ライフサイエンスコーパス: medicinal

1 uorinated motifs which are commonly found in medicinal agents and agrochemicals.

2 e we engineered baker's yeast to produce the medicinal alkaloids hyoscyamine and scopolamine, startin

3 sulfonimidamides are promising compounds for medicinal and agrochemistry.

4 fields of organic synthesis, catalysis, and medicinal and biological chemistry.

5 Copper complexes are of medicinal and biological interest, including as anticanc

6 At their most productive, medicinal and computational chemists have made significa

7 momum verum is the widely used spice for its medicinal and culinary uses since ages.

8 y history of Cannabis and Humulus, including medicinal and industrial applications.

9 on strategies have important applications in medicinal and material research.

10 role played by 2-hydroxybiaryls in organic, medicinal and materials chemistry, concise methods for t

11 in the discovery of functional molecules for medicinal and materials science.

12 that are interesting from both a biological/medicinal and origins of life chemistry point of view.

13 and boronate groups, that are ubiquitous in medicinal and process chemistry programs.

14 ected applications of the methodology within medicinal and process chemistry.

15 This statement critically reviews the use of medicinal and recreational cannabis from a clinical but

16 n is the foundation of a multibillion dollar medicinal and recreational plant bioproducts industry.

17 more states are legalizing cannabis for both medicinal and recreational purposes.

18 legalized only recently, in some states, for medicinal and/or recreational use.

19 chs two species of milkweed; A. curassavica (medicinal) and A. incarnata (non-medicinal) grown under

20 C(sp(3))-Si bonds is important in synthetic, medicinal, and materials chemistry.

21 rs sensory perception and exhibits potential medicinal benefits.

22 Floral concentrations of medicinal cannabidiol (CBD) and terpenoids were not affe

23 dies examining any type and formulation of a medicinal cannabinoid in adults (>=18 years) for treatin

24 Computational models can assist the medicinal chemist in this endeavour.

25 mprehensive and up-to-date reference for the medicinal chemist on the structure-activity-toxicity of

26 This Perspective provides the medicinal chemist with background and advice on the art

27 to be considered as a routine part of every medicinal chemist's toolbox.

28 e been used to great affect in synthesis and medicinal chemistries, homoenolates and their higher hom

29 ch as proteins, RNA or DNA nor light-induced medicinal chemistry (e.g., photodynamic therapy) are cov

30 This Perspective reviews the biological and medicinal chemistry advances over the past 3 decades wit

31 Recent advances in organic synthesis and medicinal chemistry allow further optimization of lead e

32 phatic amines - valuable building blocks for medicinal chemistry and agrochemistry.

33 enantioenriched diamines for applications in medicinal chemistry and catalysis.

34 yl compounds are valuable building blocks in medicinal chemistry and chemical industry.

35 tem, generating motifs which are valuable in medicinal chemistry and chiral ligand design.

36 ime class of heterocycles, very important to medicinal chemistry and drug design due to not only thei

37 ontaining compounds are increasingly used in medicinal chemistry and drug design in order to establis

38 thus enabling their potential application in medicinal chemistry and drug design.

39 cules is a highly desirable approach used in medicinal chemistry and drug discovery processes to alte

40 eads is still a dynamic and fertile field in medicinal chemistry and drug discovery.

41 s to building blocks which are important for medicinal chemistry and drug discovery.

42 mino alcohols, important building blocks for medicinal chemistry and drug discovery.

43 nteresting and versatile functional group in medicinal chemistry and drug discovery.

44 pha-aminoboronic acids play a unique role in medicinal chemistry and have emerged as privileged pharm

45 vo Following lead identification, subsequent medicinal chemistry and structure-activity relationship

46 d KHK inhibitors by combined use of parallel medicinal chemistry and structure-based drug design.

47 s of nucleic acids is an important branch of medicinal chemistry and the nature of these interactions

48 s together in order to improve computational medicinal chemistry and, most importantly, deliver bette

49 oms have been at the center of many rational medicinal chemistry applications in drug design.

50 lopment, macromolecular crystallography, and medicinal chemistry applications is now warranted.

51 ility in organic synthesis, particularly for medicinal chemistry applications.

52 es, which can present a potential utility in medicinal chemistry applications.

53 GPCRs and their disease indications and the medicinal chemistry approaches toward novel allosteric m

54 w, we discuss and provide an overview of the medicinal chemistry approaches toward the development of

55 ved from much wider publishing of industrial medicinal chemistry are described.

56 d BCP moieties have become widely adopted in medicinal chemistry as para-phenyl ring replacements(2).

57 attractive to practitioners of synthetic and medicinal chemistry as well as in other areas that use b

58 is the most-used bond-construction method in medicinal chemistry because the chemistry is reliable an

59 ontaining one fluorine atom are valuable for medicinal chemistry because they mimic common tertiary s

60 We now present a detailed account of the medicinal chemistry campaign leading to this molecule, w

61 In this study, a successful medicinal chemistry campaign that exploited virtual, bio

62 Here we carried out a medicinal chemistry campaign that led to the discovery o

63 We undertook a focused medicinal chemistry campaign to simultaneously preserve

64 Recent medicinal chemistry campaigns along with a brief overvie

65 The use of an acetylene (ethynyl) group in medicinal chemistry coincides with the launch of the Jou

66 interest to the computational chemistry and medicinal chemistry communities in recent decades.

67 ss" dramatically altered the behavior of the medicinal chemistry community for a long time.

68 unctional group as a structural alert by the medicinal chemistry community.

69 ides a valuable component for machine-driven medicinal chemistry design workflows.

70 ounds, ranging from approved drugs to recent medicinal chemistry developments.

71 d end-to-end prototypes realized to expedite medicinal chemistry discovery cycles.

72 We report herein the medicinal chemistry discovery of a series of LOX inhibit

73 erocycles that hold great promise in current medicinal chemistry due to their desirable pharmacokinet

74 In practice, all medicinal chemistry efforts and eventual commercializati

75 Medicinal chemistry efforts confirmed activity of 70 pur

76 Perspective highlights some of the dedicated medicinal chemistry efforts directed at inhibiting the f

77 Herein, we describe the medicinal chemistry efforts focused on a cGMP-dependent

78 This publication covers the medicinal chemistry efforts resulting in the identificat

79 pattern processing in the ER and will enable medicinal chemistry efforts targeting human 2OG oxygenas

80 These findings should help focus medicinal chemistry efforts that desire to optimize Nurr

81 ission-blocking agents, herein we report our medicinal chemistry efforts to study the potential of th

82 and serve as a starting point for subsequent medicinal chemistry efforts.

83 e lessons can be potentially extrapolated to medicinal chemistry endeavors in the taxane family, as w

84 of chemical space render decision making in medicinal chemistry exceptionally demanding.

85 principle could find a broad interest in the medicinal chemistry field as it can be useful not only f

86 ulfoximines have been largely disregarded in medicinal chemistry for a long time.

87 in protein-ligand complexes, completing the medicinal chemistry guide to rational halogen interactio

88 Recent advances in medicinal chemistry have established inhibitors targetin

89 otypes for guiding large-scale screening and medicinal chemistry have not been shown.

90 coincides with the launch of the Journal of Medicinal Chemistry in 1959.

91 ange of applications in physical organic and medicinal chemistry in the past 55+ years.

92 Herein, we report our medicinal chemistry investigation involving the explorat

93 usion, the value of spirocyclic scaffolds in medicinal chemistry is discussed.

94 Bibliometric data from seven medicinal chemistry journals between 2000 and 2019 are c

95 Further analysis revealed inherent medicinal chemistry knowledge potentially useful to chem

96 es, an heterocyclic moiety commonly found in medicinal chemistry leads and drugs.

97 structure-based drug design and traditional medicinal chemistry led to the discovery of compound 23

98 d 2019 are collated including Bioorganic and Medicinal Chemistry Letters and the Journal of Medicinal

99 of various FGs in molecules described in the medicinal chemistry literature over the last 40 years an

100 This Perspective of the published essential medicinal chemistry of cannabidiol (CBD) provides eviden

101 , it is hoped that further research into the medicinal chemistry of photopharmacological agents will

102 her advances have opened new avenues for the medicinal chemistry of PS-ASOs and research on all eleme

103 y high-throughput screening and the targeted medicinal chemistry optimization for two molecular scaff

104 We report herein the design, synthesis, and medicinal chemistry optimization of the benzylamine seri

105 Without any medicinal chemistry optimization, the most potent hit ha

106 plays a paramount role in pharmaceutical and medicinal chemistry owing to its synthetic merits and th

107 Medicinal chemistry plays a fundamental and underlying r

108 f these atypical bioisosteres when used in a medicinal chemistry program, the search to find a suitab

109 This methodology promises to enable new medicinal chemistry programs aimed at the modulation of

110 uilding blocks with potential application in medicinal chemistry programs as p-substituted aniline bi

111 2, RAD51, RAD52, and PD-1) and discusses the medicinal chemistry programs being used to interrogate t

112 e to accelerate and improve success rates in medicinal chemistry programs by more effectively leverag

113 by utilizing survey data obtained from five medicinal chemistry programs in the Midwest and recent a

114 aining ring systems are increasingly used in medicinal chemistry programs to modulate druglike proper

115 rmaceutical industry, ranging from advancing medicinal chemistry programs to self-optimizing syntheti

116 uccessfully demonstrated in several relevant medicinal chemistry projects, it is now an appropriate t

117 Finally, we calculated medicinal chemistry properties of benzenoid containing A

118 we offer a critical review of the published medicinal chemistry properties of CBD, as well as precis

119 O-trisubstituted hydroxylamines suitable for medicinal chemistry purposes in good to excellent yields

120 cient quantities of each target analogue for medicinal chemistry purposes.

121 Small molecule medicinal chemistry relies on iterative learning cycles

122 pective traces the decades long evolution of medicinal chemistry required to advance small molecule C

123 ide adaptation of this emerging reaction for medicinal chemistry requires a broad understanding of su

124 molecular entities which can be employed in medicinal chemistry research through diverse C-H activat

125 ost promising scaffold was optimized through medicinal chemistry resulting in enhanced potency and se

126 Recent high-throughput medicinal chemistry screens have identified multiple pro

127 ncluding coverage of the new developments in medicinal chemistry since 2015, and also endeavors to sp

128 e scaffold, which are also relevant from the medicinal chemistry standpoint.

129 However, SAM itself represents a poor medicinal chemistry starting point for a selective, cell

130 New medicinal chemistry strategies are being implemented to

131 hlight recent developments toward innovative medicinal chemistry strategies based on continuous flow

132 Inhibitor design and medicinal chemistry strategies for development of novel

133 In this report, we present various medicinal chemistry strategies that were used to increas

134 ified from a screen of 10k compounds and the medicinal chemistry strategies undertaken to progress th

135 Medicinal chemistry strategies used to derisk bioactivat

136 A previously untested medicinal chemistry strategy of deliberate file enrichme

137 Consequently, for decades medicinal chemistry studies aiming at developing skin de

138 ation make them useful prototypes for future medicinal chemistry studies.

139 innovative nanomaterials and applications in medicinal chemistry such as the development of protein-p

140 Using iterative cycles of medicinal chemistry synthesis and testing, we identified

141 ink predictive models can be integrated into medicinal chemistry synthesis workflows, how they are cu

142 allenges, particularly with attention to the medicinal chemistry that will be unavoidably required fo

143 host-based targets that can guide efforts in medicinal chemistry to discover new drugs for this devas

144 hat is broadly similar is a common method in medicinal chemistry to modulate the physical and biologi

145 d with an in silico support can be used as a medicinal chemistry tool to assist rational molecular de

146 of the use of chemical protein synthesis in medicinal chemistry with a special focus on the producti

147 cells have advanced and are now integral to medicinal chemistry workflows.

148 n-coupled receptors can be exploited through medicinal chemistry, a comparable pharmacological approa

149 es and disadvantages of the ethynyl group in medicinal chemistry, and (3) the impact of the ethynyl g

150 o, it only recently proved its usefulness in medicinal chemistry, as exemplified by the increasing nu

151 omplexes have recently found applications in medicinal chemistry, as well as in materials science.

152 hus creates opportunities across organic and medicinal chemistry, by enabling the wider exploration o

153 orinated pyrazoles play an important role in medicinal chemistry, drug discovery, agrochemistry, coor

154 ons (PPIs) remains an important challenge in medicinal chemistry, efforts have been made to mimic thi

155 bered rings, widespread motifs in nature and medicinal chemistry, have fascinated chemists ever since

156 For medicinal chemistry, it would be very useful to derive m

157 Through compound screening and medicinal chemistry, novel inhibitors of p300/CBP HAT wi

158 mple, combustion systems, material sciences, medicinal chemistry, planetary sciences, and biochemistr

159 we initiated an iterative program combining medicinal chemistry, structural biology, biochemical tes

160 view provides a timeline of PARP biology and medicinal chemistry, summarizes the pathophysiological p

161 earlier achievements in total synthesis and medicinal chemistry, we used chemical proteomics to iden

162 s is that between carbohydrate chemistry and medicinal chemistry, where there are equally many opport

163 ation of complex molecules is of interest in medicinal chemistry, wherein the preparation of structur

164 spectra in the optimization of compounds for medicinal chemistry, with particular application to the

165 Cyclobutane rings are important in medicinal chemistry, yet few enantioselective methods ex

166 sed bicyclic piperidines-building blocks for medicinal chemistry-is developed.

167 bly of various isotryptamine derivatives for medicinal chemistry.

168 n the female perspective within the field of medicinal chemistry.

169 his method for target molecule synthesis and medicinal chemistry.

170 with potential applications in synthesis and medicinal chemistry.

171 neurin and NFATc3, through computational and medicinal chemistry.

172 s frequently encountered within contemporary medicinal chemistry.

173 y step, emphasizing its potential utility in medicinal chemistry.

174 functional groups have thus far been rare in medicinal chemistry.

175 he molecule, form a foundation within modern medicinal chemistry.

176 the delivery of valuable building blocks for medicinal chemistry.

177 ines are ubiquitous materials in organic and medicinal chemistry.

178 of molecules to identify starting points for medicinal chemistry.

179 o a CF(2) H group would be of great value to medicinal chemistry.

180 ell with experimental properties relevant to medicinal chemistry.

181 e-based compounds are of great importance in medicinal chemistry.

182 significant applications in theoretical and medicinal chemistry.

183 e a versatile and unique functional group in medicinal chemistry.

184 oles, which are very important compounds for medicinal chemistry.

185 igh-value building blocks for application in medicinal chemistry.

186 re prolific synthons in natural products and medicinal chemistry.

187 s: a broad subset of compounds ubiquitous in medicinal chemistry.

188 cyclobutyl-spirooxindoles for direct use in medicinal chemistry.

189 l in various fields of materials science and medicinal chemistry.

190 e valuable substructures to be considered in medicinal chemistry.

191 duct identification and analysis, as well as medicinal chemistry.

192 nal scaffolds, which may find application in medicinal chemistry.

193 e functionalization of scaffolds relevant to medicinal chemistry.

194 dicinal Chemistry Letters and the Journal of Medicinal Chemistry.

195 important areas of research in the field of medicinal chemistry.

196 much attention due to their significance in medicinal chemistry.

197 e total synthesis of natural products and in medicinal chemistry.

198 nsequently, this versatile reactivity offers medicinal chemists a general strategy to rapidly prepare

199 Medicinal chemists are accountable for embedding the app

200 This raises a question: should medicinal chemists avoid making sulfonamide-containing c

201 pentanes (BCPs) have sparked the interest of medicinal chemists due to their recent discovery as bioi

202 We also highlight the opportunities for medicinal chemists in radiotracer development for bacter

203 In order to guide medicinal chemists into making more selective and potent

204 The training of new medicinal chemists is vital to the future of the field,

205 r questions that often present themselves to medicinal chemists optimizing their compounds for candid

206 tion compared with non-sulfonamides and that medicinal chemists should not avoid use of the sulfonami

207 ne focusing on recent cases in order to give medicinal chemists the full scope of this strategy which

208 ct provides a valuable synthetic roadmap for medicinal chemists to access a range of fluorinated ther

209 so highlights some of the strategies used by medicinal chemists to reduce DILI risk during the optimi

210 usually regarded as benign and often used by medicinal chemists when attempting to avoid bioactivatio

211 g coupling, is a valuable transformation for medicinal chemists, providing a modular disconnection fo

212 design, and serves as a navigation tool for medicinal chemists, structural and cell biologists explo

213 ding those of the former that are favored by medicinal chemists.

214 noxacin as a chemical template for inspiring medicinal chemists.

215 nsive overview of this important toolbox for medicinal chemists.

216 f creative tension between computational and medicinal chemists.

217 ave been established for the biosynthesis of medicinal compounds from plants.

218 ow (Salix spp.) is well known as a source of medicinal compounds, the most famous being salicin, the

219 and are among the most important targets of medicinal drugs.

220 ere remain considerable limitations to broad medicinal exploitation of the class due to lingering sci

221 cyclic terpenoid skeletons suitable to drive medicinal exploration.

222 Cannabis sativa is widely cultivated for medicinal, food, industrial, and recreational use, but m

223 urassavica (medicinal) and A. incarnata (non-medicinal) grown under ambient CO(2) (aCO(2) ) or eCO(2)

224 penoid lactone constituents of the important medicinal herb A. paniculata.

225 Muell is a medicinal herb widely used in India as a libido enhancer

226 dii and C. auriculatum, which are indigenous medicinal herbs in Korea and China, respectively.

227 lmetto) berries are one of the most consumed medicinal herbs in the United States and the wild green

228 yl-2-furfural (5HMF), a component of natural medicinal honeys, and three structurally related compoun

229 yl-2-furfural (5HMF), a component of natural medicinal honeys, blocks the ion conductance but not the

230 including for compounds of agricultural and medicinal importance, have now been discovered in plant

231 Owing to its immense medicinal importance, more well-designed in-vivo and cli

232 nes, which are of commercial, industrial and medicinal importance.

233 l plant with a long history of recreational, medicinal, industrial, and agricultural use, and togethe

234 While medicinal inorganic chemistry has been practised for ove

235 tivity, forms part of the backbone of modern medicinal inorganic chemistry research.

236 ding a route to novel molecules of potential medicinal interest.

237 The European medicinal leech has been used for medicinal purposes for

238 esent the first draft genome of the European medicinal leech, Hirudo medicinalis, and estimate that w

239 ng-term potentiation (LTP) in the CNS of the medicinal leech, Hirudo verbana, was examined, taking ad

240 rasite Ophryocystis elektroscirrha, and some medicinal milkweed (Asclepias) species, with high concen

241 However, monarchs feeding on medicinal milkweed grown under eCO(2) lose tolerance to

242 esponse of late-instar larvae was reduced on medicinal milkweed in comparison to non-medicinal milkwe

243 d on medicinal milkweed in comparison to non-medicinal milkweed.

244 Medicinal mushrooms, Coriolus versicolor and Lentinus ed

245 sponsible for the fruity, green, flowery and medicinal notes.

246 cancer bioactivities in plants with no known medicinal pedigree and it will have applications in deve

247 ons, we developed a systematic procedure for medicinal phage isolation, liter-scale cultivation, conc

248 ect incubation of leaf explants from the non-medicinal plant Arabidopsis thaliana with human breast c

249 The antimutagenicity of an extract from the medicinal plant Asclepias subulata (ASE) against heteroc

250 s two OMTs involved in BIA metabolism in the medicinal plant N. nucifera.

251 dostachys jatamansi, a critically endangered medicinal plant of alpine Himalayas.

252 We identified 16 medicinal plant species used by traditional healers for

253 salutaris) is one of the most highly valued medicinal plant species worldwide.

254 rom the fruits of Schinus terebinthifolia, a medicinal plant used for the traditional treatment of sk

255 Moringa oleifera is an edible medicinal plant used to fight malnutrition in Africa.

256 ng C.A. Meyer, which is a traditional Korean medicinal plant used to treat for muscle weakness.

257 Peppermint is widely used medicinal plant with distinguished bioactive potential,

258 imalayan paris (Paris polyphylla), a monocot medicinal plant with hemostatic and antibacterial proper

259 ithania somnifera, a high value multipurpose medicinal plant, is a rich reservoir of structurally div

260 used in a well-fulfilled production of this medicinal plant.

261 Senna tora is a widely used medicinal plant.

262 We characterized the microbiome of medicinal plants (Matricaria chamomilla L. and Calendula

263 Medicinal plants are a prolific source of natural produc

264 Numerous medicinal plants are suffering from wildcrafting, and th

265 ormation of secondary plant metabolite(s) in medicinal plants depends on several factors and in this

266 eae of magnoliids, is one of the most famous medicinal plants in Eastern China.

267 Rhubarb) is one of the most important edible medicinal plants in the Eastern Anatolia region and is c

268 the potential therapeutic efficacy of these medicinal plants in the Greater Mpigi region used for in

269 ived therapeutics are isolated directly from medicinal plants or plant cell culture(1).

270 ntly transferred from difficult-to-cultivate medicinal plants to a tobacco plant production chassis,

271 Lamiaceae family is among the most important medicinal plants, and its seed fatty acid (FA) compositi

272 ctive anthraquinone biosynthesis pathways in medicinal plants.

273 bioactive compounds, which occur in food and medicinal plants.

274 synthetic pathways of bioactive compounds in medicinal plants.

275 Following withdrawal of the investigational medicinal product (IMP), 25 of the 28 participants were

276 Use of cell-based medicinal products (CBMPs) represents a state-of-the-art

277 Medicinal products based on autologous HSPCs corrected u

278 nd Drug Administration and the Committee for Medicinal Products for Human Use of the European Medicin

279 Diagnostic allergens are defined as medicinal products in the EU.

280 eae) and is recognized for its wide range of medicinal properties and potential applications in human

281 cultivated and used around the globe for its medicinal properties for millennia(1).

282 or marijuana, has potential therapeutic and medicinal properties related to multiple compounds, part

283 he leaf its characteristic taste, aroma, and medicinal properties.

284 n, where it is popularly believed to possess medicinal properties.

285 e European medicinal leech has been used for medicinal purposes for millennia, and continues to be us

286 Cannabinoid production for medicinal purposes has renewed interest in utilizing byp

287 d engineering microbiota for agricultural or medicinal purposes.

288 valuable tools to assess the biological and medicinal relevance of individual proteasome active site

289 sulfur (S) speciation analysis in edible and medicinal Se enriched P. pulmonarius extracts was perfor

290 intermediate in the biosynthetic pathway of medicinal TAs such as scopolamine, from simple carbon an

291 could serve for the rational development of medicinal TDP1 inhibitors.

292 scientists working in a range of areas from medicinal to materials chemistry.

293 e plant that has regained its importance for medicinal use.

294 We summarise the evidence for medicinal uses of opioids, harms related to the extramed

295 of many natural products that have important medicinal utility.

296 mbo nucifera) is an ancient aquatic plant of medicinal value because of antiviral and immunomodulator

297 o impact human health, it is likely that the medicinal value of Echinacea is influenced by cultivatio

298 are well recognized for their nutritive and medicinal value worldwide, albeit their chemical profile

299 ts, such as seeds, have both nutritional and medicinal value.

300 , and many of them have horticultural and/or medicinal value.