ライフサイエンスコーパス: mechanical allodynia

1 by von Frey hairs compared with young rats (mechanical allodynia).

2 e-dependent increase in pain-like responses (mechanical allodynia).

3 nt results in the development of significant mechanical allodynia.

4 amplitudes, but also alleviated SNI-induced mechanical allodynia.

5 -mediated mechanotransduction contributes to mechanical allodynia.

6 mg/kg) provided an 11.2-fold attenuation of mechanical allodynia.

7 flammatory heat hyperalgesia and neuropathic mechanical allodynia.

8 spinal TRPV1, leading to the development of mechanical allodynia.

9 and 13-HODE by antibodies blocks CFA-evoked mechanical allodynia.

10 induction of diabetes, and protects against mechanical allodynia.

11 zed linoleic acid metabolites rapidly evokes mechanical allodynia.

12 responsible for chronic pain states such as mechanical allodynia.

13 , or in partial sciatic nerve injury-induced mechanical allodynia.

14 RG prevented but did not reverse SNL-induced mechanical allodynia.

15 oglial toxin, l-alpha-aminoadipate, reversed mechanical allodynia.

16 contribute importantly to the persistence of mechanical allodynia.

17 ay 10 after surgery also reduces established mechanical allodynia.

18 ats produces an early onset and long-lasting mechanical allodynia.

19 stimulation and thereby increase symptoms of mechanical allodynia.

20 ept (1 mg, i.p., every third day) attenuated mechanical allodynia.

21 and hindlimbs indicating the development of mechanical allodynia.

22 goat IgG (30 or 100 mg/kg) did not attenuate mechanical allodynia.

23 re known to mediate thermal hyperalgesia and mechanical allodynia.

24 significance in the pathogenesis of chronic mechanical allodynia.

25 maintenance of zymosan and formalin-induced mechanical allodynia.

26 ereby demonstrating thermal hyperalgesia and mechanical allodynia.

27 iled to affect intraplantar ODN 1826-induced mechanical allodynia.

28 s interpreted as mechanical hyperalgesia and mechanical allodynia.

29 P release, and reversed nerve injury-induced mechanical allodynia.

30 evealed that AIE exposure-induced protracted mechanical allodynia.

31 rrounding Schwann cells to evoke periorbital mechanical allodynia.

32 neurons resulted in thermal hyperalgesia and mechanical allodynia.

33 ng disorder characterized by spontaneous and mechanical allodynia.

34 lting in significant improvement of diabetic mechanical allodynia.

35 sensory nerve action potential amplitude and mechanical allodynia.

36 istant (TTX-R) Nav1.8 channels contribute to mechanical allodynia.

37 g, paralleling its reduced ability to induce mechanical allodynia.

38 ory function found that E365del mutants have mechanical allodynia.

39 compounds as a novel treatment for diabetic mechanical allodynia.

40 ce at time points at which they recover from mechanical allodynia.

41 sensory inputs, and its impairment leads to mechanical allodynia.

42 es to the development of vincristine-induced mechanical allodynia.

43 g nociceptors was required for TRPA1-induced mechanical allodynia.

44 pyramidal neuron hyperactivity and reversed mechanical allodynia.

45 evice and assay for measuring functional and mechanical allodynia.

46 uch-sensitive neuronal type recruited during mechanical allodynia.

47 e TRPA1 of ensheathed nociceptors to sustain mechanical allodynia.

48 halamic bursts attenuated cortical theta and mechanical allodynia.

49 BPbeta using siRNA against C/EBPbeta reduced mechanical allodynia.

50 ng sodium channels without producing heat or mechanical allodynia.

51 D-L1 neutralization or PD-1 blockade induced mechanical allodynia.

52 (-/-) mice in severity of paclitaxel-induced mechanical allodynia.

53 ing and that this contributes to neuropathic mechanical allodynia.

54 es to the maintenance of vincristine-induced mechanical allodynia.

55 lls delayed recovery from paclitaxel-induced mechanical allodynia.

56 ivelastat) in WT mice attenuated neuropathic mechanical allodynia.

57 pathway does not alter nerve injury-induced mechanical allodynia.

58 alretinin neurons, which we show also convey mechanical allodynia.

59 rve fibers (C-fibers) has limited effects on mechanical allodynia.

60 nents of the elusive dorsal horn circuit for mechanical allodynia.

61 rine completely reversed oxaliplatin-induced mechanical allodynia.

62 f chronic pain without affecting the sensory mechanical allodynia.

63 Rs play a critical role in the expression of mechanical allodynia.

64 but have increased thermal hyperalgesia and mechanical allodynia.

65 VZ+434 protected against mechanical allodynia 8 weeks after STZ injection.

66 eeks after nerve injury, effectively reduced mechanical allodynia, a cardinal feature of late-phase n

67 potently prevented and reversed SNL-induced mechanical allodynia, a major symptom of neuropathic pai

68 also attenuates capsaicin-induced secondary mechanical allodynia, a pain behavior reflecting hyperse

69 ain occurred in the absence of any effect on mechanical allodynia, a standard test for neuropathic pa

70 orphine withdrawal-like behavioral signs and mechanical allodynia, activates NR1 and NR2 receptors, a

71 The development of thermal hyperalgesia and mechanical allodynia after CCI also was prevented in adr

72 lagellin/QX-314) dose-dependently suppresses mechanical allodynia after chemotherapy, nerve injury, a

73 in attenuating both thermal hyperalgesia and mechanical allodynia after chronic nerve constriction in

74 est (20-30%) and nonsignificant reduction of mechanical allodynia after intraplantar Freund's adjuvan

75 neurons may contribute to the development of mechanical allodynia after L5 spinal nerve ligation.

76 afferent complexes exhibited a reduction in mechanical allodynia after nerve injury.

77 in the generation of ectopic discharges and mechanical allodynia after peripheral nerve injury.

78 All strains variously developed mechanical allodynia after SNI with the exception of str

79 ively reversed both thermal hyperalgesia and mechanical allodynia although each individual dose alone

80 a-fibers, have previously been implicated in mechanical allodynia, an A-fiber-selective pharmacologic

81 duces a rapid and sustained reversal of both mechanical allodynia and anxiodepression-like states in

82 resentation to induce heat hypersensitivity, mechanical allodynia and continuing pain.

83 tochondria-targeted O2(.-)scavenger) reduced mechanical allodynia and decreased pCREB and pC/EBPbeta.

84 ere exists a reciprocal relationship between mechanical allodynia and depression-like behavior and th

85 Here we report that both mechanical allodynia and depression-like behavior were s

86 all mice receiving verum treatment developed mechanical allodynia and distinct gait alterations.

87 emales and males had distinct differences in mechanical allodynia and DRG gene expression, even thoug

88 echanisms contributing to the development of mechanical allodynia and gait disturbances in a murine m

89 ase of interleukin-1B from macrophages, with mechanical allodynia and gait disturbances significantly

90 se-dependently attenuated paclitaxel-induced mechanical allodynia and heat hyperalgesia.

91 nto deep tissues results in a longer-lasting mechanical allodynia and heat hypoalgesia compared with

92 n injected into skin resulted in a secondary mechanical allodynia and heat hypoalgesia lasting approx

93 alidomide (50.0 mg/kg) reduced taxol-induced mechanical allodynia and hyperalgesia whereas minocyclin

94 at are normally innocuous or mildly painful (mechanical allodynia and hyperalgesia) occurs during inf

95 ted several nociceptive behaviors, including mechanical allodynia and hyperalgesia, cold allodynia, s

96 ective in decreasing the behavioral signs of mechanical allodynia and hyperalgesia, followed by cold

97 that EA would relieve the paclitaxel-induced mechanical allodynia and hyperalgesia, which was assesse

98 microglia, and macrophages, given that both mechanical allodynia and hyperexcitability of dissociate

99 ripheral mGlu1alpha receptors contributes to mechanical allodynia and inflammatory pain but not therm

100 Chronic ethanol ingestion caused prolonged mechanical allodynia and loss of intraepidermal small ne

101 trated significantly increased and sustained mechanical allodynia and loss of motor function.

102 se oligodeoxynucleotide against CREB reduced mechanical allodynia and lowered pC/EBPbeta.

103 /kainate receptor antagonist, alleviated the mechanical allodynia and lowered the threshold of respon

104 eptive Adelta fibers, giving rise to dynamic mechanical allodynia and mechanical hyperalgesia.

105 ry, almost completely abolished the signs of mechanical allodynia and ongoing pain behaviors, and it

106 exaenoic acid, prevents nerve injury-induced mechanical allodynia and ongoing pain in mice.

107 zation, including CFA- and capsaicin-induced mechanical allodynia and osteoarthritic pain.

108 in astrocyte-specific trkB.T1 KO mice; using mechanical allodynia and pain-related measurements on th

109 running with exogenous CD59 also attenuated mechanical allodynia and reduced MAC deposition at the n

110 es that FcRn blockade or deletion alleviates mechanical allodynia and reduces IgG accumulation after

111 hronic debilitating disease characterized by mechanical allodynia and spontaneous pain.

112 wo weeks after SNI, wild-type mice developed mechanical allodynia and the functionality of mu-opioid

113 ity was diminished in cKO mice, but both the mechanical allodynia and the microgliosis generated by n

114 the relationship between the development of mechanical allodynia and the reorganization of primary a

115 essary and sufficient for the development of mechanical allodynia and the transition of PVNs to adapt

116 r of mTOR, significantly blocked CFA-induced mechanical allodynia and thermal hyperalgesia 1 day post

117 eceptive dorsal horn neurons, and attenuated mechanical allodynia and thermal hyperalgesia after SCI.

118 y at T13 results in development of permanent mechanical allodynia and thermal hyperalgesia due to int

119 urgery, produced a long-duration reversal of mechanical allodynia and thermal hyperalgesia for at lea

120 ition of acute pain perception, and reversed mechanical allodynia and thermal hyperalgesia in a model

121 Proteasome inhibitors blocked mechanical allodynia and thermal hyperalgesia in all thr

122 ed the clinical scores of EAE and attenuated mechanical allodynia and thermal hyperalgesia in EAE.

123 ate and opioid receptors are involved in the mechanical allodynia and thermal hyperalgesia that devel

124 vector protected the animals from developing mechanical allodynia and thermal hyperalgesia throughout

125 N3 knockout mice exhibited similar levels of mechanical allodynia and thermal hyperalgesia to wild-ty

126 Behavioral responses assessed by mechanical allodynia and thermal hyperalgesia were almos

127 iors interpreted as mechanical hyperalgesia, mechanical allodynia and thermal hyperalgesia, which are

128 degrees C to the rat sciatic nerve produces mechanical allodynia and thermal hyperalgesia.

129 selective L5 spinal nerve ligation reversed mechanical allodynia and thermal hyperalgesia; the antia

130 etermine whether it is possible to attenuate mechanical allodynia and/or alter spinal glial activatio

131 e oligodeoxynucleotide against TNFRI reduced mechanical allodynia, and decreased mtO2(.-), pCREB and

132 ing of PKCdelta attenuated spontaneous pain, mechanical allodynia, and heat hyperalgesia in TOW mice.

133 motor and sensory nerve conduction velocity, mechanical allodynia, and loss of intraepidermal nerve f

134 vant (CFA) produced peripheral inflammation, mechanical allodynia, and thermal hyperalgesia in vector

135 trocytes was sufficient to induce persistent mechanical allodynia, and this allodynia was suppressed

136 te peripheral neuropathic pain that includes mechanical allodynia are limited.

137 Therefore, NGF-evoked thermal and mechanical allodynia are mediated by spatially distinct

138 mal hyperalgesia) and light tactile stimuli (mechanical allodynia) are rapidly induced after gp120 ad

139 ed and reversed oxaliplatin-induced cold and mechanical allodynia as well as social interaction impai

140 However, mechanical allodynia, as a marker of neuropathic pain fo

141 g antibody, normal goat or normal rat IgG on mechanical allodynia associated with L5 spinal nerve tra

142 d in a reduction of thermal hyperalgesia and mechanical allodynia associated with persistent neuropat

143 ous pain responses during the first hour and mechanical allodynia at 6 h and 1 day following injectio

144 us (thermal and mechanical) and non-noxious (mechanical allodynia) behavioral paradigms.

145 rin3A coexpression with NGF led to decreased mechanical allodynia but no significant reductions in th

146 al goat and rat IgG significantly attenuated mechanical allodynia, but not at higher doses (0.08-0.00

147 or site for the induction and maintenance of mechanical allodynia, but the circuitry that underlies t

148 Mice that lack Ccr2 also developed mechanical allodynia, but this started to resolve from 8

149 and scales basal mechanical sensitivity and mechanical allodynia by regulating auxiliary voltage-gat

150 TRPV1 agonists that evoke the development of mechanical allodynia by this receptor.

151 enduringly reduced thermal hyperalgesia and mechanical allodynia caused by inflammation, nerve injur

152 cord are associated with the pathogenesis of mechanical allodynia, changes in cortical circuits also

153 different pain behavior tests (representing mechanical allodynia, cold allodynia, ongoing pain exace

154 The mechanical allodynia depends on early activation of the

155 Following sciatic CCI neuropathy, mechanical allodynia developed in the corresponding foot

156 eased response threshold to tactile stimuli (mechanical allodynia) develops in rats after microinject

157 Piezo2 axis has a role in the development of mechanical allodynia during neuropathic pain.

158 85 mg/kg, i.p.), capsaicin-induced secondary mechanical allodynia (ED(50) approximately 100 mg/kg, i.

159 ical changes in the PNS were associated with mechanical allodynia, even in the absence of nerve injur

160 It was not correlated with mechanical allodynia, extent of L4 fiber damage [ATF3 (a

161 In the SNL model, mechanical allodynia failed to develop 1 and 2 weeks pos

162 We found that the model provided robust mechanical allodynia, fibrosis and a shift to smaller av

163 nd neuroimmune modulation in the etiology of mechanical allodynia following peripheral nerve injury.

164 Mechanical allodynia following TBI recovered more quickl

165 in, the effects of this drug were studied on mechanical allodynia following unilateral spinal nerve l

166 led to significant (P < 0.0001) reversal of mechanical allodynia for >/=3 months.

167 Bupivacaine reversed mechanical allodynia for 24 h after surgery but did not

168 the lumbar region (intrathecal), attenuated mechanical allodynia for at least one month.

169 reatments were more effective in alleviating mechanical allodynia for peripheral nerve injury than ne

170 ible, dose-dependent attenuation of hind paw mechanical allodynia for up to 1h after administration,

171 L5 nerve transection induced mechanical allodynia from day 1 to 7 which correlated wi

172 before the SNL surgery, reduces SNL-induced mechanical allodynia from day 1 to day 10, with maximal

173 ated that, by six weeks after STZ injection, mechanical allodynia had developed (mechanical withdrawa

174 response threshold to light tactile stimuli (mechanical allodynia) have been reported.

175 ns of the anterior cingulate cortex (ACC) on mechanical allodynia/hyperalgesia after L5 ligation or o

176 Our data indicate that EA at 10 Hz inhibits mechanical allodynia/hyperalgesia more potently than doe

177 , characterized by periorbital and cutaneous mechanical allodynia/hyperalgesia, motor deficits, and c

178 dergoing spared nerve injury (SNI) developed mechanical allodynia in 1 wk; nerve blockade with a sing

179 nels and exhibits dose-dependent reversal of mechanical allodynia in a behavioral rat model of neurop

180 This gene therapy reversed and prevented mechanical allodynia in a model of nerve injury and reve

181 5 (22) showed strongly effective reversal of mechanical allodynia in a mouse model of CIPN and was ad

182 presentative compound effectively attenuated mechanical allodynia in a rat model of neuropathic pain.

183 A-803467 also dose-dependently reduced mechanical allodynia in a variety of rat pain models inc

184 At Day 1, partial reversal of mechanical allodynia in aboBoNT-A groups was followed by

185 jection of the TLR9 agonist ODN 1826 induced mechanical allodynia in both sexes of WT and Tlr4 KO mic

186 r of paclitaxel-activated macrophages evoked mechanical allodynia in both sexes, which was compromise

187 sia and, to a lesser extent, also diminishes mechanical allodynia in CCI in female mice.

188 Mechanical allodynia in diabetic rats was determined by

189 Par(2)Na(v)1.8 and Lgmn deletion attenuated mechanical allodynia in female mice with carcinogen-indu

190 , TLR9 antagonism reduced paclitaxel-induced mechanical allodynia in female nude mice (T-cell and B-c

191 ckout of Lgals3 (galectin-3) markedly reduce mechanical allodynia in gp120 transgenic mice.

192 Here we show that mechanical allodynia in male mice was increased with exp

193 We observed persistent mechanical allodynia in mice lacking MKP-3 (postoperativ

194 knockout of CX3CR1 alleviated gp120-induced mechanical allodynia in mice, suggesting a critical cont

195 of dicumarol alleviated nerve injury-induced mechanical allodynia in mice.

196 Acute ethanol ingestion caused delayed mechanical allodynia in mice.

197 a inhibitors also attenuated protease-evoked mechanical allodynia in mice.

198 ction of CXCL13-activated astrocytes induced mechanical allodynia in naive mice.

199 of hypoxia with hyperbaric oxygen alleviated mechanical allodynia in nerve-injured animals.

200 ity to mechanical stimulation and alleviates mechanical allodynia in neuropathic and inflammatory pai

201 y spinal disinhibition is a key mechanism of mechanical allodynia in neuropathic pain.

202 lated with enhanced thermal hyperalgesia and mechanical allodynia in Pap(-/-) mice.

203 found that acute NTG administration induced mechanical allodynia in periorbital region and paw as we

204 (5+) produced naloxone-sensitive reversal of mechanical allodynia in rats following chronic constrict

205 and spinal cord prevented the development of mechanical allodynia in RSD-exposed mice.

206 nd the responses to thermal hyperalgesia and mechanical allodynia in streptozotocin-treated rats betw

207 evidence that the neural circuits conveying mechanical allodynia in the dorsal horn differ by the na

208 ification of an etiology-based circuitry for mechanical allodynia in the dorsal horn has important im

209 emisection that correlated with emergence of mechanical allodynia in the hind limbs of rats.

210 efficacy of TIAN at persistently alleviating mechanical allodynia in the spared nerve injury (SNI) mo

211 urons after nerve injury, and development of mechanical allodynia in the spared nerve injury model is

212 (Regenacy Pharmaceuticals, Inc), attenuated mechanical allodynia in the von Frey assay within 2 days

213 is not a prerequisite of vincristine-induced mechanical allodynia in this model.

214 vivo intrathecal injection of 5,6-EET caused mechanical allodynia in wild-type but not TRPA1-null mic

215 d exogenous delivery of SerpinA3N attenuated mechanical allodynia in WT mice.

216 istration of IL-23 produces mechanical pain (mechanical allodynia) in female but not male mice, and c

217 taxel chemotherapy-induced neuropathic pain (mechanical allodynia) in mice, without causing motor imp

218 s in neuropathic mice.SIGNIFICANCE STATEMENT Mechanical allodynia, in which innocuous touch is percei

219 10 mg/kg, i.p.) did not suppress established mechanical allodynia induced by complete Freund's adjuva

220 lorlatinib reversed thermal hyperalgesia and mechanical allodynia induced by inflammation or nerve in

221 tinin (CR) neurons in lamina II inner convey mechanical allodynia induced by inflammatory injuries, w

222 tinin (CR) neurons in lamina II inner convey mechanical allodynia induced by inflammatory injuries, w

223 ) neurons at the lamina II/III border convey mechanical allodynia induced by neuropathic injuries.

224 ) neurons at the lamina II/III border convey mechanical allodynia induced by neuropathic injuries.

225 2 channel functional expression in rats with mechanical allodynia induced by spinal nerve ligation (S

226 hic pain behaviors (thermal hyperalgesia and mechanical allodynia) induced by chronic constriction ne

227 Mechanical allodynia, induced by normally innocuous low-

228 nal IL-6 levels correlated directly with the mechanical allodynia intensity following nerve injury.

229 Mechanical allodynia is a cardinal feature of pathologic

230 Peripheral nerve injury-induced mechanical allodynia is often accompanied by abnormaliti

231 stimuli, which suggests that injury-induced mechanical allodynia is transmitted through a circuit th

232 skin mechanoreceptors in the development of mechanical allodynia is unclear.

233 threshold mechanoreceptors (Abeta-LTMRs) for mechanical allodynia-like behaviors in mice, but it rema

234 ritoneal pretreatment with l-THP reduced the mechanical allodynia (MA) induced by direct activation o

235 he sympathetic nervous system (SNS) to pain, mechanical allodynia (MA), and hyperalgesia in humans is

236 nd points, including periorbital and hindpaw mechanical allodynia, mouse grimace, anxiety, and workin

237 on of LPC induced TRPC5-dependent behavioral mechanical allodynia, neuronal mechanical hypersensitivi

238 Thermal hyperalgesia and mechanical allodynia occurred in both hind paws and fore

239 a similar pattern, with heat hypoalgesia and mechanical allodynia occurring simultaneously.

240 inflammatory pain, thermal hyperalgesia, and mechanical allodynia, of which the latter is completely

241 ested doses (15, 30 or 60 mg/kg), it reduced mechanical allodynia only at high doses (30 or 60 mg/kg)

242 ocytes are required during the initiation of mechanical allodynia or thermal hyperalgesia, these cell

243 paradoxical thermal sensations, and dynamic mechanical allodynia (pain upon light stroking of the sk

244 howed a reduced degree of paclitaxel-induced mechanical allodynia (PIMA), suggesting that complement

245 es exhibit quantitatively the same degree of mechanical allodynia post injury.

246 B afferent complexes partially contribute to mechanical allodynia produced by peripheral nerve injury

247 MSC-mediated resolution of mechanical allodynia, recovery of IENFs and restoration

248 Persistent thermal hypersensitivity and mechanical allodynia require de novo protein translation

249 lted in exacerbated thermal hyperalgesia and mechanical allodynia reversible by the noncompetitive NM

250 es bone cancer-related thermal hyperalgesia, mechanical allodynia, spontaneous and movement-evoked pa

251 everses signs of established CIPN, including mechanical allodynia, spontaneous pain, and loss of intr

252 lacking SerpinA3N developed more neuropathic mechanical allodynia than wild-type (WT) mice, and exoge

253 A single SD produced bilateral periorbital mechanical allodynia that developed within 1 hour and re

254 a unilateral dental injury develop bilateral mechanical allodynia that is delayed relative to the ons

255 malin showed a spontaneous pain response and mechanical allodynia that persisted for approximately 60

256 niscus, mice developed early-onset secondary mechanical allodynia that was maintained for 16 wk.

257 ction of capsaicin and during post-capsaicin mechanical allodynia (the perception of pain from a norm

258 Mechanical allodynia - the misperception of light touch

259 Measurements included mechanical allodynia, the efficacy of diffuse noxious in

260 Mechanical allodynia, the perception of innocuous tactil

261 or Plp1-Cre Trpa1fl/fl mice did not develop mechanical allodynia, they did not show any protection f

262 -induced persistent thermal hyperalgesia and mechanical allodynia to determine the role of transient

263 Lastly, both thermal hyperalgesia and mechanical allodynia to i.t. gp120 were blocked by spina

264 ia peripheral and spinal sites of action and mechanical allodynia via only a spinal site of action.

265 responses and reversed inflammation-induced mechanical allodynia via peripheral adenosine A1 recepto

266 tone leads to neuropathic symptoms, such as mechanical allodynia, via mechanisms that are not fully

267 a (tail-flick, TF, and Hargreaves tests) and mechanical allodynia (von Frey and touch-evoked agitatio

268 Behavioral mechanical allodynia was assessed using von Frey filamen

269 Mechanical allodynia was assessed, and glial reactivity

270 tingly, the development of paclitaxel-evoked mechanical allodynia was attenuated by TLR9 antagonism o

271 Nav1.8 knockout mice, and the development of mechanical allodynia was delayed but not abrogated in th

272 uropathic pain where significant reversal of mechanical allodynia was observed at doses that did not

273 Both thermal and mechanical allodynia was observed between 3 and 12 h pos

274 found that, in the absence of Merkel cells, mechanical allodynia was partially reduced in male mice,

275 Paclitaxel-induced mechanical allodynia was prolonged in T-cell-deficient (

276 Interestingly, mechanical allodynia was reversed if adenylate cyclase o

277 The SNE-induced mechanical allodynia was reversibly suppressed, partiall

278 rsal root ganglion neurons and, importantly, mechanical allodynia was significantly attenuated in con

279 erior insular cortex lesion, even though the mechanical allodynia was suppressed.

280 odel of neuropathic pain, the development of mechanical allodynia was totally abrogated in CCR2 knock

281 Although mechanical allodynia was unaffected, significant improve

282 anoreceptors (LTMRs) to nerve-injury-induced mechanical allodynia, we generated and characterized a n

283 Thermal hyperalgesia and mechanical allodynia were also present.

284 Additionally, thermal hyperalgesia and mechanical allodynia were enduringly enhanced when PIP(2

285 Pain behaviors (thermal hyperalgesia and mechanical allodynia) were established at one week after

286 and female HFD-fed animals exhibited robust mechanical allodynia when exposed to a subthreshold dose

287 ponses: early-phase analgesia and late-phase mechanical allodynia which requires NMDAR; both phases a

288 inistration of NMDA induces GluN2B-dependent mechanical allodynia, which is prolonged in Arrb2-KO mic

289 trocytic mGluR5-signaling pathway suppressed mechanical allodynia, while activating this pathway in t

290 heral nerve injury prevented exacerbation of mechanical allodynia with a concurrent improvement of de

291 l nerve injury prevented the exacerbation of mechanical allodynia with a concurrent improvement of de

292 lted in a long-lasting bilateral (1-4 weeks) mechanical allodynia with a simultaneous unilateral heat

293 cant improvement in potency in vivo, evoking mechanical allodynia with an EC(5)(0) of 14.4 pmol.

294 V1+ nociceptors prevented the development of mechanical allodynia without affecting clinical signs an

295 n, TRPA1 silencing in nociceptors attenuated mechanical allodynia, without affecting macrophage infil

296 When SIRT1 was depleted from skin, the mechanical allodynia worsened in diabetic neuropathy mic