ライフサイエンスコーパス: mechanism of action

1 uM), suggesting that BCH070 acts via a novel mechanism of action.

2 variants that remain poorly defined in their mechanism of action.

3 mpted us to investigate their pain-relieving mechanism of action.

4 can provide valuable insights into the drug mechanism of action.

5 ssing substrates, revealing a conserved core mechanism of action.

6 dies as tools to further characterize ERFE's mechanism of action.

7 d proteins is perceived to be ARTs' dominant mechanism of action.

8 nephrine-mediated organ dysfunction, a novel mechanism of action.

9 g-bound states, we elucidated its inhibition mechanism of action.

10 ptive antitumor immune response, as the main mechanism of action.

11 ryptase IgG antibody with a bivalency-driven mechanism of action.

12 eded our understanding of sHSP structure and mechanism of action.

13 regeneration-suggesting a paracrine-mediated mechanism of action.

14 estrator of XCI in vivo and we elucidate its mechanism of action.

15 haemolysin BL (HBL) despite having a similar mechanism of action.

16 attractant protein-1, suggesting a paracrine mechanism of action.

17 ing Parkin-mediated mitophagy as part of its mechanism of action.

18 stimulation (tDCS) suggests a generalizable mechanism of action.

19 ge in control over the SMA, the hypothesized mechanism of action.

20 crosslinking of separate CD73 dimers in its mechanism of action.

21 at modulate DNA repair pathways via a unique mechanism of action.

22 down of XPB confirmed XPB degradation as the mechanism of action.

23 is important to elucidate their function and mechanism of action.

24 is enabled to bind to the active site in its mechanism of action.

25 o eliminate several proposed models of HY5's mechanism of action.

26 d provided insights for their photocatalytic mechanism of action.

27 nd predicting a drug's activity, toxicity or mechanism of action.

28 targets and pathways involved in the drugs' mechanism of action.

29 delayed chain termination is RDV's plausible mechanism of action.

30 of newer chemotherapeutic agents with novel mechanisms of action.

31 ponse-to-toxicity profiles owing to distinct mechanisms of action.

32 he lack of chemical probes with well-defined mechanisms of action.

33 otransposable elements reflects multiple RBP mechanisms of action.

34 e is an urgent need for new drugs with novel mechanisms of action.

35 onstantly searching for antibiotics with new mechanisms of action.

36 at represent new classes, new targets or new mechanisms of action.

37 ization to antimicrobials, and have specific mechanisms of action.

38 context dependent with undefined epigenetic mechanisms of action.

39 nts treated with drugs having very different mechanisms of action.

40 t-like effects through related but divergent mechanisms of action.

41 search for B-cell regulatory phenotypes and mechanisms of action.

42 ed about their cellular roles and even their mechanisms of action.

43 antibiotic resistance in GNB by two distinct mechanisms of action.

44 erally difficult to understand its dynamical mechanisms of action.

45 in type 2 inflammation and report dupilumab mechanisms of action.

46 is important for determining their molecular mechanisms of action.

47 rphosis and test hypotheses addressing their mechanisms of action.

48 ppression, and cell cycle reentry as agrin's mechanisms of action.

49 bit the replication of HSV-1 by two distinct mechanisms of action.

50 ms for three classes of drugs with different mechanisms of action.

51 ther cases, can be beneficial based on their mechanisms of actions.

52 class of the laser adjuvant shows a distinct mechanism of action, a proper choice is necessary to cra

53 The mechanism of action against Enterobacter aerogenes of on

54 A variety of NPFFR ligands with different mechanisms of action (agonists or antagonists) have been

55 These distinct mechanisms of action allow better adaption of treatments

56 To identify the mechanism of action, analysis of EV cargo implicated miR

57 he way to a molecular understanding of their mechanism of action and assembly mechanisms.

58 ute intervention for TBI with a well-defined mechanism of action and beneficial anatomic and physiolo

59 l response components that can identify drug mechanism of action and enable prediction of long-term c

60 d teichoic acid is responsible for the added mechanism of action and enhanced antimicrobial activity.

61 Due to their broad-spectrum mechanism of action and enormous potential sequence dive

62 s faster water oxidation, to investigate the mechanism of action and factors controlling catalytic ac

63 powerful in providing insights into compound mechanism of action and gene function.

64 osphorylation activity of each in a distinct mechanism of action and in a different potency.

65 The Smc5/6 mechanism of action and its activity on DNA are largely

66 pharmacokinetics to include understanding of mechanism of action and pharmacodynamics.

67 s share the same functional organization and mechanism of action and provide insight into the assembl

68 Structure-activity relationship, mechanism of action and some research gaps has also been

69 However, our understanding of its mechanism of action and the potential of drug discovery

70 However, their precise mechanism of action and their physiological importance a

71 owing to potential adverse effects, unclear mechanisms of action and a lack of knowledge of the spec

72 by enabling in vivo studies of emicizumab's mechanisms of action and comparison with traditional FVI

73 to an increasing number of drugs with novel mechanisms of action and distinctive side-effect profile

74 However, its mechanisms of action and physiological effects on brain

75 has informed our understanding of antibiotic mechanisms of action and resistance at inhibitory concen

76 Despite widespread use of taxanes, mechanisms of action and resistance in vivo remain to be

77 rall, a better understanding of the relevant mechanisms of action and resistance will help prioritize

78 rief overview of key chemical modifications, mechanisms of action and routes of administration that h

79 val and death, encouraging research into its mechanisms of action and therapeutic potential.

80 should accompany future CQI use to elucidate mechanisms of action and to identify factors supporting

81 nhibitors in COVID-19 and explained possible mechanisms of actions and the therapeutic effects.

82 d ghrelin on breast cancer cells, define its mechanism of action, and explore the therapeutic potenti

83 tential of SERCA inhibition, discusses their mechanism of action, and highlights their potential clin

84 e accurately captures variations in compound mechanism of action, and is therefore better able to dis

85 novel insight regarding (2R,6R)-HNK's acute mechanism of action, and may inform novel antidepressant

86 osynthesis, structure-activity relationship, mechanism of action, and potential as antibiotics.

87 owever, little is known about the structure, mechanism of action, and substrate specificity of these

88 no-2,2'-stilbenedisulfonic acid [DIDS]), its mechanism of action, and the chemical properties require

89 activity, structure-activity relationships, mechanism of action, and the potential for developing ca

90 nt benefits: elucidating current therapeutic mechanism-of-action, and, back-translating to fast-track

91 microbes associated with disease risk, their mechanisms of action, and the interactions with host gen

92 uptake, subcellular distribution, molecular mechanisms of action, and toxicity of PS-ASOs.

93 nt a useful source of antifungals with novel mechanisms-of-action, and potentially provide new method

94 egulate these life history traits, yet their mechanism of action, antagonism and targets remain poorl

95 w classes of antiretroviral drugs with novel mechanisms of action are needed.

96 with several chronic diseases, although the mechanisms of action are not well understood and few hum

97 Despite the key role played by PZA, its mechanisms of action are not yet fully understood.

98 he biological processes involved in a drug's mechanisms of action are oftentimes dynamic, complex and

99 ive and anti-inflammatory actions, but their mechanisms of action are poorly understood.

100 nitors present in both regions; however, its mechanisms of action are still not fully understood.

101 ve been described, but their specificity and mechanisms of action are unclear.

102 Investigational agents with novel mechanisms of action are under active study.

103 However, little is understood about their mechanisms of action, as well as the means by which canc

104 The latter mechanism of action-as elucidated through crystallograph

105 The mechanisms of action associating diet with health outcom

106 We debate its mechanism of action at the molecular level and the possi

107 ng multi-parameter data to profile different mechanisms of action based on cluster analysis of a set

108 novel insights into the complex multifaceted mechanisms of action behind secretome-mediated interdoma

109 -resistant organisms through two synergistic mechanisms of action, both independent of d-Ala-d-Ala/d-

110 y allows for detailed understanding of their mechanism of actions but also guides the design and sele

111 what is currently known regarding underlying mechanisms of action by which diet may influence mental

112 he same pathogen with conserved function and mechanism of action can be exploited for sensing by a si

113 nical studies describing their discovery and mechanism of action, coupled with emerging clinical data

114 y, alternative chemical scaffolds, change of mechanism of action (covalents, PROTACs), increases in b

115 a) currently available activity, safety, and mechanism-of-action data from clinical trials of FcRn in

116 ve and 9 negative inotropes covering diverse mechanisms of action exerted concentration-dependent inc

117 lectively, our results describe an oncogenic mechanism of action for ACVR1 mutations, and suggest the

118 y GSDMD as a target of fumarate and reveal a mechanism of action for fumarate-based therapeutics that

119 set of putative biomarkers for propranolol's mechanism of action for IHs, namely EPAS1, LASP1, SLC25A

120 mediated cytotoxicity (ADCC) is an important mechanism of action for many therapeutic antibodies.

121 Here, we identify a key mechanism of action for the efficacy of CMP-NulOs.

122 In sum, our findings point to a novel mechanism of action for this successful immunotherapy th

123 nctional inhibitor and degrader, a different mechanism-of-action for PROTACs.

124 However, the functional importance and mechanisms of action for human lncRNAs are largely unkno

125 ative transcriptomic analysis revealed their mechanisms of action for inducing PEL cell death and ide

126 f specific activity and has helped elucidate mechanisms of action for ROS.

127 This Review examines the mechanisms of action for these anabolic agents by detail

128 CDK4/6 inhibition in TNBC and suggest novel mechanisms of action for these drugs and new vulnerabili

129 pandemic initiated intense research into the mechanisms of action for this virus.

130 , we know a great deal about these proximate mechanisms of action for virtually all antibiotics in cu

131 n the last decade, the focus regarding their mechanisms of action has been primarily on the RNA produ

132 never been experimentally validated, and no mechanisms of action have been proposed.

133 rocol poses challenges because of its unique mechanism of action (i.e., requiring an iron-depleted st

134 regarding the use of therapeutic ketosis and mechanism of action in HF, current evidence suggests pot

135 ody clearance and indirectly hint at an IVIg mechanism of action in treating autoimmune diseases and

136 min on systemic metabolism and its molecular mechanisms of action in various tissues.

137 ritical quality attribute for products whose mechanism of action includes ADCC.

138 ears to discover new targets and synergistic mechanisms of action including multicellular targets.

139 To clarify FUS bioeffects, we summarize four mechanisms of action, including thermal ablation, hypert

140 The data suggest a mechanism of action independent of the etiology of VC, w

141 New insights into this added mechanism of action, induced cell membrane permeabilizat

142 ss of DNA-PK inhibitors that act via a novel mechanism of action, inhibition of the Ku-DNA interactio

143 preclinical models are key to understanding mechanisms of action, interactions with other therapies

144 To fully identify and elucidate complex mechanisms of action, intervention studies that assess m

145 pecially useful to medications for which the mechanisms of action involve alterations in subjective r

146 Hence, the likely mechanism of action is delayed RNA chain termination.

147 unpredictable, and objective evidence of the mechanism of action is needed.

148 icity of chemical mixture and their possible mechanism of action is still a challenge for humans and

149 e 2 diabetes for over 60 years, however, its mechanism of action is still not completely understood.

150 The mechanism of action is through the interaction of TRAF3I

151 nd those with neurological disorders but its mechanism of action is unclear.

152 cosides are broad-spectrum antibiotics whose mechanism of action is under debate.

153 generation RAF kinase inhibitors with unique mechanisms of action is presented.

154 The mechanism of action may be through compound binding to A

155 Understanding the mechanism of action (MOA) of bioactive chemicals in term

156 Identification of the molecular mechanism of action (MoA) of bioactive compounds is a cr

157 e used for compound target identification or mechanism of action (MoA) prediction and other applicati

158 e have called subtype correlation (subC) and mechanism-of-action (MOA) modeling, each of which levera

159 ecause of a poor understanding of the drug's mechanisms of action (MoA).

160 tion, which is distinctly different from the mechanisms of action observed in other MORC family membe

161 ation of this TAM as well as the pleiotropic mechanism of action of anti-MARCO antibody treatment on

162 this largely MHC-class-I-negative tumor, the mechanism of action of anti-PD-1 therapy remains undefin

163 We investigated the mechanism of action of antifungal drugs in the human pat

164 To define the mechanism of action of beta-Pix in vivo, we optimize sin

165 The precise mechanism of action of beta2-adrenergic agonists at the

166 lel chemoproteomic platforms to discover the mechanism of action of clemastine and identify that clem

167 which have broad implications regarding the mechanism of action of CMCs in cardiac repair.

168 The mechanism of action of compounds 1-5 was investigated by

169 Understanding the mechanism of action of compounds capable of inhibiting a

170 These results shed light on the mechanism of action of current MenA vaccines and provide

171 The precise mechanism of action of Cyt toxins is still debated, and

172 btain classification models which assign the mechanism of action of drugs.

173 bjective of this study was to understand the mechanism of action of ezutromid which could explain the

174 se, potential for broader utility, and novel mechanism of action of FcRn inhibitors, here we review d

175 contribute to a better understanding of the mechanism of action of fingolimod in multiple sclerosis

176 titative binding measurements to address the mechanism of action of four clinical stage anti-Abeta an

177 ath nucleases and are not fundamental to the mechanism of action of genotoxic agents.

178 " and we propose they are fundamental to the mechanism of action of genotoxic chemotherapies.

179 These findings provide insight into the mechanism of action of glucocorticoids in eosinophilic d

180 The mechanism of action of GSK3-mediated SOX10 suppression i

181 nt study, we provide evidence for a possible mechanism of action of hd-anti-IFN-gamma.

182 The mechanism of action of I942 may facilitate drug design f

183 Because of the peculiar mechanism of action of immune checkpoint inhibitors (ICI

184 against a foreign body reaction as a common mechanism of action of IUDs.

185 The triple mechanism of action of JS230 cumulated into growth inhib

186 The mechanism of action of ketamine is currently unclear but

187 kinase 1/2 (ERK1/2) pathways, but the exact mechanism of action of LXA4 remains unexplored.

188 Our results offer novel insights into the mechanism of action of MAb 53C10 and indicate its potent

189 e evaluated the antihypertensive effects and mechanism of action of Mb on N(G)-Nitro-L-arginine Methy

190 Understanding the mechanism of action of methotrexate could be instructive

191 derived from ZCM-I-1 demonstrated its novel mechanism of action of modulating complex I via interact

192 Here we assess the therapeutic impact and mechanism of action of NKTR-214 in combination with anti

193 findings reveal a key role and an epigenetic mechanism of action of NONO in regulation of TET1-target

194 ation, thereby informing on the function and mechanism of action of perturbagens.

195 Overall, our study reveals the mechanism of action of PRE, which has been widely used t

196 ut the synthesis, biological evaluation, and mechanism of action of PROTACs, the characterization of

197 ntexts has triggered renewed interest in the mechanism of action of psychedelics.

198 uggests that RpsA may not be involved in the mechanism of action of PZA in Mycobacterium tuberculosis

199 The mechanism of action of Ras mutants in Costello syndrome

200 er with the identification of the target and mechanism of action of Rg3, provided an effective strate

201 gap, we aimed to determine the efficacy and mechanism of action of RIC in experimental NEC.

202 The mechanism of action of RIC involves increasing intestina

203 igate how chirality affects the activity and mechanism of action of RJW100, a racemic agonist of the

204 Specifically, we found that the simulated mechanism of action of RUTI and INH are in good alignmen

205 here the synthesis and investigation of the mechanism of action of some bis(styryl)pyrazoles, demons

206 The article also covers the mechanism of action of the different types of beta-lacta

207 which is implicated in both the therapeutic mechanism of action of the drug as well as drug toxicity

208 Discovery of the mechanism of action of the first vaccine catalyzed the d

209 bition as this is a major contributor to the mechanism of action of the most widely used tenovins; an

210 The mechanism of action of the NP mimics that of endogenous

211 However, studies on the regulation and mechanism of action of these lncRNAs are in their infanc

212 nhibitors without interfering with the known mechanism of action of these LRAs.

213 The mechanism of action of these peptides was studied in viv

214 ue of Blood, Enns et al demonstrate that the mechanism of action of TMPRSS6, a key regulator of iron

215 The novel mechanism of action of XPO1 inhibitors implies a differe

216 ment assays are crucial for establishing the mechanism-of-action of small molecules in living systems

217 gets predicted by AOPEDF are associated with mechanism-of-action of substance abuse disorder for seve

218 al addiction phenomenon as well as molecular mechanisms of action of 3D genome-disrupting drugs.

219 The oncogenic mechanisms of action of ACVR1 mutations are currently un

220 Further studies of the mechanisms of action of adjuvants may advise shorter tre

221 mouse models, have characterized in part the mechanisms of action of adjuvants on pre-existing immune

222 In parallel, the mechanisms of action of AIT were elucidated, and new ind

223 ion but also provide novel insights into the mechanisms of action of allosteric ligands, which are of

224 These data provide insights into mechanisms of action of alum and introduce a readily tra

225 consider what our knowledge of the proximate mechanisms of action of antibiotics and the pharmacodyna

226 to dissecting and understanding the precise mechanisms of action of cancer-related proteins and thei

227 Recent findings reveal multipronged mechanisms of action of CD39 antagonism that rely not on

228 hese molecular oscillators, the function and mechanisms of action of central and peripheral clocks, t

229 Reflecting upon the efficacy and mechanisms of action of csDMARDs can provide intriguing

230 These analyses test the impact and mechanisms of action of Fast Track (FT), a comprehensive

231 erall, our study evaluates the functions and mechanisms of action of HDAC10 in lung carcinogenesis th

232 The mechanisms of action of LRMP and IRAG are independent of

233 These recent insights into the mechanisms of action of MAC provide an updated framework

234 Understanding the diverse mechanisms of action of PAX8 in development and oncogene

235 scular impact, adverse effects, and possible mechanisms of action of pharmacologic agents used to tre

236 smooth muscle cells, inviting to revisit the mechanisms of action of selective modulation of ERalpha.

237 e frontline therapy for type 2 diabetes, the mechanisms of action of the biguanide drug metformin are

238 The mechanisms of action of the extracts involved in the inh

239 ls, further efforts to uncover the molecular mechanisms of action of the laser adjuvants is warranted

240 sis, irrespective of the characteristics and mechanisms of action of the therapeutic agents, which ar

241 erein, we demonstrate that the difference in mechanisms of actions of chemotherapeutic agents elicit

242 survival, limiting what can be learned about mechanisms of action, off-target effects, and heterogene

243 Here, we elucidate a mechanism of action on intestinal epithelial cells for e

244 result in a similar phenotype share the same mechanism of action or common downstream signalling path

245 he appearance of new compounds with multiple mechanisms of action, or the promulgation of new standar

246 are consistent with the iterative annealing mechanism of action proposed for the chaperonin GroEL.

247 Analogous to the mechanism of action proposed in parasites, ATO inhibits

248 roles in energy sensing, but the underlying mechanisms of action remain less clear.

249 bit amyloid fibril formation; however, their mechanisms of action remain poorly understood.

250 ortant for many cellular processes but their mechanisms of action remain poorly understood.

251 anization from bacteria to humans, but their mechanisms of action remain poorly understood.

252 However, their structures and mechanisms of action remain unclear, hampering drug deve

253 AC1), I942, was recently discovered, but its mechanism of action remains poorly understood.

254 pressive disorder (MDD); however, its neural mechanism of action remains poorly understood.

255 third onset-hastening modifier signal whose mechanism of action remains uncertain but does not invol

256 However, their mechanism of action remains unclear.

257 ol is an approved treatment for IHs, but its mechanism of action remains unclear.

258 cer cells with APC mutations, although their mechanism of action remains unknown.

259 uit, are well characterized, but the precise mechanisms of action require further attention.

260 This mechanism of action resembles that of endogenous channel

261 This review provides information on the mechanisms of action, resistance emergence, and drug sus

262 or in vitro interrogation of bioactivity and mechanisms of action; rigorous assessment and interpreta

263 Consistent with a pleiotropic mechanism of action, RMC-4550 in combination with either

264 Mechanism of action studies showed the ability of the ne

265 ic biology together with drug evaluation and mechanism of action studies.

266 Mechanism-of-action studies revealed that mast-MO target

267 ishing the utility of this approach for drug mechanism-of-action studies.

268 Other mechanisms of action such as reactivation of mutant p53,

269 ime with super-resolution to elucidate their mechanism of action, such as their behavior and distribu

270 of GBM cells to three agents with different mechanisms of action suggesting that such sophisticated

271 l activity by acting as a target degrader, a mechanism of action that has recently emerged as a succe

272 stemically in humans, lefamulin has a unique mechanism of action that inhibits protein synthesis by p

273 These findings suggest one potential mechanism of action that likely involves a tightly coord

274 drug targets while revealing an approach and mechanism of action that should be broadly applicable to

275 These findings suggest a cooperative mechanism of action that targets redox homeostasis.

276 ules, in particular antibiotics with diverse mechanism of actions that could help confront the immine

277 quires the discovery of compounds with novel mechanisms of action that are capable of treating drug-r

278 ling-level responses after PI may reveal new mechanisms of action that can be therapeutically exploit

279 Antibiotics have many different 'mechanisms of action' that converge to irreversible leth

280 What we do not know is the ultimate mechanism of action; that is, how these drugs irreversib

281 s with anticancer drugs that differ in their mechanism of action (the tyrosine kinase inhibitor pazop

282 loss even in the absence of PKMzeta, and its mechanism of action, therefore, remains elusive.

283 Given their different mechanisms of action, they might retain protective activ

284 A recent study attributed rigosertib's mechanism of action to microtubule binding.

285 stress, show that antibiotics with the same mechanism of action trigger similar transcriptomic respo

286 s interactions of tatM2NX with TRPM2 and the mechanism of action using structure-activity analysis.

287 different groups, mainly according to their mechanism of action: VEGF inhibitors or anti-angiogenic

288 murine nociceptors, and suggest an indirect mechanism of action, via immune cells.

289 The mechanism of action was established as Rg3 targeting of

290 studies, this observation confirmed an added mechanism of action was introduced by incorporation of t

291 compounds were examined in vitro, and their mechanism of action was preliminarily investigated.

292 e antitumor activity is due to the predicted mechanism of action, we undertook a study of OLIG2 dimer

293 tion and performing in-depth analysis of its mechanisms of action, we showed that this miRNA specific

294 rt to develop FR-targeted SMDCs with varying mechanisms of action, we synthesized EC2629, a folate co

295 importance of reward circuitry in ketamine's mechanism of action, which may be particularly relevant

296 data on two biological agents with different mechanisms of action, which could help guide clinical de

297 w and improved anti-TB compound with a novel mechanism of action will relieve the burden of resistanc

298 A better understanding of their molecular mechanisms of action will help uncover novel therapeutic

299 viral resistance to carvacrol supported this mechanism of action with the identification of mutations

300 tial protein components, and to define their mechanism of action, with a specific focus on the mechan