ライフサイエンスコーパス: medaka

1 (Centroptilum triangulifer), fish (Japanese medaka)).

2 i.e., the Clupeocephala lineage (zebrafish, medaka).

3 our understanding of the natural history of medaka.

4 was recently identified in another teleost, Medaka.

5 are used in fish species like zebrafish and medaka.

6 portant regulator of cystic proliferation in medaka.

7 ely low toxicity to mammalian cell lines and medaka.

8 ple proteins associated with eye function in medaka.

9 G, and fecundity measured in female Japanese medaka.

10 st to sex determination in zebrafish and the medaka.

11 n Danio species as well as distantly related medaka.

12 y which TACs can disrupt the thyroid axis in medaka.

13 the repertoire of genetic tools available in medaka.

14 NeuralPolish, Racon, MarginPolish, HELEN and Medaka.

15 bers in teleost fish such as stickleback and medaka.

16 cription among xmrk-transgenic and wild-type medaka.

17 erivate was confirmed in vivo in spiggin-gfp Medaka.

18 bility is not shared by another teleost, the medaka.

19 mutants to investigate gonadal dysgenesis in medaka.

20 ution, efflux rate, and maternal transfer in medaka.

21 n and choriogenin gene induction in the male medaka.

22 eta, generally recapitulated observations in medaka.

23 We investigated in medaka a possible meiotic function of RA during the embr

24 Aequorin-injected eggs of the medaka (a fresh water fish) show an explosive rise in fr

25 In medaka, a duplicate of dmrt1-acting as master sex-determ

26 elayed and reduced macrophage recruitment in medaka, along with delayed neutrophil clearance.

27 confirmed a conserved morphant phenotype in medaka and demonstrate a crucial role of noto and msgn1

28 The medaka and fugu TRs, when assembled with their telomeras

29 t/PK on telomerase reverse transcriptase for medaka and human is modeled based on the cryoEM structur

30 han other state-of-the-arts including Racon, Medaka and MarginPolish & HELEN.

31 function as Delta4 desaturases of Fads2 from medaka and Nile tilapia.

32 Moreover, medaka and other ricefishes exhibit striking functional

33 tes transcript stability of dmrt1 mRNAs from medaka and other vertebrates.

34 edgehog; the fish genomes of stickleback and medaka and the second example of the genomes of the sea

35 ed almost exclusively by osteocytes, in both medaka and zebrafish (a species with osteocytic bones),

36 Our systematic analysis of medaka and zebrafish demonstrates that in fish, the morp

37 how primary embryonic pluripotent cells from medaka and zebrafish efficiently assemble into anterior

38 ine (ABE) and cytosine base editors (CBE) in medaka and zebrafish to edit eye pigmentation genes and

39 ns are highly conserved in synteny blocks of medaka and zebrafish, indicating that the 3D genome arch

40 lomerulus are astoundingly different between medaka and zebrafish.

41 d for the Sec24d-deficient fish mutants vbi (medaka) and bulldog (zebrafish).

42 he mechanism between sex reversal and DMY in medaka, and suggested that XY(DMY-) medaka was a novel m

43 ved syntenies between catfish and zebrafish, medaka, and Tetraodon were established, but the overall

44 Interestingly, medaka appeared to rapidly shuttle Se to their eggs dire

45 neuromasts of the posterior lateral line in medaka are composed of two independent life-long lineage

46 Here, by using medaka as a model teleost, we successfully identify chol

47 utation produces Japanese gold-colored fish, medaka b, maps to the mouse underwhite locus.

48 i.e., internal mechanosensors), when loaded, medaka bones model in mechanically directed ways, succes

49 gamma-aminobutyric acid (GABA) levels in the medaka brain and disrupted the GABAergic system, as reve

50 (fertility, fecundity) by 7.3-57.4% in adult medaka breeding pairs, with hindrance of SSC development

51 meiosis induction and gametogenesis in adult medaka but contrary to common expectations, not for init

52 hat retain anterior pharyngeal teeth such as medaka but that medaka do not express the aldh1a2 RA-syn

53 rative genome analysis between zebrafish and medaka, common carp, grass carp, and goldfish to study t

54 ime that rather than being a single species, medaka comprises an entire species complex, so disentang

55 ve 5-iodouridines were incorporated into the medaka CR4/5 RNA fragment and UV cross-linked to the med

56 lation in non-mammalian species (Xenopus and medaka) despite their evolutionary divergence from mamma

57 quire pOKR like goldfish while zebrafish and medaka did not, demonstrating the cerebellum alone not t

58 ior pharyngeal teeth such as medaka but that medaka do not express the aldh1a2 RA-synthesizing enzyme

59 s, acid alpha-glucosidase from zebrafish and medaka does not appear to be modified with mannose 6-pho

60 conclude that the fertilization wave in the medaka egg is propagated by calcium-stimulated calcium r

61 sis of glycosidase activity in zebrafish and medaka eggs revealed selective deposition of enzymes req

62 ar and central nervous systems in developing medaka embryo through SNC-induced differential expressio

63 We treated medaka embryos at 12 h post fertilization with 50 muM Se

64 ) to be significantly more toxic to Japanese medaka embryos than 6-hydroxychrysene (6-OHCHR), an exam

65 To test this hypothesis, Japanese medaka embryos were treated with each isomer for 24 h du

66 o hatch and depleted glutathione in Japanese medaka embryos without affecting Se accumulation.

67 stimulating Toll-like receptor signaling in medaka enhanced immune cell dynamics and promoted neovas

68 ociated with differential activities of each medaka ER.

69 ively with preferential binding affinity for medaka ERbeta subtypes, which are highly expressed in ma

70 Results indicate that all three medaka ERs (mERs) are capable of initiating transactivat

71 In the in vivo bioassays, medaka exposed to individual pesticides or to AP/APEO al

72 This study uses nPbO2(s) and medaka fish (Oryzias latipes) as surrogates to investiga

73 ecently, haploid pluripotent cell lines from medaka fish (Oryzias latipes) have also been established

74 Here we report a unique medaka fish (Oryzias latipes) mutant, hirame (hir), whic

75 Larvae of medaka fish (Oryzias latipes) underwent 3-14 days' aqueo

76 In vivo injection, in medaka fish (Oryzias latipes), of the mutated miR-204 ca

77 unction of the orthologous genes in mice and medaka fish and further expands our understanding of gen

78 rally active DNA transposon derived from the medaka fish called Tol2, as an alternative system for hi

79 Consistently, Medaka fish deficient for Ezrin exhibit defective endo-l

80 Finally, knockdown assays in medaka fish demonstrated that miR-204 is necessary for n

81 Using medaka fish embryo model, the toxic effects and correspo

82 casing its performance across a large set of medaka fish embryos and compare its performance to estab

83 te imaging datasets obtained from developing Medaka fish embryos in 96-well plate format imaged on an

84 x3.2 distribution in distinct domains of the medaka fish forebrain.

85 Previously, knock-out of Arhgef18 in the medaka fish has been shown to cause larval lethality whi

86 anipulating the expression of miR-204 in the Medaka fish model system.

87 own to cause laterality defects in mouse and medaka fish models.

88 Here, we provide documentation that GM male medaka fish modified with salmon growth hormone possess

89 The Japanese medaka fish Oryzias latipes has an XX/XY sex-determinati

90 acterization of the regulatory region of the medaka fish Six3.2 ortholog and of a time/cost-effective

91 The medaka fish was chosen as the experimental aquatic model

92 Two teleost fish, (zebrafish and medaka fish) have each been shown to possess only a sing

93 ated subdomains in Oryzias latipes (Japanese medaka fish), which has the smallest vertebrate TR ident

94 ay designed to detect bold-shy behaviours in medaka fish, combining an open-field and novel-object co

95 g morpholino-mediated ablation of Slc38a8 in medaka fish, we confirmed that pigmentation is unaffecte

96 cartilage growth and bone mineralization in medaka fish.

97 of DMY as the male sex-determination gene in medaka fish.

98 transgenerational NAFLD persisted in female medaka for five generations (F4) after exposure to an en

99 bility processes and toxicity of nPbO2(s) in medaka from the aqueous particle behavior under environm

100 es, per1a and per1b, one per2, and one per3; medaka, fugu, and tetraodon each have two per2 genes, pe

101 s and xanthophores, plus leucophores e.g. in medaka), gene regulatory networks governing fate specifi

102 of identity >99.8% and length 4682 bp in the medaka genome.

103 ning pf linked to the regulatory sequence of medaka germ gene vasa and generated transgenic fish with

104 However, Japanese medaka had different basal levels of plasma E2, plasma V

105 Medaka has a high tolerance to inbreeding from the wild,

106 termine male development in sticklebacks and medaka have revealed several features associated with in

107 We have cloned a medaka homolog of the human retinoblastoma (Rb) suscepti

108 putative regulatory regions of the fugu and medaka Hoxa2(a) and -(b) genes and assayed their activit

109 stosterone at 58.8 mug/L in vivo in Japanese medaka in a 21 day exposure.

110 table genetic resource for such studies, the Medaka Inbred Kiyosu-Karlsruhe (MIKK) panel has recently

111 ture to create an inbred panel resource: the Medaka Inbred Kiyosu-Karlsruhe (MIKK) panel.

112 Here we present the Medaka Inbred Kiyosu-Karlsruhe (MIKK) panel: the first n

113 The medaka is a fish that has served as a model organism for

114 Medaka is an ideal model for sex determination and sex r

115 We establish that as in mammals, modeling in medaka is regulated by the SOST gene, demonstrating a me

116 dy other ricefishes, and to learn more about medaka itself in an evolutionary context.

117 sion of these two chemokine receptors in the medaka juvenile thymus defined two spatially distinct su

118 ver, we show that this system can be used in medaka, killifish, and mouse embryos.

119 al locomotion was observed in PFECHS-exposed medaka larvae, which was rescued by adding exogenous GAB

120 genome graph representation of 12 individual medaka lines.

121 nal transgenesis with spg1-gfp led to stable medaka lines.

122 o estrogenic metabolites was not observed in medaka liver microsomes and cytochrome P450 was not indu

123 subtypes, which are highly expressed in male medaka liver prior to estrogen exposure.

124 a short reads: Trycycler long-read assembly, Medaka long-read polishing, Polypolish short-read polish

125 Here, we found MTX treatment of adult medaka male fish (Oryzias latipes) causes cranial cartil

126 Using the transgenic medaka malignant melanoma model, we established a screen

127 utation in liver tissue of lambda transgenic medaka may be mediated through compromised liver functio

128 figuration of kinematic motifs suggests that medaka may judge distance to prey predominantly by motio

129 ional alterations characterized suggest that medaka may provide a novel model and, thus, provide addi

130 imilar to human P2ab than predicted, and the medaka minimal pseudoknot has the same tertiary interact

131 Similarly, medaka Mitf is necessary for melanophore, xanthophore an

132 The spg1-gfp medaka model provides a sensitive, specific, and physiol

133 formed ENU mutagenesis screening to identify medaka mutants with defects in embryonic cardiovascular

134 be taken into account in future analyses of medaka mutants with glomerulus defects.

135 GM medaka offspring possess a survival disadvantage relativ

136 Meanwhile, medaka oligo DNA microarray and qRT-PCR were used for ge

137 Larval medaka (Orizias latipes) readily consumed S. coeruleus i

138 productive capacity was assessed in Japanese medaka (Oryzias latipes) after exposure to two concentra

139 nalysis of orthologous genes in the Japanese medaka (Oryzias latipes) and a catfish (Synodontis multi

140 rments caused by chronic KClO(4) exposure in medaka (Oryzias latipes) and examined whether KClO(4)-in

141 In rapidly dividing blastomeres of medaka (Oryzias latipes) and in somatic cells, SSX2IP kn

142 ork for adenine and cytosine base editing in medaka (Oryzias latipes) and zebrafish (Danio rerio), id

143 epigenetic marks (H3K4me3 and H3K27ac) from medaka (Oryzias latipes) and zebrafish (Danio rerio), tw

144 y using the small cyprinodont fish, Japanese medaka (Oryzias latipes) as a model.

145 al pigmented epithelium (RPE) of the teleost medaka (Oryzias latipes) coordinate their growth rates.

146 re, we collected peptides from the plasma of medaka (Oryzias latipes) fish.

147 Mutant knockout gli3 fins in medaka (Oryzias latipes) form multiple radials and rays,

148 brates, whereas fugu (Takifugu rubripes) and medaka (Oryzias latipes) have two coparalogous genes [Ho

149 In vivo exposure studies employing Japanese medaka (Oryzias latipes) indicate that low concentration

150 The teleost medaka (Oryzias latipes) is a well-established vertebrat

151 The teleost medaka (Oryzias latipes) is an established genetic model

152 develop a sensitive and specific transgenic medaka (Oryzias latipes) model bearing an androgen respo

153 To address this question, we analyse medaka (Oryzias latipes) mutants deficient in teleost-sp

154 identify druggable pathways, we generated a medaka (Oryzias latipes) osteoporosis model, where induc

155 A full-length cDNA clone of the medaka (Oryzias latipes) p53 tumor suppressor gene was i

156 us with complementary in vivo experiments in medaka (Oryzias latipes) to systematically analyze the i

157 t eleuthero-embryonic life stages in a novel medaka (Oryzias latipes) transgenic line.

158 Adult male Japanese medaka (Oryzias latipes) were exposed to solutions of si

159 rivers (Astatotilapia burtoni) with that of medaka (Oryzias latipes), a fish found in rice paddies i

160 g the genomes of zebrafish (Danio rerio) and medaka (Oryzias latipes), a teleost with a conserved anc

161 onitoring programs: zebrafish (Danio rerio), medaka (Oryzias latipes), Atlantic killifish (Fundulus h

162 transgenic strain of a small aquarium fish, medaka (Oryzias latipes), that overexpresses the maligna

163 ative roles of three ER subtypes in Japanese medaka (Oryzias latipes), using vitellogenin (VTG) I and

164 approximately 30-fold from an inbred strain medaka (Oryzias latipes), we observed that both the sens

165 us mykiss) and in vivo studies with Japanese medaka (Oryzias latipes).

166 /Cas9-mediated endogenous protein tagging in medaka (Oryzias latipes).

167 these responses measured in female Japanese medaka (Oryzias latipes).

168 pactacin enzymes in pot-bellied seahorse and medaka (Oryzias latipes).

169 nvasive live imaging of the entire thymus in medaka (Oryzias latipes).

170 come pathways were evaluated in the Japanese medaka (Oryzias latipes).

171 ll-length CR4/5 domain from the teleost fish medaka (Oryzias latipes).

172 so appears to induce avoidance behaviours in medaka (Oryzias latipes); but etomidate could provide an

173 In this study, marine medaka (Oryzias melastigma) was exposed to environmental

174 r pipeline was developed on larvae and adult medaka ovaries but was also successfully applied to diff

175 ces in length and sequence, the structure of medaka P2ab is more similar to human P2ab than predicted

176 on NMR structure and studied the dynamics of medaka P2ab, and identified all base pairs and tertiary

177 ology between putative functional domains of medaka p53 and p53 genes from other vertebrate taxa incl

178 owed that zebrafish per1a/per1b and fugu and medaka per2a/per2b have asymmetric evolutionary rates, i

179 The medaka Rb cDNA encodes a predicted protein of 909 amino

180 ertebrate Rb sequences demonstrates that the medaka Rb cDNA is highly conserved in regions of functio

181 an pRb recognizes the protein product of the medaka Rb gene, detecting a 105 kDa protein in all tissu

182 to 576 +/- 86 L/kg in the brain and eyes of medaka, respectively.

183 gnments with tetraodon, zebrafish, fugu, and medaka resulting in assignments of homology for 199 loci

184 Here, we show that an osx mutation in medaka results in severe bone defects and larval lethali

185 stem cells (NSCs) of embryonic origin in the medaka retina.

186 ing of six MNNG-induced tumors in four adult medaka revealed no mutations within characteristic mutat

187 ling regulatory mechanism in a fish species (medaka), showing that although lacking osteocytes (i.e.,

188 viours of 307 pairs of fish from five inbred medaka strains.

189 In contrast, medaka swim continuously, track the prey monocularly wit

190 TE), WT female (WT_F_OV) and XY(DMY-) female medaka (TA_F_OV) gonad libraries.

191 horing a comparative map with the zebrafish, medaka, tetraodon, and fugu genomes.

192 strate PCOS in the same F4 generation female medaka that developed NAFLD.

193 ed from the Y chromosome of the teleost fish medaka that is functionally comparable to the mammalian

194 ctodysplasin-A receptor, in the teleost fish Medaka, that results in a failure of scale formation.

195 t the midline to form a glomerulus, while in medaka the two parts remain unmerged due to the interpos

196 Here, we study early development in medaka (the Japanese killifish, Oryzias latipes) at 12 t

197 f several fish species, including zebrafish, medaka, threespine stickleback and fugu, the amphibian X

198 GFP) in thyrocytes, under the control of the medaka thyroglobulin gene promoter.

199 Here we present the logistics of using medaka to screen compounds, as well as, the development

200 rtunities to use the resources developed for medaka to study other ricefishes, and to learn more abou

201 transgenic fish model, the lambda transgenic medaka, to evaluate the potential mutagenicity of PFOS i

202 R4/5 RNA fragment and UV cross-linked to the medaka TRBD protein fragment.

203 We show here that in medaka, two RNA-binding proteins with antagonizing prope

204 (1) The glomerular primordium of medaka - unlike the one of zebrafish - exhibits a C-shap

205 comprising 3kb promoter/enhancer regions of medaka VTGI and VTGII genes.

206 d DMY in medaka, and suggested that XY(DMY-) medaka was a novel mutant that is useful for investigati

207 After exposure, the brain and eyes of the medaka were collected to investigate the bioconcentratio

208 Adult male medaka were treated with 0.01 mg/L KClO(4), 10 mg/L KClO

209 The larvae of medaka were treated with solutions containing nPbO2(s) o

210 First, telomerase from the fish medaka, which extends the same telomeric DNA primer as h

211 haracteristics of the exocytotic wave in the medaka with that in other eggs, particularly in echinode

212 key regulators of eye development in mouse, medaka, Xenopus, and zebrafish.