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1 rvival that is, at least in part, neutrophil mediated.
6 ion against many viral pathogens, antibodies mediate additional immune functions that may have both p
8 we show that WNK1 negatively regulates LFA1-mediated adhesion and positively regulates CXCL12-induce
13 epsilonRIalpha mAbs more safely suppress IgE-mediated anaphylaxis and food allergy than divalent vari
14 E/Daughterless) and nhr-67 (NR2E1/TLX), that mediate anchor cell specification and/or invasive behavi
15 o forms of diabetes mellitus; T1DM is immune mediated and T2DM is mediated by metabolic mechanisms.
16 o enhance the expression of the Toll pathway-mediated antimicrobial peptides when the flies were chal
19 emotherapy through targeting ASS1- and GLUT1-mediated arginolysis and glycolysis, respectively, which
21 rapeutic activity in a mouse model of T cell-mediated autoimmunity that mimics multiple sclerosis (MS
22 rities are caused by misregulation of ABCB19-mediated auxin distribution in addition to light-depende
24 describes the current understanding of LapA-mediated biofilm formation by P. fluorescens and discuss
25 tion of MEK/ERK signaling overcame the HIF1a-mediated block in oligodendrocyte generation by restorin
28 itical Set1 RxxxRR motif adopts a helix that mediates bridging contacts between the nucleosome, ubiqu
29 H exchangers) by accelerating CO(2) / HCO3- -mediated buffering of acid-base equivalents, they could
30 chanism of the effect of lipid peroxidation, mediated by 4-hydroxynonenal ([4HNE] a byproduct of lipi
32 es rely on rapid and precise gene regulation mediated by accessibility of regulatory regions to trans
33 l outcomes but it is unclear whether this is mediated by an excess of extracranial vascular disease (
34 cross-linking impairs the cholesterol efflux mediated by apoA-I or HDL3 in vitro and in vivo Using LC
35 of the effect between ethnicity and DCGF was mediated by BPAR, no similar association was found for D
36 utic doses on a range of clinical pathogens, mediated by energy resources disruption, and finally saf
37 4-allyl-2,6-dimetoxypheno and the NorA pump mediated by hydrogen bonds and hydrophobic interactions.
39 The binding of Fpr to various DNA motifs are mediated by its flat DNA-binding surface, which is cente
42 sized and turned over; the latter process is mediated by PG cleavage enzymes, for example, the endope
45 r a variety of cellular processes, which are mediated by protein complexes within this subcellular co
46 versification with gene flow across species, mediated by Quaternary climate oscillations that have fa
48 uality control of misfolded C-Pro domains is mediated by recognizing stalled assembly of triple-helic
50 e metastatic suppressing ability of Zic1 was mediated by regulating the process of cell invasion, adh
51 In somatic cells, these functions are both mediated by Scc1-cohesin, which in mitosis is released f
53 of transcription and DNA damage that may be mediated by the action of HDAC and PP1CC, respectively.
54 nt CB7 effects are proposed, a base-catalyst mediated by the CB7 portal and an inhibitory role attrib
57 eviously shown that this effect of leptin is mediated by the NMDA subtype of glutamate receptors (NMD
58 ed the hypothesis that the S-OFF response is mediated by the S-ON pathway through inhibitory input fr
60 it accelerates degradation of target mRNAs, mediated by three N-terminal Repression Domains (RDs), w
64 constant in CH but decreases (tau for SERCA-mediated Ca(2+) removal changed from 6.3 to 3.0 s(-1) )
68 stinal microbiome contributes to cholestasis-mediated cell death and inflammation through mechanisms
73 ction mapping, using Hi-C, reveals condensin-mediated chromatin interactions in interphase that are q
77 lysine-binding 'cage' formed by BAHCC1(BAH), mediating colocalization of BAHCC1 and H3K27me3-marked g
78 as the thalamus and brainstem nuclei, which mediate complex interactions with the brain's cortical p
79 ehensively reveal the nature of SARAH domain-mediated complex formation and provide mechanistic insig
80 ional CD4(+) T cells that underwent TGF-beta-mediated conversion in the periphery (called peripheral
83 atalytic ability in superoxide anion radical-mediated coupling of (arylmethyl)amines and photoelectro
84 re ubiquitous throughout the nervous system, mediating critical signal transmission and integration,
93 nched architectures in regulating proteasome-mediated degradation, but the proteins that selectively
97 functional roles for RhoA and Rho-kinase in mediating depression-like behaviors via dendritic remode
98 Syk activation followed by rapid phosphatase-mediated desensitization; however, how degradation event
101 isk variants associated with multiple immune-mediated diseases are a major determinant of interindivi
104 ression during neurodevelopment, but it also mediates DNA damage repair essential to proliferating ne
105 ge-mediated immune modulation and macrophage-mediated drug delivery, which will further enhance curre
107 hs into regression models and tested for the mediating effect of low birthweight and feeding practice
113 cripts, indicating that the DAP1 risk allele mediates enhanced autophagy, leading to the survival of
114 Chromatin-conformation capture and dCas9 mediated enhancer blocking establish a direct regulatory
116 ng on VCAM-1 but inhibited eotaxin-1 (CCL11)-mediated eosinophil migration, calcium flux, cell polari
119 e for DMD, antisense oligonucleotides (ASOs) mediated exon skipping is a promising therapeutic approa
120 inhibiting TGF-beta signaling decreased tECM-mediated expression of integrin alpha1, alpha2, and beta
128 te global gene expression in trans via piRNA-mediated gene silencing that is essential for embryonic
130 despread application of viral- and non-viral-mediated gene transfer to liver, heart, skeletal muscle,
133 n and is stimulated by the UBL domain, which mediates high-affinity interaction with the polyubiquiti
135 oped a novel protocol to measure transporter-mediated histidine uptake, system L amino acid transport
136 dIL2Rgamma(null) (NSG) mouse model of T-cell-mediated human islet allograft rejection and developed a
138 gnificant room for development in macrophage-mediated immune modulation and macrophage-mediated drug
139 lation of vascular endothelial growth factor-mediated immune suppression via angiogenesis inhibition
142 ion with the oncolytic virus overcomes PD-L1-mediated immunosuppression during both the priming and e
143 as mature, terminally differentiated subsets mediate immunosurveillance through diverse peripheral si
144 eurocircuits during development, and this is mediated in part by astrocyte-released thrombospondins (
146 osinophilic esophagitis (EoE) is an allergen-mediated inflammatory disease with no approved treatment
147 these effects, as antisense oligonucleotide-mediated inhibition of Malat1 also suppresses Maf and IL
149 veal the structural determinants of tip-link-mediated inner-ear sensory perception and elucidate prot
150 e mechanistic insights into how SARAH domain-mediated interactions influence Hippo pathway activity.
157 ydroxylation on Proline residue 651 by EglN1 mediated its ubiquitination and degradation governed by
161 coid-induced macrophage migration, and siRNA-mediated knockdowns of GR and DPP4 blocked dexamethasone
168 discovery of D1-mGlu5 functional heteromers mediating maladaptive molecular and motor responses in t
169 modulin-dependent protein kinase II (CaMKII)-mediated mechanism, and CaMKII inhibition prevents both
172 A heterogeneous magnitude of CD4(+) T cell-mediated memory responses was observed in regard to lymp
174 The results reveal a paradoxical acetylation-mediated molecular clutch that tunes transcription facto
180 ere confirmed in vivo with an angiotensin II-mediated murine model of cardiac fibrosis in both preven
183 provide evidence that the alarmin S100A8/A9 mediates neutrophil accumulation during progression to c
185 ting neurons act downstream of P1 neurons to mediate nutritional modulation of the sleep-courtship ba
186 rom naive rabbits and rabbits with S. aureus-mediated osteomyelitis, and then we validated a proof of
187 rs, such as endotoxins and bile acids, might mediate parenchymal renal injury in patients with cirrho
190 ype I BMP receptor normally required for BMP-mediated patterning of the embryo, is dispensable for bo
193 link AMPK regulation of ferroptosis to AMPK-mediated phosphorylation of acetyl-CoA carboxylase and p
197 X electrophiles); (ii) sigma-bond metathesis mediated (prevalent with B-H and B-R electrophiles).
198 onceptual validity, we design a CRISPR-array-mediated primer-exchange-reaction-based biochemical circ
199 This study underlines the importance of DC-mediated priming in identifying novel regulators of T ce
200 ns of DNA NANPs significantly enhances RIG-I mediated production of both proinflammatory cytokines an
205 (NFAT5) is a transcription factor (TF) that mediates protection from adverse effects of hypertonicit
211 gests that noncanonical and nontranscription-mediated receptor signalling is more common than hithert
213 induce cholangiocytes to produce chemokines mediating recruitment of Th17 cells and more monocytes i
214 ith VPS35, a subunit of the retromer complex mediating recycling from endosomes, in a subset of axons
218 f an upstream or downstream gene by a fusion-mediated repositioning of a regulatory sequence is much
219 sought to identify the mechanism of Pumilio-mediated repression and find that it accelerates degrada
220 nd Snail and, in turn, trigger H3K27me3/EZH2-mediated repression of Snail epithelial target genes.
222 of paralogous alpha- and beta-subunits that mediates respiratory oxygen transport and exchange by co
224 liver is key for allowing complete glucagon-mediated responses and efficient metabolic adaptation to
225 nhibition of TRPM3 dampened TRPV1- and TRPA1-mediated responses in nociceptors innervating the inflam
226 ta4*nAChRs also are involved in non-nicotine-mediated responses that may predispose to addiction-rela
229 DNA ADP-ribosyl transferase, DarT(Mtb) ), to mediate reversible DNA ADP-ribosylation (Jankevicius et
232 ation, a potent form of oxidative stress, in mediating RV hypertrophy and failure in congenital heart
235 shown in vitro, and suggests that PV(+) cell-mediated short-term synaptic depression influences the e
236 plants with a requirement for G-proteins to mediate signal transduction, a situation similar, but no
237 cribe the mechanisms and consequences of TLR-mediated signal transduction with a focus on themes iden
243 minal to the substrate pTyr in EGFR and HER2 mediate specific binding by the SHP2 active site, leadin
244 est a pivotal role of caspase 3 signaling in mediating spine injury and the modulation of caspase 3 a
246 SY242CS confers a conformational change that mediates stable binding to a non-canonical DNA motif.
249 ilent synapses are generated by an astrocyte-mediated synaptogenic mechanism in response to cocaine e
250 pivotal role for LDH in modulating cytokine-mediated T cell differentiation and underscore the thera
251 ls of EET taxis, "electrokinesis" and flavin-mediated taxis, and highlight key areas in need of furth
252 involved in multisensory and spatial memory mediate the aftereffect following both trial-wise and cu
253 ics of infected critically ill patients that mediate the associated pathogenesis, including vascular
254 ates pannexin-1 channels in macrophages that mediate the attraction of neutrophils, shown previously
255 st that sigma1 conformational rearrangements mediate the efficiency of reovirus host cell binding.
256 hospholipids and amphipathic 18A peptides to mediate the formation of supported phospholipid bilayers
258 ated macrophage mobility; unexpectedly, DPP4 mediated the glucocorticoid-induced macrophage migration
260 ed the extent to which pre-pregnancy obesity mediates the association between maternal place of birth
263 this polar DprA targeting function, sigma(X) mediates the timely shut-off of the pneumococcal compete
265 the main transducers of signals from GPCRs, mediating the action of countless natural stimuli and th
266 region D1 in p27 plays a significant role in mediating the association kinetics, undergoing conformat
267 t to search for the host cellular protein(s) mediating the differential susceptibility of the two cel
268 and immune pathways with some of these genes mediating the effects of parental Holocaust exposure on
269 n changes that significantly impact pathways mediating the metabolism and transport of glucose and py
270 s express a rich set of immune-related genes mediating their interaction with the microbial environme
276 identities, computationally predicted to be mediated through a common transitional, high-plasticity
277 gulation of tumor fibrosis in lung cancer is mediated through differential SMAD3 promoter methylation
280 y which the early synergism between antibody-mediated toxin neutralization and tissue-specific neutro
282 ignaling cascades, in concert with NF-kappaB-mediated transcriptional events, control the metabolism
286 luciferase reporter assays of glucocorticoid-mediated transrepression and predicted response to ICS t
288 the triggered release mechanism of dendrimer-mediated triptolide delivery significantly reduced tript
291 nd-binding pocket conformation for capsaicin-mediated TRPV1 activation gating, and reveals multiple l
293 However, the precise mechanism of how NF2 mediates upstream signals to regulate the Hippo pathway
294 lastic vasculitis (LCV) is an immune-complex mediated vasculitis characterized by neutrophilic inflam
295 reviously, we and others showed that P130CAS mediates VEGF-A and PDGF signalling in vitro, but its ca
296 increases cerebral blood flow (CBF; +10-20%) mediated via small elevations in arterial PCO2 and metab
297 cognition of PE and PS maximizes PS receptor-mediated virus entry and efferocytosis and underscore th
298 PE synergizes with PS to promote PS receptor-mediated virus infection and clearance of apoptotic cell
299 examined associations between rod- and cone-mediated vision and HRF plus smaller hyperreflective spe