ライフサイエンスコーパス: mechanical

1 ribute to understanding of the structure and mechanical action of the NER machinery.

2 monstrated in silicone elastomers, where its mechanical activation leads to a strain-triggered color

3 egulate cardiac fibroblast phenotype through mechanical activation of p38-YAP-TEAD signaling, which l

4 tudy, we compared the efficacy and safety of mechanical adjuvants in mucosal-sparing, mechanical endo

5 imens were harvested and analyzed by dynamic mechanical analysis (DMA) measurements under dynamic loa

6 A hybrid mechanical and agent-based model (Mech-ABM), simulating

7 lves seem to be an attractive alternative to mechanical and biological prostheses as they are more du

8 fects) on the electrical, optical, magnetic, mechanical and chemical properties of nanocrystalline ma

9 The present fibers have superior mechanical and electrical properties to many other condu

10 hroughput in vitro system that combines both mechanical and electrical stimulation, and as such, we f

11 ucture, and how it plays a role in governing mechanical and other physical parameters, will help to b

12 e composite systems, we studied the relevant mechanical and rheological membrane properties.

13 ion can be an effective alternative to other mechanical and thermal treatments for NVUGIB, particular

14 facile conversion of electrical energy into mechanical and vice versa, offer applications for sensor

15 light, pH, hydration, enzymes, and electric, mechanical, and magnetic forces.

16 knee-ankle angle (HKAA) and femoral anatomic-mechanical angle (AMA).

17 with human peri-implant plaque biofilms and mechanical antimicrobial interventions were applied on t

18 The final section provides an outlook on the mechanical aspects of OSCs, activation and revival proce

19 fication of anatomic landmarks, anatomic and mechanical axes were identified and used to quantify ali

20 ting adult zebrafish and provides the tissue mechanical basis for future studies into the role of mec

21 Here, we explore the mechanical basis for the efferent system's capabilities

22 phorus becomes softened with a "liquid-like" mechanical behaviour and gains superior malleability and

23 dings to inform current predictive models of mechanical behaviour in polymer-composite materials, par

24 th stable switching behaviors after repeated mechanical bending as well as organic synapses capable o

25 Quantum mechanical calculations were used to corroborate their s

26 the hypothesis that these compositional and mechanical changes create a progressive feed-forward loo

27 termine the relationship between hysteresis, mechanical characteristics of the respiratory system, an

28 However, structural-mechanical characterization of lamin filaments assembled

29 have been studied, while the functional and mechanical characterization of major PTMs is well docume

30 onary intervention (59.2% versus 64.0%), and mechanical circulatory support (50.3% versus 59.2%; all

31 1% of cardiac surgery patients will require mechanical circulatory support using venoarterial extrac

32 cardiac arrest, mechanical ventilation with mechanical circulatory support, mechanical ventilation w

33 r diuretic infusion, respiratory support, or mechanical circulatory support.

34 membrane tension in providing the long-range mechanical communication across the cell required for sy

35 In the present work, quantum mechanical computations and kinetic isotope effect exper

36 Mechanical confinement can variably influence cell migra

37 es (CO(2)/N(2) and CO(2)/CH(4)), via precise mechanical control of the pore size aperture in a flexib

38 pairs of configurations on either side of a mechanical critical point.

39 Mechanical cues regulate the function of a broad range o

40 ments for improving the harvested energy per mechanical cycle, but they are complicated to implement

41 xons crossing this region at greater risk of mechanical damage during brain tissue deformation from t

42 Ca(2+)-dependent gene expression without any mechanical damage in the brain.

43 udes, and modes (stretch, bend, or press) of mechanical deformation.

44 he-art in stretchable conductors under large mechanical deformations.

45 rce the notion of the central stalk as a key mechanical determinant of kinesin-14 motility [3].

46 stic moduli that transiently obliterated the mechanical difference between the two types of matter be

47 Minimal mechanical disruption during digestion, warm enzymatic d

48 This structure renders it with high mechanical (e.g., modulus and strength) and interesting

49 of mechanical adjuvants in mucosal-sparing, mechanical endoscopic dacryocystorhinostomy (MMED) for p

50 The mechanical energy associated with high-strain rate defor

51 od of non-invasive neuromodulation that uses mechanical energy to affect neuronal excitability.

52 that produces on-demand, robust transport of mechanical energy using a 1D magneto-mechanical metamate

53 r strands remain associated through periodic mechanical entanglements within each sheet.

54 inning with the first isolation of graphene, mechanical exfoliation has been a key to provide high-qu

55 ophysical cues, such as electrical stimulus, mechanical feature, and surface topography, enable the c

56 Moreover, cell mechanical features and myogenic differentiation were si

57 f initial asymmetry and its reinforcement by mechanical feedback within the inner cell walls, not the

58 ts that a stretch of the membrane induced by mechanical force alters the physical state of the lipid

59 Our analysis explains how mechanical force applied to alphaE-catenin or its homolo

60 Unanticipated roles of mechanical force sensing continue to be uncovered.

61 Whether SecA generates mechanical force to overcome barriers to translocation p

62 In polymer mechanochemistry, a mechanical force, transduced along polymer chains, is us

63 iezos are ion channels that are activated by mechanical force.

64 sponse of the mechanotransduction channel to mechanical force.

65 e also define the response of the protein to mechanical force.

66 sue deformation leading to the generation of mechanical forces and the deformation of the organ in th

67 these defects move merely to comply with the mechanical forces applied on macroscopic scales, whereas

68 are essential for transduction of innocuous mechanical forces by proprioceptors and cutaneous touch

69 neurons play an important role in converting mechanical forces into the sense of touch.

70 (BPV)-induced cycle-by-cycle fluctuations in mechanical forces which vary considerably with pathology

71 r investigations of the application of these mechanical forces will provide insights into physiology

72 gating the coupling of cellular dynamics and mechanical forces.

73 eric phosphatase exclusion as well as direct mechanical forces.

74 implantable pulse generator dysfunction, and mechanical forces.

75 namic reorganization of cells in response to mechanical forces.

76 on with unexpected effects on electrical and mechanical function.

77 tive channel nanopockets are known to affect mechanical gating and may be linked to large variability

78 annels suggests the possibility of a unified mechanical gating mechanism stemming from membrane defor

79 We exposed cells to mechanical, genetic, and pharmacological perturbations,

80 HMWH attenuated mechanical hyperalgesia induced by the inflammatory medi

81 te receptors converge onto TRPV1, leading to mechanical hyperalgesia.

82 We analyzed abdominal mechanical hypersensitivity and collected tumors and ana

83 In this model, female mice develop mechanical hypersensitivity in the caudal abdomen, mild

84 neuropathic pain manifested with thermal and mechanical hypersensitivity in the ipsilateral hind paw.

85 o both the initiation and maintenance of the mechanical hypersensitivity that characterizes the neuro

86 However, testing these mechanical hypotheses on proteins in their natural envir

87 luated for its explosive properties, and its mechanical impact sensitivity was correlated to spin tra

88 ve quantified how the stiffness component of mechanical impedance varies during walking.

89 receptor that can differentiate thermal and mechanical information without signal interference.

90 rized by a skin barrier defect aggravated by mechanical injury inflicted by scratching, a T(H)2 cell-

91 Mechanical instabilities in the active cytoskeleton netw

92 We discovered that the mechanical integrity of LiF is easily compromised during

93 Mechanical interactions between flowing and coagulated b

94 counterparts; however, changes in the use of mechanical lifting devices and experiences of musculoske

95 r forces and should thus be regulated by the mechanical load acting on the MT array as a whole.

96 oreover, studying the system under different mechanical load regimes and altered dynamics of feedback

97 teria are able to sense these changes in the mechanical load through a process termed mechanosensing.

98 , domains, and new phases, can be induced by mechanical loading in functional materials, providing fu

99 Mechanical loading is an important factor in musculoskel

100 al phase image enables a combined probing of mechanical material properties together with the chemica

101 n be well reproduced, and the geological and mechanical mechanisms can be revealed in the DEM model.

102 ions by introducing an active scatterer in a mechanical meta-layer that exploits piezoelectric sensor

103 port of mechanical energy using a 1D magneto-mechanical metamaterial.

104 Mechanical metamaterials are usually designed to show de

105 ch promise, current physical realizations of mechanical metamaterials remain hindered by the lack of

106 ators to be used as building block of future mechanical metamaterials, leading to a new class of tuna

107 f paper cutting, is a promising paradigm for mechanical metamaterials.

108 -learning approach, hierarchical statistical mechanical modeling (HSM), capable of accurately predict

109 peration, we are able to parametrize several mechanical modes and estimate their optomechanical coupl

110 Switching the energy scan mechanism from a mechanical monochromator to an electronic detector thres

111 sensitive metrology, ground state cooling of mechanical motion and slowing of light.

112 oside triphosphate binding and hydrolysis to mechanical movement along a polymer lattice.

113 e efficient conversion of chemical energy to mechanical movement.

114 ingle talin proteins in response to external mechanical noise and cyclic force perturbations.

115 Quantum mechanical/nuclear magnetic resonance (NMR) approaches a

116 There were no ablation-related changes in mechanical or heat withdrawal thresholds or in capsaicin

117 a vasopressor or positive inotropic drug or mechanical or surgical intervention (HR, 0.64; 95% CI, 0

118 ectors to chip-scale quantum micro- and nano-mechanical oscillators.

119 TACAN, a putative ion channel that mediates mechanical pain in mice.

120 d highlight new behavioral methods to assess mechanical pain.

121 However, disparity in thermo-mechanical parameters has left much debate as to which f

122 Mechanical patterns control a variety of biological proc

123 hanging mechanical properties limiting their mechanical performance and service life.

124 e alloy Cu-Ta has the potential for enhanced mechanical performance in applications as a functional c

125 t was used to induce two opposite unilateral mechanical perturbations affecting the step length over

126 They also introduce mechanical perturbations that interfere with measurement

127 uction in a single osteoblast under external mechanical perturbations, was utilised to simulate and e

128 tion of the scanning-probe IR images and the mechanical phase image enables a combined probing of mec

129 The mechanical phenotyping of single cells therefore offers

130 Mechanical power and driving pressure have been proposed

131 trategies that minimized driving pressure or mechanical power consistently across pediatric and adult

132 Mechanical pressure of hyphae and extracellular polymeri

133 More importantly, mechanical programmability of the LC gels is achieved by

134 ies with tailored surface chemistry, elastic mechanical properties and chemical stability in water.

135 processable polyamides with stereocontrolled mechanical properties and high-fidelity shape memory beh

136 ality hybridization with collagen, improving mechanical properties and integrity, and decreased the e

137 sphonate to generate hydrogels with enhanced mechanical properties and preserved protein binding able

138 ctural properties of wood in relation to its mechanical properties are explored.

139 n be improved by assessing the breast tissue mechanical properties associated with pathological chang

140 ly significant differences were found in the mechanical properties between the two phases, reinforcin

141 t decrements in bone micro-architectural and mechanical properties due to hindlimb unloading alone an

142 rtilage explants (N = 10), and the resulting mechanical properties from both the creep and recovery p

143 However, unsatisfactory mechanical properties have limited the scope for wider a

144 nthetic structural materials have unchanging mechanical properties limiting their mechanical performa

145 Force volume AFM can precisely capture the mechanical properties of biological samples with force s

146 Together, our model describes how different mechanical properties of cells can contribute to the reg

147 oach provides the opportunity to explore the mechanical properties of complex tissues at the length s

148 have evaluated the architectural designs and mechanical properties of different tendons throughout th

149 The mechanical properties of extracellular vesicles (EVs) ar

150 l synthesis, while the unique combination of mechanical properties of GO/Mfp films will be attractive

151 Improvement in mechanical properties of healing MRL/MpJ vs C57Bl/6 tend

152 s and distributions may be used to infer the mechanical properties of individual tRNA molecules.

153 changes in the cardiac ECM result in altered mechanical properties of ischemic or infarcted myocardia

154 obust Features)-based algorithm to study the mechanical properties of isolated nuclei and in living c

155 ssing, providing a new avenue for tuning the mechanical properties of medium- and high-entropy alloys

156 loring the chemical, optical, electronic, or mechanical properties of MXenes.

157 nes: models that simulate the geometries and mechanical properties of soft tissue systems and multima

158 the 3D fibrillar network and the optical and mechanical properties of the macroscopic matrices, we sh

159 and mineral (ceramic) phases, the intrinsic mechanical properties of the mineral phases are poorly u

160 The mechanical properties of the MN array were investigated

161 es can merge the functional, structural, and mechanical properties of the two components and are usef

162 the well-established dependence of cartilage mechanical properties on the frequency of the applied lo

163 Alteration of membrane mechanical properties represents a potentially important

164 Cells precisely control their mechanical properties to organize and differentiate into

165 We sought to characterize the lung mechanical properties underlying these two asthma phenot

166 moc)-Asp exhibits the lowest CGC and highest mechanical properties when compared to a library of dipe

167 kappa values greater than 2 and poor thermo-mechanical properties(5).

168 nges in USL microstructure and corresponding mechanical properties, however, are not fully understood

169 precipitate mineral carbonates with enhanced mechanical properties, however, understanding exactly ho

170 embryonic stem cells (mESCs) display unique mechanical properties, including low cellular stiffness

171 f their superlative electrical, optical, and mechanical properties.

172 a manner consistent with changes in membrane mechanical properties.

173 ckness, extracellular matrix components, and mechanical properties.

174 ty, biocompatibility, biomimicry, and proper mechanical properties.

175 We suggest that the mechanical regulation of photosynthesis is a critical fa

176 "soft bilayers" with physiological levels of mechanical resistance (Young's modulus of 4 kPa).

177 of a single quantum system on a macroscopic mechanical resonator, has remained elusive.

178 troscopy to measure changes in extension and mechanical response of an HA chain as aggrecan monomers

179 nding of phase-specific contribution to bulk mechanical response of concentrated alloys and help in d

180 on to fibre-based sensors, e.g. for studying mechanical response/limitations of aerospace composite s

181 and printed elements enables differentiated mechanical responses and consistently enables and extend

182 ation provides elastic hydrogels with higher mechanical rigidity, better bio-adhesion and longer resi

183 s, including large and interconnected pores, mechanical robustness, and shape-memory.

184 haracterized in purified actin networks, its mechanical role in the cytoplasm of living cells remains

185 ntrol parameter for tuning the hair bundle's mechanical sensitivity.

186 tion of aortic stenosis (AS) based on cardio-mechanical signals collected using non-invasive wearable

187 Mechanical signals in biology change quickly over time a

188 rbon nanofibers with the corresponding chemo-mechanical simulation, revealing that, the sodiated red

189 hlear dimensions, without the need to invoke mechanical specializations of the sensory tissue.

190 ion yet the effects of ligand binding on the mechanical stability and energy landscape of proteins ar

191 iability of multiple cell types, and enhance mechanical stability in hydrogels derived from them.

192 MIEC channels suggests that the chemical and mechanical stability issues with the metal-electrolyte i

193 gical counting rules to predict the relative mechanical stability of knots and tangles, in agreement

194 ndary structures of luciferase to its fold's mechanical stability remain unknown.

195 Their mechanical stability was thoroughly investigated by mult

196 nce sample exhibits a Vickers microhardness (mechanical stability) value of ~194 H(V) that is signifi

197 nhibiting light scattering, while preserving mechanical stability, stiffness, and nonlinearity.

198 parent speed of diffusion is affected by the mechanical state of cardiomyocytes, and that cyclic cont

199 plex at branch junctions adopts two distinct mechanical states with different sensitivities to force,

200 hich cells follow gradients of extracellular mechanical stiffness, has been proposed as a mechanism d

201 strong apoptotic cellular response, whereby mechanical stimulation causes those cells near the crack

202 Dye loading experiments showed that mechanical stimulation increased open probability of car

203 evice capable of simultaneous electrical and mechanical stimulation of human induced pluripotent stem

204 In this study, we discovered that mechanical stimulation of integrin beta1 leads to the ph

205 It was found that mechanical stimulation-evoked Ca(2+) responses in astroc

206 hanotransduction on the cellular response to mechanical stimulation.

207 ation (2.30-2.72 x 10(3) W cm(-2)) with weak mechanical stimuli (0-16 mN) at a gate bias of 1 V.

208 ly advanced our understanding of how noxious mechanical stimuli are detected in mammals.

209 ly to play an important role in transmitting mechanical stimuli from the extracellular matrix to tend

210 hesion receptor, can be activated by various mechanical stimuli including stretch, shear stress, and

211 anding of how cancer cells sense and convert mechanical stimuli into biochemical signals and physiolo

212 shed direct modulation mechanism by external mechanical stimuli.

213 not detect any differences in touch-induced mechanical strain between wild-type and mutant animals.

214 es with both high porosity and extraordinary mechanical strength (>200 MPa) and a low apparent partic

215 highlighted the importance of the zeolite's mechanical strength for successful application.

216 which span the entire cytoplasm and provide mechanical strength to the cell.

217 es of resource transport, damage resistance, mechanical strength, and cost.

218 The membrane shows high flexibility and mechanical strength, owing to the improved flexibility o

219 of vascular plants, where it contributes to mechanical strength, water conduction, and plant defence

220 cbEGF domain calcium binding decreases under mechanical stress (i.e. cbEGF domains are mechanosensiti

221 We observed that the mechanical stress gradients in the tissues presaged grad

222 hematical modeling revealed that SOC reduces mechanical stress within the growth plate.

223 l area to limit larger cell elongation under mechanical stress.

224 of the spectrin tetramers to release excess mechanical stress.

225 the nuclear envelope may balance significant mechanical stresses in yeast and in cells from higher or

226 Mechanical stretch due to muscle overload causes a resto

227 for its ability to accurately apply parallel mechanical stretch in a 96 well plate format in 576 well

228 play roles in the mechanisms by which heat, mechanical stretch, and pharmacological modulators alter

229 inal truncation or mutagenesis abolished the mechanical stretch-mediated increase in I(Kv1.5) Our res

230 We highlight mechanical stretching and bending of membranes and the i

231 The type of mechanical support in place before the procedure was int

232 wofold within the cellular range of cortical mechanical tension, rendering alpha-actinin-4 a catch bo

233 Although mechanical tests can quantify corneal elasticity ex vivo

234 Ninhydrin assay, FTIR, WAXD, SEM and mechanical tests documented successful crosslinking that

235 ventional counterparts with respect to their mechanical, thermal, barrier, and processability propert

236 The pre-conditioning test stimulus, using mechanical/thermal quantitative sensory testing (MQST or

237 probe experiences forces exceeding a defined mechanical threshold (~7-21 pN).

238 with biplane (BP) angiosuites are performing mechanical thrombectomy (MT) in acute ischemic stroke pa

239 with regard to stroke severity, rates of IVT/mechanical thrombectomy, symptomatic intracranial hemorr

240 Quantum mechanical time-dependent density functional theory (TDD

241 of muscle fibers to length changes requires mechanical transduction through titin's intact polypepti

242 mperature dielectric permittivity with large mechanical tunability (a 90% change upon +/-0.1% strain

243 Not long ago, the occurrence of quantum mechanical tunneling (QMT) chemistry involving atoms hea

244 over-the-barrier process or through quantum-mechanical tunnelling).

245 h steered molecular dynamics simulations the mechanical unfolding of dystrophin's spectrin repeat 1 a

246 ne specific secondary structures that resist mechanical unfolding while minimizing the amount of comp

247 eft ventricular assist device (LVAD)-induced mechanical unloading.

248 reased risk was unrelated to AF and inserted mechanical valves.

249 Mechanical ventilation (odds ratio, 3.25; 95% CI, 2.52-4

250 The effects on the length of mechanical ventilation and ICU stay were only significan

251 association with intensive care use (use of mechanical ventilation and/or admission to intensive car

252 age, 64 years +/- 19; 52% men) with invasive mechanical ventilation had one barotrauma event (0.5%; 9

253 .7%), in-hospital death in 1302 (17.1%), and mechanical ventilation in 1602 (21.1%).

254 in the hospital, and 3 continued to receive mechanical ventilation in the ICU.

255 the deleterious effects of positive-pressure mechanical ventilation in this patient population.

256 the best strategies for optimizing invasive mechanical ventilation in this patient population.

257 ategies that may perhaps improve survival if mechanical ventilation is pursued in this set of patient

258 Among 7606 patients, in-hospital death or mechanical ventilation occurred in 2109 (27.7%), in-hosp

259 By turning the mechanical ventilation on and off, it was demonstrated t

260 Most patients requiring mechanical ventilation only require it for a short term

261 igh-flow oxygen; and 6.7% receiving invasive mechanical ventilation or extracorporeal membrane oxygen

262 ine if clinical course or characteristics of mechanical ventilation predict persistent respiratory mo

263 re unit (ICU) patients or patients requiring mechanical ventilation showed a lower proportion of medi

264 11.0); durations of vasoactive-inotropic and mechanical ventilation support were 3.0 days (2.0-6.0 d)

265 all higher in the setting of prolonged acute mechanical ventilation than short-term mechanical ventil

266 Adults requiring invasive mechanical ventilation via endotracheal tube for acute r

267 ibrotic interstitial lung disease-associated mechanical ventilation when viewed through an acute resp

268 score (worst to best: death, cardiac arrest, mechanical ventilation with mechanical circulatory suppo

269 ilation with mechanical circulatory support, mechanical ventilation with vasopressors/inotrope suppor

270 tilation with vasopressors/inotrope support, mechanical ventilation without hemodynamic support, and

271 ventilator-free days (days alive and free of mechanical ventilation) over 28 days.

272 n only require it for a short term (< 4 d of mechanical ventilation).

273 t calstabin-1 6 hours after the onset of the mechanical ventilation, 1 and 10 days after extubation.

274 [67%] with a chronic disease), 31% received mechanical ventilation, 19% had shock, and 588 (3.1%) di

275 on, intensive care unit admission, intubated mechanical ventilation, and death) due to medically atte

276 natremia was associated with encephalopathy, mechanical ventilation, and decreased probability of dis

277 linical characteristics and outcomes (death, mechanical ventilation, hospital discharge) for these gr

278 ce in initial static compliance, duration of mechanical ventilation, or ICU length of stay by timing

279 Although 27% of our patients needed mechanical ventilation, over half were discharged home b

280 ion at discharge a priori defined as one of: mechanical ventilation, supplemental oxygen, bronchodila

281 e; patients were eligible after weaning from mechanical ventilation.

282 loss of diaphragmatic force associated with mechanical ventilation.

283 user-specified inspiratory breaths while on mechanical ventilation.

284 ht sedation with a daily wake-up call during mechanical ventilation.

285 8 days, defined as being alive and free from mechanical ventilation.

286 acute mechanical ventilation than short-term mechanical ventilation.

287 e mechanical ventilation; or use of invasive mechanical ventilation.

288 In total, 175 patients received mechanical ventilation; 44.6% were female, 66.3% were Bl

289 Twenty-two patients required mechanical ventilation; at last follow-up, 16 were extub

290 high-flow nasal cannula; use of non-invasive mechanical ventilation; or use of invasive mechanical ve

291 The same mechanical-ventilation strategies were used in both grou

292 ntal approaches to investigate the potential mechanical vulnerability of axons that span the gray-whi

293 hibit responses to non-prey signals, such as mechanical water turbulence.

294 Mechanical weakness of the stem was ruled out as an expl

295 emain elusive because of degradation such as mechanical wearing.

296 In some systems, the creation of mechanical work and the processing of information become

297 The mechanical work produced by arrays of molecular motors c

298 diate waste heat are often the by-product of mechanical work, chemical or nuclear reactions, or infor

299 mical and light energy inputs into efficient mechanical work.

300 follow the steps that couple ATP turnover to mechanical work.