a high density of mature DC correlated closely to a strong infiltration of

190 h iDC was associated with the development of mature DC that were morphologically, phenotypically, and

191 ionophore for 48 h induced an expression of mature DC markers CD83 and fascin.

192 reveal significantly enhanced expression of mature DC-specific marker CD83, secondary lymphoid tissu

193 The suppression of mature DC migration through negative regulation of CCR7

194 is widely assumed to restrict the ability of mature DCs to capture and present antigens encountered a

195 We investigated the ability of mature DCs to present Ags from cells infected with HSV-1

196 ly, there was a preferential accumulation of mature DCs in the PLNs of alpha-GalCer-treated NOD mice,

197 Apoptosis of mature DCs required both NF-kappaB and STAT-1 activation

198 These data suggest that the availability of mature DCs at the site of inoculation is a critical rate

199 ibited morphologic changes characteristic of mature DCs and expressed increased levels of CD40, CD80,

200 nduced phenotypic changes, characteristic of mature DCs and the production of interleukin-12p70 (IL-1

201 latory and other molecules characteristic of mature DCs.

202 o CD11c(+) cells with the characteristics of mature DCs (CD80(+), I-A/I-E(+)) but also enhanced innat

203 Coculture of mature DCs from X-HIGM patients with autologous T cells

204 d by TDF and promotes the differentiation of mature DCs and macrophages.

205 ligand did not result in differentiation of mature DCs or macrophages.

206 ponse to IFN-alpha/beta, whereas exposure of mature DCs to IFN-alpha/beta results in signaling via ST

207 , NLRP10 activity and the immune function of mature DCs.

208 as an instructive tool for the generation of mature DCs with enhanced immunogenicity from pluripotent

209 ursors (pre-cDCs) changed the homeostasis of mature DCs or pre-DCs in the lung, dermis, and spleen.

210 This preferential infection of mature DCs may inhibit the development of an efficient i

211 Preferential infection of mature DCs was not due to differential expression of the

212 Notably, the lysis of mature DCs (mDCs) by autologous NK cells was highly impa

213 ivate naive T cells, whereas the majority of mature DCs produced IL-12 and activated naive T cells.

214 igh)) and correlated to DC-LAMP, a marker of mature DCs.

215 II can accumulate on the plasma membrane of mature DCs.

216 It enhanced the migration of mature DCs (mDCs) towards the lymph node homing chemokin

217 ripheral sites and controls the migration of mature DCs from sites of inflammation to lymph nodes.

218 at fascin1 positively regulates migration of mature DCs into lymph nodes, most likely by increasing d

219 rovides an essential signal for migration of mature DCs toward CCL19/macrophage inflammatory protein

220 allografts results from a reduced number of mature DCs in draining lymph nodes, leading to impaired

221 Conversely, numbers of mature DCs in spleen were significantly decreased in LTa

222 niae infection leads to increased numbers of mature DCs in the lung and draining lymph nodes during t

223 Numbers of mature DCs were increased 6-fold.

224 Preparation of sufficient numbers of mature DCs, however, is both costly and time-consuming.

225 h the capacity to rapidly generate a pool of mature DCs early during microbial invasion.

226 se DC1s exhibited surface marker profiles of mature DCs and produced high levels of IL-12 and CXCL10.

227 to the pronounced proinflammatory program of mature DCs, tolerogenic DCs displayed a markedly augment

228 of mature, immunogenic DCs and the ratio of mature DCs to CD4+ T cells were nearly identical in corn

229 coincident with the increased sensitivity of mature DCs to spontaneous apoptosis.

230 inhibited the glucocorticoid sensitivity of mature DCs.

231 there was a pronounced genomic signature of mature DCs in SCC, they showed different T-cell stimulat

232 sed on mature lung DCs, and only a subset of mature DCs expressed higher levels of CCR7.

233 Adoptive transfer of mature DCs (lipopolysaccharide [LPS]-induced DCs, DClps)

234 appearance of cells with markers typical of mature DCs (CD83(+), CD86(+), CD11c(+), and CD14(-)) was

235 ype as well potent immunogenicity typical of mature DCs.

236 IL-15 that emerges onto the cell surface of matured DCs does not bind to neighboring cells expressin

237 Based on a large-scale proteome analysis of maturing DCs, we identified the GPI-anchored protein sem

238 Upon inflammation, CLEC-2 on mature DCs potently attenuated PDPN-mediated contractili

239 crease in the expression of CD40 and CD54 on mature DCs capable of inducing immunity.

240 DDR1b-overexpressing THP-1 cells or DDR1 on mature DCs induced the formation of TNFR associated fact

241 ase in surface expression of MHC class II on mature DCs, the surface expression of CD1 molecules was

242 e captured by CD169-expressing HeLa cells or mature DCs, and are sequestered within non-lysosomal tet

243 nic DCs, but not unpulsed tolerogenic DCs or mature DCs, significantly inhibited disease severity and

244 phocytes, but not neutrophils, monocytes, or mature DCs.

245 Falpha/IL-1beta/IL-6/prostaglandin E2 (PGE2)-matured DCs (sDC), the current "gold standard" in DC-bas

246 assumed that the presence of phenotypically mature DCs should promote protective antitumor immunity,

247 PorB-matured DC secreted the inflammatory cytokine IL-6, whic

248 his synapse, where they are known to protect mature DCs from NK cell lysis, the NK cell also received

249 Administration of this peptide-pulsed mature DC vaccine by IN, IV, or ID routes is feasible an

250 autologous monocyte-derived allergen-pulsed mature DCs or IL-10-treated DCs.

251 ity of C albicans- and P brasiliensis-pulsed mature DCs to induce autologous T-cell proliferation, ge

252 with a homogenous subpopulation of LPS/R848-matured DCs that were CD83(Hi)/CD80+/CD86+ reduced this

253 Since mature DCs are major contributors to the inflammatory re

254 iation of CD34(pos) cells into spontaneously maturing DCs.

255 rticoids may spare immature DCs and suppress mature DCs and inflammation via differential expression

256 nt-pretreated sites were more effective than mature DC in stimulating antitumor immunity in mice.

257 MB1, LMP-7, LMP-10, TAP-1, and tapasin than mature DC.

258 3, CD80 and CD86 mRNA in Treg-DC, lower than mature-DC, higher than immature-DC.

259 lymicrobial septic challenge, we report that mature DC numbers were markedly increased in the lung du

260 However, we have previously reported that mature DC (mDC) prevented the onset of autoimmune diabet

261 le DC subsets mature in the gingiva and that mature DCs engage in antigen presentation with T-cells i

262 We found that mature DCs continue to accumulate antigens, especially b

263 ptor significantly reduced expression of the mature DC marker CD83, decreased the production of the i

264 kinase inhibitor, only partially rescued the mature DC phenotype in the presence of VEGF, suggesting

265 production of interleukin-15 (IL-15) by the mature DCs.

266 In return, the mature DCs stimulate a robust T-cell response against th

267 b4(-/-) mice had significantly more of these mature DCs after challenge with OVA, which was accompani

268 this receptor attenuates the number of these mature DCs and attendant IL-4-producing lymphocytes in t

269 We demonstrated that the density of these mature DCs was associated with favorable clinical outcom

270 After coculture with these mature DCs, the CD8+ cells showed an increase in CNAR gr

271 ligation also suppressed the ability of TLR-matured DCs to induce IFN-gamma-secreting Th1 cells but

272 in which the transfer of self-Ag-pulsed, TLR-matured DCs can induce a functional CD8 T cell response

273 beta, TNF-alpha, and IL-6 expression, and to mature DC into APC that cross-presented exogenous Ags to

274 nt M protein mutant virus (rM51R-M virus) to mature DC in vitro.

275 Cantell has a particularly strong ability to mature DCs independently of type I IFNs and TLR signalin

276 ors (CDPs), but not for transition of CDP to mature DCs.

277 the differentiation from MHCII(lo) cells to mature DCs in vitro.

278 In contrast to mature DCs, mature M-DCs induced decreased Th1 different

279 correlated with monocyte differentiation to mature DCs and their ability to stimulate proliferation

280 ce of type I IFN, which has been reported to mature DCs in a TLR-independent manner.

281 argeting of the Ag in its xenogeneic form to maturing DCs.

282 es to induce/maintain immunologic tolerance, mature DCs promote immunity.

283 increased in cultures containing MAX-treated mature DCs.

284 Unfortunately, mature DCs rapidly lose viability and function after inj

285 Immature dendritic cells (DCs), unlike mature DCs, require the viral determinant nef to drive i

286 ode migratory capacity comparable to ex vivo matured DC.

287 pacity equal to or exceeding that of ex vivo matured DC.

288 nostimulatory capacity was not enhanced when mature DC were injected into adjuvant-pretreated sites a

289 nce to NK cell-mediated elimination, whereas mature DCs exhibited increased susceptibility to NKG2D-d

290 eshly isolated DCs are myeloid-type, whereas mature DCs induced by overnight culture are both "lympho

291 tional phases; immature DCs capture Ag while mature DCs are optimized for Ag presentation.

292 Compared with mature DC, NF-kappaB ODN-treated immature DC pulsed with

293 responses over and above those obtained with mature DC.

294 ional APC, CTL generated by stimulation with mature DC were of high avidity regardless of the amount

295 t substantial amounts of IL-10 compared with mature DCs from normal individuals.

296 -2 commitment, and prolonged engagement with mature DCs is necessary, but not sufficient, for IL-2 ge

297 ith metastatic melanoma were vaccinated with mature DCs transfected with RNAs encoding melanoma antig

298 underexpressed, respectively, compared with mature-DC.

299 lex class II, CD68 and CD86, consistent with maturing DCs.

300 n large vesicular compartments deeper within mature DCs (in which macropinocytosis is down-regulated)