ライフサイエンスコーパス: mechanistic

1 neurogenetics, our results provide a causal, mechanistic account for a long-known visual illusion.

2 h changes in attentional demands, offering a mechanistic account for attentional atypicalities in ASD

3 Mechanistic analyses demonstrated that STAT1, SMCHD1, an

4 This mechanistic analysis of the etiology of HS in the HFSC c

5 The objective of this study was to provide a mechanistic analysis of TSLP-mediated type 2 airway infl

6 ronal resting Ca(2+) signals warrant further mechanistic analysis that includes the potential role of

7 view identifies and critically evaluates the mechanistic and clinical evidence of new promising thera

8 importance of tissue Na(+) excess, are both mechanistic and clinical.

9 Mechanistic and computational studies support initial re

10 y the diamine precursors, as demonstrated in mechanistic and computational studies.

11 Here, we test mechanistic and ecological explanations for the evolutio

12 vide extensive diversity to harness genetic, mechanistic and phenotypic variation associated with oil

13 toimmune response, as well as discussing the mechanistic and therapeutic implications of these findin

14 driver genes in diverse contexts and enables mechanistic and translational studies.

15 tes/pathways has been shown through numerous mechanistic animal model studies.

16 By deciphering mechanistic aspects of hepatitis C virus (HCV)-host inte

17 Emphasis is placed on the mechanistic aspects of the discussed transformations and

18 al studies until the present day, of the key mechanistic aspects that influence the reactivity and se

19 to include both sexes and to address age in mechanistic atherosclerosis studies are missed opportuni

20 ctivity of gold(III) has revealed unexpected mechanistic avenues, which can open when the barriers fo

21 The proof of concept herein points to a mechanistic basis for possible applications of pulsed ma

22 Collectively, our data provide a mechanistic basis for reports of selective autophagy in

23 ts that define the CARF domain fold, and the mechanistic basis for ring nuclease activity is discusse

24 However, the mechanistic basis for the similarity of KS lesion endoth

25 y limb defects in humans, but the underlying mechanistic basis is unclear.

26 These results pinpoint the mechanistic basis of chemotherapy-induced hyperprogressi

27 The functional relevance and mechanistic basis of the effects of the neurotransmitter

28 combine experiment and theory to examine the mechanistic basis of these different modes of regulation

29 Here, we investigated the mechanistic basis of this endogenous defense against ath

30 However, the mechanistic basis of this microbiota-brain signalling an

31 ut we are only beginning to understand their mechanistic basis.

32 icy makers to interpret monitoring data on a mechanistic basis.

33 this goal presents a considerable degree of mechanistic challenge to control the mode of substrate a

34 understanding of the signaling networks and mechanistic changes that coordinate physiological change

35 Mechanistic characterization through time-of-addition st

36 Mechanistic characterization through viral RNA profiling

37 Moreover, we describe two mechanistic classes of independently arising mutations i

38 This work provides novel mechanistic clues about SBRV in ADHD.

39 The structural and mechanistic comparison herein reported between hsNadE an

40 site movement as a search process and use a mechanistic computational model that combines polarity p

41 th analyses to generate hypotheses about the mechanistic connections between immunity and body mass u

42 Taken together, these findings unravel the mechanistic consequences of delaying Abeta aggregation v

43 a physiology and cell death, suggestive of a mechanistic convergence between aging and lysosomal stor

44 y, induce spin-state selectivity, and elicit mechanistic crossovers.

45 CONCLUSIONTaken together, these clinical and mechanistic data identify MVT-602 as having considerable

46 These findings provide the basis for a mechanistic description of trans-generational inheritanc

47 agy during mitosis remains controversial and mechanistic detail limited to the suggestion that CDK1 p

48 Enzyme kinetic models explore pathways in mechanistic detail, and we discuss different approaches

49 al reactions of these two carbasugars reveal mechanistic details hidden by conformational changes tha

50 ein-associated intermediates and elucidating mechanistic details of enzymatic processes.

51 with simple secondary structures are known, mechanistic details of the protein's interactions with R

52 me sequencing, additional mutation hotspots, mechanistic details of their formation, and the relevanc

53 Nonetheless, mechanistic details of these sensory pathways are still

54 Mechanistic details of this reaction remain sparse.

55 -L1 + macrophages and PD-L1 + tumor cells as mechanistic determinants of response.

56 Here, we focused on possible mechanistic differences of the MA-mediated plasma membra

57 crystal structure that illuminates striking mechanistic differences: SS-RJW100 adopts multiple confi

58 Results from mechanistic dissection experiments revealed that the N-t

59 g approach can be broadly applied to aid the mechanistic dissection of cell signaling, as well as non

60 Further mechanistic dissection suggests that nuclear Akt activit

61 pe of an E3 enzyme, highlighting the growing mechanistic diversity in ubiquitination cascades.

62 treatment strategies remain limited in their mechanistic diversity.

63 CotB2 mutations is studied using multiscale mechanistic docking, machine learning, and X-ray crystal

64 istry and stands as an eminent challenge for mechanistic elucidation.

65 ncy remains elusive without a comprehensive, mechanistic evaluation of photocatalysis to better under

66 ve cardiometabolic health by targeting early mechanistic events to decrease the risk for certain card

67 ities, or medication use, and show the first mechanistic evidence that the use of angiotensin-convert

68 ents, however, we currently lack a rigorous, mechanistic examination of how plasticity evolves in a l

69 Further mechanistic examination revealed that the effect of L374

70 Mechanistic experiments indicate that a silylcopper inte

71 Also provided are the results of several mechanistic experiments that suggest the process feature

72 Finally, we undertook mechanistic experiments, demonstrating that IL-36 acts d

73 Through a combination of mechanistic experiments, we conclude that rapid nonradia

74 s for the advantageous mutants and provide a mechanistic explanation for Lon's widespread impact.

75 These findings provide a mechanistic explanation for the acute O(2) regulation of

76 cs of the epileptogenic networks, provides a mechanistic explanation of the epileptic processes durin

77 Our data provide a mechanistic explanation why the same proteins can act ei

78 Mechanistic explanations are provided for many common ch

79 advances have been precluded by the lack of mechanistic explanations for the variety of its desirabl

80 ine for generating testable hypotheses about mechanistic explanations of brain function, behavior, an

81 f placental development and have some shared mechanistic features.

82 These mechanistic findings, particularly evidence obtained at

83 Here, we present a mechanistic foundation for the way spatial confinement o

84 Our work provides a mechanistic framework for the recognition of sequence-di

85 Our results provide a mechanistic framework for therapeutic targeting of ligan

86 These findings establish a mechanistic framework for understanding the role of PC-1

87 ndings provide a starting point for creating mechanistic framework of brain IR in further development

88 odeling, and field observations to develop a mechanistic framework to predict avulsion frequency on d

89 experimental animals provide a preliminary, mechanistic framework to support the emerging epidemiolo

90 ath data within a Bayesian hierarchical semi-mechanistic framework.

91 plicated in the DNA damage response, but its mechanistic function in repair is not well understood.

92 astasis promotion and characterized detailed mechanistic functions of two hits.

93 In this issue, Ellison et al. use a mechanistic home range analysis (MHRA) to uncover the dr

94 chemistry, it would be very useful to derive mechanistic hypotheses for newly discovered inhibitors.

95 tentiation profile on CFTR structures raises mechanistic hypotheses on drug action, suggesting that V

96 quantitative predictions from their embedded mechanistic hypotheses.

97 pport rapid chemical toxicity assessment and mechanistic hypothesis generation, here we present an in

98 One mechanistic hypothesis involves impaired endothelium-dep

99 This framework guides mechanistic inference by directing functional validation

100 In addition to providing important mechanistic information on attenuation of the ACE2/RBD a

101 nked by two catalytic carboxyls, reveals key mechanistic information: (a) General base catalysis by a

102 However, mechanistic insight and clinical translation continue to

103 se reactivity of the zwitterion provides new mechanistic insight for 1,1-carboboration and wider B(C(

104 These metrics provide greater mechanistic insight into behavior than measuring the amo

105 These findings provide novel mechanistic insight into BRG1-mutant lung cancers and su

106 en together, these data not only provide new mechanistic insight into how a unique collagen fragment

107 These results represent the first mechanistic insight into how O-glycan structures on cell

108 These findings provide a mechanistic insight into neurodevelopmental defects caus

109 Our study provides a mechanistic insight into saliva-aided viral transmission

110 e as a stress-responsive endocrine organ and mechanistic insight into targeting this axis in the trea

111 To enable mechanistic insight into the coordinated morphogenic cro

112 However, mechanistic insight into the DNA-mediated nanocrystal fo

113 These findings provide mechanistic insight into the opposing functional effects

114 from supramolecular gels, this work provides mechanistic insight into the way molecules with differen

115 features of the S(3) state provide valuable mechanistic insight, corresponding synthetic and spectro

116 This mechanistic insight, enabled by microsecond-timescale MD

117 To gain mechanistic insight, follow-up lipid analysis was undert

118 Our data also provide mechanistic insights about the blockade and suggest that

119 onal theory study is presented here to offer mechanistic insights and explications of experimentally

120 These mechanistic insights assisted the discovery of a new Ti(

121 These mechanistic insights delineate the scope and limitations

122 Furthermore, this work demonstrates in-depth mechanistic insights employing electrochemistry, which s

123 The mechanistic insights enabled development of an electroch

124 These findings provide mechanistic insights for an improved design and efficien

125 Furthermore, mechanistic insights have been revealed by demonstrating

126 verall, KinCon profiling provides additional mechanistic insights into full-length kinase functions b

127 ex vivo electrophysiology and ISH, provides mechanistic insights into how both chronic alcohol expos

128 These findings provide mechanistic insights into how CHRNA3 risk alleles can in

129 Our results provide mechanistic insights into how DNMDP induces PDE3A-SLFN12

130 omain-mediated complex formation and provide mechanistic insights into how SARAH domain-mediated inte

131 We also provide mechanistic insights into how these novel cyclotides int

132 e CirpT protein family, and provide detailed mechanistic insights into its inhibitory function.

133 The findings provide novel mechanistic insights into receptor-operated TRPC4 activa

134 Our new findings provide mechanistic insights into the differential host innate i

135 and metadynamics simulations provide useful mechanistic insights into the free energy of interaction

136 lecular dynamics simulations provided useful mechanistic insights into the monomer exchange rates and

137 of highly structured regions is integral for mechanistic insights into the viral infection cycle, ver

138 HNSCC to WEE1i-induced toxicity and provide mechanistic insights into WEE1i and HPV+ HNSCC therapies

139 promoter methylation in TAFs and provide new mechanistic insights on the selective poor response of S

140 To gain mechanistic insights on this unknown, a dynamic root-hyd

141 weight gain provide candidate biomarkers and mechanistic insights related to the metabolic side effec

142 ilament turnover and adhesion, and the novel mechanistic insights substantially extend our knowledge

143 and IBD-associated inflammation and provide mechanistic insights supporting further investigation of

144 irectionality of expression data provide new mechanistic insights that are consistent with a compensa

145 ly undergoes regression after birth, to gain mechanistic insights that could be therapeutically adapt

146 This model generates mechanistic insights that help in further experiments an

147 for selective CYP3A5 inhibition, along with mechanistic insights, and highlight clobetasol as an imp

148 play between networks will provide important mechanistic insights.

149 hermore, the in silico investigation yielded mechanistic insights; e.g., through simulations, bepridi

150 We report a single-molecule mechanistic investigation into 2-cyanobenzothiazole (CBT

151 A mechanistic investigation revealed that the spontaneous

152 Mechanistic investigation strongly supports a radical pr

153 Mechanistic investigations indicate that trimethyl ortho

154 singly influenced prediction of activity and mechanistic investigations of organic reactions.

155 Mechanistic investigations reveal multiple competing oxi

156 At a mechanistic level, OOC-5/torsinA promotes the assembly o

157 excessive erythrocytosis (EE); however, the mechanistic link between chronically elevated sympatheti

158 hese analyses provide support for a possible mechanistic link between early driver mutations in RAS a

159 Our results define a previously unknown mechanistic link between filamentous fungal biofilm phys

160 Thus, our work supports a mechanistic link between mitochondrial function and comm

161 s provide the first evidence in support of a mechanistic link between physiological ROS signaling, AM

162 f serine 240 on p115 RhoGEF by PKC to be the mechanistic link between PKC and RhoA.

163 These phenotypes establish a new mechanistic link between reduced transport of synaptic c

164 This model may help define the mechanistic link between transmission of pathological al

165 They provide a possible mechanistic link between viral infection, bloom terminat

166 izable N-glycosylation pattern and provide a mechanistic link to increased ROS release by neutrophils

167 an important direct metabolic and endocrine mechanistic link to the viral disease process.

168 etiologies makes it difficult to discern the mechanistic links between different alleles of a single

169 ons in light of the new findings and explore mechanistic links between the cellular and network prope

170 Here, we used a mechanistic microclimate model coupled to an animal biop

171 unity dynamics, necessary for conceptual and mechanistic model development, remains difficult to asse

172 A fitted mechanistic model showed that among the forest plots, th

173 Here, we apply a mechanistic model to climate reconstructions to simulate

174 nal complexity of an intracellular signaling mechanistic model.

175 Dynamic energy budget (DEB) theory offers a mechanistic modeling approach to describe the entire lif

176 Given recent successes of neurally mechanistic models and the surging availability of neura

177 l of analysis, leading to the development of mechanistic models at the psychological level to explain

178 Mechanistic models have been proposed to explain the ass

179 Conversely, more mechanistic models such those implementing GRNs allows f

180 This alternative mechanistic paradigm decouples the bond-breaking and bon

181 e base was found to be crucial to divert the mechanistic pathway toward the cyclopropane instead of t

182 late during prolonged hyperglycemia, but the mechanistic pathways that lead to accelerated liver fibr

183 This review provides a broad overview of the mechanistic pathways through which the kynurenines inter

184 e broad impact of PDK4 deficiency and reveal mechanistic pathways used by these cells in an attempt t

185 are reported, which proceed via two distinct mechanistic pathways: enantioselective acyl transfer pro

186 From a mechanistic perspective, we found that cognitive engagem

187 We develop a mechanistic phenology model and apply it to Aedes aegypt

188 These mechanistic, physiological results inform risk-benefit a

189 ts were linked to nanoscale interactions via mechanistic pore-scale colloid trajectory simulations th

190 This Perspective reviews the mechanistic possibilities, with a focus on the P-H activ

191 Progressing to a more mechanistic prediction of plant gas exchange is challeng

192 Therefore, the mechanistic preference of PH(2)(-) is steered to the S(N

193 Moreover, strong biological and mechanistic premises connecting elevated folic acid inta

194 Ala tailing thus follows mechanistic principles surprisingly similar to canonical

195 The mechanistic principles, however, are unclear, mainly bec

196 echniques can be used to conduct a rigorous, mechanistic program evaluation of other quality improvem

197 nal changes upon ligand binding illuminate a mechanistic rationale for understanding TRPC6 modulation

198 This mechanistic rationale is supported by detailed computati

199 en the two compounds, suggesting an intimate mechanistic relationship between them.

200 in global vegetation models requires better mechanistic representation of water and nutrient limitat

201 These findings indicate a novel mechanistic role for TSLP and CD11c-expressing IMs in th

202 Whether NGAL plays a mechanistic role in ANCA-associated vasculitis is unknow

203 uitment of cells of innate immunity exerts a mechanistic role in disease progression, determining the

204 nomenon, or whether it plays an independent, mechanistic role in early attention and learning.

205 ies that address their dynamic, kinetic, and mechanistic role in target reactions are scarce.

206 probabilistic model, CoMM-S2, to examine the mechanistic role that genetic variants play, by using on

207 Two mechanistic scenarios of the cooperative bond activation

208 nown heterocyclophanes, we outline a unified mechanistic scheme that explains competing processes und

209 patitis C virus (HCV)-like IRESs, suggesting mechanistic similarities.

210 ed triplet state upon halogenation was a key mechanistic step to achieving rapid photopolymerization

211 Stoichiometric mechanistic studies allowed the identification of aryl-

212 Mechanistic studies are presented that reveal two mechan

213 Mechanistic studies confirmed that SIRPalpha not only re

214 The mechanistic studies confirmed the involvement of aryl ra

215 els described here may be useful for further mechanistic studies in the progression of liver diseases

216 Detailed mechanistic studies including online-NMR and ESI-MS meas

217 Mechanistic studies indicate that Ni-allyl formation is

218 Mechanistic studies indicate this phenomenon results fro

219 long been a tool of choice in supporting the mechanistic studies of drug/therapeutic target interacti

220 We present here detailed mechanistic studies of electrocatalytic hydrogenation (E

221 cular biology of cell fate and tissue shape, mechanistic studies of our own development have so far b

222 Mechanistic studies of plant iron home-ostasis and plant

223 serum amine oxidase-induced cytotoxicity in mechanistic studies of the roles of polyamines in autoph

224 Mechanistic studies of transcription initiation in bacte

225 proof of principle case can stimulate future mechanistic studies on diagnostic and therapeutic strate

226 Mechanistic studies point to the crucial role of the pho

227 Mechanistic studies revealed that Synucleozid reduces al

228 Systematic mechanistic studies shed light into the working details

229 Mechanistic studies suggest a change in the turnover-lim

230 Preliminary mechanistic studies suggest inhibition of hemozoin forma

231 A potential reason for this is that mechanistic studies using rodent models do not incorpora

232 Preliminary mechanistic studies were performed to demonstrate the cr

233 Future mechanistic studies will be needed to determine the prec

234 Detailed mechanistic studies, including the isolation of key inte

235 Through a series of mechanistic studies, we identified the 2,5-dihydropyrida

236 d on results from epidemiological as well as mechanistic studies.

237 trochemical derivatization; and iii) in situ mechanistic study and capture of key radical intermediat

238 g enzymes have remained ambiguous, hindering mechanistic study and therapeutic development.

239 Mechanistic study demonstrates that IgE induces neutroph

240 We have suggested, for the first time, a mechanistic study for catecholamine redox reactions at L

241 A mechanistic study of protein-drug conjugates demonstrate

242 In this work, we present a comprehensive mechanistic study of the photochemical CO release from 3

243 The mechanistic study showed the inhibition of EGFR caused n

244 A preliminary mechanistic study shows a hitherto unrecognized inhibito

245 We identified neuronal Prkag3 mRNA as a mechanistic substrate for NMD that contributes to the UP

246 ue Psoriasis in Subjects]) participated in a mechanistic substudy where punch biopsies were collected

247 complex (TSC), a disease with overactivated mechanistic target of rapamycin (mTOR) signaling, has de

248 The mechanistic target of rapamycin (mTOR)-signaling pathway

249 As the assembly and activation of the mechanistic target of rapamycin complex 1 (mTORC1) occur

250 ogenic diets, can reduce the activity of the mechanistic target of rapamycin complex 1 (mTORC1) signa

251 genes, leading to constitutive activation of mechanistic target of rapamycin complex 1 signaling.

252 ssion and phosphorylation of proteins in the mechanistic target of rapamycin pathway were similar in

253 Inhibition of mTOR (mechanistic Target Of Rapamycin) signaling by rapamycin

254 del system in combination with an arsenal of mechanistic techniques, including (13)C kinetic isotope

255 Here, we propose a mechanistic theory of epithelial shells which resemble s

256 to, there is an urgent unmet need to develop mechanistic treatments directed at root causes of AF.

257 patterns in immune phenotypes that form the mechanistic underpinnings of important wildlife disease

258 system where improving our understanding of mechanistic underpinnings of living systems might transf

259 e that requires significant advances in both mechanistic understanding and material design.

260 chemotherapy-induced peripheral neuropathy, mechanistic understanding and treatment remain deficient

261 oretical studies have attempted to develop a mechanistic understanding for the observed behaviors, pr

262 The complex underlying genetics and poor mechanistic understanding has caused a bottleneck in the

263 Despite its prevalence, our mechanistic understanding is incomplete, the therapeutic

264 This mechanistic understanding is used to develop the magnesi

265 tissue biopsy studies that have advanced the mechanistic understanding of AD, single cell-based molec

266 A mechanistic understanding of alveologenesis remains inco

267 tial exists for developing a vastly improved mechanistic understanding of animal movements and their

268 e current status of available models and the mechanistic understanding of DILI, and proposes our visi

269 Leveraging these findings will advance our mechanistic understanding of disease and may provide nov

270 box model analysis incorporating the current mechanistic understanding of DMS oxidation chemistry and

271 In this work, mechanistic understanding of flavin-catalyzed oxidation

272 ellular excitability, as tools for advancing mechanistic understanding of HCN4 channel function, and

273 in vitro studies supporting this function, a mechanistic understanding of how Msp1 extracts its subst

274 nergetics of adsorption and catalysis, but a mechanistic understanding of how nonaqueous solvents inf

275 Second, we need a better mechanistic understanding of how physical conditions in

276 These findings establish a mechanistic understanding of LBL-lipid interactions and

277 o dose X-ray crystallography can advance our mechanistic understanding of metalloenzymes.

278 Our results provide a mechanistic understanding of N(2)O production in eukaryo

279 in regard to the molecular underpinnings and mechanistic understanding of nanotoxicity.

280 An in-depth mechanistic understanding of NCs has been hampered by la

281 neuronal genes, offering new functional and mechanistic understanding of NONO in stem cell functions

282 al model of SERCA-PLB interactions to gain a mechanistic understanding of PLB-mediated SERCA transpor

283 Detailed mechanistic understanding of protein complex function is

284 The mechanistic understanding of protein functions requires

285 highlight the use of model systems to enable mechanistic understanding of RAD51 cellular roles.

286 n ecological performance can contribute to a mechanistic understanding of species coexistence.

287 nstraint have remained elusive due to a poor mechanistic understanding of studied phenotypes.

288 Mechanistic understanding of the anticancer potential fo

289 Our findings enhance current mechanistic understanding of the genetic and epigenetic

290 This work contributes to improve our mechanistic understanding of the role of emergent macrop

291 ignaling within the OFC is fundamental for a mechanistic understanding of the sequelae for several ps

292 findings illuminate changes important for a mechanistic understanding of the virus and support conti

293 ecent research studies have yielded a strong mechanistic understanding of this disease.

294 g pathological cardiac and renal conditions, mechanistic understanding of TRPC6 function and modulati

295 of disability and significant mortality, yet mechanistic understanding remains limited.

296 y in a variety of ways, but species-specific mechanistic understanding will help highlight how to bes

297 ervational field of ecology to one rooted in mechanistic understanding.

298 will continue to be justified as a source of mechanistic understanding.

299 l-established antiviral activity but limited mechanistic understanding.

300 ymethyl)benzamide compounds, no evidence for mechanistic variation based upon the nature of the amidi