ライフサイエンスコーパス: mechanism of

1 This elucidates the general film formation mechanism of 2D halide perovskites during one-step spin-

2 cent progress in illuminating the regulatory mechanisms of ABA signal transduction, and the physiolog

3 The mechanism of acetylene bromoboration in neat boron tribr

4 s MET inhibitor may delay or prevent a novel mechanism of acquired MEKi resistance, with clinical imp

5 Understanding the mechanism of action (MOA) of bioactive chemicals in term

6 l response components that can identify drug mechanism of action and enable prediction of long-term c

7 Structure-activity relationship, mechanism of action and some research gaps has also been

8 However, their precise mechanism of action and their physiological importance a

9 lectively, our results describe an oncogenic mechanism of action for ACVR1 mutations, and suggest the

10 ody clearance and indirectly hint at an IVIg mechanism of action in treating autoimmune diseases and

11 The mechanism of action may be through compound binding to A

12 Understanding the mechanism of action of methotrexate could be instructive

13 findings reveal a key role and an epigenetic mechanism of action of NONO in regulation of TET1-target

14 Specifically, we found that the simulated mechanism of action of RUTI and INH are in good alignmen

15 here the synthesis and investigation of the mechanism of action of some bis(styryl)pyrazoles, demons

16 However, studies on the regulation and mechanism of action of these lncRNAs are in their infanc

17 AC1), I942, was recently discovered, but its mechanism of action remains poorly understood.

18 third onset-hastening modifier signal whose mechanism of action remains uncertain but does not invol

19 compounds were examined in vitro, and their mechanism of action was preliminarily investigated.

20 novel insight regarding (2R,6R)-HNK's acute mechanism of action, and may inform novel antidepressant

21 importance of reward circuitry in ketamine's mechanism of action, which may be particularly relevant

22 variants that remain poorly defined in their mechanism of action.

23 eded our understanding of sHSP structure and mechanism of action.

24 attractant protein-1, suggesting a paracrine mechanism of action.

25 uM), suggesting that BCH070 acts via a novel mechanism of action.

26 different groups, mainly according to their mechanism of action: VEGF inhibitors or anti-angiogenic

27 has informed our understanding of antibiotic mechanisms of action and resistance at inhibitory concen

28 Despite the key role played by PZA, its mechanisms of action are not yet fully understood.

29 to dissecting and understanding the precise mechanisms of action of cancer-related proteins and thei

30 Antibiotics have many different 'mechanisms of action' that converge to irreversible leth

31 tion and performing in-depth analysis of its mechanisms of action, we showed that this miRNA specific

32 data on two biological agents with different mechanisms of action, which could help guide clinical de

33 ms for three classes of drugs with different mechanisms of action.

34 y allows for detailed understanding of their mechanism of actions but also guides the design and sele

35 nhibitors in COVID-19 and explained possible mechanisms of actions and the therapeutic effects.

36 ther cases, can be beneficial based on their mechanisms of actions.

37 hts into their structures, functional roles, mechanisms of activation, and pharmacological modulators

38 However, the putative FcgammaR-dependent mechanisms of ADE overlap with the role of these recepto

39 impairs efforts to understand the molecular mechanisms of AF and cardiac conduction phenotypes.

40 ize recent findings concerning the molecular mechanisms of age-related heart failure and highlight ex

41 ) levels and F-actin reorganization, but the mechanism of, and connection between, these events is un

42 of phosphorylation is controversial and the mechanism of anti-adaptors preventing RssB-sigma(S) inte

43 a spinal cord injury model through a unique mechanism of anti-inflammation-based fibrotic scar reduc

44 dated the model by showing that the inferred mechanisms of anti-proliferation and/or cell-killing are

45 This work reveals a paracrine mechanism of antiandrogen resistance in prostate cancer

46 The scale and mechanism of antidepressant action of BoNT is unclear an

47 le ketamine biomarker that is related to the mechanisms of antidepressants.

48 search community elucidate the functions and mechanisms of APA events in human tissues.

49 In the presence of Mn, the mechanism of As removal varied with pH.

50 es novel insight into the pathophysiological mechanisms of ASD and SCZ.

51 way of PIC assembly is well established, the mechanism of assembly and the dynamics of PIC components

52 findings provide insight into the catalytic mechanism of ATP-grasp enzymes.

53 en-TG2 complexes, and they outline a general mechanism of autoimmunity with autoantibodies being prod

54 However, the mechanisms of AXL overexpression in cancer remain unclea

55 odification systems are well-studied defense mechanisms of bacteria, while phages have evolved covale

56 However, the underlying mechanism of BAX and BAK pore formation remains incomple

57 Enterobacterales isolates with characterized mechanisms of beta-lactam resistance, 180 clinical isola

58 romic devices to understand and validate the mechanism of bias-induced redox-driven color switching.

59 s in enterohepatic recycling, especially the mechanism of bile acid uptake by ASBT, and the developme

60 oped two new scientific models-one on neural mechanisms of binocular rivalry, the other on the pathop

61 BMI1 is increased in many cancer types, the mechanism of BMI1 upregulation is not yet clear.

62 Previous theory has proposed a molecular mechanism of bound-state mobility based only on transien

63 hat case, it will be crucial to identify the mechanism of breakthrough infections.

64 linical epidemiology, genetic diversity, and mechanisms of carbapenem resistance is lacking.

65 ions, and experiments to study in detail the mechanism of carbon-carbon bond formation in Ni bipyridi

66 election while maintaining common activation mechanisms of CARD-mediated dimerization.

67 elling strategy may reveal new insights into mechanisms of cardiac disease and serve as a test bed fo

68 SECM method to in situ investigate the redox mechanism of cardiomyocytes at a single-cell level.

69 ce patterns, arrhythmic risks, and molecular mechanisms of CASQ2-CPVT was sought through an internati

70 furthers our understanding of the molecular mechanism of CD81 cholesterol sensing, how this relates

71 arding the molecular genetics and pathogenic mechanisms of CDAs, through an analysis of the clinical

72 Our data suggest that the mechanism of cell death induced by CX-5461 is critical f

73 Our studies define the molecular mechanisms of cell-specific alternative splicing of a fu

74 Mechanisms of cellular and circuit-level plasticity cont

75 implications for the molecular and cellular mechanisms of cerebral cavernous malformation pathologie

76 The mechanism of CF(2) transfer from TMSCF(3) (1), mediated

77 A well-established mechanism of CIN is the overproduction of centrosomes, w

78 similarly offer important insights into the mechanisms of cognitive alterations in SCA1, we tested c

79 Unique mechanisms of cognitive decline may exist for subgroups

80 Taken together, these data suggest disparate mechanisms of cognitive vulnerability and resilience in

81 data provide insight into cultivar-specific mechanisms of cold-induced transcriptional regulation of

82 address this, we explored the cell-intrinsic mechanisms of constitutive PD-L1 and PD-L2 expression in

83 To investigate potential mechanisms of convergence between these input streams, w

84 tions of these results for understanding the mechanism of conversion of the boronate-based redox prob

85 ble model organism for elucidating molecular mechanisms of copper transport and homeostasis.

86 ifferences in immunopathogenesis will inform mechanisms of COVID-19, identify points for therapeutic

87 f care in resource-limited settings, but the mechanism of CPT's beneficial effects is unclear.

88 This study investigated mechanisms of Cr(VI) release from cast iron corrosion sc

89 The mechanism of crystallization in this spark plasma sinter

90 significant insights into the functions and mechanisms of CusS-CusR and related TCSs.

91 However, the mechanism of CYP24A1-mediated cancer cell proliferation

92 of POLGARF unveils a previously undescribed mechanism of de novo protein-coding gene evolution.

93 Although there has been important work on mechanisms of decline in some species, it generally rema

94 The mechanism of delayed OP toxicity is thought to involve o

95 r diseases, although they may be mediated by mechanisms of delivery.

96 Notably, the triggered release mechanism of dendrimer-mediated triptolide delivery sign

97 -effect experimental model to understand the mechanisms of direct virus-induced neural-cell damage le

98 protein activation is a druggable epigenetic mechanism of disease pathogenesis in this heritable HF s

99 the gut-CNS axis will shed new light on the mechanisms of disease pathogenesis, and may help to guid

100 atric disorders, making it possible to study mechanisms of disease risk and initiation in otherwise i

101 strates a systematic approach to uncover the mechanisms of diverse cellular membrane remodeling proce

102 r results provide insight into the molecular mechanism of drug export and inhibition of a major multi

103 t novel method with which to assess detailed mechanisms of drug-induced effects on cardiac muscle con

104 Together, these results demonstrate a mechanism of dystrophic Cx43 remodeling and suggest that

105 These results suggest a novel mechanism of early childhood asthma and demonstrates the

106 A better understanding of mechanisms of early viral clearance and the development

107 To better understand the physical mechanisms of earthquake generation, subduction zones wo

108 An increasing number of mechanisms of endocrine resistance have been reported, i

109 We characterized a regulatory mechanism of endodermal differentiation driven by the mi

110 e G-protein-coupling interface, suggesting a mechanism of engaging G-proteins that may have a distinc

111 This filament-based mechanism of enhanced cooperativity demonstrates how the

112 This study investigates the molecular mechanisms of environmental factors in FECD pathogenesis

113 se results provide critical insight into the mechanism of enzalutamide resistance in PCa, potentially

114 The composition and mechanisms of EPS matrix formation, and its role in biof

115 xploit murine organoid models to uncover the mechanism of ERG-mediated tumorigenesis and subsequent o

116 iding valuable information for the molecular mechanisms of ESCC.

117 To decipher the molecular mechanism of estrogens at the estrogen receptor (ER) com

118 nteraction, providing insight into potential mechanisms of exercise-induced phase shifts.

119 isk of cardiovascular disease and mortality, mechanisms of exercise-mediated health benefits remain l

120 rotective measures against fire, and release mechanisms of explosive dispersers.

121 Here, we address the mechanism of F-actin-driven NE rupture by correlated liv

122 The mechanism of feedback inhibition and its role in pathoge

123 The regulatory mechanism of FgMsb3 has been further investigated by gen

124 The structures define the mechanism of filament assembly, and reveal how filament-

125 provide much-needed insight into the mechanism of gammaTuRC-mediated nucleation by determinin

126 negative prognostic indicator in T-ALL, the mechanisms of GC resistance remain poorly understood.

127 To analyze the extent and mechanism of generalism, we measured host growth benefit

128 The exact mechanism of GrlA activation, however, remained unknown.

129 uito vector and provide new insight into the mechanisms of halofenozide-mediated immune activation th

130 ouse model to investigate the expression and mechanisms of HE4 in the pathogenesis of renal fibrosis.

131 Here we study the molecular mechanism of hGBP1 polymer formation as it is a crucial

132 This study uncovers previously unknown mechanisms of Hippo regulation by heat shock, as well as

133 However, the impact and underlying mechanisms of HIV Tat in KSHV-infected endothelial cells

134 ain a better understanding of the regulatory mechanisms of HIV-1 replication, we adapted a recently d

135 We propose a new mechanism of how absolute discrimination by T cells migh

136 Our study proposes a synaptic-level mechanism of how memory consolidation is affected by sen

137 However, the precise mechanism of how NF2 mediates upstream signals to regula

138 Here, we show a molecular mechanism of how plants can sense parasitic Cuscuta.

139 Therefore, deciphering the mechanisms of how autophagy supports tumor cell metaboli

140 Understanding the mechanisms of HPgammaCD-induced cellular pathways could

141 t bone marrow and embryonic fetal liver, the mechanism of HSC self-renewal has remained elusive.

142 results provide insights into the molecular mechanism of HSF2BP-S167L in human ovarian insufficiency

143 ide physiological EV-based insights into the mechanisms of human malaria pathology and support the ex

144 a powerful gateway for exploring underlying mechanisms of hyperacusis and auditory dysfunction in AS

145 Objective: To determine the mechanisms of IL-10 (interleukin-10) deficient-EPC-deriv

146 fective, and multi-modal therapies targeting mechanisms of immunotherapy resistance are likely needed

147 ations in the efflux pump mtrCDE operon as a mechanism of increased antibiotic susceptibility and dem

148 The dual mechanisms of increased mitochondrial respiration and en

149 odels those consider only firing rate as the mechanism of information transfer.

150 The mechanism of initiation of neuroinflammation during SAE,

151 REBOA details, demographics, mechanism of injury, complications, and outcomes were co

152 Such organization indicates a mechanism of interplay between the expression and assemb

153 ions not only for our understanding of basic mechanisms of iron biology but also for the development

154 In our quest to determine the molecular mechanisms of its antiviral activity, we show that PG sp

155 This finding suggests a multi-step mechanism of kinase activation.

156 This reveals multiple cellular mechanisms of kinetic and thermodynamic control that mai

157 cations using Primo to examine the molecular mechanisms of known susceptibility loci and to detect an

158 otein secretion, providing insights into the mechanisms of large cargo secretion that may be relevant

159 researcher, helping to decipher the complex mechanisms of life.

160 thus providing insights into the integration mechanisms of light and temperature signaling pathways i

161 a tractable system for investigating neural mechanisms of limb motor control.

162 X genes, we anticipate this as a generalized mechanism of macrolide resistance used by several bacter

163 onal basis to address the heretofore unknown mechanism of magnetogenetics.

164 his work not only supplies insights into the mechanisms of methane coupling reactions but also illust

165 responses and downstream anorexia as driver mechanisms of microbial dysbiosis after infection with a

166 20" (Milan, February 2020) will focus on the mechanisms of microbiota-related functions in health and

167 h primary and metastatic tumors followed the mechanism of microhomology-mediated end joining mostly,

168 Here, we dissected the mechanism of miRNA dependency of the pestivirus bovine v

169 Studies are needed to determine the mechanisms of mucosal dysregulation in patients with inf

170 exes abound in the literature, the molecular mechanisms of multivalent WW domain-PPXY assemblies are

171 ymerase exonuclease deficiency shed light on mechanisms of mutation accumulation and considerations f

172 racellular tumor microenvironment due to the mechanism of nanoscale macromolecular cooperativity.

173 Based on the discussion, the mechanisms of nDEP localizations and phase-tuning manipu

174 ne interaction to investigate the underlying mechanism of neuroinflammation, rather than focusing on

175 or function, and provide insight into basic mechanisms of neutrophil biology.

176 We propose that the allosteric mechanism of nickel-activated DNA binding by HpNikR is d

177 sed multiple mouse models to investigate the mechanisms of NMJ reinnervation in both sexes, specifica

178 eloped a network model to identify plausible mechanisms of nomadic animal movement by comparing the p

179 in flavodoxin and elucidates the fundamental mechanism of nonequilibrium ET dynamics, which is critic

180 e-based recognition and histone-modification mechanisms of NSD2 and NSD3, which could lead to strateg

181 orption and Raman spectroscopy, to study the mechanism of OER on cobalt oxyhydroxide (CoOOH), an arch

182 We hypothesize that there are many genetic mechanisms of on-drug persistence, which are differentia

183 networks is important for rationalizing the mechanisms of oncogenesis and for individualizing antica

184 r understanding of the fundamental signaling mechanisms of opioid receptors.

185 ductive period of life due to the protective mechanisms of oxidative shielding and revealed only afte

186 ective, we describe the understanding of the mechanisms of oxygen sensing and hypoxia signaling that

187 We also explored the mechanism of Pax8-mediated activation of potential targe

188 We also discuss the mechanism of persistent HRP2 positivity after effective

189 l and design parameters, as well as reported mechanisms of PFAS degradation at the anode surface.

190 teins; thus, the WW-PPIase domain cross-talk mechanisms of Pin1 may be relevant for their mechanisms

191 are well characterized, the cell-biological mechanisms of platelet recruitment to inflammatory micro

192 The cellular mechanisms of polycystin- and cilia-dependent cyst progr

193 Multisite phosphorylation is an important mechanism of post-translational control of protein kinas

194 siella pneumoniae to determine the molecular mechanisms of PR and the role of polymyxin exposure vers

195 The mechanisms of pressure adaptation are also important in

196 bodies have been proposed as a potential key mechanism of protection against many viral pathogens, an

197 mistic simulations, we explore the molecular mechanism of protein diffusion along MTs.

198 Allostery is a fundamental regulatory mechanism of protein function.

199 The mechanism of PS exposure remains uncertain but it can fo

200 n focus of these studies has been epigenetic mechanisms of psychomotor sensitization and drug reinfor

201 We sought to identify the mechanism of Pumilio-mediated repression and find that i

202 However, the mechanism of R-loop formation remains unknown.

203 r eventual focus is on predictors with known mechanisms of reactions involved in drug resistance (dru

204 an experimental injury model used to examine mechanisms of regeneration and repair in organs.

205 ciated inhibition of the activity is a novel mechanism of regulation in metalloproteins.

206 future work aiming at deciphering molecular mechanism of regulation of secondary metabolism and gene

207 Mechanisms of regulation at each step, from initiation t

208 more extensively, very little is known about mechanisms of regulation or signaling of the longer isof

209 vide the experimental flexibility to analyze mechanisms of remyelination, here we discuss the challen

210 ovides an unprecedented opportunity to study mechanisms of repeat expansion, and a framework for eval

211 ly repressive chromatin modification but the mechanism of repression remains unclear.

212 issue acquisition, to identify the molecular mechanism of resistance and to guide second-line therapy

213 One mechanism of resistance observed in around 10-20% of the

214 This study identifies a novel mechanism of resistance to anti-PD-1/PD-L1 immunotherapy

215 g PgABCA2 are the primary, but not the only, mechanism of resistance to Cry2Ab in pink bollworm.

216 mentarium of treatment options, to elucidate mechanisms of resistance, and to continue the pursuit of

217 However, regardless of the mechanisms of resistance, complete and durable therapeut

218 We identify distinct mechanisms of resistance, in which HUWE1 loss increases

219 ponse to high blood alcohol levels support a mechanism of reversible osmolarity disturbances due to t

220 rate for the first time a microglia-specific mechanism of RICD involving an upstream complement casca

221 Moreover, we elucidated the neuronal mechanism of RLN3/RXFP3 signaling in PVN in male and fem

222 i-viral and anti-plasmid immunity via a dual mechanism of RNA and DNA destruction.

223 Unlike mechanisms of RNA stabilization that depend on direct co

224 The mechanism of RPE65 protein regulation remains to be eluc

225 By revealing the structural mechanisms of SA perception by NPR proteins, our work pa

226 cal environment have uncovered fluid dynamic mechanisms of seed flight, protective measures against f

227 Yet, the mechanisms of self-assembly remain largely obscure due t

228 foundations for further revealing the neural mechanism of sensory selection and distractor suppressio

229 Additional mechanisms of SGLT2 inhibitors that might be beneficial

230 r suspected neuromodulatory activity, define mechanisms of signalling pathways from the gut microbiot

231 The mechanism of sodium retention and its location in kidney

232 change in chromosome number, is an important mechanism of speciation.

233 ranspeptidase substrates, (b) reveal a novel mechanism of stereochemical editing within peptidoglycan

234 ates opportunities to uncover the underlying mechanisms of stress-related diseases with an immune com

235 h computational simulation to understand the mechanism of structural formation for different types of

236 Putative mechanisms of suboptimal efficacy of DARA include downre

237 ts may have a function in directing distinct mechanisms of T cell tolerance.

238 One such prominent gap is the mechanism of Tau condensation and fibrillization.

239 This distinctive feature stems from the mechanism of TCR activation, which is thought to involve

240 is uncharacterized, let alone the molecular mechanism of the calcium transport activity.

241 scale but also reveals the potentiality and mechanism of the comprehensive ANLI to characterize the

242 But the mechanism of the Ealpha and its downstream CTCF binding

243 The mechanism of the effect of lipid peroxidation, mediated

244 etic studies in yeast to establish the basic mechanism of the eukaryotic cell division cycle.

245 However, the underlying mechanism of the inability of phosphorylated AKT to phos

246 ward as neuroprotective, the specificity and mechanism of the inhibitor used is controversial.

247 We find that the mechanism of the initial bimolecular association to form

248 iscrepancy, we dissected the physicochemical mechanism of the interaction of 10 human IgG1 to human F

249 Although some aspects of the catalytic mechanism of the Msr enzymes have been reported, several

250 The formation mechanism of the oxides is also investigated.

251 ts at C4, giving important insights into the mechanism of the photolysis reaction.

252 es of computational models of the biological mechanism of the RNA interference (RNAi) pathway.

253 and mutagenesis studies reveal the molecular mechanisms of the catalyzed reaction and of finasteride

254 o block or slow down AD progression, and the mechanisms of the disease are not fully understood.

255 Understanding the driving mechanisms of the interannual variability (IAV) of the n

256 sent study, we examined, for the first time, mechanisms of the long-range traffic of DAT in intact br

257 gh levels of H-RasV12 overriding anti-cancer mechanisms of the naked mole rat.

258 Therefore, understanding the p53-independent mechanisms of the netrin-UNC5B axis, such as those invol

259 allowing detailed questions about functional mechanisms of the structures, and the biology enabled by

260 synergize to promote actin assembly, but the mechanism of their synergy is controversial.

261 Our work provides insight into the assembly mechanism of these bacterial organelles and will aid dow

262 Here, we probed the structure and mechanism of these two enzymes using crystallographic, s

263 Here, we elaborate on the molecular mechanisms of these 2 emerging key pathways driving the

264 Understanding the mechanisms of these processes may enable synthetic impro

265 However, the mechanisms of these tissue-specific actions remain uncle

266 and FgGS provide insights into the catalytic mechanism of this cryptic function.

267 Here, we investigate a potential causal mechanism of this effect driven by the neuropeptide gala

268 provide information regarding the catalytic mechanism of this important enzyme.

269 of intermediates, elucidating the catalytic mechanism of this multi-redox reaction on metal-oxide ph

270 The mechanism of this transformation has been studied in-dep

271 e provide the first evidence for the binding mechanism of this unique fold.

272 otein adsorption on biomaterials and related mechanisms of thrombus formation (thrombosis).

273 veal the synergistic interfacial interaction mechanisms of Ti-O-C covalent bonding, sliding of MXene

274 cture provides a framework for understanding mechanisms of trans-histone cross-talk and the dynamic r

275 However, the molecular mechanism of transcription processing of Gh and Sp remai

276 and transcription factors, have detailed the mechanisms of transcription initiation in phylogenetical

277 The underlying mechanism of transcriptional co-repressor ETO2 during ea

278 facilitate analyses of one of the two major mechanisms of transcriptome diversity, namely, different

279 nable protein abundance estimation and infer mechanisms of translation.

280 Escherichia coli and Salmonella identified a mechanism of translational repression of manY mRNA by th

281 IF4A], eIF4B, and Ded1), indicating a common mechanism of translational repression.

282 Our findings shed light on the potential mechanism of translocating folded proteins across a memb

283 The only currently known mechanism of transmission of BRRV is through vegetative

284 However, its mechanism of transport into plants is poorly understood.

285 DNA methylation is a major silencing mechanism of transposable elements (TEs).

286 The aims of the present study were to define mechanisms of Treg subpopulation imbalance and identify

287 airway inflammation METHODS: To dissect the mechanisms of TSLP-mediated type 2 responses, mice were

288 MTEX emerge as the major mechanism of tumor-induced immune suppression and as an

289 anges in mRNA and protein levels to identify mechanisms of tumor cell survival and proliferation in a

290 decipher the underlying mechanism of two antibodies that cooperatively target Eb

291 The mechanisms of ubiquitin chain formation remain unclear a

292 This study identifies mechanisms of V-ATPase assembly and biogenesis that rely

293 s highly relevant to understanding metabolic mechanisms of various biological processes.

294 se simulations elucidate the molecular-scale mechanisms of viral capsid cellular compartmentalization

295 was developed in our previous study, but the mechanisms of virulence attenuation are not fully unders

296 fusogenicity of MuV and its influence on the mechanisms of virus spread within infected tissues.

297 V-2 infection susceptibility of brain cells, mechanisms of virus-induced brain dysfunction, and treat

298 y have implications for understanding of the mechanisms of virus-mediated pain linked to latency and

299 protein transcytosis to the healthy brain, a mechanism of widespread BBB dysfunction with age and a s

300 ur findings provide insight into the disease mechanism of Wolfram syndrome and highlight new targets