ライフサイエンスコーパス: mediator complex

1 protein kinase) and MED19 (a subunit of the Mediator complex).

2 ts, suggesting that MED23 links CR3 with the mediator complex.

3 components of TFIID and 4 components of the Mediator complex.

4 hat the minimal TAD interacts with the human Mediator complex.

5 a thyroid receptor-associated protein in the Mediator complex.

6 ntified as MED28, a subunit of the mammalian Mediator complex.

7 1 and transcriptional regulation through the Mediator complex.

8 he enhancement of CTD kinase activity by the Mediator complex.

9 omplex, consistent with the size of the core Mediator complex.

10 dule components Sin4, Pgd1, and Gal11 to the mediator complex.

11 ol, is in fact the most abundant form of the Mediator complex.

12 entified and they all encode subunits of the mediator complex.

13 of the subunit composition of the mammalian Mediator complex.

14 CREB binding protein (CBP) and the mammalian mediator complex.

15 mplex, and the other bore a component of the Mediator complex.

16 sh4 recombination proteins and the Zip2-Zip4 mediator complex.

17 pressed by the Srb10 kinase, a member of the mediator complex.

18 ing frame, as a new subunit of the mammalian Mediator complex.

19 w light on the architecture of the mammalian Mediator complex.

20 w light on the architecture of the mammalian Mediator complex.

21 -anchored cofactor complex with PBP-anchored mediator complex.

22 d25, is a bona fide subunit of the mammalian Mediator complex.

23 the underlying architecture of the mammalian Mediator complex.

24 of SRC family members, p300, SWI/SNF and the Mediator complex.

25 est indirect association with a multisubunit Mediator complex.

26 an TRAP230, a component of a transcriptional mediator complex.

27 ion, followed by the recruitment of the TRAP/Mediator complex.

28 he multisubunit TR-associated protein (TRAP)/Mediator complex.

29 specific manner, similar to functions of the mediator complex.

30 fic interaction with the Gal11 module of the Mediator complex.

31 coactivation complex homologous to the yeast Mediator complex.

32 tivation depends on the integrity of the Srb/mediator complex.

33 nts decommissioning partly by inhibiting the mediator complex.

34 ation of phenylpropanoid biosynthesis by the Mediator complex.

35 customized, tissue-specific functions of the Mediator complex.

36 cription in vivo at a step downstream of the Mediator complex.

37 rs such as the RNA polymerase II-interacting Mediator complex.

38 l mechanisms for PRDM16 function through the Mediator complex.

39 roach to determine a 3-D model of the entire Mediator complex.

40 ation of diverse pathways is mediated by the mediator complex.

41 ith the MED25 subunit of the transcriptional Mediator complex.

42 uced genes, Hic-5 facilitated recruitment of Mediator complex.

43 n part by Med12-dependent recruitment of the Mediator complex.

44 including histone acetyltransferases and the Mediator complex.

45 tween cytoplasmic signaling proteins and the Mediator complex.

46 nase 8 (CDK8) module of the enigmatic "large Mediator" complex.

47 iprotein histone acetyltransferase (HAT) and Mediator complexes.

48 etween Saccharomyces cerevisiae and metazoan Mediator complexes.

49 ogeneity, and functional specificity of TRAP/Mediator complexes.

50 cluding histone acetyl-transferases and TRAP/mediator complexes.

51 ude the TRAP/SMCC, NAT, DRIP, ARC, and human Mediator complexes.

52 ctivator protein, and the SAGA, SWI/SNF, and Mediator complexes.

53 The gene encodes Med15, a subunit of the Mediator Complex, a conserved protein complex in eukaryo

54 ors, the screen identified components of the Mediator complex, a large multiprotein coactivator requi

55 CDK8 is a key subunit of Mediator complex, a large multiprotein complex that is a

56 promoter, and enables P-TEFb to contact the Mediator complex, a potential target for the Brd4-mediat

57 The Mediator complex, a ubiquitous conserved complex of appr

58 The Mediator complex acts as a bridge between specific trans

59 rted previously that MED13, a subunit of the Mediator complex, acts in the heart to control obesity i

60 The TRAP100-deficient TRAP/Mediator complex also lacks TRAP95 and TRAP150 beta/SUR2

61 Several other mutations in the Mediator complex also result in significant derepression

62 Here, we show that TREX-2 interacts with the Mediator complex, an essential regulator of RNA Polymera

63 mammalian MED8 is a subunit of the mammalian Mediator complex and (ii) that MED8 can assemble with El

64 lts establish a mechanistic link between the Mediator complex and a critical chromatin modification i

65 thus consistent with a dynamic nature of the Mediator complex and further extend the functional simil

66 ex of four proteins associated with the core Mediator complex and has been found to function both in

67 ited by liganded estrogen receptor, the DRIP/Mediator complex and p160 proteins, although the relativ

68 study, we show that GR binds directly to the Mediator complex and that both LXXLL motifs of MED1/TRAP

69 CycC interactions are stabilized within the Mediator complex and the activity of Cdk8-CycC is regula

70 Our results link the Mediator complex and the basal transcription machinery b

71 tone acetylation readers including BRDs, the Mediator complex and the positive transcription elongati

72 rms distinct puncta that colocalize with the Mediator complex and with mRNAs of target lysosomal gene

73 ficient for stable association with the TRAP/Mediator complex and, further, that TRAP220-dependent TR

74 cyclin-dependent kinase associated with the Mediator complex) and Hda1 (a class I histone deacetylas

75 CRSP130/Sur-2 (a Ras-linked subunit of human mediator complexes) and ESX (an epithelial-restricted tr

76 encodes a component of the RNA polymerase II mediator complex, and CG7998, which encodes a putative m

77 or a functional role of REF4 and RFR1 in the Mediator complex, and for Mediator in the maintenance of

78 h encodes a component of the transcriptional Mediator complex, and mutations in the two genes are syn

79 erase II (Pol II) in eukaryotes requires the Mediator complex, and often involves chromatin remodelin

80 physically binds to MED1, a component of the Mediator complex, and recruits it to superenhancers at b

81 und in only a fraction of the total cellular Mediator complexes, and the mechanisms regulating its bi

82 Mediator complexes are large multiprotein assemblies tha

83 Mediator complexes are required for activators to stimul

84 Based on the function of the Mediator complex as a bridge between DNA-bound transcrip

85 We investigated the role of the mediator complex as a coactivator for vitamin D receptor

86 of evidence have converged on a multiprotein Mediator complex as a conserved interface between gene-s

87 Our results identify the human Mediator complex as the transducer of activating ncRNAs

88 id screen identified PC2, a component of the Mediator complex, as a PLAGL2-binding protein.

89 We identified mouse Sur2, a subunit of Mediator complex, as a protein that binds to MAV-1 E1A.

90 ation of MDT-15, a subunit of the C. elegans Mediator complex, as an NHR-49-interacting protein and t

91 e partner of cyclin C and a component of the mediator complex, associated with the Pol II holoenzyme.

92 The mediator complex-associated cyclin dependent kinase CDK8

93 The Mediator complex-associated cyclin-dependent kinase CDK8

94 The Mediator complex associates with RNA polymerase II (RNAP

95 We demonstrate that a single Mediator complex associates with the enhancer and core p

96 roximately 1 to 10% of large E1A is bound to Mediator complex at 18 h postinfection and in transforme

97 kinases removes their ability to repress the Mediator complex at enhancers.

98 Sep10, a component of the Pol II Mediator complex, becomes essential in mcs6 or pmh1 muta

99 stitutively active promoters, depends on the Mediator complex but is independent of Mediator at the i

100 more rapid promoter recruitment of the TRAP/Mediator complex but not p160/SRC proteins.

101 participate in all of the activities of the mediator complex, but form a submodule that is required

102 PP2A may be recruited to CDK8 in the Mediator complex by a specific PP2A B subunit or additio

103 at the recruitment of CBP, SWI/SNF, and TRAP/Mediator complexes by RTA is the principal mechanism to

104 portantly, we show that both the SWI/SNF and Mediator complexes can be targeted to chromatin by p300,

105 decommissioned by the ecdysone receptor and mediator complex, causing them to shrink during metamorp

106 th transcriptional regulation as part of the mediator complex, cell cycle regulation, and other funct

107 lations had mutations in the transcriptional mediator complex, cohesin-related genes, and cell cycle

108 equires the Hth/Meis ortholog UNC-62 and the Mediator complex component SUR-2.

109 The Mediator complex connects transcriptional activators bou

110 A MED1/TRAP220-containing Mediator complex constitutively occupies the GC box regi

111 o and cellular approaches, we show here that Mediator complexes containing the CDK8 module are specif

112 uction, and plant infection, as a subunit of mediator complex contributing to transcriptional regulat

113 The human Mediator complex controls RNA polymerase II (pol II) fun

114 g domains to Gal11, a component of the yeast mediator complex, creates a powerful activator of genes

115 ssays show that TRAP220/MED1-containing TRAP/Mediator complexes directly bind to the Aurora-A promote

116 on origins, whereas the MED30 subunit of the Mediator complex directs Nipped-B and Vtd in Drosophila

117 The Mediator complex directs signals from DNA-binding transc

118 Consequently, this derivative 'T/G-Mediator' complex does not directly activate transcripti

119 e for MED25 as an integrative hub within the Mediator complex during the regulation of JA-associated

120 AF9-GCN5-acetylase) and a "core" form of the Mediator complex during transcription activation by the

121 1 (beta-catenin) and Crebbp; subunits of the Mediator complex; E3 ubiquitin ligase Nedd4; nuclear tra

122 e Med12 and Med13 subunits of the Drosophila mediator complex, encoded by kohtalo and skuld, are esse

123 we have found that in the fasted state, the Mediator complex exists primarily as an approximately 1.

124 ionally, G9a is important in stabilizing the Mediator complex for gene activation, whereas its repres

125 further by the isolation of an ERalpha-TRAP/Mediator complex from cultured cells expressing an epito

126 ed8 and partially purified a Med8-containing Mediator complex from rat liver nuclei.

127 dentified and partially purified a mammalian Mediator complex from rat liver nuclei.

128 viously partially purified a Med8-containing Mediator complex from rat liver nuclei.

129 latform we purify the human Cohesin, CCC and Mediator complexes from as little as 4 micrograms of inp

130 The Mediator complex functions as a hub for transcriptional

131 Mediator complex functions at the recruitment as well as

132 his phenotype results from a mutation in the Mediator complex gene Med31, which causes degradation of

133 lel to ERK and function redundantly with the Mediator complex gene sur-2 and the functionally related

134 The Mediator complex governs gene expression by linking upst

135 The Mediator complex harbouring disease- displays diminished

136 s of embryos defective in a component of the Mediator complex have revealed new insights into discret

137 th the intact and Head-Tail Deltamed19(rox3) Mediator complexes have defects in enhanced basal transc

138 ral transcription factors, in particular the mediator complex, have also been implicated as Gal4 targ

139 were used to investigate whether the RNAPII.Mediator complex (holo-RNAPII) can be disrupted by CTD p

140 how that Med1 and Med12, two subunits of the mediator complex implicated in transcription initiation

141 associates with the endogenous TRAP/DRIP/ARC/Mediator complex in a ligand-dependent manner.

142 onal synergism between TAF(II)s and the TRAP/Mediator complex in activated transcription, manifested

143 results support a physiological role of the Mediator complex in conveying regulatory signals to the

144 rm the CDK-cyclin pair as a component of the mediator complex in F. graminearum.

145 in a two-component homologous recombination mediator complex in genome maintenance and tumor suppres

146 lecules, histone acetyltransferase SRC1, and mediator complex in leptin-mediated regulation of CYCLIN

147 . (2016) describe a role for a member of the Mediator complex in maintaining HSC-specific enhancers a

148 gests that SOP-3 may act at the level of the Mediator complex in regulating transcription initiation.

149 Our results implicate the mediator complex in the mechanism of CSR and are consist

150 ATOR8 (MED8) and MED25 subunits of the plant Mediator complex in the regulation of root system archit

151 hese results define a role for Med25 and the Mediator complex in the regulation of xenobiotic metabol

152 that large E1A, but not small E1A, binds to Mediator complex in vivo.

153 ast, demonstrating the modular nature of the Mediator complex in vivo.

154 It is unclear whether Mediator complex in yeast is necessary for all RNA polym

155 /TRAP100) important for the integrity of the Mediator complex, indicating a general Mediator requirem

156 (Arabidopsis thaliana) MED15 subunit of the Mediator complex interacts directly with WRI1 in the nuc

157 RNAPII initiation and elongation and how the Mediator complex intervenes in this molecular tug-of-war

158 The Mediator complex is a central transcriptional coactivato

159 The multiprotein Mediator complex is a coactivator required for activatio

160 The multiprotein Mediator complex is a coactivator required for transcrip

161 The Mediator complex is a conserved multiprotein complex tha

162 The Mediator complex is a greater than 1-megadalton complex,

163 The multisubunit TRAP/Mediator complex is a mammalian counterpart of the yeast

164 MEDIATOR25 (MED25) subunit of the eukaryotic Mediator complex is a positive regulator of jasmonate (J

165 The Mediator complex is a regulatory hub for nearly all gene

166 As the Mediator complex is a transcriptional co-activator, our

167 The Mediator complex is an essential transcription regulator

168 Mediator complex is an evolutionarily conserved transcri

169 The multisubunit Mediator complex is an important coactivator for a broad

170 The Mediator complex is believed to recruit RNA polymerase I

171 column, only on the order of 1% of cellular Mediator complex is bound by E1A in vivo.

172 The evolutionarily conserved Mediator complex is central to the regulation of gene tr

173 Furthermore, the assembly state of the Mediator complex is dysregulated in states of obesity an

174 The 26-subunit, 1.2 MDa human Mediator complex is essential for expression of perhaps

175 The mediator complex is essential for the transcription of R

176 Mediator complex is essential for transcription by RNA p

177 The human Mediator complex is generally required for expression of

178 The Mediator complex is known to be a master coordinator of

179 it (Sur2/TRAP150beta/DRIP130/CRSP130) of the Mediator complex is not essential for IE62-mediated acti

180 The Mediator complex is required for basal activity of the R

181 te to the regulation of pol II activity, the Mediator complex is required for expression of most, if

182 ple mutant suggests that the function of the Mediator complex is required for the crosstalk.

183 The multiprotein Mediator complex is required for the regulated transcrip

184 The yeast Mediator complex is required for transcription by RNA po

185 The evolutionarily conserved Mediator complex is required for transcription of nearly

186 We propose that the Mediator complex is responsible for subtle but significa

187 Finally, the complete TRAP/Mediator complex is shown to enhance ER function directl

188 formed by RNA polymerase II (RNAPII) and the Mediator complex is the target of transcriptional regula

189 The Mediator complex is vital for the transcriptional regula

190 the MEDIATOR25 (MED25) subunit of the plant Mediator complex, is degraded by the proteasome and that

191 ited co-factor (ARC) complex or the metazoan Mediator complex, is essential for TGF beta/Activin/Noda

192 e genes, CDK8, which encodes a member of the mediator complex, is located at 13q12.13, a region of re

193 ectly interacts with the MED1 subunit of the Mediator complex, is recruited to the enhancer of the br

194 mSur2, a subunit of the Mediator complex, is required for efficient mouse adenov

195 port that Med25, an associated member of the Mediator complex, is required for the association of HNF

196 nts revealed a novel connection to Cdk8, the Mediator complex kinase subunit, and Skn7, a key transcr

197 s to selectively interact with a form of the Mediator complex lacking CDK8.

198 findings imply that a single subunit of the Mediator complex, MDT-15, integrates the activities of s

199 The human Mediator complex (MED) is composed of 28 elements and re

200 The evolutionarily conserved multiprotein Mediator complex (MED) serves as an interface between DN

201 protein (CBP), and the key component of the Mediator complex Med1.

202 Friend of GATA-1 (FOG-1), a component of the Mediator complex, Med1, facilitates GATA-1-dependent tra

203 In the liver, the key subunit of the Mediator complex, Med1, interacts with several nuclear r

204 tion in the component of the transcriptional mediator complex MED25 gene is responsible for the near

205 entified as a subunit of the transcriptional mediator complex MED25.

206 pherin (TNPO3) in viral integration, and the Mediator complex (Med28) in viral transcription.

207 o subunits of the transcriptional regulatory Mediator complex, MED5a and MED5b, results in an increas

208 tor function, we isolated two forms of human Mediator complexes (Mediator-P.5 and Mediator-P.85) and

209 activator (SRC), as well as the multisubunit mediator complexes ("Mediator"), which may help recruit

210 required the transcription factor ELT-2 and mediator complex member MDT-15.

211 d31 mutant phenotype is not similar to other Mediator complex mouse mutants, and target genes of othe

212 , the two largest subunits of the Drosophila mediator complex; mutations in either gene cause identic

213 ecently has it been shown that in yeast, the Mediator complex normally occupies promoters only transi

214 of many critical metabolic pathways, and the Mediator complex occupies a central role in recruiting R

215 ibody indicated that at least two classes of Mediator complexes occur, one containing CDK8 and cyclin

216 The Mediator complex of approximately 25 proteins is broadly

217 identified SIN4, encoding a component of the Mediator complex of RNA polymerase II.

218 ith Med12 and Med13, associate with the core mediator complex of RNA polymerase II.

219 Structures of yeast Mediator complex, of a related complex from mouse cells

220 The transcriptional Mediator complex offers a mechanism to coordinate the ti

221 The Mediator complex orchestrates multiple transcription fac

222 recruitment of transcription factors to form mediator complexes, phosphorylating RNA polymerase II, a

223 The Mediator complex plays a critical role in the regulation

224 rging evidence suggests that the Arabidopsis Mediator complex plays a crucial role in these transcrip

225 The evolutionary conserved Mediator complex plays a key coregulatory role in steroi

226 min D-interacting protein 205 (DRIP205) is a mediator complex protein that anchors the complex to the

227 -1, which encodes a homolog of the mammalian Mediator complex protein TRAP230.

228 levels include cyclin-dependent kinase, the mediator complex, protein phosphatase 2A, and ribosomal

229 The multiprotein transcriptional Mediator complex provides a key link between RNA polymer

230 machinery (chromatin remodelling factors and Mediator Complex), punctate nuclear localisation in euch

231 a regulatory subunit of the transcriptional Mediator complex recently associated with two human synd

232 inding on one side and co-regulated with the Mediator complex recruitment and H3K27ac level changes a

233 The human Mediator complex regulates RNA polymerase II transcripti

234 e roles of three proteins in the RNA Editing Mediator Complex (REMC).

235 larities to Med150/Rgr1-like subunits of the Mediator complex required for transcriptional activation

236 tations in components of the transcriptional Mediator complex, resulting in synthetic lethality and l

237 Further analysis of the multi-subunit Mediator complex revealed that a specific subset of its

238 rometry of proteins in immunoprecipitates of mediator complexes revealed specific interactions betwee

239 The TRAP/Mediator complex serves as a coactivator for many transc

240 hyroid hormone receptor associated proteins)/Mediator complex serves as a transcriptional coactivator

241 Previously, subunits of the Sin4 Mediator complex (Sin4, Pgd1, Gal11, and Med2) have been

242 ator complex, analyze the composition of the Mediator complex solely from our data to demonstrate the

243 th cisplatin; a truncating mutation in MED1 (mediator complex subunit 1) following treatment with tam

244 Mediator complex subunit 12 (MED12) exon 2 variants are

245 lity group AT-hook 2 (HMGA2) rearrangements, mediator complex subunit 12 (MED12) mutations, biallelic

246 isolated from adjacent myometrium carried a mediator complex subunit 12 mutation, a genetic marker o

247 ion in monocytes via increased production of mediator complex subunit 14 (MED14).

248 ociation on chromosome 6 at the Homo sapiens mediator complex subunit 23 gene/arginase I locus.

249 This Mediator complex subunit associates with Med 12, Med13,

250 Mutation of the Mediator complex subunit Med12 impairs the specification

251 We show that the Mediator complex subunit MED13L is required for Rb/E2F c

252 an unexpected binding between Elmo1 and the Mediator complex subunit Med31.

253 Here, we show that conditional loss of a Mediator complex subunit protein, Med23 in mouse neural

254 oylated Gcn4 requires the protein kinase and Mediator complex subunit Srb10, linking activator remova

255 ith decreased enrichment of H3K27ac and MED (Mediator complex subunit)-1, and reduced recruitment of

256 c mutations solely in MED12, which encodes a Mediator complex subunit.

257 ansformed cells, an in vivo interaction with Mediator complex subunits has not been described previou

258 n with live-cell imaging revealed a role for Mediator complex subunits in regulating the duration of

259 Disruption of the Mediator complex subunits MED5a (also known as REF4) and

260 n transformed cells, probably explaining why Mediator complex subunits were not identified among cell

261 id metabolism, and MED13, a component of the Mediator complex that controls nuclear hormone receptor

262 prevented binding of both MED1, a subunit of Mediator complex that facilitates enhancer-promoter inte

263 especially for the multicomponent TRAP/SMCC/Mediator complex that has emerged as the central regulat

264 he protein acetyl transferase p300, the TRAP/Mediator complex that interacts with the general transcr

265 t MED1 exists only in a subpopulation of the Mediator complex that is enriched with a number of disti

266 w that Trap220(-)(/)(-) cells possess a TRAP/Mediator complex that is relatively intact and compromis

267 dk8) is a component of the RNA polymerase II Mediator complex that predominantly represses the transc

268 k between Sox10 and the Med12 subunit of the Mediator complex that serves as a conserved multiprotein

269 I, a common set of initiation factors, and a Mediator complex that transmits regulatory information t

270 Unlike the coactivator CRSP/Mediator complex that undergoes drastic and global struc

271 target gene transcription by recruiting the mediator complex through interactions with Med12 and Med

272 F) transcription factors to recruit the core Mediator complex to cold-regulated genes.

273 ptor-mediated transcription by anchoring the Mediator complex to diverse promoter-bound nuclear recep

274 hanistically, YAP interacts and recruits the Mediator complex to enhancers, allowing the recruitment

275 ein-coding gene SLC3A2 in cis by binding the Mediator complex to facilitate the establishment of enha

276 transcriptional regulators interact with the Mediator complex to initiate transcription and how those

277 ed proteins that act in association with the Mediator complex to negatively regulate transcription.

278 that HIF1A employs a specific variant of the Mediator complex to stimulate RNAPII elongation.

279 uence (UAS), and SAGA, in turn, recruits the Mediator complex to the UAS.

280 posed that human adenovirus E1A recruits the Mediator complex to transactivate transcription of viral

281 monstrated intranuclear translocation of the Mediator complex to viral replication compartments.

282 ontaining versus MED1/TRAP220-deficient TRAP/Mediator complexes to estrogen receptor (ER) and p53 tar

283 lusters of enhancers densely loaded with the Mediator complex, transcription factors and chromatin re

284 The 21-subunit Mediator complex transduces regulatory information from

285 a demonstrate that the assembly state of the Mediator complex undergoes physiologic regulation during

286 the IE62 activation domain targets the human Mediator complex via the Med25 (ARC92) subunit and that

287 d hormone receptor-associated protein (TRAP)-Mediator complex was originally identified as a large mu

288 itamin D receptor interacting protein (DRIP)/mediator complex was purified from primary keratinocytes

289 Components of the Mediator complexes were identified by mass spectrometry

290 e, and Tail modules form the core functional Mediator complex, whereas a fourth, the Cyc-C module, is

291 mplex, consistent with the size of the large Mediator complex, whereas following feeding, it converts

292 SPL10 interacts with MED25, a subunit of the Mediator complex, which bridges transcription factors an

293 ergy homeostasis via MED13, a subunit of the Mediator complex, which controls transcription by thyroi

294 components of the CDK8 kinase module of the Mediator complex, which is a deeply conserved regulator

295 The multiprotein human TRAP/Mediator complex, which is phylogenetically related to t

296 subsequently it recruits the PALB2 and BRCA2 mediator complex, which stabilizes RAD51-DNA nucleoprote

297 a component of the evolutionarily conserved Mediator complex, whose in vivo function is not well und

298 by interaction of the CDK8 submodule of the mediator complex with beta-catenin/TCF transcriptional c

299 Similarly, an analysis of isolated TRAP/Mediator complexes with mutations in either or both of t

300 a gene that encodes a component of the yeast Mediator complex within the RNA polymerase II holoenzyme