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1 neage representation, including erythro- and megakaryopoiesis.
2 uired for both definitive erythropoiesis and megakaryopoiesis.
3 thropoiesis but permitted granulopoiesis and megakaryopoiesis.
4 for hematopoietic stem cell maintenance and megakaryopoiesis.
5 verexpression of GATA-2 facilitates aberrant megakaryopoiesis.
6 sion was able to limit the effects of PF4 on megakaryopoiesis.
7 this receptor's importance in PF4's role in megakaryopoiesis.
8 d overexpression of ETS proteins in aberrant megakaryopoiesis.
9 pa J region (RBPJ) and caused abnormal fetal megakaryopoiesis.
10 LRP1, which is transiently expressed during megakaryopoiesis.
11 suggesting FLI1 negatively regulates ETS1 in megakaryopoiesis.
12 disorders that shed light on the process of megakaryopoiesis.
13 -) mice manifested splenomegaly and abnormal megakaryopoiesis.
14 n of the alphaIIb gene at high levels during megakaryopoiesis.
15 erentiation in vitro, but absent during late megakaryopoiesis.
16 or -2 as part of its essential role in early megakaryopoiesis.
17 vel role of PI3K and PKCzeta in steady-state megakaryopoiesis.
18 ms have distinct and specific roles in adult megakaryopoiesis.
19 at they may be regulated coordinately during megakaryopoiesis.
20 ion, demonstrating that CBFA2 dosage affects megakaryopoiesis.
21 e at once several Sp1-dependent genes during megakaryopoiesis.
22 ly to share common regulatory domains during megakaryopoiesis.
23 hematopoietic growth factor that stimulates megakaryopoiesis.
24 s receptor (MPL) are important regulators of megakaryopoiesis.
25 the c-Mpl receptor, is a major regulator of megakaryopoiesis.
26 fects of thrombopoietin on these measures of megakaryopoiesis.
27 ion of pDCs by SARS-CoV-2 leads to excessive megakaryopoiesis.
28 ulated and skewed hematopoiesis toward myelo-megakaryopoiesis.
29 s accounted for the shift of function during megakaryopoiesis.
30 act with TAL-1, a host protein important for megakaryopoiesis.
31 ocytopenia, and (3) a novel role for XPO1 in megakaryopoiesis.
32 ith their function as homeostatic sensors of megakaryopoiesis.
33 ed increased platelet counts and bone marrow megakaryopoiesis.
34 at 4 different loci of PEAR1 during in vitro megakaryopoiesis.
35 ing with their generation via the process of megakaryopoiesis.
36 omprehensive and definitive understanding of megakaryopoiesis.
37 te, thus contributing little to steady-state megakaryopoiesis.
38 -HPA-1a antibodies (F/NAIT sera) on in vitro megakaryopoiesis.
39 g an explanation for the observed defects in megakaryopoiesis.
40 stinct critical stages of erythropoiesis and megakaryopoiesis.
41 further reveal that miR-142 is critical for megakaryopoiesis.
42 five transcription factors key in regulating megakaryopoiesis.
43 scription factor complex required for normal megakaryopoiesis.
44 study, we demonstrate a role for VEGFR-3 in megakaryopoiesis.
45 isms underlying MkP biology and more broadly megakaryopoiesis.
46 suggesting a regulatory role for VEGFR-3 in megakaryopoiesis.
47 rrode the inhibitory effects of forskolin on megakaryopoiesis.
48 yte, and is specifically up regulated during megakaryopoiesis.
49 energic-receptor(AR)-interleukin-6-dependent megakaryopoiesis.
50 differences between fetal/neonatal and adult megakaryopoiesis.
51 hematopoietic progenitor cell expansion and megakaryopoiesis.
52 astic leukemia, and plays a critical role in megakaryopoiesis.
53 xpression of miR-146a has minimal effects on megakaryopoiesis.
54 TL1 and SGK2 dysregulated erythropoiesis and megakaryopoiesis, 2 lineages commonly affected in chroni
55 tic stem/progenitor cells were primed toward megakaryopoiesis, accompanied by expanded megakaryocyte-
56 termediate progenitor populations in erythro-megakaryopoiesis, allowing for in-depth study of disorde
57 d in the bone marrow and spleen, with normal megakaryopoiesis and absence of myelofibrosis in histopa
58 ropose miR-125b-2 as a positive regulator of megakaryopoiesis and an oncomiR involved in the pathogen
60 nstrate an in vivo requirement for ZBP-89 in megakaryopoiesis and definitive erythropoiesis but not p
61 rated profound defects in erythropoiesis and megakaryopoiesis and deregulated expression of RUNX1 tar
62 uence of overexpression of c-myc oncogene on megakaryopoiesis and endomitosis in vivo, using transgen
63 ough MLL3/4 double deficiency does not alter megakaryopoiesis and endomitosis, the final step of mega
66 Here, we investigated PAF-AH function during megakaryopoiesis and found that human CD34(+) cells accu
67 RUNX1 and FLI1, both important regulators of megakaryopoiesis and hematopoietic development, with sig
68 of the role of SDF-1 and TPO in normal human megakaryopoiesis and indicates the molecular basis of th
69 anding of PF4's negative paracrine effect in megakaryopoiesis and its potential clinical implications
71 providing insights into mechanisms of normal megakaryopoiesis and megakaryocytic abnormalities that a
72 ntiation, but also simultaneously suppresses megakaryopoiesis and myelopoiesis in primary human stem
73 t impaired erythroid potential, but enhanced megakaryopoiesis and myelopoiesis, recapitulating the ma
76 d to thrombopoietin, specifically stimulates megakaryopoiesis and platelet production and reduces the
80 ERK/AKT/CREB activation, driving a bias for megakaryopoiesis and platelet production without causing
84 ill increase our insight in the processes of megakaryopoiesis and proplatelet formation, and it may a
85 ifferentially regulated miRNAs during murine megakaryopoiesis and provide a useful new dataset for he
86 e findings reveal a unique role for STAT1 in megakaryopoiesis and provide new insights into how GATA-
87 ions establish a critical role for GATA-1 in megakaryopoiesis and raise the question as to how GATA-1
88 role of downstream mediators of NOTCH during megakaryopoiesis and report crosstalk between the NOTCH
89 DKN1A transcriptional axis in the control of megakaryopoiesis and reveal the lineage-selective inhibi
90 on pathway is required for regulating proper megakaryopoiesis and suggests that it is likely to funct
91 KZF5 is a novel transcriptional regulator of megakaryopoiesis and the eighth transcription factor ass
93 tant tool for the study of ex-vivo models of megakaryopoiesis and the production of functional platel
94 show that Cul5-deficient mice develop excess megakaryopoiesis and thrombocytosis revealing a novel me
95 standing of the mechanisms underlying normal megakaryopoiesis and thrombopoiesis that can inform effo
99 e to introduce the physiological pathways of megakaryopoiesis and to present landmark studies on acqu
100 ar level, the features of fetal and neonatal megakaryopoiesis are the result of a complex interplay o
101 iming, GATA2 plays an extensive role in late megakaryopoiesis as a transcriptional repressor at loci
102 s will be very useful for further studies of megakaryopoiesis as well as the elucidation of their gen
103 mal-derived factor 1 (SDF-1) in normal human megakaryopoiesis at the cellular and molecular levels an
105 eased myeloid differentiation and suppressed megakaryopoiesis because of increased activation of pros
106 pe zinc finger protein that is essential for megakaryopoiesis, binds to the amino-terminal finger of
108 s transcriptional complex regulates not only megakaryopoiesis but also alpha-granule generation and s
109 risomy of approximately 80% of Hsa21 perturb megakaryopoiesis but are insufficient to induce leukemia
111 1 mice resulted in a synergistic increase in megakaryopoiesis, but did not result in leukemia or a TM
112 et factor 4 (PF4) is a negative regulator of megakaryopoiesis, but its mechanism of action had not be
114 ed that Ikaros-deficient mice have increased megakaryopoiesis, but the molecular mechanism of this ph
115 al anti-HPA-1a antibodies can suppress fetal megakaryopoiesis by inducing early cell death and that t
118 ion of hematopoietic stem cells and enhanced megakaryopoiesis, demonstrating reduced LNK function and
120 f MDS in the mouse and re-establishes normal megakaryopoiesis, erythropoiesis, BM function, and perip
122 aryocytes in hematopoietic tissues, studying megakaryopoiesis heavily relies on the availability of a
125 d sustains progenitor cell proliferation and megakaryopoiesis in a TPO-independent fashion, inducing
128 Prior studies have shown that EP stimulates megakaryopoiesis in BM cells from patients with acute my
133 rescued multiple defects in Gata1-deficient megakaryopoiesis in mice, inducing polyploidization and
134 de a new paradigm for understanding aberrant megakaryopoiesis in MPNs and identify B4GalT1 as a poten
135 he cellular and molecular basis for aberrant megakaryopoiesis in myelofibrosis, we performed single-c
140 ta1 (TGFbeta1) pathway and rescued defective megakaryopoiesis in vitro, corrected the thrombopoietic
142 We have now examined whether PF4 regulates megakaryopoiesis in vivo by studying PF4 knockout mice a
146 he megakaryocyte lineage, several aspects of megakaryopoiesis, including progenitors, maturing megaka
148 data suggest that CIB1 plays a dual role in megakaryopoiesis, initially by negatively regulating TPO
154 he expression of megakaryocytic genes during megakaryopoiesis is controlled by specific transcription
159 These data demonstrate that Jak2 in terminal megakaryopoiesis is not required for PLT production, and
161 tal liver also refute early suggestions that megakaryopoiesis is unaffected by the absence of c-Myb.
162 d for HSC specification, erythropoiesis, and megakaryopoiesis, is a negative regulator of murine lymp
163 h progressively increases along normal human megakaryopoiesis, is decreased in platelets of patients
164 ation of Lyn kinase, a negative regulator of megakaryopoiesis, is severely attenuated in FAK-null meg
166 from four patients were used to investigate megakaryopoiesis, megakaryocyte morphology and platelet
167 in uncovering novel molecular mechanisms of megakaryopoiesis, modeling and correcting relevant disea
168 hese results demonstrate that the defects in megakaryopoiesis observed in FPD/AML are, in part, relat
179 ukemia virus (MPL), a key regulator of adult megakaryopoiesis, play in prenatal platelet-forming line
180 l role for Pak2 as an important regulator of megakaryopoiesis, polyploidization, and cytoskeletal dyn
181 maturity, the features of fetal and neonatal megakaryopoiesis reflect a developmentally unique uncoup
182 ontrast, Tpo-mediated activation of positive megakaryopoiesis regulators such as ERK1/2 and AKT is in
185 e to nestin-positive niche cells and reduces megakaryopoiesis, resulting in decrease of myelofibrosis
186 ey exhibit an exacerbated mafG deficiency in megakaryopoiesis, specifically in proplatelet formation,
187 may play a GATA-1-independent role in early megakaryopoiesis, suggesting that FOG proteins might act
188 sis toxin did not affect the peak of splenic megakaryopoiesis, supporting the hypothesis that these m
190 pathway of irreversible P-TEFb activation in megakaryopoiesis that is mediated by dissolution of the
191 ns may identify enhancer domains involved in megakaryopoiesis that may be useful in the selective exp
192 insight into regulators of hematopoiesis and megakaryopoiesis that would otherwise be unapparent and
193 nized role for DNM2-dependent endocytosis in megakaryopoiesis, thrombopoiesis, and bone marrow homeos
194 found that Pf4-Grin1-/- mice had defects in megakaryopoiesis, thrombopoiesis, and platelet function,
195 occurs independently of the key regulator of megakaryopoiesis thrombopoietin, and may occur during si
196 lineage potential between erythropoiesis and megakaryopoiesis uncovers differential fate commitment d
200 rmine whether Lyl1 can substitute for Scl in megakaryopoiesis, we examined the platelet phenotype of
201 investigate the role of calcineurin-NFAT in megakaryopoiesis, we examined wild-type mice treated wit
202 consequences of ETS protein misexpression on megakaryopoiesis, we expressed ETS2, ERG, and the relate
205 that forms a complex with RUNX1 to regulate megakaryopoiesis, whereas MYH10 persistence was not obse
206 fic requirement for the P1-RUNX1C isoform in megakaryopoiesis, which cannot be entirely compensated f
207 anisms underlying developmental disorders of megakaryopoiesis, which either uniquely affect fetuses a
208 ombocytopenia and an increased extramedullar megakaryopoiesis with an enhanced proportion of prematur