ライフサイエンスコーパス: mechanism

1 hrough a type I interferon (IFN)-independent mechanism.

2 ting of L. monocytogenes by a RavZ-dependent mechanism.

3 s simulation approaches to reveal a detailed mechanism.

4 s starvation-induced autophagy by an unknown mechanism.

5 rt-range, mechanosensory collision-avoidance mechanism.

6 on functional status, suggesting a buffering mechanism.

7 ycin (mTOR) signaling pathway as a candidate mechanism.

8 bolite, and identify an excision-independent mechanism.

9 t product, confirming an apicoplast-specific mechanism.

10 ilize Sn through a structural reconstruction mechanism.

11 ar for catalysts based on a single metal ion mechanism.

12 Study 4 found evidence consistent with this mechanism.

13 As yet, little is known about the underlying mechanism.

14 two phenotypes and, hence, shared biological mechanisms.

15 al species pool and local community assembly mechanisms.

16 ulation via kinase dependent and independent mechanisms.

17 ight in in vitro gastric molecular lipolysis mechanisms.

18 g on several synergistic cancer cell killing mechanisms.

19 scriptional regulation but through different mechanisms.

20 idemiology, aetiology and pathophysiological mechanisms.

21 competition between the NRs governed by two mechanisms.

22 y dependencies that point to potentially new mechanisms.

23 hts into channel activation and inactivation mechanisms.

24 res considering both atmospheric and oceanic mechanisms.

25 As the mechanism accounting for cardiovascular disease is preva

26 ty, and weather, we investigated the complex mechanisms affecting reproductive success in an aerial i

27 signaling pathway that surprisingly invoked mechanisms akin to Hebbian plasticity: Ca(2+)-permeable

28 Overall, this mechanism allows access to both traditional C-N adducts

29 The rate-detection mechanism allows continuous stimulus sampling over a wid

30 Based on the mechanism, an ultrahigh projected charge density of 1.85

31 It is possible to defeat this mechanism and activate T cells with solution ligands by

32 , including hypotension, Glasgow Coma Scale, mechanism and intent of injury, and Injury Severity Scor

33 Herein, we describe the mechanisms and consequences of TLR-mediated signal trans

34 Together, our results reveal the fundamental mechanisms and constraints with which convergence enable

35 To gain insight into the molecular mechanisms and determinants of gene expression evolution

36 perfusion but the involved vascular-sensing mechanisms and disease consequences remain unclear.

37 To identify the molecular mechanisms and novel therapeutic targets of late-onset A

38 Analysing mechanisms and pathways modulated by these genes, we fin

39 , in the NAc that modifies behavioral coping mechanisms and stress resiliency in mice.

40 tunities to better understand OSN modulation mechanisms and their relationship to animal physiology.

41 rch opportunity for uncovering novel disease mechanisms and therapies.

42 establish robust materials basis, formation mechanism, and geological viability of these Xe-Fe oxide

43 methionine consumption is an immune evasion mechanism, and targeting cancer methionine signalling ma

44 es not characterized for specific resistance mechanisms, and 128 isolates with CFDC MICs of >=8 mug/m

45 tion, and down-regulation of quality control mechanisms are all hallmarks of cellular decline.

46 milar (impaired QS response), the underlying mechanisms are different.

47 that anti-inflammatory and immunosuppressive mechanisms are not necessarily associated with a decreas

48 pers its treatment; the underlying molecular mechanisms are poorly understood and warrant investigati

49 er, the function of GPR139 and its signaling mechanisms are poorly understood.

50 ition state, radical and polar anti-addition mechanisms are postulated, both triggered by HBr, which

51 me and multiple resistance provided by these mechanisms are required in this area to avoid future con

52 Together, these data provide a mechanism as to how TIH, prevalent in people with impair

53 ions differ in E. muscae-specific resistance mechanisms as well as generic defences effective against

54 of various substrates supports the proposed mechanism, as does a TEMPO trapping experiment.

55 findings suggest a more biologically-driven mechanism associated with photosynthate transport in yie

56 information is known regarding the molecular mechanisms associated with the regulation of these trait

57 To identify the underlying mechanisms associated with this phenomenon, we identifie

58 insertion site is recognized through defined mechanisms, at least in members examined to date, wherea

59 are demonstrated to exert a gain-of-function mechanism, augmenting transforming growth factor (TGF) b

60 The mechanism behind the enhanced permeability is the tempor

61 The mechanism behind this photoelectron-induced reduction wa

62 ed to regulation of gene expression, but the mechanisms behind this directed movement have remained u

63 l roles in insulin sensitization, suggesting mechanisms bridging the association of their genomic loc

64 teatohepatitis barely affects the core clock mechanism but leads to a reprogramming of circadian gene

65 They target eukaryotic cells using different mechanisms, but all require the presence of cholesterol

66 nt sex differences in acute and chronic pain mechanisms, but we are only beginning to understand thei

67 Collectively, our study uncovered a novel mechanism by which AtPRMT3 cooperates with RPS2B to faci

68 Our findings also uncover a new pathogenic mechanism by which beta-catenin promotes podocyte injury

69 Our results demonstrate a novel mechanism by which cystic epithelial cells stimulate myo

70 ng single-molecule analyses, we examined the mechanism by which E449K activates Int for gp3-independe

71 ggesting that sensing of iron depletion is a mechanism by which plants recognize a pathogen threat.

72 Here, we describe a mechanism by which the innate immune system allows rapid

73 n with protein engineering, we explicate the mechanism by which the intrinsically unstructured N-term

74 nd blood pressure substantially, providing a mechanism by which the RVLM could contribute chronically

75 However, the mechanism by which the UBQLN2 mutations cause disease re

76 k to quantitatively infer community assembly mechanisms by phylogenetic bin-based null model analysis

77 cause familial hemiplegic migraine, but the mechanisms by which alpha2-Na/K ATPase mutations lead to

78 These data provide direct mechanisms by which an MHC-II SE contributes to expressi

79 Elucidating the mechanisms by which CHIKV subverts antiviral immunity to

80 observed in some gliomas(1-5); however, the mechanisms by which hypermutation develops and whether i

81 ource of the inflammatory mediators, and the mechanisms by which inflammation may inhibit immunity.

82 ells specific for proinsulin, we studied the mechanisms by which LNSC regulate low-avidity autoreacti

83 The mechanisms by which mutant huntingtin (mHTT) leads to ne

84 We therefore lack a consolidation of the mechanisms by which sociality impacts reproduction.

85 mutations is well established; however, the mechanisms by which the background interacts with Mendel

86 se findings advance our understanding of the mechanisms by which the early synergism between antibody

87 We investigated the mechanisms by which the Western diet promotes tumor recu

88 The mechanisms by which these immune cells converge on targe

89 hogen invasion-but little is known about the mechanisms by which this occurs.

90 elevant cell types/states, target genes, and mechanisms by which variants can cause diseases or alter

91 Many other regulatory mechanisms can influence RNA metabolism and the capacity

92 ereomutation involving a M(B2) permutational mechanism (Channel B).

93 egulation, our study highlights an important mechanism conferring tamoxifen resistance via both ERalp

94 and an aberrant gut microbiota are proposed mechanisms contributing to chronic inflammation and incr

95 powerful opportunity to explore pathways and mechanisms contributing to pathophysiology.

96 We show the cellular and molecular mechanisms contributing to the dysfunctional immune resp

97 r results, which further revealed a built-in mechanism controlling Gc membrane insertion for fusion,

98 n of eukaryotic cells, and in particular the mechanisms controlling the self-organisation and dynamic

99 Through incompletely defined mechanisms, CovR/S and RocA repress the expression of mo

100 ene lpp promoted capsule retention through a mechanism dependent on its C-terminal lysine residue; it

101 advances in our understanding of arrhythmia mechanisms, diagnosis, and new therapies.

102 We also put forward an alternate mechanism, drawing on new insights into the role of the

103 current knowledge of cellular and molecular mechanism driving root development is mainly based on st

104 icates redox dysregulation as a pathological mechanism driving the emergence of psychosis.

105 serve" genetic screens to uncover regulatory mechanisms driving complex mammalian signaling networks.

106 mited experimental models to investigate the mechanisms driving influenza virus-induced inflammation

107 diversity of molecular, cellular and circuit mechanisms, embedded in a dynamic, recurrent circuit arc

108 The uncovered mechanism enables a pathogen to express foreign virulenc

109 Efficacy and Mechanism Evaluation (EME) Programme, an MRC and NIHR pa

110 shrub belowground productivity, one possible mechanism explaining the "shrubification" of northern pe

111 derlying these two asthma phenotypes and the mechanisms explaining the paradox of severe asthmatic ch

112 higher driving simulator crash risk, though mechanisms explaining this relationship remain unknown.

113 ces for survival, a fact that necessitates a mechanism for associating taste experiences with particu

114 study provides novel insight into a possible mechanism for CBD interactions with sodium channels.

115 on to the direct emissions, is an overlooked mechanism for explaining decadal-scale changes in the la

116 We thus establish a simple mechanism for femtosecond spatiotemporal current control

117 The mechanism for growth inhibition does not, however, invol

118 ased on CsMAF1 structural data, we propose a mechanism for how CsMAF1 represses Pol III transcription

119 Our work provides a mechanism for how early clonal dynamics imprint the hier

120 Here, we propose a multi-process causal mechanism for injection-induced earthquakes through a ca

121 tation associated with ASGM is an additional mechanism for mobilizing naturally occurring and anthrop

122 anation alone while also uncovering a common mechanism for phenomena observed in experiments on both

123 serves as a ligand-independent developmental mechanism for post-translational beta-catenin activation

124 Thus, our findings provide a new mechanism for social memory formation, through regulatin

125 provides key insights into the thermodynamic mechanism for the nucleation of intermixing-induced buff

126 amic nuclei and elucidate a novel functional mechanism for the preoptic DA neurons in the initiation

127 siological levels of acetate and a metabolic mechanism for the recovery of carbon that would otherwis

128 These findings establish a cellular mechanism for the representation of temporal information

129 e define the single-carrier and multicarrier mechanisms for axis-dependent conduction polarity and th

130 nistic studies are presented that reveal two mechanisms for C-H borylation, (i) electrophilic aromati

131 elps understand the comprehensive regulatory mechanisms for craniofacial development.

132 nce is defined at most synapses or about the mechanisms for establishing or maintaining this balance

133 ochemical properties and of oxidative damage mechanisms for multiple strains in a species.

134 While many bacterial mechanisms for overcoming nutritional immunity have been

135 However, mechanisms for preferential malignant transformation at

136 or understanding xenon chemistry and physics mechanisms for the possible deep-Earth Xe reservoir.

137 that will serve to elucidate the underlying mechanisms further.

138 regulators modulate these networks, yet the mechanisms governing how tissue specificity of their fun

139 e (TSR) and nontarget-site resistance (NTSR) mechanisms have evolved to most herbicide classes.

140 Two major mechanism hypotheses, both involving ESAA relief, were e

141 tabolic shift from glucose to lipid is a key mechanism in neurodegeneration.

142 erated by an astrocyte-mediated synaptogenic mechanism in response to cocaine experience and embed cr

143 In this paper, the crystallization mechanism in spark plasma sintered Fe(48)Cr(15)Mo(14)Y(2

144 i surface-driven, revealing a novel ordering mechanism in this nickelate that reflects a coupling amo

145 nce for a previously unknown quality control mechanism in which the abundant ribosome assembly factor

146 ances our fundamental understanding of redox mechanisms in disordered rocksalt oxyfluorides, highligh

147 othesized that impaired memory consolidation mechanisms in hippocampal-cortical networks could accoun

148 ond, we show how the heterogeneity of autism mechanisms in humans can be broken down by functional gr

149 ch may point to compensatory neurofunctional mechanisms in persons at familial risk for schizophrenia

150 d to avoid the litany of antiviral detection mechanisms in the cytoplasm remains relatively uncharact

151 However, little is known about homeostatic mechanisms in the intact central brain in vivo.

152 emonic periods interact with activity-silent mechanisms in the prefrontal cortex (PFC).

153 ls may induce neurotoxicity through multiple mechanisms including the oxidative stress, DNA damage, l

154 s with cirrhosis, suggesting that concurrent mechanisms, including those traditionally associated wit

155 However, the mechanisms integrating light and temperature signaling p

156 opose a general acid base-promoted catalytic mechanism, invoking direct nucleophilic attack by the su

157 The biological mechanisms involved in fear transmission within families

158 mmune diseases can reveal pathophysiological mechanisms involved in more common autoimmune diseases.

159 venues to understand alternative translation mechanisms involved in stress tolerance and drug resista

160 ctivations interact, less is known about the mechanisms involved.

161 mediated cell death and inflammation through mechanisms involving activation of the inflammasome in m

162 The patterning mechanism is elucidated by in-depth investigation of the

163 tching between homolytic and heterolytic HER mechanisms is reported.

164 acute gamma-radiation exposure and the major mechanisms it uses to recover from this stress.

165 agy and proteasomal degradation, the precise mechanism leading to neurodegeneration in both sporadic

166 In addition, the mechanism leading to suppression of predicted sensory in

167 However, the underlying intracellular mechanisms leading to product aggregate formation remain

168 day 130 postimmunization did not trigger the mechanisms necessary to generate immunological memory ab

169 lectively, our results describe an oncogenic mechanism of action for ACVR1 mutations, and suggest the

170 uM), suggesting that BCH070 acts via a novel mechanism of action.

171 y allows for detailed understanding of their mechanism of actions but also guides the design and sele

172 This work reveals a paracrine mechanism of antiandrogen resistance in prostate cancer

173 furthers our understanding of the molecular mechanism of CD81 cholesterol sensing, how this relates

174 A well-established mechanism of CIN is the overproduction of centrosomes, w

175 The mechanism of crystallization in this spark plasma sinter

176 Notably, the triggered release mechanism of dendrimer-mediated triptolide delivery sign

177 This filament-based mechanism of enhanced cooperativity demonstrates how the

178 The regulatory mechanism of FgMsb3 has been further investigated by gen

179 The exact mechanism of GrlA activation, however, remained unknown.

180 Here, we show a molecular mechanism of how plants can sense parasitic Cuscuta.

181 racellular tumor microenvironment due to the mechanism of nanoscale macromolecular cooperativity.

182 ne interaction to investigate the underlying mechanism of neuroinflammation, rather than focusing on

183 Multisite phosphorylation is an important mechanism of post-translational control of protein kinas

184 bodies have been proposed as a potential key mechanism of protection against many viral pathogens, an

185 One mechanism of resistance observed in around 10-20% of the

186 ranspeptidase substrates, (b) reveal a novel mechanism of stereochemical editing within peptidoglycan

187 The mechanism of the effect of lipid peroxidation, mediated

188 ward as neuroprotective, the specificity and mechanism of the inhibitor used is controversial.

189 and FgGS provide insights into the catalytic mechanism of this cryptic function.

190 The mechanism of this transformation has been studied in-dep

191 IF4A], eIF4B, and Ded1), indicating a common mechanism of translational repression.

192 However, its mechanism of transport into plants is poorly understood.

193 DNA methylation is a major silencing mechanism of transposable elements (TEs).

194 Antibiotics have many different 'mechanisms of action' that converge to irreversible leth

195 Enterobacterales isolates with characterized mechanisms of beta-lactam resistance, 180 clinical isola

196 elling strategy may reveal new insights into mechanisms of cardiac disease and serve as a test bed fo

197 implications for the molecular and cellular mechanisms of cerebral cavernous malformation pathologie

198 -effect experimental model to understand the mechanisms of direct virus-induced neural-cell damage le

199 This study investigates the molecular mechanisms of environmental factors in FECD pathogenesis

200 nteraction, providing insight into potential mechanisms of exercise-induced phase shifts.

201 Understanding the mechanisms of HPgammaCD-induced cellular pathways could

202 fective, and multi-modal therapies targeting mechanisms of immunotherapy resistance are likely needed

203 ions not only for our understanding of basic mechanisms of iron biology but also for the development

204 cations using Primo to examine the molecular mechanisms of known susceptibility loci and to detect an

205 are well characterized, the cell-biological mechanisms of platelet recruitment to inflammatory micro

206 Unlike mechanisms of RNA stabilization that depend on direct co

207 By revealing the structural mechanisms of SA perception by NPR proteins, our work pa

208 r suspected neuromodulatory activity, define mechanisms of signalling pathways from the gut microbiot

209 Understanding the driving mechanisms of the interannual variability (IAV) of the n

210 sent study, we examined, for the first time, mechanisms of the long-range traffic of DAT in intact br

211 anges in mRNA and protein levels to identify mechanisms of tumor cell survival and proliferation in a

212 V-2 infection susceptibility of brain cells, mechanisms of virus-induced brain dysfunction, and treat

213 remain in our understanding of the molecular mechanisms ProQ uses to interact with RNA.

214 Thus, GLD may be caused by at least two mechanisms: psychosine-induced demyelination and seconda

215 Here we report a mechanism regulated by the oncogenic SOX2-GLI1 transcrip

216 regulates gene expression by a non-canonical mechanism relative to well-characterized sigmaA4-depende

217 ll GTPase MglA, but the underlying molecular mechanisms remain elusive.

218 Though its therapeutic mechanisms remain unclear, it has been suggested that an

219 ences in at least 200 years, yet the trigger mechanism remains elusive(1).

220 ene expression, yet the underlying molecular mechanism remains uncertain.

221 d with the observed phenotype change but the mechanism remains unknown.

222 ein complexes, but little is known about the mechanisms required for assembly membrane proteins.

223 s such as Salmonella Here, we show that this mechanism requires aconitate decarboxylase 1 (IRG1), whi

224 However, the mechanisms responsible for these phenomena remain incomp

225 However, the mechanism(s) driving this sex bias in neutrophil killing

226 To elucidate the mechanism(s) of RBC-MV-induced coagulation activation, t

227 To dissect the activation mechanism, structural homology was used to identify an u

228 and we identify a widespread antitermination mechanism that antagonizes Rho to facilitate complete tr

229 mble inteins but they operate by a different mechanism that does not require protein splicing.

230 Here we identify an adaptive circuit-based mechanism that enables Drosophila to form sleep-dependen

231 siology work has characterized an intriguing mechanism that enhances V1 responses to perceptual figur

232 tophagy, self-eating, is a pivotal catabolic mechanism that ensures homeostasis and survival of the c

233 We reveal a gating mechanism that involves two ion-conducting pathways.

234 genesis and synaptic transmission by a novel mechanism that is independent of neurexins and neuroligi

235 horylated by mTORC1 via a substrate-specific mechanism that is mediated by Rag GTPases.

236 ability to switch to a memory consolidation mechanism that is not contingent on sleep may confer an

237 32 coordinates a cell-intrinsic host defense mechanism that restricts the replication of intravacuola

238 These findings represent a novel cellular mechanism that supports reliable synaptic transmission a

239 ain insight into the genes and physiological mechanisms that contribute to sex differences in fat sto

240 ver the molecular architecture and catalytic mechanisms that distinguish SIRT6 from other NAD(+)-depe

241 Gonadal hormones are linked to mechanisms that govern appetitive behavior and its suppr

242 have been utilized for decades, knowledge of mechanisms that induce gene expression is limited.

243 The functional mechanisms that lead to their clearance of harmful subst

244 r results indicate several immunosuppressive mechanisms that may be simultaneously responsible for th

245 treatment provides insights into the immune mechanisms that mediate this antiviral effect.

246 Exploring the molecular mechanisms that prevent inflammation during caloric rest

247 1) provides one of the long-sought molecular mechanisms that promotes cell size homeostasis.

248 scopy analyses, we sought to investigate the mechanisms that regulate AXL over-expression in pancreat

249 We focus on phenotypes and mechanisms that underlie microvascular aging, the greate

250 ges in several brain areas, but the cellular mechanisms that underlie these defects are not understoo

251 This structure-dependent mechanism therefore enables cells to selectively regulat

252 Besides the syn-addition mechanism through a four-center transition state, radica

253 ty of brain regions; and (ii) understand the mechanism through which verubecestat might cause hippoca

254 g., hepatitis C) and add additional cellular mechanisms (tissue recovery and variable cell susceptibi

255 ly assess the impact of telomere maintenance mechanism (TMM) on clinical outcomes in high-risk neurob

256 , the auditory system relies on a consistent mechanism to elicit correlate firing of neurons that wil

257 osphorylation of Ser(3) may be an additional mechanism to protect RGS2 from FBXO44-mediated proteasom

258 Here, we explored autophagy as a mechanism to reduce tau burden in human neurons and, fro

259 anced HCC by evaluating potential resistance mechanisms to AR-targeted therapy.

260 nt, it's unclear whether HY5 uses additional mechanisms to inhibit hypocotyl elongation.

261 inguishes between them and invokes different mechanisms to resolve each roadblock.

262 irreversible or reversibly covalent binding mechanisms towards cysteine thiols and other amino acids

263 We studied the mechanisms triggering these post-MI arrhythmias in vivo

264 and dysregulation of these adaptive-response mechanisms underlies the development of myeloid leukaemi

265 I(KACh)), called I(KH); this is an important mechanism underlying not only the genesis, but also the

266 1 and CRY2 provide a previously unrecognized mechanism underlying the different photosensitivity and

267 The mechanism underlying these symptoms can be explained by

268 Intriguingly, the mechanism underlying this association remained unknown.

269 part of the complex landscape of regulatory mechanisms underlying cell differentiation.

270 However, the mechanisms underlying changes in soil C storage are not

271 One of the mechanisms underlying EE is mediated through enhanced Me

272 eview current understanding of the molecular mechanisms underlying hyaluronan and HAS2 regulation and

273 se outcomes provide insights into the neural mechanisms underlying memory enhancement, which has valu

274 Here, we explored the mechanisms underlying MHV68 activation of SINE ncRNAs.

275 The mechanisms underlying n-3 PUFAs potential therapeutic pr

276 Finally, we summarize what is known of the mechanisms underlying opioid exposure and sleep.

277 Q331K) knock-in mice may help to unravel the mechanisms underlying sex-specific vulnerability in ALS-

278 Elucidating mechanisms underlying susceptibility of host cells to MN

279 However, the molecular mechanisms underlying the failure of beta-cells to respo

280 The molecular mechanisms underlying the formation of coronary arteries

281 Mechanisms underlying the variable severity of peanut-al

282 nonverbal expressions and the physiological mechanisms underlying them, potentially influencing coop

283 Further studies are needed to understand the mechanisms underlying these brain abnormalities and to e

284 g and drought stress and reveals the genetic mechanisms underlying these processes.

285 contributor to malarial anemia; however, the mechanisms underlying this pathology are not well unders

286 quired from past experiences, but the neural mechanisms underlying this process are poorly understood

287 An improved understanding of the mechanisms underlying UC has led to the emergence of new

288 ing plausible candidate genes and biological mechanisms underlying ventricular excitability.

289 nal modeling revealed that dominant learning mechanisms underpinning flexible behavior differed acros

290 nvasiveness of breast cancer by noncanonical mechanisms unrelated to the previously cytotoxic propert

291 tidine kinase 2 and characterize selectivity mechanisms using molecular dynamics and X-ray crystallog

292 For the established mechanism, we compare and analyze the activity of these

293 cance of the 'off' component of the proposed mechanism, we created a controllable transgenic mouse li

294 Unlike other extrinsic mechanisms, we find that liquid crystals with high ancho

295 s attributed to particular cell size control mechanisms, we identify dependencies that point to poten

296 undamaged DNA, suggesting a 'kinetic gating' mechanism whereby lesion discrimination relied on effici

297 Our studies highlighted another mechanism wherein 5-AzadC induced DNA damage, which then

298 a plausible temperature-dependent molecular mechanism, which contributes to the robustness of TC thr

299 haustive analytical methods which detail the mechanism while confirming the structural integrity of t

300 l multi-omics analysis demonstrates a shared mechanism with lymphoid malignancy in the formation of p