ライフサイエンスコーパス: mediation

1 rising unifying phenomenon of "alkali-metal mediation".

2 rly folding postcentral cortices (three-path mediation).

3 experimental design, with embedded tests for mediation.

4 tributed-consistent with feedforward pathway mediation.

5 es of this expanding field of high-dimension mediation.

6 n a straightforward manner to high-dimension mediation.

7 dients resulting from nonelectronic forms of mediation.

8 tive risk was due to neither interaction nor mediation, 24.9% (95% CI: 15.4, 50.0) was due to interac

9 erminal high spin Fe(III) sites and electron mediation ability of CN ligands lead to the observation

10 m provides a unique opportunity to study cis-mediation across human tissue types.

11 d conflict appears to benefit from Bioethics Mediation, an approach that uses a neutral, unaligned me

12 Partial correlations and causal mediation analyses (mediation R package) were then perfo

13 Causal mediation analyses agreed with these estimates.

14 cause sample size and power calculations for mediation analyses are typically not conducted or are cr

15 Mediation analyses are valuable for examining mechanisms

16 Mediation analyses assessed relationships among CBF/sPDG

17 nding effects in biological systems can make mediation analyses challenging and prone to confounding

18 Moderated mediation analyses demonstrated that positive memory spe

19 Causal mediation analyses estimated the contribution of convent

20 Causal mediation analyses examined the role of intermediate var

21 Mediation analyses further suggested that PCC response t

22 However, mediation analyses indicated that 15% of the effect of a

23 Mediation analyses indicated that 33% of excess hazard f

24 Mediation analyses indicated that both higher WHR and hi

25 Exploratory moderated-mediation analyses indicated that DMN suppression was as

26 Rapid methodologic developments in mediation analyses mean that there are a growing number

27 Mediation analyses of colocalized genes and cardiometabo

28 Mediation analyses proposed that visceral obesity contri

29 Importantly, mediation analyses revealed that the negative associatio

30 Mediation analyses revealed: (i) a significant total eff

31 Moderated mediation analyses show that, in low-density conditions,

32 Mediation analyses showed a significant association path

33 Mediation analyses showed sulfadoxine-pyrimethamine conf

34 Mediation analyses showed that neurodegenerative disease

35 Mediation analyses showed that shifts in FOV partially m

36 Mediation analyses showed that the higher risk of IS the

37 Mediation analyses suggested that stage at diagnosis had

38 Mediation analyses suggested that the increased HS risk

39 Mediation analyses suggested that this asymmetry may ste

40 Using multiple mediation analyses to analyze data from 209 HCC cases an

41 tivariable linear regression and statistical mediation analyses to determine whether and to what exte

42 Here, we use mediation analyses to explore how cognitive and neural f

43 We performed causal mediation analyses to separate the overall effects of th

44 We performed mediation analyses using a statistical approach that all

45 Using mediation analyses we show for the first time that infla

46 Cox regression and mediation analyses were conducted to assess associations

47 Mediation analyses were conducted to quantify the impact

48 Mediation analyses were conducted.

49 Mediation analyses were performed on a composite measure

50 Correlation and mediation analyses were performed to assess the relation

51 Two-sample t-tests, regression and mediation analyses were used to assess AMC group differe

52 Multivariable linear regression and mediation analyses were used to investigate the associat

53 fects of IPTp on birth outcomes using causal mediation analyses, accounting for confounders.

54 In causal mediation analyses, chronic hypertension explained 64% o

55 Mediation analyses, with 12-month weight as mediator, ad

56 need further confirmation in the context of mediation analyses.

57 x [BMI]) and area-based SES were included in mediation analyses.

58 utcomes were assessed in adjusted models and mediation analyses.

59 nt to birth weight-the placenta-using formal mediation analyses.

60 and the multilevel structure of the data in mediation analyses.

61 y response, an effect corroborated in formal mediation analyses.

62 d Cox regression, Kaplan-Meier survival, and mediation analyses.

63 VanderWeele's 2015 book on mediation analysis (Explanation in Causal Inference; Oxf

64 amines the role of unmeasured confounding in mediation analysis allowing for normally distributed or

65 We compared these models with linear mediation analysis and quantitative MRI indices (from di

66 ow potassium or phosphate blood levels using mediation analysis and the primary outcome was hospital

67 Mediation analysis assessed the effect of LV mass index

68 d to survival outcomes a method for multiple mediation analysis based on the computation of appropria

69 Mediation analysis demonstrated that alterations in long

70 Mediation analysis estimated that decreases in mitochond

71 A single mediation analysis for exposure, "physical-inactivity in

72 Adjusted univariable mediation analysis found no suggestion of a causal media

73 Mediation analysis found that mitochondrial respiration

74 Moderated-mediation analysis found that these sex-specific changes

75 s for power and sample-size calculations for mediation analysis has lagged far behind the development

76 In mediation analysis if unmeasured confounding is present,

77 Mediation analysis indicated that FGF23 explained 31% of

78 Mediation analysis is concerned with the decomposition o

79 The main aim of mediation analysis is to study the direct and indirect e

80 Mediation analysis is used in epidemiology to identify p

81 Mediation analysis is useful for understanding mechanism

82 However, high-dimensional mediation analysis methods for time-to-event outcome dat

83 2011;174(1):99-108) for causal mediation analysis of a binary mediator and a binary out

84 ver, the development of methods for multiple mediation analysis of survival outcomes is still limited

85 hallenges, we propose a new high-dimensional mediation analysis procedure for survival models by inco

86 Collectively, the proposed high-dimensional mediation analysis procedure has good performance in med

87 Finally, we provide an example write-up of mediation analysis results as a model for applied resear

88 Mediation analysis revealed a significant indirect effec

89 Mediation analysis revealed that attention bias and the

90 A multi-level moderated mediation analysis revealed that behavioral responses ar

91 Mediation analysis revealed that linkage to care contrib

92 Mediation analysis revealed that the association between

93 Further, mediation analysis showed that depressive problems signi

94 Mediation analysis showed that striatal kicer mediated t

95 Mediation analysis showed that the prefrontal-motor cort

96 Mediation analysis shows an association between nurse st

97 Mediation analysis suggested a role for partial cis-epig

98 Mediation analysis suggested that the association of the

99 Mediation analysis suggested that the detrimental associ

100 Mediation analysis supported white matter damage causing

101 Mediation analysis supports the hypothesis that CHO inta

102 Crucially, we demonstrate through mediation analysis that activation in the VS mediates th

103 smoking through age 18 years and performed a mediation analysis to determine the extent to which offs

104 th multivariate logistic regression and used mediation analysis to determine which care process measu

105 We performed causal mediation analysis to estimate indirect (mediation) and

106 We conducted mediation analysis to examine the role of leptin in the

107 Finally, we used mediation analysis to show that AD in the NAcc-OFC tract

108 We performed mediation analysis to understand the indirect effects of

109 Mediation analysis using a Cox proportional hazards mode

110 Mediation analysis was conducted to determine whether ac

111 using adjusted competing risk analyses, and mediation analysis was conducted to determine whether BP

112 using adjusted competing risk analyses; and mediation analysis was conducted to determine whether BP

113 Counterfactual-based mediation analysis was performed to establish whether ob

114 Finally, mediation analysis was performed to explore the cognitiv

115 Causal mediation analysis was used to evaluate warm ischemia ti

116 egression-based Mendelian randomization (MR) mediation analysis were performed to assess any role of

117 interactions with cesarean delivery and used mediation analysis with 4-way decomposition to estimate

118 technologies gives opportunities to perform mediation analysis with a high-dimension pool of covaria

119 Trans-association has been studied in the mediation analysis with a single mediator.

120 is problem, we propose a new method: Genomic Mediation analysis with Adaptive Confounding adjustment

121 -analysis, CPT1A transcription analysis, and mediation analysis with CHO and FAT intakes as exposures

122 Mediation analysis with high-dimensional DNA methylation

123 e have been some methodology developments of mediation analysis with high-dimensional mediators.

124 To date, the literature on mediation analysis with multiple mediators has mainly fo

125 Mediation analysis with multiple mediators improves powe

126 , we conducted a bias corrected bootstrapped mediation analysis with the neural substrate score from

127 Utilizing causal mediation analysis within a counterfactual framework, we

128 ships in order to see how the results of the mediation analysis would change in the presence of unmea

129 relation between covariates is required for mediation analysis, and it is expected to be more limite

130 nt (ABCD) Study, using a linear mixed model, mediation analysis, and structural equation methods in a

131 of no unmeasured confounders for the causal mediation analysis, and the limited generalizability of

132 ongitudinal measurements pose challenges for mediation analysis, because the mediators and outcomes m

133 In mediation analysis, known factors explained 65.3% (95% C

134 In the mediation analysis, lower cow milk consumption only part

135 In a mediation analysis, odds ratios for the indirect and dir

136 In mediation analysis, the direct effect was significant (H

137 In a mediation analysis, the effect of the genetic score on d

138 In the mediation analysis, visceral and liver fat jointly accou

139 In a mediation analysis, we estimated the amount of change in

140 s modeling, network construction, and causal mediation analysis, we identified genes, CpGs, and their

141 Employing virtual reality and mediation analysis, we implicate shifts in FOV as a mech

142 f our understanding of power when conducting mediation analysis.

143 ation between smoking and birth weight using mediation analysis.

144 th behavioural-cognitive scores, including a mediation analysis.

145 tion analysis, multivariable regression, and mediation analysis.

146 t Oft-Forgotten) Practices" series considers mediation analysis.

147 r property values and performing exploratory mediation analysis.

148 inking drought and IPV, prohibiting a formal mediation analysis.

149 g out power and sample-size calculations for mediation analysis.

150 cular phloem plays a significant role in the mediation and control of host responses during infection

151 een understood to have a component of immune mediation and has been responsive to immune-based therap

152 Unification analysis of mediation and interaction on HCC risk further showed tha

153 on, and 10.3% (95% CI: 5.4, 20.3) was due to mediation and interaction.

154 ct of multiple risk factors on disease using mediation and multivariable MR frameworks.

155 in development intend to break from calcium mediation and the associated detrimental long-term effec

156 contrast between our conceptual drive toward mediation and the difficulty of obtaining meaningful evi

157 bility, solvent type, evaporation rate, seed mediation and thermal treatment), and thoroughly exploit

158 ourse (regular service attendance and prayer/mediation) and a wide range of health endpoints and beha

159 ourse (regular service attendance and prayer/mediation) and a wide range of health endpoints and beha

160 sal mediation analysis to estimate indirect (mediation) and direct effects of sRAGE on recurrent whee

161 fect combinations such as interdependencies (mediation) and interactions (moderation).

162 elivery, 9.6% (95% CI: 3.4, 15.2) was due to mediation, and 10.3% (95% CI: 5.4, 20.3) was due to medi

163 cotherapies, such as aspirin, lipid-lowering mediations, and cardiometabolic agents.

164 r illustrative purposes: the Baron and Kenny mediation approach, because it is the most commonly used

165 ion to 4-tetralones under N-bromosuccinimide mediation are described.

166 to CKD risk and the underlying mechanism of mediation are unknown.

167 potential targets for potential therapeutic mediation as well as biomarkers of negative responses to

168 rtial least-squares regression) using causal mediation BKMR models.

169 We also investigated potential causal mediation by air pollution.

170 ause of severe maternal morbidity (SMM), yet mediation by cesarean delivery is largely unexplored.

171 irect effect for PM(2.5), PM(10), NO(2), and mediation by cross-omic signatures (identified using spa

172 erm delivery, and assessed whether there was mediation by diagnoses of pregnancy complications and he

173 h Abeta and form heterocomplexes; suggesting mediation by other pathways.

174 The proportion eliminated by eliminating mediation by PTB and SGA was reported if the mortality r

175 , and portion eliminated (PE) by eliminating mediation by PTB and SGA.

176 ld be considered in the context of potential mediation by the insect gut microbiome.

177 h-dimension data, analysis of high-dimension mediation currently requires great caution and effort to

178 d two hypothesis tests for testing the total mediation effect (TME) and the component-wise mediation

179 Two hypothesis tests on the overall mediation effect are proposed and their statistical sign

180 5% CI, 57.69-63.07, d = 0.15), a test of the mediation effect between training and patient care sugge

181 iated, 31.7%; P = 0.0054), and a significant mediation effect by both viral load and ALT was also evi

182 Importantly, we found a significant mediation effect for FA (indirect effect: -2.70; p = 0.0

183 potassium levels, but identified a possible mediation effect for fluid balance (average causal media

184 We did not observe the mediation effect in men.

185 ation" package of R was used to evaluate the mediation effect of DNA methylation on the association b

186 We sought to assess the potential mediation effect of left ventricular (LV) remodeling on

187 cure attachment style and also confirmed the mediation effect of left-OFC GMV reduction on the relati

188 hy subjects that showed significant indirect mediation effect of meaningfulness on TD.

189 ion effect for fluid balance (average causal mediation effect, 0.95; 95% CI, 0.89-1.00; p = 0.060) an

190 ements with hypophosphatemia (average causal mediation effect, 0.96; 95% CI, 0.92-1.00; p = 0.055).

191 inly mediated by maternal pre-pregnancy BMI (mediation effect: 64%; P value = 0.001).

192 r all of the inter-generational association (mediation effect: 99%; P value < 0.001).

193 ediation effect (TME) and the component-wise mediation effects (CME), respectively.

194 more powerful than the TME test when the two mediation effects are in opposite direction.

195 more powerful than the CME test when the two mediation effects are in the same direction, while the C

196 ed arterial stiffness in adolescence and any mediation effects by common metabolic risk factors.

197 formed only by their direct effects, not by mediation effects of high AST or ALT.

198 Additionally, mediation effects of high-sensitive C-reactive protein a

199 al direct effect of treatment and the causal mediation effects of microbiome at both the community an

200 any methods, for simultaneously testing the mediation effects of multiple correlated SNPs via some m

201 Analysis of the mediation effects of resilience was not significant, ind

202 These mediation effects remained after we adjusted for the eff

203 finding of extensive evidence of genome-wide mediation effects suggests a critical role of cryptic ge

204 No mediation effects were seen in males.

205 the PA-neurocognitive associations, but the mediation effects were small (change in beta <= 0.4).

206 We propose the neural network linkage mediation experiment as an approach to collecting eviden

207 ppropriate for that while our language takes mediation for granted.

208 research, investigators should employ causal mediation frameworks to consider additional factors and

209 If other forms of mediation give rise to "bonds" that act like conventiona

210 The mediation in women was driven by improved pancreatic bet

211 n prematurity and reduced adult IQ (two-path mediation), indicating that aberrant gyrification of tem

212 We propose multi-SNP mediation intersection-union test (SMUT) to fill in this

213 I review evidence that such mediation may be compatible with proposed Bayesian infor

214 Understanding the mediation mechanisms by which an exposure or interventio

215 Given the use of formal mediation methods and measurement in a mechanistically r

216 t, and continued use of intervention-focused mediation methods are needed before the impact of these

217 Here, we provide a brief overview of the mediation methods available and discuss points for consi

218 However, there are no existing causal mediation methods specifically designed to handle high d

219 e propose a rigorous Sparse Microbial Causal Mediation Model (SparseMCMM) specifically designed for t

220 atherosclerosis were identified, a multiple mediation model was created to quantify the effect of SE

221 emain a significant mediator in the multiple mediation model.

222 Statistical mediation modelling suggests that both aberrant gyrifica

223 ts, and structural equation modeling to test mediation models between the PRSBMI, eating behavior pat

224 tuition, and intuition as a basis of belief, mediation models support a hypothesized effect pathway w

225 tic risk factor for Alzheimer's disease, and mediation models support an upstream role for microglial

226 We used mediation models to examine whether brain developmental

227 the present study also provides two possible mediation models to explain the potential mechanisms beh

228 Sequential mediation models were used to investigate associations b

229 multilevel cross-sectional and longitudinal mediation models were used to test whether prenatal alco

230 connectivity was evaluated in patients with mediation models.

231 Notably, however, such mediation occurs subcortically as well as cortically, co

232 One of sleep's putative functions is mediation of adaptation to waking experiences.

233 has been reported that ST is involved in the mediation of autophagy; however, its regulatory role in

234 the synaptic structure that supports mGluR5 mediation of CB1 activation in the prefrontal cortex (PF

235 e target article does not address the neural mediation of complex social behavior.

236 separate docking sites, allowing allosteric mediation of CST decamer assembly.

237 Cognitive mediation of cultural information shapes these contents

238 e been reported to play a functional role in mediation of cytokines involved in inflammation and immu

239 ignaling in the SPZ1-TWIST1-BRD4 axis in the mediation of EMT and its regulation during tumor initiat

240 age of human telomere G-quadruplexes without mediation of external molecules.

241 DAC11 suppresses Sox2 expression through the mediation of Gli1, the Hedgehog pathway transcription fa

242 its hepcidin production, and its role in the mediation of hepatic iron overload has been dissected ou

243 c uncertainties and gaps remain regarding Se mediation of Hg behavior and toxicity in abiotic and bio

244 ion of key viral receptor expression and the mediation of inflammatory activity.

245 eview the renal effects of VEGF inhibition's mediation of key downstream signaling pathways, specific

246 by sodium and potassium, as the alkali-metal mediation of organic reactions in general has started br

247 transmission and cellular signalling, in the mediation of permissive gene expression.

248 nd potentially constitutes a signalosome for mediation of sex-reward mechanism in males.

249 ) can directly photo-oxidize DNA without the mediation of singlet oxygen or other reactive oxygen spe

250 e emerged as key molecular regulators in the mediation of such interactions.

251 (ii) stereoselectivity toward (R)-PZQ; (iii) mediation of sustained Ca(2+) signals in response to PZQ

252 We examined mediation of the association between phthalate exposure

253 To investigate mediation of the HP CNV effect by haptoglobin expression

254 This demonstrates mediation of the phthalate-preterm birth relationship by

255 the care provided by the nurses, through the mediation of the quality of the working environment (in

256 Evidence for mediation of the relation between combat trauma and PTSD

257 Supporting mediation of the response by CB(2) receptors, the CB(2)

258 This experiment quantified the mediation of the TET1 survival effect through eight canc

259 ine, the proportion who have met through the mediation of third persons has declined over time.

260 Although mediation of this trade-off is essential to adaptive beh

261 the role of COX2, produced by mast cells, in mediation of visceral hypersensitivity using mice with t

262 he strong attribution supports the necessary mediation of warming impacts to the general public.

263 Photo-mediation offers unparalleled spatiotemporal control ove

264 The "mediation" package of R was used to evaluate the mediati

265 We tested a mediation path model of three structural and functional

266 ssessed with Cox models, log-rank tests, and mediation (path) analyses.

267 ion analysis found no suggestion of a causal mediation pathway for this effect by blood pressure, vas

268 These mediation pathways were diagnostically specific and were

269 longitudinal data, we examined the effect of mediation practice on intra-individual changes in the co

270 s and suggest that consensus was driven by a mediation process [7, 8].

271 Flexibility of cognitive mediation processes and resulting beliefs and pathologie

272 ta-cell dysfunction, as indicated by HOMA-B (mediation proportion: 11.19%-42.42%; all P < 0.001).

273 , and processing speed, with 69.22% of joint mediation proportion; (2) Relative to the combined Z val

274 % confidence intervals, indirect effects and mediation proportions were estimated.

275 correlations and causal mediation analyses (mediation R package) were then performed in brain region

276 tion effects on use of coping strategies and mediation regression models with bias-corrected bootstra

277 Survey data were analyzed using moderated mediation regressions with the PROCESS macro on SPSS.

278 gning a study for the purpose of answering a mediation-related research question remains challenging

279 an approach to collecting evidence of hazard mediation relationships with prognostic capacity useful

280 to ultimately improving power assessment in mediation studies.

281 The mediation techniques used for a single mediator cannot b

282 Using Mendelian randomization (MR) and mediation techniques, we leverage these genetic maps to

283 Mediation testing and colocalization analysis demonstrat

284 Mediation tests also showed low birthweight in the causa

285 DNA repair, and apoptosis displayed greater mediation than the randomized gene set.

286 gh exercise (5.38%; P <= 0.001) and negative mediation through alcohol frequency (-2.55%; P = 0.03) a

287 xygen extraction fraction (OEF) and possible mediation through amyloid burden by using MRI-based brai

288 Among social factors, we observed mediation through contact with friends (10.73%; P = 0.00

289 Among health behaviors, we observed mediation through exercise (5.38%; P <= 0.001) and negat

290 positive psychological factors, we observed mediation through increased life satisfaction (5.27%; P

291 sions of psychological distress, we observed mediation through reductions in hopelessness (1.92%; P =

292 ssion in adolescence was explained by serial mediation through testosterone to hippocampus to emotion

293 It then applies tests of statistical mediation to determine the cis genes predictive of the t

294 a linear probability model, and we assessed mediation using inverse odds ratio weighting.

295 ing a linear probability model, and assessed mediation using inverse odds ratio weighting.

296 Mediation was assessed using structural equation modelin

297 ed: 12%, 95% CI = 4-20%), but no evidence of mediation was found for average blood glucose.

298 In addition, modest serial mediation was found, mapping a pathway from polygenic ri

299 tein IIb/IIIa inhibitor (GPI) use, a test of mediation was performed using the IV.

300 tists want to understand neurons in terms of mediation; we want to understand how neurons are involve