ライフサイエンスコーパス: mediator of inflammation

1 ide (NO) has been recognized as an important mediator of inflammation.

2 ereas bradykinin is a potent vasodilator and mediator of inflammation.

3 mediator of antiviral defenses, it is also a mediator of inflammation.

4 the myelomonocytic lineage and an important mediator of inflammation.

5 e the CTpr level, which is a potential toxic mediator of inflammation.

6 rse physiological actions, particularly as a mediator of inflammation.

7 We concluded that endogenous NO acts as a mediator of inflammation.

8 ive at low doses, induces autophagy and is a mediator of inflammation.

9 cell types such as cardiomyocytes; and as a mediator of inflammation.

10 kinetic factor to an activated and efficient mediator of inflammation.

11 Nuclear factor kappa B (NF-kappaB) is a key mediator of inflammation.

12 40 gene and the genes encoding several other mediators of inflammation.

13 amines and a reduction in canonical cytokine mediators of inflammation.

14 such as periodontitis, with a focus on lipid mediators of inflammation.

15 initiating the biosynthesis of lipid-derived mediators of inflammation.

16 nes with a prominent increase in markers and mediators of inflammation.

17 ed metabolites mapping to pathways for lipid mediators of inflammation.

18 to release peptides in response to trauma or mediators of inflammation.

19 precursor (CTpr) levels are both markers and mediators of inflammation.

20 eukin (IL-1)alpha and IL-1beta are important mediators of inflammation.

21 ing peptides, which are proposed to be major mediators of inflammation.

22 gamma(+/+) cells appear to involve different mediators of inflammation.

23 r enhanced synthesis of paracrine eicosanoid mediators of inflammation.

24 rostaglandins and glucocorticoids are potent mediators of inflammation.

25 on and tissue injury could thus be important mediators of inflammation.

26 is (RA), and can secrete cytokines and other mediators of inflammation.

27 ndins (PGs) and are among the most important mediators of inflammation.

28 rienes (CysLTs) have been defined as central mediators of inflammation.

29 nex multiplex array analysis for established mediators of inflammation.

30 ly active IL-1beta, IL-18, and other soluble mediators of inflammation.

31 ide and hydrogen sulfide are key signals and mediators of inflammation.

32 genase (COX)-derived oxylipins are important mediators of inflammation.

33 lly similar, but functionally distinct lipid mediators of inflammation.

34 osynthesis to the production of proresolving mediators of inflammation.

35 mily of cytokines comprises a set of pivotal mediators of inflammation.

36 act as upstream facilitators and downstream mediators of inflammation.

37 erleukin-1 beta and -18, which are important mediators of inflammation.

38 oxygenase pathways are known to be important mediators of inflammation.

39 h mobility group box 1 are critical cytokine mediators of inflammation.

40 rging evidence that specialized proresolving mediators of inflammation accelerate wound healing by pr

41 nt studies have implicated HMGB1 as an early mediator of inflammation after HS/R and organ ischemia/r

42 Herein, we describe LPA as an important mediator of inflammation after spinal cord injury (SCI)

43 Proinflammatory macrophages are important mediators of inflammation after myocardial infarction an

44 ls of expression of messenger RNA (mRNA) for mediators of inflammation, aggrecanases, MMPs, and their

45 noids and platelet-activating factor, potent mediators of inflammation, allergy, apoptosis, and tumor

46 These results suggest that on stimulation by mediators of inflammation, although the basal transcript

47 Interleukin-1 beta (IL-1beta) is a major mediator of inflammation and a growth promoter for many

48 As a critical mediator of inflammation and apoptosis in various cell t

49 sed by Egr-1, suggesting that Egr-1 is a key mediator of inflammation and apoptosis in vascular cells

50 The CD40 pathway is a key mediator of inflammation and autoimmunity.

51 lator of CDC42 small G-protein signaling and mediator of inflammation and candidate coregulator of am

52 Moreover, NO is also a critical mediator of inflammation and carcinogenesis.

53 Interleukin (IL)-1 is an important mediator of inflammation and cardiovascular disease.

54 rachidonic acid, a omega-6 PUFA, is a potent mediator of inflammation and cell proliferation.

55 TNF-alpha is a central mediator of inflammation and critical for host response

56 Nitric oxide (NO) is a ubiquitous mediator of inflammation and immunity, involved in the p

57 Interleukin-1 (IL-1) is a key mediator of inflammation and immunity.

58 The interleukin (IL)-1 pathway is a key mediator of inflammation and innate immune responses.

59 terleukin-1 beta (IL-1beta) is a pleiotropic mediator of inflammation and is produced in response to

60 Much evidence implicates IL-8 as a major mediator of inflammation and joint destruction in rheuma

61 These results suggest that fibrin is a mediator of inflammation and may impede the reparative p

62 results indicate that LOX-1 is an important mediator of inflammation and neutrophil dysfunction in s

63 The TAK1 (MAP3K7) is a key mediator of inflammation and non-canonical TGF-beta sign

64 in contrast to the role of HMGB1 as an early mediator of inflammation and organ damage in hepatic I/R

65 flammation of sepsis, HMGB1 acts as an early mediator of inflammation and organ damage in hepatic isc

66 that scavenges isolevuglandins-a downstream mediator of inflammation and oxidative stress.

67 E(2) (PGE(2)) is a prevalent and established mediator of inflammation and pain in numerous tissues an

68 IL-13 is an important mediator of inflammation and remodeling.

69 the gene encoding chemokine receptor Ccr2, a mediator of inflammation and several disease processes.

70 hat epithelial-derived MMP-9 is an important mediator of inflammation and tissue damage in colitis.

71 complement C5a system, which is an important mediator of inflammation and tissue regeneration, is act

72 phospholipase A2alpha (cPLA2alpha)] is a key mediator of inflammation and tumorigenesis.

73 as the immune-suppressive function of lipid mediators of inflammation and alarmins, are just some ex

74 thesis of leukotrienes, potent extracellular mediators of inflammation and allergic disorders.

75 of arachidonic acid to leukotrienes, potent mediators of inflammation and allergy.

76 hesis of eicosanoids and other lipid-derived mediators of inflammation and allergy.

77 Eicosanoids are powerful mediators of inflammation and are known to drive both th

78 CD4+ T helper 1 (TH1) cells are important mediators of inflammation and are regulated by numerous

79 T cells are critical mediators of inflammation and as such, their migration t

80 pro-HGF in vitro raises the possibility that mediators of inflammation and blood coagulation may also

81 ransfusion requirements, and levels of serum mediators of inflammation and cardiac troponin I were si

82 These elevated gene products are molecular mediators of inflammation and collagen degradation in ac

83 dent atrial fibrillation was associated with mediators of inflammation and fibrosis (MMP2 [matrix met

84 ern recognition receptors that are essential mediators of inflammation and host defense in the gastro

85 Genes encoding mediators of inflammation and host defense, including CD

86 Cytokines are critical mediators of inflammation and host defenses.

87 e derived from arachidonic acid and serve as mediators of inflammation and immediate hypersensitivity

88 A (dsRNA)-activated genes, including several mediators of inflammation and immune cell recruitment.

89 Statins have diverse effects on the cellular mediators of inflammation and immunity that may be parti

90 t of direct interactions between the soluble mediators of inflammation and infectious agents.

91 thelial cells were cultured and assessed for mediators of inflammation and injury, such as ICAM-1, AP

92 airways quantitatively with respect to known mediators of inflammation and intercellular communicatio

93 synovial intimal lining of the joint are key mediators of inflammation and joint destruction in rheum

94 scle (SkM) atrophy and dysfunction, decrease mediators of inflammation and normalize metabolic pertur

95 Prostaglandins and NO. are important mediators of inflammation and other physiological and pa

96 expression with indices of disease severity, mediators of inflammation and outcome indicates a key ro

97 the synthesis of leukotrienes LTB4 and LTC4, mediators of inflammation and pain, were found in the UT

98 that this was, in part, due to the effect of mediators of inflammation and predicted that greater cha

99 ood pressure (BP), heart rate, cortisol, and mediators of inflammation and reductions in heart rate v

100 NOS; NOS-2) and cyclooxygenase-2 (COX-2) are mediators of inflammation and regulators of epithelial c

101 sis of eicosanoids and other bioactive lipid mediators of inflammation and resolution underlying dise

102 , these cytokines are also recognized as key mediators of inflammation and the pathobiology of divers

103 LPG's inhibitory activity for several mediators of inflammation and the persistence of signifi

104 Eicosanoids are potent mediators of inflammation and tightly associated with mo

105 ophil cationic protein (ECP), are well-known mediators of inflammation and tissue damage in asthma.

106 Macrophages are important mediators of inflammation and tissue remodeling.

107 ctivation and mRNA stabilization of numerous mediators of inflammation and tissue repair.

108 ) and prostaglandin E(2) (PGE(2)), important mediators of inflammation and tumor promotion.

109 xygenase-2), which is an important enzymatic mediator of inflammation, and a target of aspirin.

110 Nitric oxide (NO.), an important mediator of inflammation, and beta-catenin, a component

111 e, CO blocked expression of Egr-1, a central mediator of inflammation, and decreased tissue damage; i

112 rosis factor alpha (TNF-alpha) is a critical mediator of inflammation, and its production is tightly

113 Prostaglandin E2 (PGE2) is a lipid mediator of inflammation, and its tissue concentration i

114 ONOOCO(2)(-)), a macrophage-derived chemical mediator of inflammation, and the classical one-electron

115 Monocytes are major mediators of inflammation, and apoptosis provides a mech

116 Inflammasomes are mediators of inflammation, and constitutively activated

117 Expression is modulated by serum factors, mediators of inflammation, and kinase activators and inh

118 ritic inflammation and inhibited the defined mediators of inflammation, angiogenesis, cell survival,

119 sis factor alpha (TNF-alpha) is an important mediator of inflammation, apoptosis, and the development

120 Accordingly, these mediators of inflammation are the targets of several ant

121 Both of these mediators of inflammation are thought to contribute to t

122 to generate arachidonate-derived eicosanoid mediators of inflammation are uncertain.

123 are members of the specialized pro-resolving mediators of inflammation, are produced.

124 Here, we examine the association of upstream mediators of inflammation as ascertained by fatty-acid d

125 exists between vascular cellular hypoxia and mediators of inflammation associated with aortic aneurys

126 We hypothesized that mediators of inflammation associated with atherosclerosi

127 Nitric oxide is believed to be a prominent mediator of inflammation based in part on the correlativ

128 TGF-beta1 is an important suppressive mediator of inflammation, but it can also drive fibrosis

129 COX2 activity is an important mediator of inflammation, but it is not known whether CO

130 ensitivity is differentially associated with mediators of inflammation by studying 2 chronic inflamma

131 onstitutive decay of instable mRNAs encoding mediators of inflammation by various experimental approa

132 ults of these studies indicate that a common mediator of inflammation can lead to the induction of SS

133 ntation abolished the expression of mRNA for mediators of inflammation (cyclooxygenase 2, 5-lipoxygen

134 Resolvin E1 (RvE1) is a potent proresolving mediator of inflammation derived from omega-3 eicosapent

135 ienes (cys-LTs) are a family of potent lipid mediators of inflammation derived from arachidonic acid.

136 Leukotrienes (LTs) are potent mediators of inflammation derived from the 5-lipoxygenas

137 for the first time that ONOO(-) is a potent mediator of inflammation-derived hyperalgesia operating

138 Specialized proresolving mediators of inflammation drive macrophage efferocytosis

139 though TNF-alpha is believed to be a central mediator of inflammation-driven atherosclerosis, genetic

140 response to inflammatory cytokines and novel mediators of inflammation-driven degradation in tissue-e

141 eased by many cell types and is an important mediator of inflammation during infection.

142 ents of microorganisms and are critical host mediators of inflammation during infection.

143 highly conserved and regulated, pleiotropic mediators of inflammation, essential to respond adequate

144 Mediators of inflammation, fibrosis, and regeneration we

145 iator of lethality in sepsis and as an early mediator of inflammation following injury.

146 tivating factor (PAF), a potent phospholipid mediator of inflammation, for its ability to activate CR

147 Leukotriene B(4) (LTB(4)) is a potent lipid mediator of inflammation formed by the 5-lipoxygenase (5

148 Leukotrienes (LTs) are lipid mediators of inflammation formed by enzymatic oxidation

149 The leukotrienes are potent lipid mediators of inflammation formed by the 5-lipoxygenase-c

150 se), the expression of which is regulated by mediators of inflammation, had a strong, positive associ

151 ucible nitric-oxide synthase (iNOS), a major mediator of inflammation, has been implicated in beta-ce

152 Inducible nitric-oxide synthase (iNOS), a mediator of inflammation, has been implicated in many hu

153 ur data support the hypothesis that cellular mediators of inflammation have a role in atherogenesis a

154 Neutrophils and macrophages, as key mediators of inflammation, have defined functionally imp

155 or necrosis factor (TNF) alpha is a critical mediator of inflammation; however, TNFalpha is rarely re

156 Although PAF plays a key role as a mediator of inflammation in acute pancreatitis, the site

157 estigated why the production of IL-23, a key mediator of inflammation in autoimmunity, is blocked whe

158 rP was induced in glia by TNF-alpha, a known mediator of inflammation in brain and of PTHrP induction

159 valuated whether prostacyclin is a necessary mediator of inflammation in graded bacteremia or is suff

160 oncanonical inflammasome activation as a key mediator of inflammation in macrophages.

161 otubule dysfunction has been implicated as a mediator of inflammation in multiple diseases such as di

162 Thus, TNF-alpha appears to be an important mediator of inflammation in patients with poor viral con

163 by antibody to cyclophilin A (CyPA), a known mediator of inflammation in peripheral tissues, and by c

164 Tumor necrosis factor (TNF) is a powerful mediator of inflammation in rheumatoid arthritis (RA).

165 ypothesis that osteopontin may be a critical mediator of inflammation in specific disease and injury

166 rt the conclusion that MCP-1 is an important mediator of inflammation in the CNS.

167 TING signalling pathway has emerged as a key mediator of inflammation in the settings of infection, c

168 Originally identified as a potential mediator of inflammation in the skin, we recently report

169 ogenesis of bacterial meningitis as a potent mediator of inflammation in the subarachnoid space.

170 Therefore, PDE3 is a novel mediator of inflammation in VSMCs.

171 Recent work indicates T cells are important mediators of inflammation in a mouse model of T2D.

172 e cyclooxygenase (COX) enzymes are important mediators of inflammation in arthritis.

173 Expression of CARD8 was correlated to mediators of inflammation in atherosclerotic lesions usi

174 ic DNA (cytoDNA) species are emerging as key mediators of inflammation in diverse physiological and p

175 arachidonyl-phosphatidyl choline (PAPC), are mediators of inflammation in endothelial cells (ECs) and

176 staglandin E2 (PGE2) have been implicated as mediators of inflammation in OA.

177 The mediators of inflammation in spondyloarthropathies have

178 demonstrates the differential expression of mediators of inflammation in the esophageal mucosa of pa

179 te immune complement component C5a, a potent mediator of inflammation, in the pathogenesis of DKD in

180 anscription factor that is activated by many mediators of inflammation including IL-1, IL-6, and bact

181 ern diet, are precursors for a number of key mediators of inflammation including the 2-series of pros

182 ve target for inhibiting Ca(2+) responses to mediators of inflammation, including C5a, UDP, PAF, and

183 tion of SCW-induced arthritis and changes in mediators of inflammation, including T cell subsets, pro

184 peralgesia and interacts with many different mediators of inflammation, including the MAPK signaling

185 oleamine 2,3-dioxygenase (IDO), is a pivotal mediator of inflammation-induced depression, its mechani

186 However, the specific mediators of inflammation-induced injury remain unclear.

187 st invading pathogens but are also important mediators of inflammation-induced injury.

188 the optimal 10 mg/kg dose downregulated key mediators of inflammation-induced lymphangiogenesis, cor

189 mis, are the sites for the expression of two mediators of inflammation, inducible nitric oxide syntha

190 at prostaglandin E(2) (PGE(2)), a well-known mediator of inflammation, inhibits mucosal T(regs) in a

191 As an established mediator of inflammation, interleukin-6 (IL-6) is implic

192 An important mediator of inflammation is extracellular adenosine trip

193 Insight into pathogenic mediators of inflammation is essential for targeted and

194 r necrosis factor-alpha (TNF-alpha), a major mediator of inflammation, is chronically produced in the

195 tivity of the NLRP3 inflammasome, a critical mediator of inflammation, is controlled by accessory pro

196 COX-2, a key mediator of inflammation, is upregulated in activated mo

197 e synthesis of prostanoids, which are potent mediators of inflammation, is dramatically increased.

198 Although originally identified as mediators of inflammation, it is now apparent that chemo

199 45) for the presence of cytokines and lipid mediators of inflammation (LMIs).

200 ammation and cancer, and it is believed that mediators of inflammation may be responsible for this ph

201 The reduction in the mediators of inflammation may thus be responsible for th

202 n vivo may represent previously unrecognized mediators of inflammation-mediated protein modification

203 and c) changes in the inflammatory cells and mediators of inflammation of the respiratory secretions

204 essed the effect of myeloperoxidase (MPO), a mediator of inflammation, on nitrosation observed during

205 the production of prostaglandins, important mediators of inflammation, pain, cardiovascular disease,

206 Circulating mediators of inflammation participate in the mechanisms

207 s recent developments in the role of soluble mediators of inflammation, particularly arachidonic acid

208 Information on mediators of inflammation permeated many sessions, havin

209 Because the lipid mediator of inflammation, platelet-activating factor (PA

210 )-irradiated keratinocytes secrete the lipid mediator of inflammation, platelet-activating factor (PA

211 ucible nitric-oxide synthase (iNOS), a major mediator of inflammation, plays an important role in obe

212 Cellular senescence is a plausible mediator of inflammation-related tissue dysfunction.

213 ust is compartmentalized, involving specific mediators of inflammation released by macrophages, neutr

214 inflammatory trigger as well as a potential mediator of inflammation resolution.

215 These findings establish CSPGs as critical mediators of inflammation resolution failure after SCI i

216 Lipid mediators of inflammation resolution, e.g., resolvin D2,

217 Platelet-activating factor (PAF) is a mediator of inflammation shown to orchestrate inflammato

218 and APCs, are major producers of the central mediator of inflammation, soluble TNF-alpha (sTNF).

219 The biliary epithelium is exposed to mediators of inflammation such as bacterial endotoxin or

220 nnate sources of type 2 cytokines and innate mediators of inflammation such as the alarmins.

221 Important mediators of inflammation such as the cytokine tumor nec

222 nd its expression is markedly upregulated by mediators of inflammation such as tumor necrosis factor

223 AS1 is a transcription factor that activates mediators of inflammation, such as tumor necrosis factor

224 chronic hyperglycemia seems to be a stronger mediator of inflammation than cigarette smoking in patie

225 Prostaglandin E(2) is a potent lipid mediator of inflammation that effects changes in cell fu

226 The anaphylatoxin C5a is a potent mediator of inflammation that exerts a broad range of ac

227 CD95 is a mediator of inflammation that has also been proposed as

228 factor (PAF) is a phosphoglycerylether lipid mediator of inflammation that is implicated in infection

229 These findings identify TGR5 as a negative mediator of inflammation that may serve as an attractive

230 GMP-AMP synthase (cGAS) has emerged as a key mediator of inflammation that underlies cardiovascular d

231 lso possess a repertoire of potent preformed mediators of inflammation that are released on activatio

232 s suggest that the production of pleiotropic mediators of inflammation that influence cartilage homeo

233 elet-activating factor (PAF) is an important mediator of inflammation, the action of which in endothe

234 s an initial step in the production of lipid mediators of inflammation: the Ca2+-dependent translocat

235 They are mediators of inflammation through the production of path

236 ism is key to the control of essential early mediators of inflammation, TNF, CXCL1, and CXCL2, as wel

237 ed for the renal induction of genes encoding mediators of inflammation (vcam-1, s100A9, and Il-1b) an

238 y throughout the lung, caused by blood-borne mediators of inflammation, voluminous aspiration, or inh

239 KLF4 was an epithelial-specific mediator of inflammation; we developed a new mouse model

240 ation of hepatic stellate cells, but hepatic mediators of inflammation were not significantly differe

241 Levels of key mediators of inflammation were reduced in patient tears

242 latelet-activating factor (PAF), both potent mediators of inflammation, were used as triggers for gen

243 uce the aggregation of HMGB1 protein, a late mediator of inflammation, which subsequently stimulates

244 products of arachidonic acid metabolism are mediators of inflammation with an important role in the

245 Prostaglandins (PGs) are mediators of inflammation with pronociceptive actions wi