ライフサイエンスコーパス: mechanistic insight

1 interacting partners, has led to significant mechanistic insight.

2 arly lipid oxidation assessment and generate mechanistic insights.

3 lving problems in synthesis and to obtaining mechanistic insights.

4 te between the two conditions and could give mechanistic insights.

5 follow-up, providing potential clinical and mechanistic insights.

6 play between networks will provide important mechanistic insights.

7 ce supporting these associations and link to mechanistic insights.

8 cipients, providing therapeutically relevant mechanistic insights.

9 ulations collectively revealed the following mechanistic insights: (1) The rapid O(2) addition to the

10 Our data also provide mechanistic insights about the blockade and suggest that

11 This study in mice provides a fundamental mechanistic insight and a paradigm into how an immune re

12 rough the postgenomic era and towards deeper mechanistic insight and clinical applications.

13 However, mechanistic insight and clinical translation continue to

14 ed, however, translating this knowledge into mechanistic insight and patient benefit remains a challe

15 The mechanistic insight and quantitative kinetic parameters

16 ndependence in human ILC cell lines provides mechanistic insights and clinical implications for metas

17 onal theory study is presented here to offer mechanistic insights and explications of experimentally

18 /9 inhibitor Val-boroPro, focusing on recent mechanistic insights and highlighting unresolved questio

19 propriate to use in patients at risk for HF, mechanistic insights and observations from randomized tr

20 There is a paucity in the development of new mechanistic insights and therapeutic approaches for trea

21 sy is a major health burden, calling for new mechanistic insights and therapies.

22 ics represents a powerful strategy to obtain mechanistic insights and to develop individualized diagn

23 ty gene for eosinophilia and asthma, provide mechanistic insight, and implicate targeting of the IL33

24 ble to quantify occult abnormalities, derive mechanistic insights, and define a new feature class for

25 for selective CYP3A5 inhibition, along with mechanistic insights, and highlight clobetasol as an imp

26 A discussion of the reaction scope, mechanistic insights, and synthetic applications of the

27 Furthermore, mechanistic insights are presented and these data have r

28 Mechanistic insights are provided that account for the h

29 Key mechanistic insights are summarized here that informed r

30 uction and repression by budesonide provides mechanistic insight as to how adding a LABA to an inhale

31 These mechanistic insights assisted the discovery of a new Ti(

32 Mechanistic insight based on DFT data, as well as cyclic

33 ovascular structure and function may provide mechanistic insight behind the associations of FGF23 wit

34 Animal models provide valuable mechanistic insights, but their translation to a clinica

35 contexts, RNA-sequencing (RNA-seq) provides mechanistic insights by identifying transcriptome change

36 NA within cells is a powerful means by which mechanistic insight can be gained.

37 This mechanistic insight, combined with simulated docking tec

38 features of the S(3) state provide valuable mechanistic insight, corresponding synthetic and spectro

39 These mechanistic insights delineate the scope and limitations

40 to develop pan-genome analyses that provide mechanistic insights, detail the selection pressures on

41 hermore, the in silico investigation yielded mechanistic insights; e.g., through simulations, bepridi

42 Novel mechanistic insights emerged at all scales of the system

43 Furthermore, this work demonstrates in-depth mechanistic insights employing electrochemistry, which s

44 The mechanistic insights enabled development of an electroch

45 This mechanistic insight, enabled by microsecond-timescale MD

46 To gain mechanistic insight, follow-up lipid analysis was undert

47 se reactivity of the zwitterion provides new mechanistic insight for 1,1-carboboration and wider B(C(

48 Our findings provide mechanistic insight for pathological accumulation of MSI

49 Taken together, our study provides mechanistic insight for the prolonged viral replication

50 These findings provide mechanistic insights for an improved design and efficien

51 h (18)O-labeled water and TEMPO provided key mechanistic insights for delineating the reactivity para

52 ffecting full-length dystrophins may provide mechanistic insights for developing more effective treat

53 Our results provide mechanistic insights for the retention of residual H3K27

54 ave been developed to extract functional and mechanistic insight from bulk transcriptome data.

55 Through the mechanistic insight from control and trapping experiment

56 A useful way to extract mechanistic insight from the data is by integrating them

57 ta in isolation will allow for validation of mechanistic insights from animal studies while also allo

58 Guided by the mechanistic insights from spatial cellular maps, combina

59 ynthesis and catalysis, with emphasis on the mechanistic insight gained in these investigations.

60 The mechanistic insight gained in this study will facilitate

61 This work unequivocally demonstrates that mechanistic insights gained from cell lines can translat

62 The atomic structures and mechanistic insights gained should facilitate the manipu

63 clinical utility of these scores, pertinent mechanistic insights gleaned, and practical consideratio

64 This new mechanistic insight has the potential to inform syntheti

65 Furthermore, mechanistic insights have been revealed by demonstrating

66 le for this database is to be able to derive mechanistic insights in protein-DNA readout modes from s

67 e-regulatory role of LMs, these data provide mechanistic insight into an immuno-lipidomic imbalance i

68 ional molecular datasets can help us develop mechanistic insight into associations between genetic va

69 These metrics provide greater mechanistic insight into behavior than measuring the amo

70 The results also yield new mechanistic insight into beta2m's amyloidogenic structur

71 These findings provide novel mechanistic insight into BRG1-mutant lung cancers and su

72 ystems and limitations, and propose that new mechanistic insight into cell biology can be revealed us

73 This disruptive mechanistic insight into chiral polymer thin films will

74 e reconstruction, that can offer fundamental mechanistic insight into development.

75 active particle-active electrode can provide mechanistic insight into electrochemical reactions.

76 tural and functional data provide compelling mechanistic insight into FtsEX-mediated regulation of En

77 human cell lines and mouse models to provide mechanistic insight into H. pylori's ability to delay ap

78 en together, these data not only provide new mechanistic insight into how a unique collagen fragment

79 argue that computational methods can provide mechanistic insight into how aesthetic judgments are for

80 This paper offers mechanistic insight into how beta-HPV E6 causes this cha

81 a single simple framework, and it provides a mechanistic insight into how decision processes and lear

82 Our findings provide mechanistic insight into how different mammalian mutatio

83 These results represent the first mechanistic insight into how O-glycan structures on cell

84 Overall results provide mechanistic insight into how personalized differences in

85 PHF8 as a TopBP1-binding protein and provide mechanistic insight into how PHF8 regulates TopBP1 stabi

86 Our data provide mechanistic insight into how TFL1-FD sculpt inflorescenc

87 benefits of oestradiol, and also provides a mechanistic insight into how they extend healthspan or p

88 n active promoter configuration, providing a mechanistic insight into hTERT activation during tumorig

89 otency and neural differentiation, providing mechanistic insight into its function with potential imp

90 ing of taste in mosquitoes could provide new mechanistic insight into many aspects of their behavior.

91 The lack of mechanistic insight into MDSC suppressive activity and a

92 These data provide mechanistic insight into microglial-mediated synapse pru

93 These findings provide a mechanistic insight into neurodevelopmental defects caus

94 of the BXD21/TyJ RI strain mice in offering mechanistic insight into Nrf2's role in the inflammatory

95 Lack of mechanistic insight into NUP98-fusion-dependent oncogeni

96 tion is particularly exciting as it provides mechanistic insight into OA susceptibility.

97 specificity, Spec/SEAM-seq provides detailed mechanistic insight into off-target activity.

98 her studies are required, our study provides mechanistic insight into one of the few well-replicated

99 Together these studies provide further mechanistic insight into PAR4 regulation of cellular fun

100 Our study provides a mechanistic insight into saliva-aided viral transmission

101 These findings provide mechanistic insight into sex differences in myocardial p

102 To gain mechanistic insight into ST6Gal-I's role in EMT, we exam

103 Our structure provides mechanistic insight into substrate recognition and trans

104 Here, we present a mechanistic insight into such heteromerization using a s

105 e as a stress-responsive endocrine organ and mechanistic insight into targeting this axis in the trea

106 etation for disparate fusion speeds provides mechanistic insight into the assembly and aging of biomo

107 In this work, we provide new mechanistic insight into the assembly of an amphiphilic

108 To enable mechanistic insight into the coordinated morphogenic cro

109 cr4-Not complex and the ribosome and provide mechanistic insight into the coupling of decoding effici

110 These findings provide a mechanistic insight into the decreased OM stability afte

111 Our work provides mechanistic insight into the dependence of MCC on LSD1 a

112 ies for targeting MAGEA antigens and provide mechanistic insight into the divergent roles of MAGEA6 d

113 However, mechanistic insight into the DNA-mediated nanocrystal fo

114 Ca(2+) and water dynamics, providing unique mechanistic insight into the effect of pulsed infrared l

115 This study provides mechanistic insight into the evolution of lncRNA functio

116 These data provide structural and mechanistic insight into the evolutionary divergence of

117 These results provide mechanistic insight into the factors driving seasonal ch

118 rimental and calculated acidities to provide mechanistic insight into the factors influencing MutY ba

119 By providing mechanistic insight into the formation and regulation of

120 These results provide mechanistic insight into the formation of PrPSc plaques

121 These results provide mechanistic insight into the function and regulation of

122 pigenetic regulators of mRNA metabolism with mechanistic insight into the functional manipulation of

123 Further, these data provide mechanistic insight into the functions of basophils and

124 To develop mechanistic insight into the influence of vector motion

125 New mechanistic insight into the inhibition pathways reveals

126 polar cargo clustering and provides initial mechanistic insight into the maintenance of polarity in

127 In summary, our findings provide mechanistic insight into the new function of GAPDH in DN

128 These findings provide mechanistic insight into the opposing functional effects

129 sclerotic cardiovascular disease and provide mechanistic insight into the pathways governing plaque r

130 This study offers mechanistic insight into the PRF dependence of ultrasoun

131 urination(1-3), there is a lack of in-depth mechanistic insight into the process.

132 mechanosensitive NET production, and provide mechanistic insight into the protective effect of the SL

133 periment and modeling to provide an exciting mechanistic insight into the relationship between stress

134 omplexity of Cyp-virus interactions, provide mechanistic insight into the remarkably broad antiviral

135 on factor loading to the promoter, providing mechanistic insight into the role of APE1 in G4-mediated

136 These studies offer mechanistic insight into the SLE-associated regulatory a

137 However, a detailed mechanistic insight into the transition pathways and kin

138 from supramolecular gels, this work provides mechanistic insight into the way molecules with differen

139 tracking by live imaging allowed us to gain mechanistic insight into the wound perception and coordi

140 c subset of mRNAs to the ribosome, providing mechanistic insight into their cap-independent translati

141 inct from multivesicular bodies, and provide mechanistic insight into their crosstalk.

142 To gain a deeper mechanistic insight into these rhenium anticancer agents

143 Our work provides detailed mechanistic insight into this biosynthetic peculiarity a

144 The current study provides mechanistic insight into this phenomenon by showing that

145 -resistant disease, and our findings provide mechanistic insight into this process while revealing ra

146 To gain mechanistic insight into transcriptional control in B. b

147 on of pharmacokinetics, can be used to glean mechanistic insight into underlying phenomena in skin ph

148 Thus, our study provides mechanistic insight into when, where and how commensal B

149 ations in the spatial environment, providing mechanistic insight into why and how stress can alter pl

150 The study provides mechanistic insights into AD-HIES pathophysiology and su

151 Thus, our study provides new mechanistic insights into Ag delivery and B cell activat

152 These findings provide mechanistic insights into airway defense and a general m

153 ation of PPIs presents opportunities to gain mechanistic insights into amyloid assembly, particularly

154 We report mechanistic insights into an iridium/nickel photocatalyt

155 ed multiscale computational modeling to gain mechanistic insights into clinical seizure dynamics base

156 o develop a mathematical model that provides mechanistic insights into COMET performance characterist

157 oretical simulations to obtain comprehensive mechanistic insights into complex morphogenetic processe

158 in gene regulation, but also to genetic and mechanistic insights into congenital heart defects.

159 perturbed protein response signals provides mechanistic insights into drug resistance, increases the

160 sis is placed on the historical contexts and mechanistic insights into each of the selected reactions

161 e extraordinarily reactive C621 in TRPA1 and mechanistic insights into electrophile-dependent conform

162 Our findings provide novel mechanistic insights into epidermal barrier formation an

163 These findings provide pathological and mechanistic insights into ferroptotic damage in PDAC tum

164 verall, KinCon profiling provides additional mechanistic insights into full-length kinase functions b

165 These findings provide key mechanistic insights into homologous recombination.

166 rulence in F. graminearum Our results reveal mechanistic insights into host-recognition strategies em

167 In summary, our studies provide mechanistic insights into how accumulation of R-loops at

168 Recent efforts have provided us with mechanistic insights into how B cells can positively and

169 ex vivo electrophysiology and ISH, provides mechanistic insights into how both chronic alcohol expos

170 These findings provide mechanistic insights into how CHRNA3 risk alleles can in

171 Our results provide mechanistic insights into how DNMDP induces PDE3A-SLFN12

172 riatum shapes behavior, thus providing novel mechanistic insights into how flexibility in action cont

173 This research provides mechanistic insights into how HH signaling is generated

174 Overall, our results provide mechanistic insights into how IL-4 treatment mitigates e

175 ng non-CG methylation and highlight emerging mechanistic insights into how non-CG methylation and MeC

176 omain-mediated complex formation and provide mechanistic insights into how SARAH domain-mediated inte

177 motility in B. burgdorferi, but also unveils mechanistic insights into how spirochetes control their

178 Our results provide mechanistic insights into how the immune system may inte

179 ntibiotics have provided causal evidence and mechanistic insights into how the microbiota controls im

180 Thus, our results provide mechanistic insights into how the spinal CPG transforms

181 We also provide mechanistic insights into how these novel cyclotides int

182 reports published in Cell (2020) provide new mechanistic insights into how this enteric neuro-immune

183 To generate mechanistic insights into impaired protein synthesis, we

184 ost important emerging fungal pathogens, yet mechanistic insights into its immune recognition and con

185 e CirpT protein family, and provide detailed mechanistic insights into its inhibitory function.

186 l therapeutic target in cancer and offer new mechanistic insights into its significant role in cancer

187 Here, we unveil structural and mechanistic insights into LINP1's ability to facilitate

188 This review provides mechanistic insights into metal-mediated bond-cleavage r

189 Overall, mTPP provides unique mechanistic insights into missense mutation dysfunction

190 ese predictions in humans in vivo, providing mechanistic insights into neurodegenerative disease.

191 Our results provide detailed mechanistic insights into NMDAR pharmacology, activation

192 al model built from these data sets revealed mechanistic insights into off-target cleavage.

193 However, there is a lack of mechanistic insights into Pf drug action on inflammatory

194 and single-molecule levels, bringing us new mechanistic insights into physiochemical processes.

195 type II-A integration complexes and provide mechanistic insights into prespacer insertion.

196 ical information can be derived and the more mechanistic insights into protein function may be inferr

197 -derived model systems, and highlight recent mechanistic insights into protein quality control that h

198 The findings provide novel mechanistic insights into receptor-operated TRPC4 activa

199 ources of soil microbes and can thus provide mechanistic insights into soil C loss pathways.

200 This induced fit model provides mechanistic insights into the 2'-O methylation of the vi

201 To gain mechanistic insights into the actions of TurNP-based ECT

202 D12 on the CDK8/Cyclin C complex and to gain mechanistic insights into the activation of CDK8 by MED1

203 Our work provides mechanistic insights into the allosteric gating and regu

204 Overall, these results uncover new mechanistic insights into the binding action of TALEs an

205 More detailed mechanistic insights into the complex CRC-associated mic

206 Our work provides mechanistic insights into the complex dynamics of a ribo

207 Our findings provide mechanistic insights into the complex roles of +TIPs in

208 This study provides novel mechanistic insights into the consequences of climate ch

209 Collectively, our study provides mechanistic insights into the cytotoxicity instigated by

210 These inhibitors provide mechanistic insights into the determinants of specificit

211 , and quantum chemical calculations provided mechanistic insights into the diastereoselective formati

212 Our new findings provide mechanistic insights into the differential host innate i

213 Such measurements offer unprecedented mechanistic insights into the dynamics of biomolecular f

214 oss scales and over time additionally offers mechanistic insights into the ecological processes shapi

215 This study aims to gain mechanistic insights into the effects of the antiarrhyth

216 Detailed mechanistic insights into the enzyme repair chaperones o

217 nding in living tumors and have yielded many mechanistic insights into the factors that affect antibo

218 and metadynamics simulations provide useful mechanistic insights into the free energy of interaction

219 These findings give new mechanistic insights into the functional adaptation of h

220 se findings provide molecular and biological mechanistic insights into the GWAS association of ACKR2-

221 ting trophoblastic ferroptosis, and provided mechanistic insights into the ill-defined placental lipo

222 with the pathogenesis of SLE and may provide mechanistic insights into the increased incidence of SLE

223 This study provides mechanistic insights into the intriguing link between li

224 yte maturation and proliferation and provide mechanistic insights into the link between hyperplastic

225 Taken together, our findings provide novel mechanistic insights into the machinery controlling chro

226 Our results provide mechanistic insights into the Mla pathway, which could a

227 y proteins function together may provide new mechanistic insights into the molecular etiologies of ne

228 lecular dynamics simulations provided useful mechanistic insights into the monomer exchange rates and

229 This work provides mechanistic insights into the novel oncogene-like functi

230 ognized in KS, and these results provide new mechanistic insights into the pathogenesis of KS-associa

231 These findings provide new mechanistic insights into the pathophysiology of BAD.

232 Together, these findings provide systematic, mechanistic insights into the plasticity and robustness

233 c fibrosis lung microbiota have provided few mechanistic insights into the polymicrobial basis of dis

234 of SAM cleavage, thereby providing important mechanistic insights into the radical SAM-dependent carb

235 These findings provide new mechanistic insights into the regulatory mechanisms that

236 signaling during organogenesis and provides mechanistic insights into the regulatory network control

237 Raman spectroscopy thus reveals new mechanistic insights into the role of GAGs during amyloi

238 stant from template bovine RH1, and provided mechanistic insights into the role of known spectral tun

239 d noncovalent ligand/Hsp90 complexes provide mechanistic insights into the role of ligand conformatio

240 Together, our findings provide mechanistic insights into the role of Mgr2 in regulating

241 behavior within cells will continue to lend mechanistic insights into the role of mitochondria under

242 This review focuses on the structural and mechanistic insights into the roles of cGAS and STING in

243 and show that this approach provides crucial mechanistic insights into the transcriptional regulation

244 Overall, our findings provide mechanistic insights into the tumor immune surveillance

245 rom epidemiology and behavioral science with mechanistic insights into the underlying biology of sitt

246 of highly structured regions is integral for mechanistic insights into the viral infection cycle, ver

247 urnover conditions and thereby gain detailed mechanistic insights into their mode of action.

248 ome dysfunction disorders and discuss recent mechanistic insights into their pathogenesis, with a foc

249 s of these animals could provide fundamental mechanistic insights into this devastating disorder.SIGN

250 To gain mechanistic insights into this dynamic pattern-formation

251 of participating 1,2,4,5-tetrazines, and key mechanistic insights into this reaction are detailed.

252 Mechanistic insights into this system were obtained from

253 f DSBs relative to pausing sites can provide mechanistic insights into transcriptional regulation.

254 These results provide the first mechanistic insights into transport flux-dependent signa

255 EM) has been extensively employed to provide mechanistic insights into understanding the behavior of

256 HNSCC to WEE1i-induced toxicity and provide mechanistic insights into WEE1i and HPV+ HNSCC therapies

257 ions for drug binding and design and provide mechanistic insights into why a leading INSTI retains ef

258 opaminergic (DAergic) activity, but specific mechanistic insight is missing.

259 exclude Cdc10-like central subunits, our new mechanistic insights likely apply throughout phylogeny.

260 A deeper understanding of these novel mechanistic insights may inform potential translational

261 he low-cell-dose microgel group, providing a mechanistic insight of pathways modulated in vivo.

262 Here we report further mechanistic insight of the mode of action and translatio

263 ains of TNFRSF members, our findings provide mechanistic insights of defects in subcellular trafficki

264 In summary, our results demonstrate new mechanistic insights of functionally distinct CHK1 activ

265 ective hydrogenation of such olefins and the mechanistic insights of the reaction.

266 Collectively, these mechanistic insights offer potential therapeutic avenues

267 text of AD pathophysiology, providing recent mechanistic insights on AD-mediated autophagic flux disr

268 trophy and animal disease models; 2) provide mechanistic insights on how truncation of the amino and

269 These data provide mechanistic insights on synapse and circuit specificity

270 promoter methylation in TAFs and provide new mechanistic insights on the selective poor response of S

271 To gain mechanistic insights on this unknown, a dynamic root-hyd

272 cines and with age is still limited, current mechanistic insights provide a framework for improved de

273 Preliminary mechanistic insights provided by density functional theo

274 lso a gap between gene discovery and crucial mechanistic insights provided by studies in model system

275 Moreover, in situ studies provide important mechanistic insights regarding surface-confined nanopart

276 Overall, our study reveals novel mechanistic insights regarding the molecular pathogenesi

277 weight gain provide candidate biomarkers and mechanistic insights related to the metabolic side effec

278 n interaction landscape of SS-31 and provide mechanistic insight relevant to SS-31 mitochondrial ther

279 Altogether, these mechanistic insights reveal a role for Snx14 in FA and E

280 show that this approach generated important mechanistic insights, revealing two functionally converg

281 ilament turnover and adhesion, and the novel mechanistic insights substantially extend our knowledge

282 These mechanistic insights suggest new therapeutic strategies

283 and IBD-associated inflammation and provide mechanistic insights supporting further investigation of

284 involved in coronary vessel formation, with mechanistic insights taken from developmental studies.

285 me of complex immune interactions, providing mechanistic insight that allows us to precisely modulate

286 ate model of domain function while providing mechanistic insight that may have assisted in the domain

287 lysis for C-H functionalization and provides mechanistic insight that we anticipate will contribute t

288 irectionality of expression data provide new mechanistic insights that are consistent with a compensa

289 ere experimentally validated, thus providing mechanistic insights that are useful for future cancer r

290 ght the power of simulation to provide novel mechanistic insights that augment experimental studies a

291 ly undergoes regression after birth, to gain mechanistic insights that could be therapeutically adapt

292 We review mechanistic insights that have been revealed by structur

293 This model generates mechanistic insights that help in further experiments an

294 Besides providing mechanistic insights, these results have direct implicat

295 curate sequence classifiers thus contributes mechanistic insights to GWAS, a field thus far dominated

296 This work provides a mechanistic insight toward understanding the functional

297 We discuss the most recent data and mechanistic insights underlying these epidemiologic find

298 To gain further mechanistic insight, we studied mice under two complemen

299 To obtain mechanistic insights, we identified C19ORF57/BRME1 as a

300 However, mechanistic insights were limited because these effects