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1 egulation of Cyp27b1 expression represents a mechanism whereby 1,25(OH)2D3 can fulfill separate funct
3 r findings reveal an extracellular signaling mechanism whereby a cell-surface receptor for a chemorep
4 se findings unveil a previously unrecognized mechanism whereby a core circadian clock output signal c
6 dentify the JNK/S6K1 axis as a key molecular mechanism whereby a high fat/sucrose diet impairs insuli
9 cued by the MEK inhibitor SL327, revealing a mechanism whereby a neurofibromin/Ras/MEK pathway regula
14 distinctive feature in their transcriptional mechanism whereby a specific Spliced Leader (SL) sequenc
16 motor output, or through a population coding mechanism, whereby a group of neurons, each with local e
17 e proteins share a bipartite transactivation mechanism, whereby a transactivation domain in the middl
18 acteria can be mediated by target protection mechanisms, whereby a protein binds to the drug target a
19 P*(Mg(2+))2 structure highlights a two-metal mechanism, whereby: a ligase-bound "catalytic" Mg(2+)(H2
24 ed what we believe is a new, ROS-independent mechanism whereby activated tissue-infiltrating PMNs rel
25 uron chemosensitivity was not explained by a mechanism whereby activation of 5-HT(7) receptors enable
26 Our results provide a cellular and molecular mechanism whereby activation of OXTRs exerts anxiolytic
27 e, we demonstrate the following: (1) a novel mechanism whereby activity-independent GABA release can
30 , these data establish a potential molecular mechanism whereby adversity during puberty can enact las
33 ukemia, and their MSC niche, and a molecular mechanism whereby AML impairs normal hematopoiesis by re
35 ed, it is essential that there are inherited mechanisms whereby an individual can navigate-first, to
36 e jaw skeleton and then to evaluate possible mechanisms whereby an osteoporotic phenotype might affec
37 vely in astrocytes to evaluate the molecular mechanisms, whereby an astrocyte genetic vulnerability c
38 idence for a self-electrophoretic propulsion mechanism, whereby anodic oxidation and cathodic reducti
39 , Rivera-Chavez et al. (2016) identify a new mechanism whereby antibiotic-mediated depletion of anaer
40 the AR-regulated morphogenetic genes and the mechanisms whereby AR controls prostate development are
41 Therefore, our study has revealed a cellular mechanism whereby arginine-rich C9orf72 dipeptide repeat
43 suggests a new, unifying 'Brownian ratchet' mechanism, whereby ATP binding and hydrolysis bias the d
46 [Ca(2+)](cyto) coupling affords an important mechanism whereby [Ca(2+)](mito) decodes brain activity
48 RAS4b-CaM interaction and suggest a possible mechanism whereby CaM can regulate KRAS4b membrane local
50 oss and Slug upregulation, providing a novel mechanism whereby cancer stem cells acquire metastatic p
51 Hence, this may represent one of the primary mechanisms whereby cannabinoids induce disruptions in at
53 well as clinical specimens, we identified a mechanism whereby CD8+ T cell activation in response to
54 revious studies have established recruitment mechanisms whereby Cdc45-Mcm2-7-GINS (CMG) helicase bind
55 identify a previously unrecognized guidance mechanism whereby cell adhesion molecules act in trans t
57 ophagy is a fundamental cellular homeostatic mechanism, whereby cells autodigest parts of their cytop
58 s, it has become important to understand the mechanisms whereby certain therapies are more prone to H
61 ide a novel example of a potentially general mechanism whereby climate change-mediated range shifts c
63 Our results point toward a transcriptional mechanism whereby cocaine alters specific gene networks
66 r, our results reveal an important molecular mechanism whereby coordinated cytoskeletal dynamics cont
67 ontext retrieval on each trial, suggesting a mechanism whereby cues trigger retrieval of context, whi
71 A decapping scavenger enzyme (DcpS), but the mechanism whereby DcpS inhibition leads to therapeutic b
72 esolution imaging and provide evidence for a mechanism whereby DDR1 kinase activity is determined by
75 is identifies and validates a cell-intrinsic mechanism whereby differential protein phosphorylation c
76 esis and muscle disease, and uncover a novel mechanism whereby disruption of the LINC complex may con
83 of Neuron, Stempel et al. (2016) describe a mechanism whereby endocannabinoid production leads to a
84 entral MHb pathway may represent a potential mechanism whereby endocannabinoids exert anxiolytic and
86 se findings highlight a potential regulatory mechanism whereby epiblast cells, via their shed EVs, cr
87 sly unrecognized extrinsic tumor-suppressive mechanism, whereby epithelial polarity proteins dictate
89 ese studies enhance our understanding of the mechanisms whereby Etv2 governs mesodermal fate decision
90 his study, we critically review the proposed mechanisms whereby exemplary misfolded proteins associat
91 o bypass this limitation, cells have evolved mechanisms whereby exposure to mild stress increases the
92 his apparent contradiction by a depositional mechanism whereby fibers are preferentially removed from
94 ciated with drug resistance, demonstrating a mechanism whereby fitness costs associated with resistan
96 ort of a sterically (kinetically) controlled mechanism, whereby gauche interactions between appendage
97 nds of puberty initiation over time, and the mechanisms whereby genetic, metabolic, and other factors
98 esults presented herein lead us to propose a mechanism whereby genomic ssDNA secondary structure form
99 cell-cell signaling (induction) or a derived mechanism whereby germ cells are specified by using germ
101 on with ChREBP as a previously unappreciated mechanism whereby glucose signals are both relayed to Ch
104 eases and H. pylori gene expression, and the mechanisms whereby H. pylori regulates NO synthesis by h
105 lator of lipid metabolism as well as a novel mechanism whereby hepatic TG storage is promoted in resp
106 r data demonstrate a hetero-tissue crosstalk mechanism, whereby hepatic hepcidin regulated intestinal
107 I2 and ORAI3, revealing an intricate control mechanism whereby heteromerization of ORAI channels medi
109 e also describe a novel chromatin regulatory mechanism whereby histone-H2B ubiquitylation stimulates
111 V-infected individuals, although the precise mechanisms whereby HIV infection impedes successful T ce
112 dies provide new insights into the molecular mechanisms whereby HMGNs affect chromatin structure.
114 oteins is likely an evolutionarily conserved mechanism whereby HopAF1 orthologs from multiple plant p
115 o-stage microtumor progression and migration mechanism whereby hypoxia induces a migratory phenotype
116 uces plaque vulnerability, providing a novel mechanism whereby IGF-1 exerts antiatherogenic effects.
119 ciated with more severe asthma; however, the mechanisms whereby IL-17A can contribute to IL-13-driven
120 together, our results provide evidence for a mechanism whereby imagined movements can directly affect
122 Collectively, these findings identify new mechanisms whereby impaired lysosomal targeting can impa
124 e origins of inflammation in tumors, and the mechanisms whereby inflammation drives tumor initiation,
126 Together, these findings highlight a novel mechanism whereby interactions between Cat-1 and its bin
128 Magnetite is produced via a pipe-diffusion mechanism whereby iron diffuses into radiation-damaged z
129 r etiology of nemaline myopathy and reveal a mechanism whereby KLHL41 stabilizes sarcomeres and maint
130 de of LTCC regulation and establish a unique mechanism whereby Kv2.1-associated EPJs provide a molecu
131 s cell proliferation; however, the molecular mechanism whereby La supports cell proliferation is not
133 undamaged DNA, suggesting a 'kinetic gating' mechanism whereby lesion discrimination relied on effici
135 lacking nuclear localization uncover a novel mechanism whereby lipid phosphatase activity in the nucl
136 ncodes a transcription factor, and propose a mechanism whereby loss of phenotypic inheritance causes
139 t in lung injury and fibrosis and fit with a mechanism whereby lung lymphatic network expansion reduc
140 specifically addresses a potential unifying mechanism whereby marijuana could exert rewarding and ad
141 escribe a novel, to our knowledge, molecular mechanism whereby maternal decidual chemokines can funct
142 ken together, these findings suggest a novel mechanism whereby MCs may contribute to HRV-induced asth
143 nces required for replication.IMPORTANCE The mechanism whereby members of the order Picornavirales sp
145 these findings show a previously unreported mechanism whereby Meth functions as a novel T-cell activ
147 ly affect gut and systemic diseases, but the mechanism whereby microbiota affect systemic diseases is
148 vel insights into the cellular and molecular mechanisms whereby mitochondria control neurotransmitter
149 sis of our structural analyses, we suggest a mechanism whereby molecular interactions within the acti
151 bility and delayed apoptosis, highlighting a mechanism whereby MPO mutations affect granulocyte numbe
152 beta in osmoregulation and identify multiple mechanisms, whereby mutations of HNF-1beta produce defec
154 lexible earlier in development, suggesting a mechanism whereby neural circuits begin as flexible syst
155 odulus-controlled morphogenesis and define a mechanism whereby neuronal cells respond to environments
156 e of the JCI, Butin-Israeli et al. outline a mechanism whereby neutrophils control epithelial fitness
159 by noradrenaline in nociceptive neurons is a mechanism whereby noradrenaline may suppress incoming no
160 ied-rather than backbone atoms and propose a mechanism whereby not only their charge sign but also th
161 th and progression and implicate a molecular mechanism whereby nuclear MET promotes aberrant Wnt/beta
162 We demonstrated a previously unrecognized mechanism whereby nuclear PXN enhances angiogenesis by t
166 immune arthritis model, we elucidate a novel mechanism whereby oral AM80 administration suppressed lu
169 accumulate within this window, suggesting a mechanism whereby Paf1 loss leads to aberrant, premature
170 or itch transmission and illustrate a spinal mechanism whereby pain inhibits itch by suppressing the
172 m padi as a model, we propose an alternative mechanism whereby parasitoids are more efficient at find
173 nditions, deciphering chemical and molecular mechanisms whereby pathogens can influence vectors, expa
176 productive tract thus represents a potential mechanism whereby periodontitis can lead to adverse preg
177 receptor-alpha in sepsis and to identify the mechanism whereby peroxisome proliferator-activated rece
178 anoid experiments, we identified a molecular mechanism whereby PGE(2) promotes Yap dephosphorylation,
184 ether, our findings reveal a novel virulence mechanism whereby plant pathogens target host RNA Pol IV
186 hought to have antihypertensive effects, the mechanism whereby pomegranate extract lowers blood press
187 d 2 p45-related factor 2 (Nrf2) pathway as a mechanism whereby pomegranate extract reduces oxidative
188 he activation of the NLRP3 inflammasome is a mechanism whereby preterm labor and birth occur in the c
189 , these findings reveal a conceptually novel mechanism whereby pro-metastatic collagen linearization
193 n can therefore provide insight into general mechanisms whereby protein disorder regulates events tha
195 recent study by Ramirez et al. elucidated a mechanism whereby RAS controls V-ATPase association with
200 l of tendinopathy and thereafter, to explore mechanisms whereby S100 proteins may regulate release of
202 provide new insights into the CD40 signaling mechanisms whereby Ser-11 phosphorylation controls RING
209 We then identified the underlying molecular mechanism whereby SORLA promotes insulin-induced suppres
212 de new data that extend our knowledge on the mechanisms whereby Streptococcus pneumoniae is cleared b
213 eatest change in gene expression, offering a mechanism whereby stress timing might lead to markedly d
215 hought to occur through a 'molecular corset' mechanism, whereby structural elements within the epithe
216 s activity reveals a previously unrecognized mechanism whereby such antibodies might impact HIV trans
218 Together, our findings highlight a novel mechanism whereby SUMOylation and phosphorylation of the
219 gether, results of our study support a novel mechanism whereby sumoylation of La promotes cell prolif
221 ative rounds of screening, we reveal a novel mechanism whereby target engagement by Argonaute 2 (AGO2
223 heimer's disease (AD), however, the cellular mechanism whereby tau accumulation causes neurodegenerat
225 ut downstream T-cell signaling pathways, the mechanism whereby TCR engagement by pMHC is first commun
227 rs authentic transport vesicles via the same mechanism whereby the ALPS motif senses lipid-packing de
228 ity functional theory calculations support a mechanism whereby the borepin initially rearranges to a
229 observed after stress reflect a compensatory mechanism whereby the brain drives neural systems to cou
230 We also reveal an evolutionarily conserved mechanism whereby the cell redirects its energy from mai
231 epressor complex activity as a key molecular mechanism whereby the environment influences DSL ligand
232 ectively, the findings are consistent with a mechanism whereby the excess CRF that characterizes stre
238 These results support a newly identified mechanism whereby the levels of fructose 2,6-bisphosphat
243 CATC-interacting vertex triplexes, suggest a mechanism whereby the portal orchestrates procapsid form
247 rk reveals a previously undescribed invasive mechanism whereby the secretion of a glutathione-depende
248 hange provide strong evidence for a two-step mechanism whereby the tetramer dissociates to dimers tha
249 by a "displacement insertion intercalation" mechanism, whereby the acridine moiety is inserted into
250 rate a cooperative, self-chaperone refolding mechanism, whereby the beta-subunits independently refol
252 binding typically follow a dock-and-coalesce mechanism, whereby the docking of one IDP segment initia
253 achieve peptide selectivity via an indirect mechanism, whereby the TCR sensed the first residue of t
254 regions and the availability of one or more mechanisms whereby the absorbed photon energy can be dis
255 These receptors represent one of the main mechanisms whereby the gut microbiome affects vertebrate
257 w describes the current understanding of the mechanisms whereby the lung is known to resolve fibrosis
258 linked to major depressive disorder, but the mechanisms whereby the microbiota modulates mood remain
259 tural and biochemical studies, the molecular mechanisms whereby the MLL complexes recognize histone H
260 lite oxidation states and elucidation of the mechanisms whereby the redox state influences circadian
264 ranscription profile; however, the molecular mechanism whereby these ubiquitous nucleosome binding pr
266 breast cancer subtypes, and review potential mechanisms whereby these factors may influence breast ca
268 m-negative pathogens with a unique virulence mechanism whereby they grow a needle-like structure in o
269 ed individuals and we provide evidence for a mechanism whereby this might contribute to the TD phenot
270 cess of macroautophagy, although the precise mechanism whereby this occurs has not been identified.
271 mulation of lipid in hepatocytes, though the mechanisms whereby this leads to hepatocyte dysfunction,
272 ere, we provide an overview of the different mechanisms whereby three different chaperones, Spy, Hsp7
275 2 (Th2) cells drive allergic asthma, yet the mechanisms whereby tissue-resident memory Th2 (Th2 Trm)
276 e PVN following AngII infusion, suggesting a mechanism whereby TNFR1 activation contributes to hypert
278 , proposed to occur through a majority-rules mechanism, whereby trace chiral materials can promote th
280 riptional regulation incorporates a feedback mechanism whereby transcribed RNAs initially stimulate b
281 ted data provide insights into the molecular mechanisms whereby transcriptional programs drive cortic
282 e discusses various endogenous and exogenous mechanisms whereby transport is controlled in the gut, p
283 vely, these studies illustrate an additional mechanism whereby Tregs control the immune response to n
285 In this study, we characterized molecular mechanisms whereby trimethoprim treatment results in cel
286 TTP-CNOT interaction that shape an emerging mechanism whereby TTP targets inflammatory mRNAs for dea
287 trometry and modelling studies, we propose a mechanism whereby TTR can form amyloid fibrils via a par
290 ed when they undergo ubiquitination, yet the mechanism whereby ubiquitination activates the adaptors
292 uPAR (Plat(GFDhu/GFDhu)) to investigate the mechanism whereby uPA promotes neurorepair in the ischem
293 years of experiments, the precise molecular mechanism whereby vacuolar (V-type) ATP synthase fulfill
294 tions and in doing so gain insights into the mechanisms whereby variants affect AF risk, using electr
296 dentify multifactorial functions and diverse mechanisms whereby VCP regulates cardiomyocyte protein a