ライフサイエンスコーパス: medullary

1 1 malignant FNA, 5 oncocytic/Hurthle cell, 2 medullary, 1 follicular, and 4 metastases from underlyin

2 ced V-ATPase apical membrane accumulation in medullary A-ICs but not in cortical A-ICs or other IC su

3 Our study shows that medullary A-ICs respond to luminal adenosine through ADO

4 nsepithelial resistance, and defective renal medullary accumulation of sodium and other osmolytes.

5 -pituitary-adrenal axis, sympathetic adrenal-medullary activation and catecholamine levels, the infla

6 Reconstructions reveal that many trans-medullary-afferents (TmAs) connect the eye with each LGM

7 e targeting of RET and BRAF in patients with medullary and anaplastic thyroid cancers, respectively.

8 other, more rare subtypes of thyroid cancer-medullary and anaplastic-are ideally treated by physicia

9 of the sympathetic nervous system, expanded medullary and extramedullary hematopoiesis.

10 n of SLAMF7-CAR T cells led to resolution of medullary and extramedullary myeloma manifestations in a

11 rons in the medial aspect of the superficial medullary and spinal dorsal horn from the trigeminal sub

12 g pyelonephritis based on renal cortical and medullary apparent diffusion coefficient (ADC) values.

13 d into the preBotzinger complex (preBotC), a medullary area that is critical for breathing.

14 eses that in conditions of MeCP2 deficiency, medullary astrocytes are unable to produce/release appro

15 (ii) MeCP2 deficiency impairs the ability of medullary astrocytes to sense changes in PCO2/[H(+) ].

16 tude of CO2 -induced [Ca(2+) ]i responses in medullary astrocytes was markedly reduced in conditions

17 MA) expression, and a 75% reduction in renal medullary atrophy in mice subjected to unilateral ureter

18 ice with normal angiopoietin-Tie2 signaling, medullary AVR exhibited an unusual hybrid endothelial ph

19 servations highlight not only the ability of medullary B cells to influence blood cell production, bu

20 Increases in medullary blood flow and decreases in distal tubule sodi

21 some also prevented the secondary decline in medullary blood flow and ischemia that develops 2 hours

22 ctive role in renal IR injury by maintaining medullary blood flow and that a genetic deficiency in th

23 ses in blood pressure did not increase renal medullary blood flow, tubular sodium reabsorption was no

24 ncing lithium clearance, but did not restore medullary blood flow.

25 Medullary bone (MB), an estrogen-dependent reproductive

26 r knowledge, no other occurrence of Mesozoic medullary bone is associated with indications of reprodu

27 he femur preserves small amounts of probable medullary bone, a tissue found today only in reproductiv

28 ning REM sleep is located in the pontine and medullary brainstem and includes ascending and descendin

29 atory muscle, and in patients with defective medullary breathing pattern generators.

30 nce of Wnt7b signaling, the periureteric bud medullary capillaries displayed narrower lumens lined wi

31 ing and the ureteric bud epithelium in renal medullary capillary development.

32 Renal medullary carcinoma (RMC) is a highly lethal malignancy

33 Renal medullary carcinoma (RMC) is a rare and deadly kidney ca

34 ndocrine glands-like C cells of the thyroid (medullary carcinoma), the parasympathetic and sympatheti

35 eir lowest values in mucinous, papillary and medullary carcinomas, whereas the highest values were fo

36 vealed the presence of an abscess within the medullary cavity consistent with a subacute form of hema

37 st PSB-0739 in primary cultures of rat inner medullary CD cells potentiated the expression of AQP2 an

38 iption 3 phosphorylation in hypothalamic and medullary centers, whereas intraperitoneal leptin had no

39 ine and norepinephrine released from adrenal medullary chromaffin cells and norepinephrine released l

40 P levels in cell lysates prepared from inner medullary collecting duct (IMCD) suspensions.

41 Mice lacking the inner medullary collecting duct (IMCD) urea transporter A1 (UT

42 n regulates NO production in the renal inner medullary collecting duct (IMCD), the segment with the g

43 hibition of p38MAPK activity in murine inner medullary collecting duct 3 (mIMCD3) cells decreased exp

44 (PI3K-C2alpha) in renal tubule-derived inner medullary collecting duct 3 cells and show that PI3K-C2a

45 genetic knockdown of TRIP13 in murine inner medullary collecting duct cells in the presence of hydro

46 ctivation of potential target genes in inner medullary collecting duct cells.

47 tuents inhibit HCO(3) transport in the outer medullary collecting duct from the inner stripe (OMCDi)

48 s from the proximal tubule through the inner medullary collecting duct of rat kidneys.

49 ely integrated into the aquaporin 2-positive medullary collecting duct when microinjected into the ki

50 ubule and decreased slightly in the cortical/medullary collecting duct, whereas BK channel abundance

51 onate exchanger expressed in the renal outer medullary collecting duct.

52 urine ciliated epithelial cells of the inner medullary collecting duct.

53 nts with the highest expression in the inner medullary collecting duct.

54 We employed proteomic analysis of inner medullary collecting ducts (IMCD) from rats fed with a p

55 de use of primarily cultured rat renal inner medullary collecting-duct cells and microarray analysis

56 to expand and contract along a rostrocaudal medullary column during behavioral or metabolic challeng

57 artment kidney phantom (70% cortical and 30% medullary compartment), a sphere, and an ellipsoid of eq

58 TECs and in addition affects the size of the medullary compartment, TEC-specific HIPK2 deletion only

59 nt, where quiescent follicles reside and the medullary compartment, where the larger follicles grow a

60 s sensed higher concentrations of S1P in the medullary cords than in the T cell zone and that the S1P

61 omplete SCI, we created bilaterally complete medullary corticospinal tract lesions in adult mice, eli

62 utosomal dominant polycystic kidney disease, medullary cystic kidney disease, diabetic nephropathy, o

63 cells of a patient affected with progressive medullary cystic kidney disease.

64 Medullary deletion events were detected at both the semi

65 We also found that both cortical and medullary deletion rely heavily on CD28 costimulation.

66 ucleus complex, and central sensitization of medullary dorsal horn neurons is a critical factor in mu

67 ters by projection neurons in the spinal and medullary dorsal horn.

68 euronal detection thresholds at the level of medullary electrosensory neurons, it seems that the beha

69 Mechanisms promoting thymocyte medullary entry and interactions with APCs are incomplet

70 microscopy to demonstrate that CCR4 promotes medullary entry of the earliest post-positive selection

71 vation with 5-thioglucose stimulated adrenal medullary epinephrine (Epi) release (3,153%) and feeding

72 whose expression and presentation by thymic medullary epithelial cells (mTECs) is controlled predomi

73 alysis of Aire-sufficient and Aire-deficient medullary epithelial cells (mTECs).

74 rent types of epithelial cells: cortical and medullary epithelial cells.

75 To further define mTEC development and medullary epithelial lineage relationships, we combined

76 diated control of migration, we propose that medullary epithelium and dendritic cells collectively en

77 d CD40-CD40L pathways is required for normal medullary epithelium and for maintenance of self-toleran

78 ssion of tissue-specific genes in the thymic medullary epithelium.

79 iesces, thereby impairing maintenance of the medullary epithelium.

80 Here we examine the medullary expression of sst2a with particular reference

81 d chemogenetic manipulations showed that the medullary GABAergic neurons also promote NREM sleep, and

82 t histological damages, delayed cortical and medullary Gadolinium elimination (perfusion), and reduce

83 owed a 14-24 fold increase from baseline for medullary GRP78, sXBP-1, and CHOP.

84 Medullary hyperosmolarity is protected from washout by c

85 Medullary hypoxia due to intrarenal blood flow redistrib

86 ll mice was markedly increased, resulting in medullary hypoxia.

87 ependent protein phosphorylation in purified medullary ICs that were isolated from mice.

88 hat adenosine activates V-ATPase in isolated medullary ICs.

89 cal deficit that was attributable to lateral medullary infarction.

90 een ADGRV1 and GRIK2 in substantia nigra and medullary inferior olivary nucleus, and between ADGRV1 a

91 giant cell reaction (60%), and cortical and medullary inflammation (95% and 75%, respectively).

92 Medullary inflammation, giant cell reaction, and the ext

93 Here we investigate whether neurons in the medullary intermediate reticular nucleus (IRt) are compo

94 e mice, an effect accompanied by a hypotonic medullary interstitium and impaired countercurrent multi

95 The hyperosmolality in the renal medullary interstitium is of major importance as a drivi

96 al reabsorption of water into the hypertonic medullary interstitium mediated by collecting ducts.

97 rapid accumulation of fluid and cysts in the medullary interstitium, loss of medullary vascular bundl

98 s canonical Wnt signaling in the surrounding medullary interstitium, where the capillaries reside.

99 ith predominant involvement of glomeruli and medullary interstitium.

100 ) mTEC were randomly dispersed within thymic medullary islands.

101 CXCR3, aberrantly accumulate at the cortico-medullary junction and subsequently fail to sustain AIRE

102 ne-independent activation of the renal outer medullary K(+) channel and ENaC, to which angiotensin II

103 iets induced upregulation of the renal outer medullary K(+) channel in AS(-/-) mice, whereas upregula

104 s, epidermal progenitors generate cortex and medullary keratinocytes, guided by Bmp and transforming

105 and unveils a previously undefined role for medullary LECs in human immunity.

106 All patients showed a new medullary lesion on brain magnetic resonance imaging.

107 s to positions adjacent to both cortical and medullary lymphatic sinuses where the T cells exhibited

108 age commitment and positive selection, while medullary (m) TECs impose central tolerance on the T cel

109 vant MF59 localizes in subcapsular sinus and medullary macrophage compartments of mouse draining LNs,

110 CD169(+) SIGNR1(+) subcapsular medullary macrophages are the primary cells to take up G

111 the development and functional importance of medullary microenvironments during self-tolerant T-cell

112 ire are involved in the regulation of thymus medullary microenvironments.

113 indicate that a functional compromise of the medullary mTEC(high) compartment may link alloimmunity t

114 and micropapillary carcinomas); and group C (medullary, mucinous and papillary carcinomas).

115 chromophobe (n = 5), papillary (n = 5), and medullary (n = 2) RCC and unclassified RCC (uRCC, n = 23

116 mmunoblotting revealed downregulation of the medullary Na(+)-K(+)-2Cl(-) cotransporter NKCC2 in these

117 ain AIRE expression in the medulla, escaping medullary negative selection.

118 ation between chronic hyperaldosteronism and medullary nephrocalcinosis has rarely been made, with on

119 a long- standing history in whom associated medullary nephrocalcinosis was established.

120 s a causal factor in the etiopathogenesis of medullary nephrocalcinosis.

121 identification of a discrete JAG1(+) thymic medullary niche enriched for DC-lineage cells expressing

122 in multiple cortical areas, and thalamic and medullary nuclei.

123 urn, the PAG has strong access to the caudal medullary nucleus retroambiguus (NRA).

124 (Grhl2(CD-/-)), which display reduced renal medullary osmolality.

125 to mammalian water balance and depends on a medullary osmotic gradient generated by a countercurrent

126 cal oxygenation and perfusion, but decreased medullary oxygenation and perfusion.

127 3 to 36.3 +/- 3.5 mm Hg (p < 0.001), whereas medullary oxygenation decreased from 29.6 +/- 4.7 to 13.

128 The improvement in medullary oxygenation dissipated following the third flu

129 Jugular vagal inputs to SubM via the medullary paratrigeminal nucleus were confirmed using an

130 %) and cortical perfusion (+25% +/- 4%), but medullary perfusion (-48% +/- 5%), medullary PO2 (-56% +

131 Stenotic kidney cortical/medullary perfusion and RBF were measured using contrast

132 perfusion was not significantly changed, but medullary perfusion decreased (671 BPU [500-900 BPU] to

133 However, the pressure dependence of medullary perfusion was not restored, suggesting persist

134 The pressure dependence of renal medullary perfusion, considered a key factor in the inte

135 mic accumulation of mature thymocytes within medullary perivascular spaces and reduced numbers of rec

136 he absence of histodifferentiated cortex and medullary pith of the rachis and barb rami.

137 245% +/- 65%), cardiac output (+11% +/- 2%), medullary PO2 (+280% +/- 90%), urinary PO2 (+164% +/- 80

138 4%), but medullary perfusion (-48% +/- 5%), medullary PO2 (-56% +/- 4%), and urinary PO2 (-54% +/- 3

139 rapy transiently improved renal function and medullary PO2, as also reflected by increased urinary PO

140 y, urinary PO2 correlated significantly with medullary PO2.

141 ition of the potassium-excretory renal outer medullary potassium (ROMK) channel have also been implic

142 The renal outer medullary potassium (ROMK) channel is a member of the in

143 The renal outer medullary potassium (ROMK) channel is essential for pota

144 me is caused by mutations in the renal outer medullary potassium (ROMK) channel, but the molecular me

145 elial sodium channel (ENaC), the renal outer medullary potassium channel (ROMK), and other transport

146 The renal outer medullary potassium channel (ROMK, or Kir1.1, encoded by

147 A, SUR1B, SUR2A, SUR2B, or ROMK (renal outer medullary potassium channel).

148 epithelial sodium channel-alpha, renal outer medullary potassium channel, and Na(+), K(+)-ATPase in t

149 on functional expression of the renal outer medullary potassium channel.

150 The medullary pre-Botzinger complex (preBotC) and the pontin

151 at changes in the electrical excitability of medullary pre-sympathetic neurones are the main causal m

152 Concomitantly, a medullary precursor cell quiesces, thereby impairing mai

153 on of both AQP2 and pAQP2 in the renal inner medullary principal cells appeared more dispersed, and t

154 increased InCO(2) increased IL-1beta in the medullary raphe (MR), ventral respiratory column, and cu

155 us (RTN) and serotonin (5-HT) neurons in the medullary raphe have both been proposed to be central re

156 lamic nucleus [PaMP]) and autonomic (rostral medullary raphe pallidus [RPa]) responses were targeted

157 inase drivers targeted different portions of medullary raphe serotonergic, tryptophan hydroxylase 2 (

158 Medullary raphe transcriptome comparisons revealed lower

159 pontine and midbrain vestibular nuclei, and medullary raphe.

160 m several respiratory centres, including the medullary raphe.

161 (vertical phloem and inter-connected radial medullary rays [MR]).

162 g in the pre-Botzinger complex (pre-BotC), a medullary region generating the inspiratory phase of bre

163 These mice lacked a thymic medullary region, exhibited thymocyte retention, had a p

164 cluding the rostral and caudal ventrolateral medullary regions (RVLM and CVLM, respectively).

165 of spindle-shaped cells in both cortical and medullary regions of the kidney.

166 ) has previously been identified as an extra-medullary reservoir for normal hematopoietic stem cells

167 We examine here the features of these medullary resident cells and their roles in T cell toler

168 cytes to act as acute hypoxia sensors in the medullary respiratory center.

169 d apnea, indicating that invasion of SD into medullary respiratory centers initiated apnea and hypoxi

170 nimals with MeCP2 removed from specific pons medullary respiratory circuits, we performed whole-body

171 nctional connection between the amygdala and medullary respiratory network in humans.

172 esults indicate that MeCP2 expression in the medullary respiratory network is sufficient for normal r

173 e from lumbar locomotor CPG circuitry to the medullary respiratory networks that is able to depolariz

174 lterations in the electrical excitability of medullary respiratory neurones and their central modulat

175 Lower medullary RO(2):GFR was associated with lower M/I (r = 0

176 lox) kidneys showed more cell death in outer medullary S3 segments at 2 hours but less tubular damage

177 NMDA receptor antagonists prevented medullary SD and apnea, which may be of translational va

178 We show that brainstem seizure-related medullary SD is followed by local hypoxia and recovers d

179 rons of the retrotrapezoid nucleus (RTN) and medullary serotonin (5-HT) neurons are both candidates f

180 lized to the thymic medulla, suggesting that medullary signals might instruct NKT2 cells to produce I

181 il chemoattractants, whereas LECs lining the medullary sinus (MS) expressed a C-type lectin CD209.

182 adult LECs decreased the network of SSMs and medullary sinus macrophages (MSMs).

183 ressive increase of neuronal excitability in medullary slices containing the pre-BotC produces mixed-

184 Indeed, in medullary slices from neonatal mice, the mu-opioid recep

185 We used rhythmically active medullary slices from wild-type (WT) and Lmx1b(f/f/p) ne

186 resent an opportunity to evaluate the entire medullary space non-invasively, yielding information abo

187 ts a significantly higher rate of unspecific medullary spots (P = 0.0006).

188 pithelial morphology is under the control of medullary stromal signals, revealing a previously unreco

189 cell autonomous role in the development of a medullary subset of the interstitium and that this non-a

190 a from an optical probe positioned above the medullary surface and hypoglossal motor nucleus elicited

191 ein, we evaluated the involvement of ventral medullary sympatho-excitatory catecholaminergic C1 neuro

192 heart rate variability (sympathetic adrenal medullary system), EEG event-related potentials (nocicep

193 and spinal sensory processing, including the medullary targets of the endogenous analgesia system, an

194 oid Association intermediate, high-risk, and medullary TC were positive whereas all MT- malignancies

195 s of p53 primarily disrupts the integrity of medullary TEC (mTEC) niche, a defect that spreads to the

196 1 target genes and delayed maturation of the medullary TEC compartment in nu/+ mice.

197 a crucial transcription factor implicated in medullary TEC function.

198 ression of thymotropic chemokines, decreased medullary TEC to cortical TEC ratios, and altered thymic

199 In mature medullary TEC, AIRE-driven pGE upregulates non-TRA codin

200 antigens or presenting a neo-self-antigen by medullary TECs, displaying decreased negative selection-

201 The medullary thick ascending limb (mTAL) plays a key role i

202 (2+)]i oscillations were markedly reduced in medullary thick ascending limbs isolated from P2Y2 recep

203 nd type II taste cells to ex-Aire-expressing medullary thymic cells and small-intestine cells that me

204 thymocytes, and expression of its ligands by medullary thymic dendritic cells (DCs).

205 The cortical and medullary thymic epithelial cell (cTEC and mTEC) lineage

206 Here we examine medullary thymic epithelial cell (mTEC) heterogeneity an

207 o-step terminal differentiation model of the medullary thymic epithelial cell (mTEC) lineage from imm

208 sting of a branching structure that contains medullary thymic epithelial cell (mTEC) networks to supp

209 ism, we have previously reported that mature medullary thymic epithelial cells (mTEC(high)) expressin

210 Both medullary thymic epithelial cells (mTEC) and dendritic c

211 To induce central T-cell tolerance, medullary thymic epithelial cells (mTEC) collectively ex

212 Medullary thymic epithelial cells (mTEC) contribute to t

213 ize the developmental pathways that generate medullary thymic epithelial cells (mTEC) from their imma

214 In the thymus, medullary thymic epithelial cells (mTEC) regulate T cell

215 c APCs capable of mediating deletion, namely medullary thymic epithelial cells (mTECs) and dendritic

216 ulate transcription of a battery of genes in medullary thymic epithelial cells (mTECs) and, consequen

217 Medullary thymic epithelial cells (mTECs) eliminate self

218 of tissue-restricted self antigens (TRAs) in medullary thymic epithelial cells (mTECs) is essential f

219 roles for bone marrow (BM)-derived APCs and medullary thymic epithelial cells (mTECs) on the convent

220 Medullary thymic epithelial cells (mTECs) play a critica

221 plethora of tissue-restricted Ags (TRAs) by medullary thymic epithelial cells (mTECs) plays an essen

222 In medullary thymic epithelial cells (mTECs), the Autoimmun

223 Autoimmunity is largely prevented by medullary thymic epithelial cells (TECs) through their e

224 First, we increase medullary thymic epithelial cells by using mice lacking

225 Strikingly, medullary thymic epithelial cells expressing the autoimm

226 r of surface MHC-self peptide complexes from medullary thymic epithelial cells to thymic DC.

227 nity by promoting self-antigen expression in medullary thymic epithelial cells, such that developing

228 Unlike medullary thymic epithelial cells, which express and pre

229 ngly autoimmune regulator-expressing, mature medullary thymic epithelial cells, which play a pivotal

230 cells, cortical thymic epithelial cells, and medullary thymic epithelial cells.

231 a transcription factor which is expressed in medullary thymic epithelial cells.

232 xpression, particularly in keratinocytes and medullary thymic epithelial cells.

233 ssues of patients with APECED, especially in medullary thymic epithelial cells.

234 a key role in the self-antigen expression in medullary thymic epithelial cells.

235 ugh RANK in a manner that depends on AIRE(+) medullary thymic epithelial cells.

236 ession of tissue-restricted self-antigens in medullary thymic epithelial cells.

237 n of Bim during early/cortical, but not late/medullary, thymic development controls the agonist selec

238 s, as well as efficient interactions between medullary thymocytes and DCs.

239 ytes exhibit a stochastic migration, whereas medullary thymocytes show confined migratory behavior.

240 were located in the medulla and conditioned medullary thymocytes.

241 Familial medullary thyroid cancer (MTC) and its precursor, C cell

242 Medullary thyroid cancer (MTC) can be caused by germline

243 ng chemicals targeting a Drosophila model of Medullary Thyroid Cancer (MTC) characterized by a transf

244 Patients with metastatic medullary thyroid cancer (MTC) have limited systemic tre

245 e III trial involving patients with advanced medullary thyroid cancer (MTC) to assess the efficacy an

246 ttee on Cancer (AJCC) TNM staging system for medullary thyroid cancer (MTC).

247 tumors including small cell lung cancer and medullary thyroid cancer (MTC).

248 Medullary thyroid cancer arises from calcitonin-producin

249 ycaemia, pancreatitis, pancreatic cancer, or medullary thyroid cancer reported between GLP-1 receptor

250 The discovery of a locally advanced medullary thyroid cancer that is not amenable to surgery

251 In 88 patients with RET-mutant medullary thyroid cancer who had not previously received

252 secutively enrolled patients with RET-mutant medullary thyroid cancer who had previously received van

253 nly low-grade toxic effects in patients with medullary thyroid cancer with and without previous vande

254 ment and treatment of patients with advanced medullary thyroid cancer with emphasis on current target

255 We enrolled patients with RET-mutant medullary thyroid cancer with or without previous vandet

256 s cabozantinib (FDA-approved for progressive medullary thyroid cancer) and PF-04217903 block their ac

257 from a genome-wide association study of non-medullary thyroid cancer, including in total 3,001 patie

258 CALCA, a biomarker for medullary thyroid cancer, was hypersecreted in metastati

259 Knockdown of RET by shRNA in medullary thyroid cancer-derived cells stimulated expres

260 tient (0.6%) died from incidentally detected medullary thyroid cancer.

261 MET in addition to VEGFR and is approved for medullary thyroid cancer.

262 ctivation of ATF4 during the pathogenesis of medullary thyroid cancer.

263 docrine neoplasia type 2 as well as sporadic medullary thyroid cancer.

264 nts that are approved for differentiated and medullary thyroid cancers have prolonged progression-fre

265 t breast cancers, non-Hodgkin lymphomas, and medullary thyroid cancers represent novel indications fo

266 One of 5 medullary thyroid cancers was positive with the agonist,

267 RET mutations occur in 70% of medullary thyroid cancers, and RET fusions occur rarely

268 t frequently mutated malignant subtypes were medullary thyroid carcinoma (9/12, 75%) and PTC (14/30,

269 nase, are associated with the development of medullary thyroid carcinoma (MTC) and pathogenesis of mu

270 Medullary thyroid carcinoma (MTC) is a neuroendocrine tu

271 Treatment of patients with advanced medullary thyroid carcinoma (MTC) is still a challenge.

272 Sequencing for Familial Colon Cancer Genes, Medullary Thyroid Carcinoma (MTC) Surveillance Study, Os

273 efines these 2 phenotypes is the presence of medullary thyroid carcinoma (MTC).

274 d peptides labeled with (111)In or (131)I in medullary thyroid carcinoma (MTC).

275 nical management of patients with metastatic medullary thyroid carcinoma and other CCK2R-expressing m

276 ilar expression pattern was recapitulated in medullary thyroid carcinoma cells in vivo, consistent wi

277 onal activation of mutated RET gene in human medullary thyroid carcinoma TT cells.

278 uals (2 patients died of causes unrelated to medullary thyroid carcinoma).

279 ce of acute pancreatitis, pancreatic cancer, medullary thyroid carcinoma, and serious adverse events

280 l in patients with progressive or metastatic medullary thyroid carcinoma, as well as other advanced-s

281 We also assessed remission of medullary thyroid carcinoma, incidence and treatment of

282 germline RET mutation, and characterised by medullary thyroid carcinoma, phaeochromocytoma, and extr

283 ives were to determine overall survival, and medullary thyroid carcinoma-specific survival based on w

284 Medullary thyroid carcinoma-specific survival curves did

285 ogene and virtually all of them will develop medullary thyroid carcinoma.

286 L881V) mutation previously found in familial medullary thyroid carcinoma.

287 ressed in various human cancers (e.g., lung, medullary thyroid, pancreatic, colon, and gastrointestin

288 normal sheep, resting levels of cortical and medullary tissue PO2 were 29.5 +/- 4.4 and 29.1 +/- 4.3

289 In one model, approximately one-third of medullary Tph2(+) neurons are silenced by postnatal (P)

290 in the other, approximately three-fourths of medullary Tph2(+) neurons, also with some Tph2(low or ne

291 ng autophagic defects in epithelial cells of medullary tubules.

292 t majority of thyroid cancers are of the non-medullary type.

293 patients with Lynch syndrome develop a rare "medullary" variant of adenocarcinoma, intraductal papill

294 cysts in the medullary interstitium, loss of medullary vascular bundles, and decreased urine concentr

295 rast and to microscale visualization of deep medullary vasculature and neuronal perikarya.

296 We identify multiple subsets, including a medullary venous population whose gene signature predict

297 s, larger cortical nephron size, and smaller medullary volume in healthy donors modestly predict deat

298 n size (but not nephron number), and smaller medullary volume.

299 We measured cortical and medullary volumes, perfusion, and RBF using multidetecto

300 ation of the prohemocytes located within the medullary zone and the secondary lobes of the lymph glan