1 and motor circuits that can be interrogated
mechanistically.
2 Mechanistically,
6-4PPs, but not CPDs, impeded DNA repli
3 Mechanistically,
ACC2 iKO prevented HFD-induced downregu
4 Mechanistically,
Acvr1(G328V) upregulates transcription
5 Mechanistically,
afatinib treatment decreased CSC marker
6 Mechanistically,
AhR transcriptionally suppresses FoxM1
7 Mechanistically,
ALKBH5 exerts tumor-promoting effects i
8 Mechanistically,
alphaCD40/ICB primed durable T cell res
9 Mechanistically,
alphaKG decreases the accumulations of
10 Mechanistically,
AMD1 depletion induced loss of mitochon
11 Mechanistically,
AMPK localizes in the mitochondrial mat
12 Mechanistically,
AMPKalpha1 regulate the glutathione red
13 The activation and desensitization data were
mechanistically analyzed in the framework of a three-sta
14 Mechanistically,
Angpt2 activated integrin alpha5beta1 s
15 Mechanistically,
ARID1A interacted with EZH2 via its car
16 em cells, we show that this phenotype can be
mechanistically ascribed to increased levels of the cell
17 Mechanistically,
BAP1 regulates genomic stability, in a
18 Mechanistically,
BF(3).OEt(2) activates the isocyanide t
19 Mechanistically,
BGL3 is recruited to DNA double-strand
20 Mechanistically,
both the Ecm29 N-terminal domain and an
21 platin treatment, which is poorly understood
mechanistically but correlates with incidence and severi
22 Mechanistically,
butyrate induced small intestinal IL-10
23 Mechanistically,
butyrate suppresses levels of specific
24 Mechanistically,
CAF-CD73 expression is enhanced via an
25 provide strong support for studies aimed at
mechanistically characterizing the interaction between t
26 Mechanistically,
chronic T1D leads to glucolipotoxicity
27 Mechanistically,
CISH(-/-) iPSC-NK cells display improve
28 Mechanistically,
CLSY1 mediates the transcriptional repr
29 Mechanistically,
co-immunoprecipitation studies reveal t
30 Mechanistically,
coculture experiments of tumor organoid
31 of photosystems using naturally diverse but
mechanistically complementary components can be achieved
32 However, how the brain
mechanistically coordinates neural communication to impl
33 Mechanistically,
Cosmc-deficient B cells have normal rol
34 ere adhesive and cytoskeletal components are
mechanistically coupled by an IQGAP1-CLIP170 complex.
35 e reduction and water molecules that connect
mechanistically crucial elements and constitute proton-t
36 Mechanistically,
CXorf67 interacts with PALB2 and inhibi
37 Mechanistically,
decorin increased the VEGFA clearance r
38 Mechanistically,
depletion of Snf2h results in dysregula
39 Mechanistically,
DEPTOR depletion not only activated bot
40 ocess was often observed in competition with
mechanistically distinct C-H insertion into a tetrahydro
41 ant successfully determines the magnitude of
mechanistically distinct catabolic pathways that ensure
42 ovascularization can arise from a second and
mechanistically distinct cause.
43 gous recombination (HR) DNA repair, which is
mechanistically distinct from Ino80 function in YY1-asso
44 This scaling growth is
mechanistically distinct from synaptic plasticity driven
45 -exacerbated respiratory disease (AERD) is a
mechanistically distinct subtype of chronic rhinosinusit
46 nism but is instead brought about in several
mechanistically distinct ways.
47 in, we report a one-pot process that marries
mechanistically distinct, traditional cross-coupling rea
48 ent to the identification of a conserved yet
mechanistically divergent ESCRT-mediated lentivirus budd
49 This work details the
mechanistically-
driven development of an electrochemical
50 Mechanistically,
DZIP3 utilized its two different domain
51 Mechanistically,
E-Syt2S, the predominant isoform of E-S
52 Mechanistically,
EHMT2 impacted Sp1 and p300 enrichment
53 Mechanistically,
EMD eliminated c-Myc in the cells and i
54 Mechanistically,
EPN3 drives breast tumorigenesis by inc
55 adenosyl-l-ethionine (SAE) and show SAE is a
mechanistically-
equivalent SAM-alternative for HydG, bot
56 e 1960s, this step has been considered to be
mechanistically essential based on studies of the IGPS-p
57 Mechanistically,
fatty acids and oxygen are distinct sig
58 Mechanistically,
fetal GC exposure increased GC receptor
59 Mechanistically,
FGF4-ERK1/2-RSK signalling inhibits EPH
60 Mechanistically,
Fzr interacts with chromatin-associated
61 Mechanistically,
GABPB1-AS1 acted as a competing endogen
62 Mechanistically,
GATA6 directly activates key regulators
63 Mechanistically,
Gdown1 is associated with elongating Po
64 Mechanistically,
Gish restricts JNK activation by phosph
65 Mechanistically GLP-2 substitution promoted regeneration
66 Mechanistically,
glucocorticoids together with IL-12, IL
67 Mechanistically,
glucose uptake via GLUT (glucose transp
68 Mechanistically,
GPX4 inactivation increased production
69 Mechanistically,
HDAC3 directly binds to Pparg enhancers
70 Mechanistically,
higher Abeta42 reduced endothelial NO s
71 he SNORC protein biochemical properties, and
mechanistically how the gene is regulated transcriptiona
72 Mechanistically,
HSV-1 replication after viral entry dep
73 Mechanistically,
Htl regulates the activity of Rho/Rac G
74 Mechanistically,
Hvcn1 deficiency delayed endosomal acid
75 Mechanistically,
IGF2BP1 interacted with the mRNA of the
76 Mechanistically,
IL-33 triggered calcium influx via a no
77 Mechanistically,
IL6 diminished engraftment of FoxP3(+)
78 le to that of the target, many intuitive yet
mechanistically important issues can begin to be address
79 Mechanistically,
in the absence of Tet2 and Tet3, downre
80 Mechanistically,
in vivo aPC generation was higher with
81 Mechanistically,
in vivo in BMP9/10ib mouse ECs, sirolim
82 Mechanistically,
increased endothelin-1 levels were dete
83 ular catabolism of endothelial VEGFA that is
mechanistically independent of mTOR, but requires an aut
84 The physiological changes were
mechanistically independent of protein synthesis but sen
85 Mechanistically,
induction of kidney NLRP3 inflammasome
86 , as well as in mice fed with high-fat chow;
mechanistically,
inflammasome-activating short intersper
87 onset, which may support the development of
mechanistically informed early interventions for psychos
88 Mechanistically,
interference with HDAC1/-2 elicited a s
89 of a rodent SN would provide the ability to
mechanistically interrogate this network in preclinical
90 Mechanistically,
IRAK1 induced PTB in the mouse model of
91 Mechanistically,
IRAK2 suppressed respiratory super-comp
92 Mechanistically,
iron chelation-induced mTORC1 inhibitio
93 Mechanistically,
JAM-A promoted C/EBP-alpha expression t
94 Mechanistically,
KDM4C regulates ALKBH5 expression via i
95 Mechanistically,
KDM5B governed PI3K/AKT signaling in pr
96 Mechanistically,
Klf5 deacetylation activates Notch sign
97 Mechanistically,
Kras(G12D)-RAC1 activation induces reac
98 nt) and is a first-step towards representing
mechanistically leaf ontogenetic processes into physiolo
99 rough its posttranslational modification, 3)
mechanistically link diabetes, which frequently activate
100 These data provide additional clues to
mechanistically link nutrient excess to adipose insulin
101 findings indicate that CIC dysregulation is
mechanistically linked and restricted to specific cancer
102 nt evolution of DNA binding capabilities are
mechanistically linked to methylation variability in mam
103 ial compartments that are at least partially
mechanistically linked to the powerful BDNF-TrkB neurotr
104 data highlights a novel signaling axis that
mechanistically links CBS with mitochondrial function an
105 Mechanistically,
lipids stored in lung neutrophils are t
106 Mechanistically,
lnc-IL7R mediated a repressive chromati
107 Mechanistically,
lncRNA-MAP3K4 regulates inflammation th
108 Mechanistically,
loss of mDia2 disrupts HSPC polarizatio
109 Mechanistically,
loss or inhibition of MLK3 down-regulat
110 Mechanistically,
LRG1 mediates NETosis in an Akt-depende
111 Mechanistically,
LRP4 promotes Abeta uptake by astrocyte
112 Mechanistically,
LRRC31 interacts with Ku70/Ku80 and the
113 Mechanistically,
m(6)A-deficient virion RNA induces high
114 Mechanistically,
MAARS knockdown alters HuR cytosolic sh
115 Mechanistically,
macroH2A1.2 counteracts its structurall
116 Mechanistically,
Malat1 regulates IL-10 through enhancin
117 Mechanistically,
MANF knockdown in cultured neonatal rat
118 Mechanistically,
MAOA enhances IL-6 transcription throug
119 Mechanistically,
MASTL associated with MRTF-A and increa
120 Mechanistically,
Mdm4 interacts with members of the Poly
121 Mechanistically,
MEK5 downregulation impairs phosphoryla
122 Mechanistically,
Mettl3 or Mettl14 loss promoted IFN-gam
123 Mechanistically,
mice expressing human Nox5 in endotheli
124 Mechanistically,
miR-142 directly targets Tgfbr1 for rep
125 Mechanistically,
miR-15a/16-1 translationally represses
126 Mechanistically,
miR-26a in beta cells enhances peripher
127 Mechanistically,
miR-344 is activated by DUX and post-tr
128 Mechanistically,
mitochondria aggregate and depolarize a
129 Mechanistically,
MLL1-mediated epigenetic alterations in
130 Mechanistically,
MOF/FAO inhibition acts through reducin
131 Mechanistically,
Mst1 enforces iNKT cellular and transcr
132 Mechanistically,
myeloid cell-derived angiogenin promote
133 Mechanistically,
NEIL3 is recruited to psoralen-ICL in a
134 Mechanistically,
nervonic acid supplementation increased
135 Mechanistically,
NETs triggered by SARS-CoV-2 depend on
136 Mechanistically,
neutrophils induce iron-dependent accum
137 s s-isomer, Esketamine (Spravato), the first
mechanistically new treatment for depression in over 60
138 Mechanistically,
newly generated, circulating neutrophil
139 ological 2-AG augmentation could represent a
mechanistically novel therapeutic approach for the treat
140 nt to which current lead compounds represent
mechanistically novel, extremely G protein-biased agonis
141 Mechanistically,
NRP1 cell-intrinsically limited the sel
142 Mechanistically,
nuclear YAP/TAZ interact with Groucho/T
143 Mechanistically,
our data show that G9a-derived dimethyl
144 Mechanistically,
our data strongly suggest that reactive
145 Mechanistically,
PADI4 inhibition resulted in a widespre
146 Mechanistically,
Pak1 phosphorylates the Mid1 N-terminus
147 lie the inflammatory response in obesity and
mechanistically participate in the beta-cell hyperplasia
148 Mechanistically,
PAX2 and tamoxifen coexert an antitumor
149 Mechanistically,
persistent CM proliferation required bo
150 Mechanistically,
persistent upregulation of the HBP trig
151 Mechanistically,
PGAM5 is required for mitochondrial fis
152 Mechanistically,
PGM3 inhibition, reducing protein glyco
153 Mechanistically,
PHD1 interacts with and stabilizes LRS.
154 Mechanistically,
phenformin induces the nuclear transloc
155 Mechanistically,
Phf21b targets the regulatory regions o
156 Mechanistically,
phosphoproteomics identify an ITGA2-dep
157 Mechanistically,
phosphorylation of JMJD3 at Thr-1044 by
158 Mechanistically,
PI3K/Akt-mediated SRF activation promot
159 Mechanistically,
PKM2 translocates into the nucleus and
160 Mechanistically,
PP2A-Cdc55 ceramide-activated phosphata
161 Mechanistically,
PRDM15 regulates a transcriptional prog
162 OC models; as a result, we are challenged to
mechanistically predict how environmental change will im
163 e amount of SNCA mRNA loaded into polysomes,
mechanistically providing a cytoprotective effect in cel
164 Mechanistically,
pyruvate uptake through Mct2 supported
165 ase' of ALS is crucial in the development of
mechanistically rationalized therapies.
166 Mechanistically,
REDD1 loss triggers HIF-dependent activ
167 This study paves the way for
mechanistically related biomarkers needed for early inte
168 aged us to test this optimal catalyst in the
mechanistically related Friedel-Crafts alkylation of ind
169 Levels of zinc, along with its
mechanistically related metabolites citrate and aspartat
170 signaling, such as Alagille syndrome, maybe
mechanistically related to ciliopathies.
171 Here, we assess
mechanistically relevant features of pericentric heteroc
172 ion-based studies we show that these effects
mechanistically rely on HUalphaalpha promiscuity in form
173 Mechanistically,
RNA sequencing revealed that RvD1 induc
174 Mechanistically,
RNF168 overexpression recruited RAD18 t
175 Mechanistically,
ROS promoted uncoupling protein 2 (UCP2
176 We show,
mechanistically,
SAGA signaling regulates the compositio
177 Mechanistically,
SARS-CoV-2 restriction occurred indepen
178 Mechanistically,
secretion of exosomes by these spheres
179 leophilic aromatic substitution, providing a
mechanistically selective and irreversible scaffold for
180 Methanol formation is
mechanistically separated from the formation of coproduc
181 We
mechanistically show that Pkm2 regulates the cardiomyocy
182 TSs
mechanistically showed a transient increase in prolifera
183 Mechanistically,
Shp deletion in hepatocytes activated N
184 naked mole rats (NMRs), and bats possess two
mechanistically similar systems to prevent the generatio
185 Mechanistically,
single-cell RNA-sequencing analyses of
186 Mechanistically,
SNX5 interacts with beclin 1 and ATG14-
187 Mechanistically,
Spata2 recruits the deubiquitinase CYLD
188 Mechanistically,
SRC-2-bound AR formed a repressive comp
189 Mechanistically,
stimulation of specific bone marrow cel
190 Mechanistically studying such multiscale processes in th
191 Mechanistically,
STXBP4 assembles a protein complex comp
192 Mechanistically,
Tak1 activation leads to increased inte
193 Mechanistically,
talin1 was required for the formation o
194 Mechanistically,
TALP-3 and ANKR-26 form a complex with
195 To guide the development of novel,
mechanistically targeted treatments to better resolve OC
196 Mechanistically,
targeting EZH2 promotes transition from
197 Mechanistically,
TCR ligation leads to clathrin-mediated
198 Mechanistically,
the apoptotic metabolite secretome is n
199 Mechanistically,
the CagA-ASPP2 interaction is a key eve
200 Mechanistically,
the cell killing effects of PP were a r
201 Mechanistically,
the Csk-recruiting ITAM of CD3epsilon r
202 Mechanistically,
the dehydrogenation of secondary alcoho
203 Mechanistically,
the failure of neurovascular coupling i
204 Mechanistically,
the function of lincNORS requires the p
205 Mechanistically,
the introduction of a second IQ domain
206 Mechanistically,
the motif stringency of XBP1s promoter
207 Mechanistically,
the presence of 6mA could repress DNA b
208 Mechanistically,
the pro-proliferative effects of LYCAT
209 Mechanistically,
the proline-rich motif-mediated interac
210 Mechanistically,
the reaction starts with a condensation
211 Mechanistically,
the reduced fibrosis and nintedanib res
212 Mechanistically,
the severe DNA damages induced by uPtDs
213 Mechanistically,
the tumour-suppressive effects of mutan
214 How
mechanistically these proteins function together to prim
215 Mechanistically,
this information transfer is thought to
216 Mechanistically,
this is because p53 regulates expressio
217 Mechanistically,
this is due to increasing oxidative str
218 Mechanistically,
this is the first report describing the
219 Mechanistically,
this LD accumulation during aging is no
220 Mechanistically,
this phenotype is ascribed to nuclear t
221 Mechanistically,
this response involves src-homology pho
222 Mechanistically,
this was explained in neonatal mice, in
223 Mechanistically,
through OCA-B-MED1 interactions, this c
224 Mechanistically,
TIMP1 loss reprograms the senescence-as
225 Mechanistically,
Tir clustering triggers rapid Ca2+ infl
226 Mechanistically,
TMEM173 binding to ITPR1 controls calci
227 Mechanistically,
Tn/STn antigens impair homo-oligomeriza
228 Mechanistically,
TNF-alpha and IFN-gamma co-treatment ac
229 Mechanistically,
TOPBP1 recruitment is mediated by phosp
230 Mechanistically,
transactivation of miR-802 by aromatic
231 Mechanistically,
tumor-derived prostaglandin E2 (PGE2) a
232 Mechanistically,
tumour cells avidly consumed methionine
233 Mechanistically,
unbiased RNA sequencing and single-cell
234 However, it is
mechanistically unclear how germinal center (GC) B cells
235 cal for crossover resolution, which involves
mechanistically unclear interplay between MutLgamma and
236 Given the protective, but
mechanistically unclear role of steroid hormones in fema
237 which prion propagation and toxicity can be
mechanistically uncoupled.
238 ge asymmetry" are local in nature and can be
mechanistically understood, for instance, from the degre
239 energy- and TonB-dependent, but otherwise a
mechanistically undetermined process involving its inter
240 Mechanistically,
USP36 is deubiquitinated following DNA
241 Mechanistically,
visceral fat maintains a high level of
242 4-deficient macrophages as well as by PGE(2)
Mechanistically,
WDFY1 was involved in Toll-like recepto
243 Mechanistically we demonstrate that FAK-depletion in CAF
244 Mechanistically we found that TFEB regulates the secreti
245 Mechanistically,
we define a signaling axis linking PIM1
246 Mechanistically,
we demonstrate that ABCB5 blockade inhi
247 Mechanistically,
we demonstrate that APP-103 exerts prot
248 Mechanistically,
we demonstrate that BB0270 localizes at
249 Mechanistically,
we demonstrate that glutamine deficienc
250 Mechanistically,
we determined that nitrate induces thes
251 Mechanistically,
we discovered that K270A mutation disru
252 Mechanistically,
we discovered that the epithelial-speci
253 Mechanistically,
we establish that both tamoxifen and fu
254 Mechanistically,
we established that enriched conditioni
255 Mechanistically,
we find that androgens suppress CDCP1 e
256 Mechanistically,
we find that glutamine supplementation
257 Mechanistically,
we find that loss of the Elf5-regulated
258 Mechanistically,
we find that phosphorylation of serine-
259 Mechanistically,
we find that WNT11-FZD7-DAAM1 activates
260 Mechanistically,
we find the stress-responsive p38 MAPK-
261 Mechanistically,
we find Zbtb11 facilitates the recruitm
262 Mechanistically,
we found evidence that adipocyte death
263 Mechanistically,
we found that a cytosolic pool of human
264 Mechanistically,
we found that ABHD5 elevates intracellu
265 Mechanistically,
we found that ALK expression in hypotha
266 Mechanistically,
we found that CAMK4 phosphorylates GSK3
267 Mechanistically,
we found that CD177-deficiency is assoc
268 Mechanistically,
we found that cells that exclusively ex
269 nt PCa to the drug both in vitro and in vivo
Mechanistically,
we found that EPHB4 stimulates the AR b
270 Mechanistically,
we found that in the absence of BD(L),
271 Mechanistically,
we found that RGS12 associated with pho
272 Mechanistically,
we found that the B55alpha/PP2A complex
273 Mechanistically,
we found that the increased ULBP2/5 exp
274 Mechanistically,
we have identified FOXO3 as a key downs
275 Mechanistically,
we identified PTEN as a putative PRL2 s
276 Mechanistically,
we identify ATF3 as the factor transcri
277 Mechanistically,
we observed elevated AMPK activity and
278 Mechanistically,
we observed that TICAM2 is involved in
279 Mechanistically,
we propose that the HS immobilizes secr
280 Mechanistically,
we provide evidence that the spliced fo
281 Mechanistically,
we report here that alpha-synuclein pre
282 Mechanistically,
we show a pivotal role for ESRRB in reg
283 Mechanistically,
we show that acetate enhances innate im
284 Mechanistically,
we show that ectopic YAP expression inh
285 Mechanistically,
we show that ERK2 binds Shank3 and phos
286 Mechanistically,
we show that knockdown of GPRC5B increa
287 Mechanistically,
we show that mTOR and its positive regu
288 Mechanistically,
we show that P130Cas mediates Bmp2b-ind
289 Mechanistically,
we show that RUNX1 is a component of th
290 Mechanistically,
we show that the altered antibody glyco
291 Mechanistically,
we show that the disruption of mitochon
292 Mechanistically,
we show that these bystander T cells ex
293 Mechanistically,
we showed that Yap/Taz mutant bile duct
294 Mechanistically,
we suggest that SIRT1 promotes progress
295 The method thus described constitutes a
mechanistically well-defined and operationally robust ma
296 Mechanistically,
Wing2 mutations display increased chrom
297 Mechanistically,
WT HNF-1beta recruits the polycomb-repr
298 Mechanistically,
YTHDF3 enhances the translation of m(6)
299 Mechanistically,
ZL0580 inhibits Tat transactivation in
300 Mechanistically,
ZNF367 interacted with chromatin remode