ライフサイエンスコーパス: mature neutrophil

1 neutropenia due to bone marrow retention of mature neutrophils).

2 f human CD15+ cells, primarily consisting of mature neutrophils.

3 primary human haematopoietic stem cells into mature neutrophils.

4 r the characteristic lobulated morphology of mature neutrophils.

5 imary source for immune cell renewal, and in mature neutrophils.

6 inflammatory infiltrate consisting mainly of mature neutrophils.

7 ygen species, although less efficiently than mature neutrophils.

8 functional shift toward PSGL-1 dependence in mature neutrophils.

9 ctivity in vitro but did not prevent loss of mature neutrophils.

10 oproliferative disorder (MPD) with increased mature neutrophils.

11 w, in which it is expressed predominately in mature neutrophils.

12 without the need of sorting for isolation of mature neutrophils.

13 eosinophils, and immature, intermediate, and mature neutrophils.

14 ctivation of all three functional markers of mature neutrophils.

15 to support the production of morphologically mature neutrophils.

16 -CSF) enhance the antimicrobial functions of mature neutrophils.

17 loped the segmented nuclei characteristic of mature neutrophils.

18 n the bone marrow and an overall increase in mature neutrophils.

19 ent and show significantly higher numbers of maturing neutrophils.

20 l proliferation decreased in the presence of mature neutrophils (0.5-fold; P = .016), and the cytotox

21 n would affect its antiapoptotic activity in mature neutrophils, a chimeric PCNA fused with the SV40

22 n steady state granulopoiesis, as well as in mature neutrophil activation and function.

23 cid (ATRA) causes them to differentiate into mature neutrophils, an effect thought to be mediated by

24 inase 3 [PR3]) are expressed specifically in mature neutrophils and are thought to play an important

25 Mature neutrophils and eosinophils are not observed in t

26 xis, which describes degenerative changes of mature neutrophils and hyperplasia of bone marrow myeloi

27 egenerative changes and hypersegmentation of mature neutrophils and hyperplasia of bone marrow myeloi

28 essential for PCNA antiapoptotic activity in mature neutrophils and is dependent on the newly identif

29 (A23187) was of similar magnitude to that of mature neutrophils and monocytes.

30 ascorbic acid seldom exceed 150 micromol/L, mature neutrophils and mononuclear phagocytes accumulate

31 may affect the proinflammatory functions of mature neutrophils and raise the possibility that dasati

32 Both the GM-CSF-permitted survival of mature neutrophils and the generation of granulocytes fr

33 showed myeloid hyperplasia with predominant mature neutrophils, and decreased progenitor cells and l

34 ated that NGAL is also stored in granules of mature neutrophils, and recent data suggest that NGAL ma

35 Mature neutrophils are notoriously short-lived immune ce

36 Mature neutrophils are terminally differentiated and sho

37 tion to their direct antimicrobial activity, mature neutrophils are thus endowed with immunoregulator

38 The differences between CD62L(dim) and mature neutrophils are unlikely to have been a direct re

39 onsisting of banded neutrophils at day 3 and mature neutrophils at day 7.

40 GEM2012MENOS65 trial), only the frequency of mature neutrophils at diagnosis was significantly associ

41 cells in bone marrow, being downregulated on mature neutrophils but maintained on monocytes in the pe

42 g, integrin activation, and extravasation of mature neutrophils, but only the combined deficiency in

43 on), a programmed death pathway initiated in mature neutrophils by pathogens and inflammatory mediato

44 neutrophils indicates that large numbers of mature neutrophils can be produced from pluripotent ES c

45 trophil activation, increased circulation of mature neutrophils (CD10(+)CD33(-)), and decreased circu

46 functionally competent T cells (CD127+), and mature neutrophils (CD10+); and lower percentages of act

47 An increased number of CD4 T cells and mature neutrophils (CD11b(+)Ly6g(high)) in the inflamed

48 We demonstrated that mature neutrophils differentiated from X-CGD iPSCs lack

49 Furthermore, a significant number of the mature neutrophils display abnormal morphological featur

50 Mature neutrophils expressing zeta- and gamma-CIR were g

51 body increased notably with the depletion of mature neutrophils (fourfold; P = .0007).

52 ales with unusually high LPS responsiveness, mature neutrophil frequency, and increased inflammatory

53 Moreover, mature neutrophils from -/- mice failed to chemotax in v

54 ation of CXCR4 results in failure to release mature neutrophils from bone marrow.

55 Mature neutrophils from Hbb(th3/+) mice displayed a sign

56 e used as a phenotypic marker discriminating mature neutrophils from immature neutrophil populations

57 lated genes were specifically upregulated in mature neutrophils from MM patients vs controls because

58 iferation of precursor cells, the release of mature neutrophils from the bone marrow, margination, tr

59 C1) enhances the migration of imNeu, but not mature neutrophils, from the BM into inflamed liver tiss

60 crucial role in emergency granulopoiesis and mature neutrophil function.

61 O, strongly suggesting its potential role in mature neutrophil function.

62 is adaptor in neutrophil differentiation and mature neutrophil function.

63 d that most myelomonocytic cells, especially mature neutrophil granulocytes, were fluorescence-positi

64 Expansion of mature neutrophils has been observed in mice lacking the

65 ethal and its role in L-selectin shedding by mature neutrophils has not been determined.

66 les of lymph nodes, spleen, and tonsils; (b) mature neutrophils (high) versus myeloid progenitor cell

67 ral blood were of a similar phenotype to the mature neutrophils, ie, mainly PNH.

68 d CXCL12 and to an increased accumulation of mature neutrophils in the bone marrow.

69 of GM-CSF and G-CSF generated more than 95% mature neutrophils in the C/EBPalpha(-/-) cultures.

70 receptor, morphologically differentiates to mature neutrophils in the presence of 10 microM retinoic

71 of four of five measured granule proteins in mature neutrophils, including the proantibacterial prote

72 st, these proteins were completely absent in mature neutrophils, indicating that CTSC mutation promot

73 The loss of mature neutrophils induced by Mcl-1 deletion was not res

74 h disturbance of a feedback circuit in which mature neutrophils inhibit cell proliferation, thereby h

75 is this adaptation mediated by reprogramming mature neutrophils inside the tumoral mass, or rather by

76 Although the mature neutrophil is one of the better characterized mam

77 its specificity of action on developing and mature neutrophils, its effects on neutrophil kinetics,

78 d proteins was analyzed by flow cytometry on mature neutrophils, late stem cells (CD34+/CD38+), and p

79 ia (SCN) is characterized by a deficiency of mature neutrophils, leading to recurrent bacterial and f

80 psis patient plasma, these mediators shorten mature neutrophil lifespan and correlate with neutrophil

81 Our results suggest that mature neutrophils may be irrevocably committed to autoc

82 Splenic mature neutrophils mediated pneumococcal clearance in th

83 nt dogma states that the segmentation of the mature neutrophil nucleus has evolved to favor migration

84 ibuted to immunologically mediated injury to mature neutrophils or their precursors.

85 to the extreme bactericidal environment of a mature neutrophil phagosome, a property dependent upon C

86 r kinetics regarding the replenishing of the mature neutrophil pool is discussed in light of recent c

87 ococcal stimulation to increase the effector mature neutrophil pool.

88 In mature neutrophils, PR3 was sequestered in granules and

89 pre-neutrophils, largely in bone marrow, to mature neutrophils predominantly in blood and spleen.

90 Here we show that both immature and mature neutrophils purified from mouse bone marrow diffe

91 1 and 2 d postinfection and that KC-mediated mature neutrophil recruitment is impaired in IL-36gamma(

92 Gene expression in maturing neutrophils requires combinatorial actions of l

93 chronic myeloid leukemia: leukocytosis with maturing neutrophils, splenomegaly, hepatomegaly, and my

94 anulocyte-macrophage colony-forming unit and mature neutrophil stages of granulopoiesis.

95 ctor-alpha/interleukin-10 ratio than that of mature neutrophils, suggesting a proinflammatory phenoty

96 gnated MEFV, and found it to be expressed in mature neutrophils, suggesting that it functions as an i

97 associated with patient outcome, and a high mature neutrophil/T-cell ratio resulted in inferior prog

98 Here, we demonstrate that immature and mature neutrophils that enter tumors undergo irreversibl

99 factor (G-CSF) and a negative feedback from mature neutrophils (the chalone).

100 nhancement only to DBP in serum, but, unlike mature neutrophils, this cell line cannot respond to DBP

101 Following lethal influenza infection, mature neutrophils undergo two infection-dependent and o

102 eir ability to terminally differentiate into mature neutrophils was observed.

103 Dissection of this phenotype showed that mature neutrophils were required both in the BM and in t

104 of transcriptional factors and culminates in mature neutrophils with a broad armamentarium of antimic

105 filtrates were perivascular and consisted of mature neutrophils with leukocytoclasia, which were admi

106 (BMCs), which resulted in the production of mature neutrophils within 2 weeks.

107 study compared the mechanical properties of mature neutrophils within the BM and the circulating blo

108 the retention of granulocyte precursors and mature neutrophils within the bone marrow, and disruptio