ライフサイエンスコーパス: mechanosensation

1 r membrane through processes referred to as "mechanosensation".

2 his active tension is essential for cellular mechanosensation.

3 ntify a role for integrin signaling genes in mechanosensation.

4 ith the myocardial Z-disk, playing a role in mechanosensation.

5 is important in metazoan cell migration and mechanosensation.

6 r TRP proteins simply play indirect roles in mechanosensation.

7 understanding how TRP channels contribute to mechanosensation.

8 odulate chemosensation, thermosensation, and mechanosensation.

9 t formation is not simply caused by impaired mechanosensation.

10 brain injury, whereas ASIC2a is involved in mechanosensation.

11 ntral nervous system regions associated with mechanosensation.

12 nt defects in peripheral thermosensation and mechanosensation.

13 ave a function in noxious cold sensation and mechanosensation.

14 n viability, cell-to-cell communication, and mechanosensation.

15 echanoreceptors, such as integrins, initiate mechanosensation.

16 ide variety of receptor cells, especially in mechanosensation.

17 the contribution of ASIC3 to nociception and mechanosensation.

18 t implications for mammalian nociception and mechanosensation.

19 family perform diverse functions, including mechanosensation.

20 le is known of molecular mechanisms of human mechanosensation.

21 nnel proteins in the process of gentle touch mechanosensation.

22 le is known about the molecular machinery of mechanosensation.

23 of temperature to modify taste sensation and mechanosensation.

24 ated in touch sensitivity and other forms of mechanosensation.

25 hat PPK may be a channel subunit involved in mechanosensation.

26 likely functioning as heteromers to mediate mechanosensation.

27 nano-pockets of ion channels is linked with mechanosensation.

28 echanisms of mRNA export, NPC biogenesis and mechanosensation.

29 short isoform functions in olfaction but not mechanosensation.

30 propriate compensatory responses to vascular mechanosensation.

31 ding ion channel-delimited processes such as mechanosensation.

32 s, myocardial fibrosis and regeneration, and mechanosensation.

33 sponsible for chemosensation, olfaction, and mechanosensation.

34 glia and accessory cells play a key role in mechanosensation.

35 ladder stretch is a key modulator of bladder mechanosensation.

36 Neither is sufficient for mechanosensation.

37 ranging from cell and organelle motility to mechanosensation.

38 ssociated lipids have distinct roles in MscS mechanosensation.

39 moreover, are crucial for an aspect of lung mechanosensation.

40 a mechanism for a specific effect of DBI on mechanosensation.

41 philic irritants, as well as cold, heat, and mechanosensation.

42 1 and the adjacent sensory neurons conveying mechanosensation.

43 evealing an unexpected function of nAChRs in mechanosensation.

44 or currents, the initiating step of cellular mechanosensation.

45 ermine whether Piezo2 is involved in EC cell mechanosensation.

46 lity most tightly linked to motor control is mechanosensation.

47 hanism for innate defensive behavior through mechanosensation.

48 hysical properties and queried their role in mechanosensation.

49 vel way in which Merkel cells participate in mechanosensation.

50 ng a specific role for UNC-7 hemichannels in mechanosensation.

51 worms that have defects in head movement or mechanosensation.

52 ironment, and therefore exhibits features of mechanosensation.

53 proximity, independent of genes required for mechanosensation.

54 hannel(s) must account for noxious (painful) mechanosensation.

55 in line with its proposed functional role in mechanosensation.

56 cient transport but can also be employed for mechanosensation.

57 nsor, implicating them directly in inner ear mechanosensation.

58 nt of the fly chordotonal organs and mediate mechanosensation.

59 ns, especially membrane proteins involved in mechanosensation.

60 CNQ4), which is involved in both hearing and mechanosensation.

61 age-dependent ion channels to play a role in mechanosensation.

62 n, cell shape regulation, contractility, and mechanosensation.

63 ally found in the TRNs, is not essential for mechanosensation.

64 haviors of the myosin II accumulation during mechanosensation.

65 not required for sensory neuron survival or mechanosensation.

66 ar stress sensing represents a vital mode of mechanosensation.(1) Previous efforts have mainly focuse

67 nd on the 'force-from-lipids' model for MscS mechanosensation(4,11).

68 rchetypal example in this regard is cellular mechanosensation, a process by which mechanical forces a

69 which is thought to be responsible for their mechanosensation ability, also spontaneously generating

70 nsive range of cellular functions, including mechanosensation, acid sensation and synaptic modulation

71 We explored how mechanosensation affords exquisite awareness of the geni

72 genetic and molecular dissection of auditory mechanosensation and auditory behavior.

73 act is crucial for elucidating mechanisms of mechanosensation and cellular homeostasis.

74 esulting in behavior defects associated with mechanosensation and chemosensation.

75 eveloped to examine links between integrins' mechanosensation and effects on mechanotransduction, ECM

76 annel that plays a major role in light-touch mechanosensation and has recently been identified as the

77 Here, we discuss recent progress in noxious mechanosensation and highlight new behavioral methods to

78 amine P2X(3) receptor contributions to colon mechanosensation and hypersensitivity, electrophysiologi

79 e Caenorhabditis elegans are central to both mechanosensation and locomotion.

80 e show that plexin D1 (PLXND1) has a role in mechanosensation and mechanically induced disease pathog

81 Impaired mechanosensation and mechanotransduction associated with

82 precise molecular mechanisms underlying both mechanosensation and mechanotransduction in late-osteobl

83 ant role of nuclear pore protein in cellular mechanosensation and metastasis.

84 echanism by which opioids modulate cutaneous mechanosensation and provide a rationale for targeting D

85 expressed in the inhibitory pathway linking mechanosensation and pumping activity.

86 n the cilium, cell-cycle, and cilia-mediated mechanosensation and signaling activity will hopefully p

87 g concepts in podocyte biology, particularly mechanosensation and signaling at the slit diaphragm.

88 to ion channel activity, a prerequisite for mechanosensation and the integrity of the kidney filtrat

89 lion (DRG) neurons play an important role in mechanosensation and thermal hypersensitivity; however,

90 of skin, suggesting it might participate in mechanosensation and/or acid-evoked nociception.

91 duction, including olfaction, osmosensation, mechanosensation, and chemosensation.

92 TAT is important in neuronal polarity and mechanosensation, and decreased tubulin acetylation leve

93 y accelerated reinnervation, the recovery of mechanosensation, and epithelial wound healing.

94 regulation, nociception, neuronal function, mechanosensation, and even defaecation.

95 to socially aggregate [3, 4] and use vision, mechanosensation, and gustation to recognize each other

96 physiological processes such as nociception, mechanosensation, and learning-memory, and in the pathol

97 ons of ASICs in mammals include nociception, mechanosensation, and modulation of synaptic transmissio

98 pore domain (K2P) K(+) channel important for mechanosensation, and recent studies have shown how incr

99 , the two species differ in sweet sensation, mechanosensation, and their integration, which are all l

100 Mechanisms of cellular and nuclear mechanosensation are unclear, partially because of a lac

101 de the host, thus opening the exploration of mechanosensation as a prerequisite for protozoan infecti

102 ogical friction, we propose a model for cell mechanosensation as opposed to previous more biochemical

103 mplexes involved in structural integrity and mechanosensation, as well as cell signaling.

104 l activity in lamina III and IV and impaired mechanosensation associated with light touch.

105 tations in tmc1, tmc2a, and tmc2b on in vivo mechanosensation at the onset of hearing and balance, be

106 lls acquire apical stereociliary bundles for mechanosensation, basolateral ion channels that shape re

107 Our findings demonstrate that deviations of mechanosensation behaviors of VSMC is detrimental for AA

108 d to unexpected insights into other types of mechanosensation beyond the skin.

109 TRP family channels have been implicated in mechanosensation, but none have been demonstrated to for

110 ell type evolved to allow for fine-tuning of mechanosensation by light.

111 Mechanosensation - by which mechanical stimuli are conve

112 Finding that texture mechanosensation can modulate longevity suggests a role

113 ortant physiological roles in osmosensation, mechanosensation, cell barrier formation, and bone homeo

114 s that have diverse cellular roles including mechanosensation, cell-fate determination, neurodevelopm

115 nesis, cell disorientation caused by loss of mechanosensation could be a pathogenic mechanism for oth

116 ophysiological activity, resulting in larval mechanosensation defects.

117 We show that mechanosensation dominates in the larval peripheral nerv

118 we uncovered a central role for kinocilia in mechanosensation during development.

119 s acts as a mechanostat to modulate cellular mechanosensation during differentiation.

120 es two TMCs (TMC-1 and TMC-2), which mediate mechanosensation, egg laying, and alkaline sensing.

121 orchestrated cellular behaviors required for mechanosensation, embryogenesis, and physiological contr

122 tallisation, has provided a new paradigm for mechanosensation, enabling a deeper understanding of the

123 Despite the potential importance of genital mechanosensation for sexual reproduction, little is know

124 ets, but the biophysical mechanisms coupling mechanosensation, growth, and branching are not fully un

125 Aberrant mechanosensation has an important role in different pain

126 ng molecules and wiring patterns involved in mechanosensation has been dramatic over the past few yea

127 Mechanosensation has been studied for decades, but under

128 Among sensory modalities, mechanosensation has been the most elusive with regard t

129 logenetic framework, we show that peripheral mechanosensation has evolved with limb biomechanics, evo

130 Molecules required for mechanosensation have been identified from invertebrate

131 a number of intriguing mutants defective in mechanosensation have recently been described.

132 s of sensory perception, thermosensation and mechanosensation, highlighting pathways whose perturbati

133 We conclude that mechanosensation, if it originates in primary cilia, is

134 ealistic membrane models for the analysis of mechanosensation in a continuum mechanics framework.

135 ave yielded fundamental insights relevant to mechanosensation in all animals, and also to point out h

136 , several of which have been associated with mechanosensation in animals.

137 In the case of mechanosensation in aquatic animals, the exafferent inpu

138 In order to demonstrate mechanosensation in artificial cells, we develop a novel

139 l for gating cation permeation and executing mechanosensation in B cells upon antigen stimulation.

140 pou4-2 RNAi resulted in impaired mechanosensation in both uninjured and regenerating plan

141 teins, which are required for TMC-1-mediated mechanosensation in C. elegans OLQ neurons and body wall

142 sion could explain cell tension response and mechanosensation in different environments.

143 annel has a role in both hearing and bristle mechanosensation in fruit flies and in proprioception in

144 e use of Yvc1p as a molecular model to study mechanosensation in general is discussed.

145 results show that PIEZO2 is a determinant of mechanosensation in humans.

146 onstrate a physiological role for PIEZO1 and mechanosensation in immunity.

147 Here, we review our current understanding of mechanosensation in insects and its role in adaptive mot

148 While the ubiquity of mechanosensation in living cells is evident, the ion cha

149 Piezo channels have a physiological role in mechanosensation in mammals.

150 is a stretch-gated ion channel required for mechanosensation in many organ systems.

151 Mechanosensation in many organs (e.g. lungs, heart, gut)

152 by mechanical tension are thought to mediate mechanosensation in many systems.

153 as been shown to be essential for aspects of mechanosensation in model organisms.

154 iquitous and diverse, the molecular bases of mechanosensation in most cases remain mysterious MscL, a

155 these findings, mammalian mTMC1 can mediate mechanosensation in nematodes, while mTMC3 can mediate a

156 rimary cilia function may also shed light on mechanosensation in other organ systems.

157 uding insulin-stimulated transport of GLUT4, mechanosensation in sensory hair cells, endocytosis, tra

158 A new study has revealed a role for mechanosensation in shaping social avoidance responses i

159 thermore, we demonstrate stiffness-dependent mechanosensation in stem cells cultured on customized gr

160 Their role in mechanosensation in the animal kingdom, identified by ge

161 ASICs have also been implicated in mechanosensation in the peripheral nervous system and in

162 dout of polycystin function and that loss of mechanosensation in the renal tubular epithelia is a fea

163 been suggested to contribute to thermal and mechanosensation in the tooth via expression of transien

164 els, which together are necessary for normal mechanosensation in the worm.

165 tudies have shown the importance of antennal mechanosensation in various aspects of insect flight con

166 a calcium transporter relevant for auditory mechanosensation in vertebrates.

167 th muscle cell differentiation, adhesion and mechanosensation in vitro.

168 Amiloride and gadolinium, which block mechanosensation in vivo, inhibited RPK channels.

169 These findings support a model of mechanosensation in which the activities of Abeta-, Adel

170 d system in fact broadly regulates cutaneous mechanosensation, including touch.

171 long isoform completely rescues mec-8 mutant mechanosensation, indicating a single MEC-8 touch-neuron

172 it is still unclear how genetic programs and mechanosensation interact during heart valve development

173 licated in varied biologic functions such as mechanosensation, ion homeostasis, cell growth, and phos

174 Mechanosensation is a primitive and somewhat ubiquitous

175 Mechanosensation is central to a wide range of functions

176 Mechanosensation is emerging as a general principle of m

177 In bacteria, mechanosensation is mediated by the mechanosensitive cha

178 Mechanosensation is perhaps the last sensory modality no

179 sitivity to pain (CIP), whilst low threshold mechanosensation is reportedly normal.

180 Mechanosensation is the ability to detect dynamic mechan

181 Mechanosensation is unmatched in speed and its diverse r

182 For the mechanism of mechanosensation, it was hypothesized that load-induced

183 ted in perception of pain, ischaemic stroke, mechanosensation, learning and memory.

184 s the sensitivity of a specific component of mechanosensation: low-threshold rapidly adapting mechano

185 licit changes in adhesion complex stability, mechanosensation, matrix assembly, and migration, but th

186 well studied, the dynamic interplay between mechanosensation, mechanotransduction and cellular respo

187 We report that Piezo2-dependent mechanosensation mediates wet dog shakes evoked by water

188 Although previous data indicated that mechanosensation might contribute to hygrosensation, the

189 How do mechanosensation, nutrient consumption, and reproductive

190 d spinal cord and a significant reduction in mechanosensation occurs before detectable fibrillar tau

191 Mechanosensation of cells is an important prerequisite f

192 and cell-cycle-stage-specific control of the mechanosensation of myosin IIB, but not myosin IIA or II

193 anization (centrosomal function) but also in mechanosensation of urine flow (a primary ciliary functi

194 cyte to the microvasculature, and astrocytic mechanosensation of vascular changes.

195 nd distribution emphasizes the importance of mechanosensation on osteoblastic cell function in a 3D e

196 Mechanosensation, one of the fastest sensory modalities,

197 This flow-induced ciliary mechanosensation opens the calcium (Ca(2+)) channel poly

198 impaired thermoregulation but did not impair mechanosensation or beta-alanine itch-stimuli associated

199 approach devoid of unwanted abnormalities in mechanosensation or pain perception.

200 e direction of flow is sensed either through mechanosensation, or via the detection of chemical signa

201 elegans TRPV channels function in olfaction, mechanosensation, osmosensation, and activity-dependent

202 family serve diverse functions ranging from mechanosensation over Na(+) reabsorption to H(+) sensing

203 cently identified, but mechanisms underlying mechanosensation, particularly in vertebrate organisms,

204 the mechanotransducer Piezo is involved in a mechanosensation pathway in Drosophila nephrocytes, the

205 portunity to discern the respective roles of mechanosensation (perception and proprioception) and mec

206 The force-from-lipids hypothesis of cellular mechanosensation posits that membrane channels open and

207 ibe findings that implicate cardiac cilia in mechanosensation potentially linking haemodynamic and co

208 well-established roles in sight, smell, and mechanosensation, primary cilia are key participants in

209 cross-linking proteins observed in cellular mechanosensation, provided that a similar mechanism oper

210 It is not known how mechanosensation regulates physiological vs. pathologica

211 tential (TRP) channel NOMPC is important for mechanosensation-related behaviours such as locomotion,

212 A recent investigation shows that this mechanosensation relies on a force-sensitive mechanical

213 The functional role of the polycystins in mechanosensation remains largely unknown.

214 Mechanosensation requires the transduction of mechanical

215 ring development, liquid flow in the kidney, mechanosensation, sight, and smell.

216 TMCs bind other proteins essential for mechanosensation, suggesting a larger transduction compl

217 pathological processes such as nociception, mechanosensation, synaptic plasticity, and acidosis-medi

218 ribution includes a novel role for ASIC1a in mechanosensation that is not present in healthy rats.

219 a touch-transducing ion channel critical for mechanosensation that when hyperactivated by a mec-4(d)

220 Mechanosensation, the ability to detect mechanical force

221 Hearing and balance rely on mechanosensation, the fastest sensory signals transmitte

222 ous proteins, are thought to be important in mechanosensation, the process by which the cell senses a

223 Mechanosensation, the transduction of mechanical force i

224 Mechanosensation, the transduction of mechanical forces

225 eral genes encoding channels associated with mechanosensation, thermosensing or water transport.

226 mating computational parameters of gut-brain mechanosensation, these findings highlight a unique form

227 have become the current structural models of mechanosensation to atomic detail.

228 ic screens that allowed molecules needed for mechanosensation to be identified without any prior unde

229 r data define a central role of B-plexins in mechanosensation to couple cell density and cell divisio

230 biological processes ranging from chemo- and mechanosensation to signaling.

231 al activities, ranging from cell motility to mechanosensation to solute uptake.

232 ons, akin to shoaling, rely on vision, while mechanosensation underlies rapid in-phase movements and

233 The sensing of physical force, mechanosensation, underlies two of five human senses-tou

234 that Merkel cells have a role in vertebrate mechanosensation using Piezo2, particularly in shaping t

235 The mechanosensation via receptor unfolding may be applicabl

236 oles of the nucleus and ion channel-mediated mechanosensation, whether acting independently or in tan

237 We propose a membrane deformation model of mechanosensation, which posits that tension shifts the g

238 hanosensitive TMC, inhibits Piezo2-dependent mechanosensation, with implications for the importance o

239 a role for somatosensory neurons: Excessive mechanosensation within these neurons disrupts musculosk

240 ry plantar skin with restoration of punctate mechanosensation without hypersensitivity.