ライフサイエンスコーパス: mechanosensor

1 esponse to a mechanical stimulus are called "mechanosensors".

2 A acts as an autoinhibited force-activatable mechanosensor.

3 investigated whether polycystin-1 is a bone mechanosensor.

4 drite anchor may have evolved into part of a mechanosensor.

5 er of putative binding domains, may act as a mechanosensor.

6 indicated that it might be a part of such a mechanosensor.

7 egans, may be components of the baroreceptor mechanosensor.

8 positive (ER+) breast cancer and a cellular mechanosensor.

9 is independent of the filament as a possible mechanosensor.

10 ed receptor superfamily, also functions as a mechanosensor.

11 hich has a domain homologous to a eukaryotic mechanosensor.

12 esponse to stretch, indicating that APJ is a mechanosensor.

13 teractions, may be common to other candidate mechanosensors.

14 hair cell development and their function as mechanosensors.

15 ss the evidence supporting these proteins as mechanosensors.

16 pted by force seem more likely than singular mechanosensors.

17 s, and fungi are primary chemo-, thermo-, or mechanosensors.

18 alized bone matrix, are the primary skeletal mechanosensors.

19 hannels have been classified as a subtype of mechanosensors.

20 ling that is unique and independent of other mechanosensors.

21 increasing cell surface area, and acting as mechanosensors.

22 raction between individual integrin-mediated mechanosensors.

23 ignalling and suggest Spectrins as potential mechanosensors.

24 ins that have been independently proposed as mechanosensors.

25 ls and innervating afferents act together as mechanosensors.

26 arge conductance, is one of the best studied mechanosensors.

27 pears that stators themselves act as dynamic mechanosensors.

28 gle-headed myosin I molecule is an exquisite mechanosensor, able to sense strain over a very small fo

29 rthermore, it is currently impossible to use mechanosensor activity to drive gene expression.

30 k has been done to develop assays to monitor mechanosensor activity.

31 , our data imply the existence of sequential mechanosensor alphabetaTCR repertoire tuning via the pre

32 The nucleus has been implicated as a key mechanosensor and can directly influence chromatin organ

33 Here, we have investigated the mechanosensor and downstream signaling pathway that regu

34 It acts as a molecular spring and mechanosensor and has been linked to striated muscle dis

35 necessary and sufficient roles of Yap, a key mechanosensor and mechanotransducer, in biochemical sign

36 However, the mechanosensor and the molecular mechanisms by which auto

37 nes in epithelial cells and regulated by the mechanosensor and transcriptional co-activator Yes-assoc

38 c) One research focus is to identify various mechanosensors and decipher their downstream MCT pathway

39 r matrix adhesion area in the aggregation of mechanosensors and develop a theoretical model for the c

40 IRL exerts opposing effects on low-threshold mechanosensors and high-threshold nociceptors.

41 wo sensory modalities using data from insect mechanosensors and mammalian primary visual cortex.

42 tabolic changes in endothelial cells through mechanosensors and mechanosignal transduction pathways.

43 lect collaborative efforts involving several mechanosensors and mechanotransducers.

44 This review describes mechanosensors and mechanotransduction pathways associat

45 Despite this, the specific mechanosensors and mechanotransduction pathways involved

46 that normalize these abnormalities or block mechanosensors and mechanotransduction pathways.

47 f families are now candidates for eukaryotic mechanosensors and proprioception, as well as cardiovasc

48 pared with nonventilated CONCLUSIONS:: TRPV4 mechanosensors and purinergic receptors are involved in

49 How many of them are mechanosensors and quantitative relationships between te

50 ationship between the activation of specific mechanosensors and surface sensing.

51 ovide important clues to the location of the mechanosensors and the kinds of mechanical forces they c

52 al and functional evidence that filamins are mechanosensors and/or mechanotransducers playing essenti

53 The EC cell is a specialized mechanosensor, and it is well known that it releases 5-H

54 Myosin II and cortexillin I form the core mechanosensor, and mechanotransduction is mediated by IQ

55 Whether animal ion channels functioning as mechanosensors are directly activated by stretch force o

56 Mechanosensors are important for many life functions, in

57 have to be in a sensory capacity, perhaps as mechanosensors as hypothesised in two-cilia physical mod

58 hrough changes in the actin cytoskeleton and mechanosensors at focal adhesions, adherens junctions, a

59 ions, insects rely on feedback from antennal mechanosensors but it is not clear how these inputs comb

60 mains has been proposed to act as a cellular mechanosensor, but so far evidence linking their mechani

61 FAK has also been shown to act as a mechanosensor by modulating cell proliferation in respon

62 e is thought to depend on arrays of embedded mechanosensors called campaniform sensilla that are arra

63 ay originating from peripherally distributed mechanosensors can promote daytime sleep of flies Drosop

64 trophysiological techniques exist(1-3), most mechanosensors cannot access luminal structures non-inva

65 giotensin II-independent and mediated by the mechanosensor caveolae, as caveolin-1 (Cav1)-deficient e

66 tabilized, suggesting that multiple antennal mechanosensors contribute to flight regulation.

67 addition, the polar flagellum functions as a mechanosensor controlling lateral gene expression.

68 myogenic response, a vascular smooth muscle mechanosensor controls tone predominantly through alteri

69 dings suggest that the TCR is an anisotropic mechanosensor, converting mechanical energy into a bioch

70 A small set of mechanosensors, conveying strain information at key loca

71 model that accounts for the feedback between mechanosensors, cyclic-di-GMP signaling, and production

72 -kB pathway, possibly through a mechanism of mechanosensor de-activation.

73 hypothesis that polycystin-1 could act as a mechanosensor, detecting changes in fluid flow in the ki

74 The mechanosensors discussed here include integrins, Piezo c

75 asts is force-dependent, mediated by a novel mechanosensor domain located in the C-terminus of XIRP2.

76 g us to hypothesize that YAP/TAZ, as central mechanosensors, drive the functionality of agrin-MMP12 s

77 been suggested to function as an anisotropic mechanosensor during immune surveillance, converting mec

78 Our data reveal a novel mechanosensor/effector role for endogenous fibroblast S1

79 Cell surface and intracellular mechanosensors enable cells to perceive different geomet

80 into vinculin demonstrate that 13 % of this mechanosensor experiences forces >9.9 pN within focal ad

81 We report that primary cilia act as a mechanosensor for CMS-induced autophagy and identified a

82 sulfate proteoglycan glypican-1 is a primary mechanosensor for shear-induced NO production.

83 we demonstrated that immotile LRO cilia are mechanosensors for shear force using a methodological pi

84 air cells of the mammalian inner ear are the mechanosensors for the detection of sound and head movem

85 Hair cells are mechanosensors for the perception of sound, acceleration

86 Hair cells of the cochlea are mechanosensors for the perception of sound.

87 , an ion channel in a family that includes a mechanosensor from C. elegans, is shown by Lu et al. in

88 ich probably contribute, possibly via faulty mechanosensor function, to the development of manifest D

89 se components have been speculated to be the mechanosensor (FUSE) and effectors (FBP/FIR) of a real-t

90 osttranslational regulatory mechanism of the mechanosensor GrlA, whereby virulence gene expression ca

91 The identity of the mechanosensor has not been established.

92 Our analysis demonstrates that this mechanosensor has three critical elements: the myosin mo

93 noxious cold nociceptors and innocuous touch mechanosensors; high levels of activation drive cold-evo

94 This Ca(2+)-responsive mechanosensor hypothesis for primary cilia has been invo

95 nature of such mechanical stimulations, the mechanosensor identity, and how they interact with guida

96 of force application between pre-TCR and TCR mechanosensors, impacting signal initiation.

97 nnel conductance of the vertebrate hair-cell mechanosensor, implicating them directly in inner ear me

98 ed receptor-like protein that functions as a mechanosensor in a variety of cell types and is present

99 in is an actin cross-linker and may act as a mechanosensor in adhesion sites.

100 hat NOTCH1 is atheroprotective and acts as a mechanosensor in adult arteries, where it integrates res

101 ve multiple functions, including acting as a mechanosensor in bone (re)modeling.

102 Integrins are considered to be an important mechanosensor in cardiac myocytes.

103 r results establish a previously undescribed mechanosensor in endothelial cells that regulates cardio

104 PIEZO1, a mechanosensor in endothelial cells, plays a critical rol

105 ' sensor in Salmonella typhimurium, and as a mechanosensor in other bacteria.

106 se findings demonstrate Cav1 is an important mechanosensor in pressure-induced vascular and renal inf

107 Dysfunction of a mechanosensor in sensory neurons causes joint contractur

108 of-function mutations in PIEZO2, a principal mechanosensor in somatosensation, cause DA subtype 5 (DA

109 and identifies the AT1 cell as an important mechanosensor in the alveolar niche.

110 ponse suggests that the CRD is not a generic mechanosensor in this kinase family.

111 These findings reveal PIEZO1 as a crucial mechanosensor in trophoblasts and highlight its essentia

112 This study identifies PIEZO2 as a key mechanosensor in urinary function.

113 cytes have been hypothesized to be the major mechanosensors in bone.

114 ropose that paraspeckles may prove of use as mechanosensors in cancer mechanobiology.

115 rings that have the potential to function as mechanosensors in cells and as building blocks in spring

116 h as talin, vinculin and filamin function as mechanosensors in cells, but it has yet to be tested whe

117 Here, we show that Piezo1 channels act as mechanosensors in central nervous system capillaries.

118 sensing ion channel 3 (ASIC3) are peripheral mechanosensors in colon afferent neuronal fibers that me

119 anobiological processes, but also act as key mechanosensors in diverse functions including intracellu

120 been repurposed in eukaryotes to function as mechanosensors in multiple developmental and environment

121 Thus, mechanosensors in the enteric nervous system modulate or

122 a result, they have developed highly robust mechanosensors in the form of bacterial mechanosensitive

123 ity and selectivity, synchronization between mechanosensors in the mosquito arises from entrainment t

124 and polycystin-2 function as flow-sensitive mechanosensors in the same signal-transduction pathway.

125 an sense of touch is also array-based; using mechanosensors in the skin that differentiate surfaces b

126 r results suggest that podosomes are dynamic mechanosensors in which interactions of myosin tension a

127 ells (ECs) lining blood vessels express many mechanosensors, including platelet endothelial cell adhe

128 nction for neutral sphingomyelinase as a new mechanosensor initiating the ERK cascade and possibly ot

129 By incorporating these mechanosensors into multicellular spheroids, we capture

130 op a theoretical model for the clustering of mechanosensors into nascent focal adhesions on this cont

131 Here we examine the role of the mechanosensor ion channel PIEZO1 in this process.

132 ithin the extracellular domain of the Piezo1 mechanosensor ion channel.

133 However, the molecular identity of the mechanosensor is not known, nor is it clear whether mult

134 Li, and colleagues provide evidence that the mechanosensor is the transmembrane 63 (TMEM63) ion chann

135 LECs sense matrix stiffness through YAP/TAZ mechanosensors leading to the activation of their downst

136 and whether podosomes can function as direct mechanosensors, like focal adhesions [6-9].

137 The T cell receptor (TCR) is thought to be a mechanosensor, meaning that it transmits mechanical forc

138 uplex and i-motif structures, along with the mechanosensor mechanism for control of gene expression,

139 nally induced superhelicity in maintaining a mechanosensor mechanism for controlling the firing rate

140 We show that the mechanosensor Mid2 senses heat-induced membrane stretch

141 e a model for how information from different mechanosensors might be integrated to govern remodeling.

142 nclude with proposed criteria that bacterial mechanosensors must satisfy to successfully mediate surf

143 on identified nociceptors and low-threshold mechanosensors (non-nociceptors) isolated from rats.

144 sed by most large DRG neurons (low-threshold mechanosensors not involved in acid-induced nociception)

145 ogether, our studies reveal that Piezo1 is a mechanosensor of stiffness in macrophages, and that its

146 ng that the nucleus may also act as a direct mechanosensor of substratum topography.

147 formation, i.e. the flagellum is acting as a mechanosensor of surfaces.

148 MEM63 (DmTMEM63) ion channel as an intrinsic mechanosensor of the lysosome, a major degradative organ

149 They have been proposed to function as mechanosensors of cell wall stress induced by wall remod

150 Integrins are mechanosensors of shear stress in endothelial cells, and

151 r ear hair cells that function as biological mechanosensors of sound and acceleration.

152 enteroendocrine cells (EECs) are specialized mechanosensors of the gastrointestinal (GI) epithelium t

153 Exposure to intense sound can damage the mechanosensors of the inner ear and their afferent inner

154 However, mechanosensors of this class are restricted to ion chann

155 y from membrane to channel as in prokaryotic mechanosensors or are they mediated through macromolecul

156 of cell adhesion-related genes including the mechanosensor p66Shc.

157 ally, short interfering RNA-knockdown of the mechanosensor PECAM-1 reverses frequency-dependent regul

158 FN fibril assembly that was dependent on the mechanosensor PECAM.

159 in vivo approaches, we demonstrated that the mechanosensor Piezo1 in PMN plasmalemma induced spike-li

160 Herein, we establish that the mechanosensor Piezo1 is functionally expressed in cholin

161 We explored if the professional mechanosensor Piezo1 plays any role during integrin-depe

162 Activation of the mechanosensor Piezo1 with Yoda1 restored MLV function an

163 inhibits Epac1-mediated sensitization of the mechanosensor Piezo2 and that Piezo2 contributes to infl

164 iceptors, express the recently characterized mechanosensor Piezo2, an ion channel that endows cells w

165 of proteinuria and expression levels of the mechanosensor protein Filamin-B.

166 lar protein redistribution, we show that the mechanosensor protein, vinculin, is necessary and suffic

167 Mechanosensor proteins regulate the interaction of the c

168 oncept of the thick filament as a regulatory mechanosensor provides a novel explanation for the dynam

169 /30) that are rapidly adapting low threshold mechanosensors (RAR-like fibres).

170 e suggests that polycystin-1 (PC1) acts as a mechanosensor, receiving signals from the primary cilia,

171 that require more or less force to open the mechanosensor region demonstrate that filamin mechanosen

172 odel in which the opening and closing of the mechanosensor region regulates filamin binding to cellul

173 rowth and metabolism; however, the molecular mechanosensor remains unknown.

174 ise on a surface-adherent cell and how known mechanosensors respond to these stimuli.

175 Under shear flow, it acts as a mechanosensor responding with a size-dependent globule-s

176 However, the identity of the mechanosensor(s) in the kidneys and their physiological

177 e establish that tensin3 associates with the mechanosensors such as talin and vinculin.

178 romised assembly of the Myosin VI-E-cadherin mechanosensor that activates RhoA.

179 e we identify the B. subtilis flagellum as a mechanosensor that activates the DegS-DegU regulatory pa

180 tyrosine kinase SRC as a fibroblast-enriched mechanosensor that can be targeted selectively in stroma

181 system, evidence supports the AT1 R being a mechanosensor that contributes to arteriolar myogenic co

182 II and cortexillin I define a cellular-scale mechanosensor that controls cell shape during cytokinesi

183 PC1 is a mechanosensor that controls PC2, a Ca(2+)-permeable cati

184 nt secretion mechanisms, the identity of the mechanosensor that couples breathing to surfactant secre

185 tablish the adhesion receptor as a bona fide mechanosensor that directly senses and responds to the f

186 idence suggesting that PIEZO2 is a polymodal mechanosensor that engages different protein domains for

187 gether, these data implicate YAP1 as a fluid mechanosensor that functions to regulate genes that prom

188 These stimuli are detected by a mechanosensor that initiates a variety of signaling syst

189 animals CONCLUSION: PC-1 is a cardiomyocyte mechanosensor that is required for cardiac hypertrophy t

190 II and cortexillin I define a cellular-scale mechanosensor that monitors and corrects shape defects,

191 that the S1-S2 linker of Kv1.5 represents a mechanosensor that regulates the activity of this channe

192 the actin cross-linker cortexillin I form a mechanosensor that responds to mechanical stress, which

193 Piezo1 is an endothelial mechanosensor that senses hyperemia-associated forces.

194 MscL is a bacterial mechanosensor that serves as a biological emergency rele

195 as aeruginosa has been implicated as a novel mechanosensor that stimulates virulence in response to s

196 ical strain and the identity of the cellular mechanosensor that triggers subsequent responses.

197 s manner, neutrophils use focal adhesions as mechanosensors that convert shear stress-mediated tensil

198 aganglionic laminar endings (IGLEs; putative mechanosensors that coordinate peristalsis) and intramus

199 ive experimental techniques engage different mechanosensors that detect different local strain and st

200 indicate that Piezo1 channels are capillary mechanosensors that initiate crucial Ca(2+) signals and

201 identity of microvascular endothelial (MVE) mechanosensors that sense blood flow in response to mech

202 We speculate that platelet integrins are mechanosensors that test their ligands across the platel

203 Hair cells of the inner ear are mechanosensors that transduce mechanical forces arising

204 of the vertebrate inner ear are specialized mechanosensors that transduce mechanical forces arising

205 Here, we develop ultrasoft mechanosensors that visibly deform under less than 10 Pa

206 As a specialized mechanosensor, the EC cell releases this serotonin in re

207 as ion channels and focal adhesions as local mechanosensors, the investigation of how mechanical pert

208 They are mechanosensors through which cells exert actin cytoskele

209 ion with ERK1/2, calcium activation, and YAP mechanosensor, thus providing a mechanistic link between

210 nosensitive channel MscL is the best-studied mechanosensor, thus serving as a paradigm of how a prote

211 e mechanical forces (mechanosensing) through mechanosensors, thus triggering physiological responses

212 a indicate that the cilium can function as a mechanosensor to detect fluid flow through the lumen of

213 al activation of cardiac nNOS by acting as a mechanosensor to regulate AMPK activity, and that pharma

214 physical state of the lipid bilayer, driving mechanosensors to assume conformations better matched to

215 ells that line the vasculature use molecular mechanosensors to directly detect shear stress profiles

216 Here we introduce non-toxic ingestible mechanosensors to enable the quantitative study of lumin

217 ted muscle, harbors factors that function as mechanosensors to ensure coordinated contractile activit

218 from nociceptors to their SONs, but not from mechanosensors to the same SONs, which suggests striking

219 tyrosine kinases and integrins can serve as mechanosensors to transduce mechanical stimuli into chem

220 Type IV pili (TFP) function as mechanosensors to trigger acute virulence programs in Ps

221 kin, the molecular details that enable these mechanosensors to tune their responses over a vast dynam

222 f a role of lipidated signaling molecules as mechanosensors, transducing mechanical stimuli to chemic

223 independent of resistance upon blocking the mechanosensor TRPM7.

224 Like the alphabetaTCR, the pre-TCR is a mechanosensor undergoing force-based structural transiti

225 turnover of the IAC component Talin, a known mechanosensor, was analyzed using fluorescence recovery

226 Based on the idea that YAP/TAZ is a mechanosensor, we find that inhibiting myosin assembly a

227 although lacking osteocytes (i.e., internal mechanosensors), when loaded, medaka bones model in mech

228 this study implicate filamin-A as a tunable mechanosensor, where its sensitivity can be modulated by

229 vitro, we discovered that formin Cdc12 is a mechanosensor, whereby myosin pulling on formin-bound ac

230 MyoII acts as a mechanosensor, which directs its force-induced recruitme

231 The role of these mechanosensors within the interoceptive nervous system i

232 rformed on HF cardiac fibroblasts pointed at mechanosensor YAP as a key player in ECM remodeling in t

233 act between the SASP regulator GATA4 and the mechanosensor YAP on the expression of the Rho family of

234 changes in the microenvironment requires the mechanosensor YAP.

235 pressure activates RA signaling through the mechanosensor Yap.

236 deling through activation of actin-dependent mechanosensors Yes-associated protein (YAP) and myocardi